WO2009056965A3 - Una vacuna multicomponente o monocomponente para ser utilizada contra ia enfermedad de chagas, composiciones farmacéuticas que las contienen, procedimiento para ia obtención del inmunógeno de dichas vacunas y acido nucleico utilizado en dicho procedimiento - Google Patents

Una vacuna multicomponente o monocomponente para ser utilizada contra ia enfermedad de chagas, composiciones farmacéuticas que las contienen, procedimiento para ia obtención del inmunógeno de dichas vacunas y acido nucleico utilizado en dicho procedimiento Download PDF

Info

Publication number
WO2009056965A3
WO2009056965A3 PCT/IB2008/002923 IB2008002923W WO2009056965A3 WO 2009056965 A3 WO2009056965 A3 WO 2009056965A3 IB 2008002923 W IB2008002923 W IB 2008002923W WO 2009056965 A3 WO2009056965 A3 WO 2009056965A3
Authority
WO
WIPO (PCT)
Prior art keywords
vaccine
chagas disease
cruzi
multicomponent
immunogenic
Prior art date
Application number
PCT/IB2008/002923
Other languages
English (en)
French (fr)
Other versions
WO2009056965A2 (es
Inventor
Baeremaecker Barros Carlos De
Original Assignee
Terramark Markencreation Gmbh
Baeremaecker Barros Carlos De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terramark Markencreation Gmbh, Baeremaecker Barros Carlos De filed Critical Terramark Markencreation Gmbh
Priority to MX2010004626A priority Critical patent/MX2010004626A/es
Priority to ES08844056.5T priority patent/ES2569943T3/es
Priority to CA2702534A priority patent/CA2702534C/en
Priority to US12/740,393 priority patent/US8900598B2/en
Priority to EP08844056.5A priority patent/EP2206513B1/en
Publication of WO2009056965A2 publication Critical patent/WO2009056965A2/es
Publication of WO2009056965A3 publication Critical patent/WO2009056965A3/es
Priority to US14/529,454 priority patent/US9662378B2/en
Priority to US15/492,365 priority patent/US10213500B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/005—Trypanosoma antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

El objeto principal de la presente invención es una vacuna contra la enfermedad de Chagas, capaz de estimular la respuesta inmune contra el factor de virulencia trans-sialidasa del parásito Trvpanosoma cruzi, caracterizada dicha vacuna porque comprende una vacuna multicomponente para la enfermedad del Chagas {tripanosomiasis americana) caracterizada porque comprende: (a) una porción inmunógenica conformada por uno o mas polipéptidos recombinantes o sintéticos, o fracciones de ellos, y (b) uno o mas polinucleótidos que comprenden a las regiones que codifican a uno o mas polipéptidos inmunogénicos, ambas porciones para los derivados de los Trypanosoma cruzi ( es decir de un T. Cruzi y/o una región conservada común a varios de ellos) donde la administración de dicha vacuna protege de la infección del parásito, lo elimina o atenúa las consecuencias clínicas de dicha infección. Otro objeto de la presente invención es una vacuna monocom ponente para la enfermedad del Chagas que comprende al menos un componente seleccionado entre una porción inmunógenica conformada por uno o mas polipéptidos recombinantes o sintéticos, o fracciones de ellos y un grupo de polinucleótidos que comprenden a las regiones que codifican a uno o mas polipéptidos inmunogénico derivados de los Trypanosoma cruzi ( es decir de un T. Cruzi y/o una región conservada común a varios de ellos), donde la porción inmunógenica o el grupo de polinucleótido estimula una respuesta de anticuerpos, de células T CD4+ sesgadas Th 1 o T CD8+ contra el Tripanosoma cruzi. También se incluyen en la presente invención las composiciones farmacéuticas que contienen dichas vacunas multicomponentes y monocomponentes, procedimientos para la obtención de la porción inmunogena de dichas vacunas y el acido nucleico utilizado en dicho procedimiento.
PCT/IB2008/002923 2007-10-31 2008-10-30 Una vacuna multicomponente o monocomponente para ser utilizada contra ia enfermedad de chagas, composiciones farmacéuticas que las contienen, procedimiento para ia obtención del inmunógeno de dichas vacunas y acido nucleico utilizado en dicho procedimiento WO2009056965A2 (es)

