WO2009069610A1 - 縮合インダン化合物 - Google Patents

縮合インダン化合物 Download PDF

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Publication number
WO2009069610A1
WO2009069610A1 PCT/JP2008/071370 JP2008071370W WO2009069610A1 WO 2009069610 A1 WO2009069610 A1 WO 2009069610A1 JP 2008071370 W JP2008071370 W JP 2008071370W WO 2009069610 A1 WO2009069610 A1 WO 2009069610A1
Authority
WO
WIPO (PCT)
Prior art keywords
nmda receptor
compound
antagonistic activity
indane compound
fused indane
Prior art date
Application number
PCT/JP2008/071370
Other languages
English (en)
French (fr)
Inventor
Satoshi Hayashibe
Shingo Yamasaki
Nobuyuki Shiraishi
Hiroaki Hoshii
Takahiko Tobe
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2706171A priority Critical patent/CA2706171C/en
Priority to MX2010005928A priority patent/MX2010005928A/es
Priority to CN2008801180038A priority patent/CN101878201B/zh
Priority to AU2008330653A priority patent/AU2008330653B2/en
Priority to PL08853617T priority patent/PL2221296T3/pl
Priority to EP08853617A priority patent/EP2221296B1/en
Priority to DK08853617.2T priority patent/DK2221296T3/da
Priority to ES08853617T priority patent/ES2391235T3/es
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Priority to US12/741,307 priority patent/US8211907B2/en
Priority to BRPI0819795A priority patent/BRPI0819795B8/pt
Priority to SI200830759T priority patent/SI2221296T1/sl
Priority to KR1020107011747A priority patent/KR101497747B1/ko
Priority to JP2009543802A priority patent/JP5251885B2/ja
Publication of WO2009069610A1 publication Critical patent/WO2009069610A1/ja
Priority to ZA2010/03112A priority patent/ZA201003112B/en
Priority to IL205551A priority patent/IL205551A/en
Priority to HRP20120944AT priority patent/HRP20120944T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

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  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

【課題】NMDA受容体拮抗剤として有用な化合物を提供する。 【解決手段】本発明者らは、NMDA受容体に対する拮抗作用を有する化合物について検討した結果、本発明に係る縮合インダン化合物が優れたNMDA受容体拮抗作用を有することを確認し、本発明を完成させた。本発明に係る縮合インダン化合物は、NMDA受容体に対する優れた拮抗作用を有し、アルツハイマー病、脳血管性認知症、パーキンソン病、難治性鬱病、注意欠陥・多動性障害、偏頭痛等の予防及び／又は治療剤の有効成分として使用することができる。
PCT/JP2008/071370 2007-11-28 2008-11-26 縮合インダン化合物 WO2009069610A1 (ja)

Priority Applications (16)

Application Number Priority Date Filing Date Title
US12/741,307 US8211907B2 (en) 2007-11-28 2008-11-26 Fused indane compound
MX2010005928A MX2010005928A (es) 2007-11-28 2008-11-26 Agentes antihelminticos y su uso.
BRPI0819795A BRPI0819795B8 (pt) 2007-11-28 2008-11-26 compostos de indano fundidos e seus usos no tratamento de doenças relacionadas ao receptor nmda, bem como composição farmacêutica compreendendo os mesmos
PL08853617T PL2221296T3 (pl) 2007-11-28 2008-11-26 Skondensowany związek indanowy
EP08853617A EP2221296B1 (en) 2007-11-28 2008-11-26 Fused indane compound
DK08853617.2T DK2221296T3 (da) 2007-11-28 2008-11-26 Kondenserede indanforbindelser
ES08853617T ES2391235T3 (es) 2007-11-28 2008-11-26 Compuesto de indano condensado
CA2706171A CA2706171C (en) 2007-11-28 2008-11-26 Fused indane compound
CN2008801180038A CN101878201B (zh) 2007-11-28 2008-11-26 稠合茚满化合物
AU2008330653A AU2008330653B2 (en) 2007-11-28 2008-11-26 Fused indane compound
SI200830759T SI2221296T1 (sl) 2007-11-28 2008-11-26 Kondenzirana indanska spojina
KR1020107011747A KR101497747B1 (ko) 2007-11-28 2008-11-26 축합 인단 화합물
JP2009543802A JP5251885B2 (ja) 2007-11-28 2008-11-26 縮合インダン化合物
ZA2010/03112A ZA201003112B (en) 2007-11-28 2010-05-04 Fused indane compound
IL205551A IL205551A (en) 2007-11-28 2010-05-05 Compressed indan compounds, pharmaceuticals containing them and their uses
HRP20120944AT HRP20120944T1 (hr) 2007-11-28 2012-11-20 Kondenzirani spoj indana

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007307753 2007-11-28
JP2007-307753 2007-11-28

Publications (1)

Publication Number Publication Date
WO2009069610A1 true WO2009069610A1 (ja) 2009-06-04

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ID=40678506

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071370 WO2009069610A1 (ja) 2007-11-28 2008-11-26 縮合インダン化合物

Country Status (21)

Country Link
US (1) US8211907B2 (ja)
EP (1) EP2221296B1 (ja)
JP (1) JP5251885B2 (ja)
KR (1) KR101497747B1 (ja)
CN (1) CN101878201B (ja)
AU (1) AU2008330653B2 (ja)
BR (1) BRPI0819795B8 (ja)
CA (1) CA2706171C (ja)
CY (1) CY1113634T1 (ja)
DK (1) DK2221296T3 (ja)
ES (1) ES2391235T3 (ja)
HR (1) HRP20120944T1 (ja)
IL (1) IL205551A (ja)
MX (1) MX2010005928A (ja)
PL (1) PL2221296T3 (ja)
PT (1) PT2221296E (ja)
RU (1) RU2451671C2 (ja)
SI (1) SI2221296T1 (ja)
TW (1) TWI422578B (ja)
WO (1) WO2009069610A1 (ja)
ZA (1) ZA201003112B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9469601B2 (en) 2012-12-04 2016-10-18 Pierre Fabre Medicament Aminocyclobutane derivatives, method for preparing same and the use thereof as drugs

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113234036B (zh) * 2021-05-12 2023-07-14 斯莱普泰(上海)生物医药科技有限公司 Nmda受体拮抗剂及其用途

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WO2006033318A1 (ja) 2004-09-21 2006-03-30 Astellas Pharma Inc. 環状アミン誘導体又はその塩
WO2006094602A1 (de) 2005-03-04 2006-09-14 Merck Patent Gmbh Indane

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DK12293D0 (da) * 1993-02-02 1993-02-02 Novo Nordisk As Heterocykliske forbindelser og deres fremstilling og anvendelse
US5574060A (en) * 1993-08-12 1996-11-12 The United States Of America As Represented By The Department Of Health And Human Services Selective inhibitors of biogenic amine transporters
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WO2006033318A1 (ja) 2004-09-21 2006-03-30 Astellas Pharma Inc. 環状アミン誘導体又はその塩
WO2006094602A1 (de) 2005-03-04 2006-09-14 Merck Patent Gmbh Indane

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* Cited by examiner, † Cited by third party
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US9469601B2 (en) 2012-12-04 2016-10-18 Pierre Fabre Medicament Aminocyclobutane derivatives, method for preparing same and the use thereof as drugs
US9687459B2 (en) 2012-12-04 2017-06-27 Pierre Fabre Medicament Aminocyclobutane derivatives, method for preparing same and the use thereof as drugs

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