Priority Applications (7)

Application Number Priority Date Filing Date Title
MX2010004626A MX2010004626A (es) 2007-10-31 2008-10-30 Vacuna multicomponente o monocomponente para ser utilizada contra la enfermedad de chagas.
ES08844056.5T ES2569943T3 (es) 2007-10-31 2008-10-30 Una vacuna multicomponente o monocomponente para usar contra la enfermedad de Chagas
CA2702534A CA2702534C (en) 2007-10-31 2008-10-30 A multicomponent or monocomponent vaccine to be used against chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure
US12/740,393 US8900598B2 (en) 2007-10-31 2008-10-30 Multicomponent or monocomponent vaccine to be used against Chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure
EP08844056.5A EP2206513B1 (en) 2007-10-31 2008-10-30 A multicomponent or monocomponent vaccine to be used against chagas disease
US14/529,454 US9662378B2 (en) 2007-10-31 2014-10-31 Multicomponent or monocomponent vaccine to be used against Chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure
US15/492,365 US10213500B2 (en) 2007-10-31 2017-04-20 Multicomponent or monocomponent vaccine to be used against chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ARP070104827A AR064593A1 (es) 2007-10-31 2007-10-31 Una vacuna multicomponente o monocomponente para ser utilizada contra la enfermedad de chagas, composiciones farmaceuticas que las contienen, procedimiento para la obtencion del inmunogeno de dichas vacunas y acido nucleico utilizado en dicho procedimiento.
ARP20070104827 2007-10-31

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/740,393 A-371-Of-International US8900598B2 (en) 2007-10-31 2008-10-30 Multicomponent or monocomponent vaccine to be used against Chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure
US14/529,454 Division US9662378B2 (en) 2007-10-31 2014-10-31 Multicomponent or monocomponent vaccine to be used against Chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure

Publications (2)

Publication Number Publication Date
WO2009056965A2 WO2009056965A2 (es) 2009-05-07
WO2009056965A3 true WO2009056965A3 (es) 2009-07-23

Family

ID=40591558

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/002923 WO2009056965A2 (es) 2007-10-31 2008-10-30 Una vacuna multicomponente o monocomponente para ser utilizada contra ia enfermedad de chagas, composiciones farmacéuticas que las contienen, procedimiento para ia obtención del inmunógeno de dichas vacunas y acido nucleico utilizado en dicho procedimiento

Country Status (18)

Country Link
US (3) US8900598B2 (es)
EP (1) EP2206513B1 (es)
AR (1) AR064593A1 (es)
BR (1) BRPI0805753A2 (es)
CA (1) CA2702534C (es)
CO (1) CO6280407A2 (es)
CR (1) CR11334A (es)
DO (1) DOP2010000083A (es)
EC (1) ECSP10010055A (es)
ES (1) ES2569943T3 (es)
GT (1) GT201000066A (es)
HN (1) HN2010000750A (es)
MX (1) MX2010004626A (es)
NI (1) NI201000071A (es)
PA (1) PA8816401A1 (es)
PE (2) PE20091161A1 (es)
UY (1) UY31451A1 (es)
WO (1) WO2009056965A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR064593A1 (es) * 2007-10-31 2009-04-15 Baeremaecker Barros Carlos De Una vacuna multicomponente o monocomponente para ser utilizada contra la enfermedad de chagas, composiciones farmaceuticas que las contienen, procedimiento para la obtencion del inmunogeno de dichas vacunas y acido nucleico utilizado en dicho procedimiento.
WO2011031317A2 (en) 2009-09-10 2011-03-17 The Board Of Regents Of The University Of Texas System Vaccine for control of trypanosoma cruzi infection and chagas disease
CN103890004B (zh) 2011-07-21 2018-02-02 西班牙国家研究委员会 由具有特定免疫显性表位的婴儿利什曼虫pfr1蛋白片段组成的嵌合分子可用于抗利什曼病的免疫疗法
US10279023B2 (en) 2013-09-24 2019-05-07 Board Of Regents, The University Of Texas System Mucin-associated surface protein as a vaccine against chagas disease
US9566320B2 (en) 2013-09-24 2017-02-14 The Board Of Regents Of The University Of Texas System Mucin-associated surface protein as vaccine against Chagas disease
BR112017028052A2 (pt) * 2015-06-23 2018-09-11 Epivax Inc peptídeo, método para induzir uma resposta imune em um sujeito e formulação de vacina
BR102021010469A2 (pt) * 2021-05-28 2022-12-13 Fundação Oswaldo Cruz Proteína quimérica recombinante, seu uso, e, composição

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6875584B1 (en) * 1999-03-02 2005-04-05 University Of Georgia Research Foundation, Inc. Prophylactic and therapeutic immunization against protozoan infection and disease
US20070178100A1 (en) * 2005-07-15 2007-08-02 Tarleton Rick L Trypanosoma cruzi proteome compositions and methods
WO2007107488A2 (en) * 2006-03-17 2007-09-27 Vib Vzw Vaccine against trypanosoma cruzi infection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018787A1 (en) 1992-03-25 1993-09-30 New York University Trans-sialidase and methods of use and making thereof
US7060676B2 (en) * 1999-12-20 2006-06-13 Trustees Of Tufts College T. cruzi-derived neurotrophic agents and methods of use therefor
AR064593A1 (es) * 2007-10-31 2009-04-15 Baeremaecker Barros Carlos De Una vacuna multicomponente o monocomponente para ser utilizada contra la enfermedad de chagas, composiciones farmaceuticas que las contienen, procedimiento para la obtencion del inmunogeno de dichas vacunas y acido nucleico utilizado en dicho procedimiento.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6875584B1 (en) * 1999-03-02 2005-04-05 University Of Georgia Research Foundation, Inc. Prophylactic and therapeutic immunization against protozoan infection and disease
US20050158347A1 (en) * 1999-03-02 2005-07-21 The University Of Georgia Research Foundation, Inc. Prophylactic and therapeutic immunization against protozoan infection and disease
US20070178100A1 (en) * 2005-07-15 2007-08-02 Tarleton Rick L Trypanosoma cruzi proteome compositions and methods
WO2007107488A2 (en) * 2006-03-17 2007-09-27 Vib Vzw Vaccine against trypanosoma cruzi infection

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ALVAREZ PAULA ET AL: "Multiple overlapping epitopes in the repetitive unit of the shed acute-phase antigen from Trypanosoma cruzi enhance its immunogenic properties", INFECTION AND IMMUNITY, vol. 69, no. 12, December 2001 (2001-12-01), pages 7946 - 7949, XP002528992, ISSN: 0019-9567 *
ARAUJO A F S ET AL: "CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, vol. 73, no. 9, 1 September 2005 (2005-09-01), pages 6017 - 6025, XP002394211, ISSN: 0019-9567 *
BUSCAGLIA CARLOS A ET AL: "The repetitive domain of Trypanosoma cruzi trans-sialidase enhances the immune response against the catalytic domain", JOURNAL OF INFECTIOUS DISEASES, vol. 177, no. 2, February 1998 (1998-02-01), pages 431 - 436, XP002529162, ISSN: 0022-1899 *
FOUTS D L ET AL: "Nucleotide sequence and transcription of a trypomastigote surface antigen gene of Trypanosoma cruzi", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 46, no. 2, 1 June 1991 (1991-06-01), pages 189 - 200, XP023887939, ISSN: 0166-6851, [retrieved on 19910601] *
FUJIMURA A E ET AL: "DNA sequences encoding CD4+ and CD8+ T-cell epitopes are important for efficient protective immunity induced by DNA vaccination with a Trypanosoma cruzi gene", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, vol. 69, no. 9, 1 September 2001 (2001-09-01), pages 5477 - 5486, XP002394218, ISSN: 0019-9567 *
GAO W ET AL: "The Trypanosoma cruzi trans-sialidase is a T cell-independent B cell mitogen and an inducer of non-specific Ig secretion", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB, vol. 14, no. 3, 1 March 2002 (2002-03-01), pages 299 - 308, XP002394212, ISSN: 0953-8178 *
MORELL M ET AL: "The genetic immunization with paraflagellar rod protein-2 fused to the HSP70 confers protection against late Trypanosoma cruzi infection", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 24, no. 49-50, 30 November 2006 (2006-11-30), pages 7046 - 7055, XP025152065, ISSN: 0264-410X, [retrieved on 20061130] *
PEREIRA-CHIOCCOLA VERA LUCIA ET AL: "Comparison of antibody and protective immune responses against Trypanosoma cruzi infection elicited by immunization with a parasite antigen delivered as naked DNA or recombinant protein", PARASITE IMMUNOLOGY (OXFORD), vol. 21, no. 2, February 1999 (1999-02-01), pages 103 - 110, XP002528993, ISSN: 0141-9838 *
PITCOVSKY T A ET AL: "A functional network of intramolecular cross-reacting epitopes delays the elicitation of neutralizing antibodies to Trypanosoma cruzi trans-sialidase", JOURNAL OF INFECTIOUS DISEASES, UNIVERSITY OF CHICAGO PRESS, CHICAGO, IL, vol. 186, no. 3, 17 July 2002 (2002-07-17), pages 397 - 404, XP002394213, ISSN: 0022-1899 *

Also Published As

Publication number Publication date
ES2569943T3 (es) 2016-05-13
US20150056243A1 (en) 2015-02-26
UY31451A1 (es) 2009-05-29
NI201000071A (es) 2010-11-10
EP2206513B1 (en) 2016-02-17
US10213500B2 (en) 2019-02-26
EP2206513A2 (en) 2010-07-14
PE20140520A1 (es) 2014-05-05
HN2010000750A (es) 2013-08-19
PE20091161A1 (es) 2009-08-28
CO6280407A2 (es) 2011-05-20
US9662378B2 (en) 2017-05-30
MX2010004626A (es) 2010-10-04
DOP2010000083A (es) 2010-07-15
AR064593A1 (es) 2009-04-15
US8900598B2 (en) 2014-12-02
CA2702534C (en) 2016-10-18
GT201000066A (es) 2012-04-03
US20170290896A1 (en) 2017-10-12
CA2702534A1 (en) 2009-05-07
WO2009056965A2 (es) 2009-05-07
PA8816401A1 (es) 2009-09-17
CR11334A (es) 2010-05-26
BRPI0805753A2 (pt) 2012-04-17
ECSP10010055A (es) 2010-06-29
US20100297186A1 (en) 2010-11-25

Similar Documents

Publication Publication Date Title
WO2009056965A3 (es) Una vacuna multicomponente o monocomponente para ser utilizada contra ia enfermedad de chagas, composiciones farmacéuticas que las contienen, procedimiento para ia obtención del inmunógeno de dichas vacunas y acido nucleico utilizado en dicho procedimiento
US20210069323A1 (en) Vaccine composition containing synthetic adjuvant
ES2729967T3 (es) Formulaciones de adyuvante mejoradas que comprenden agonistas de TLR4 y métodos para usar las mismas
JP6741580B2 (ja) 単一バイアルのワクチン製剤
WO2005116270A3 (en) Influenza virus vaccine composition and method of use
WO2007022151A3 (en) Immunization of avians by administration of non-replicating vectored vaccines
WO2006068663A3 (en) Vaccine compositions for treating coronavirus infection
BR112015002131A8 (pt) Vírus vaccinia ankara modificado (mva) recombinante, composição farmacêutica e uso do referido mva recombinante
US10220086B2 (en) Synergistic co-administration of computationally optimized broadly reactive antigens for H1N1 influenza
WO2015031904A3 (en) Serum antibody assay for determining protection from malaria, and pre-erythrocytic subunit vaccines
WO2011044698A8 (en) Multi epitope vaccine for poultry
CA3149593A1 (en) Methods of increasing vaccine efficacy
WO2002103002A3 (fr) Gene associe a la virulence du parasite leishmania
RU2007142203A (ru) Вакцина против кокцидий и способы ее получения и применение
EP1987840A1 (en) Prime-boost vaccine for the protection of equines against viral infection
WO2009117365A3 (en) Vaccine compositions for inducing immune responses against components of drusen

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08844056

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2008844056

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 201011334

Country of ref document: CR

Ref document number: D2010052

Country of ref document: CU

Ref document number: CR2010-011334

Country of ref document: CR

WWE Wipo information: entry into national phase

Ref document number: 2702534

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: MX/A/2010/004626

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 12740393

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 10058905

Country of ref document: CO