WO2009054432A1 - 口腔内速崩壊性医薬組成物およびその製造方法 - Google Patents

口腔内速崩壊性医薬組成物およびその製造方法 Download PDF

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Publication number
WO2009054432A1
WO2009054432A1 PCT/JP2008/069183 JP2008069183W WO2009054432A1 WO 2009054432 A1 WO2009054432 A1 WO 2009054432A1 JP 2008069183 W JP2008069183 W JP 2008069183W WO 2009054432 A1 WO2009054432 A1 WO 2009054432A1
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
salt
cetirizine
production
rapidly disintegrating
Prior art date
Application number
PCT/JP2008/069183
Other languages
English (en)
French (fr)
Inventor
Hiroaki Nakagami
Yoshio Kuno
Hideaki Tanabe
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Priority to JP2009538242A priority Critical patent/JPWO2009054432A1/ja
Publication of WO2009054432A1 publication Critical patent/WO2009054432A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

薬効成分としてセチリジンまたはその塩を含有し、速やかな崩壊性と充分な硬度を併せ持つ医薬組成物を提供する。 （ｉ）セチリジンまたはその塩、（ｉｉ）シクロデキストリン類、（ｉｉｉ）トウモロコシデンプン、および（ｉｖ）セルロース類を含有する医薬組成物は、口腔内における速やかな崩壊性と、通常の製造工程、流通および使用に耐え得る充分な硬度を併せ持ち、さらにセチリジンまたはその塩に由来する苦味をマスクすることを見出した。
PCT/JP2008/069183 2007-10-26 2008-10-23 口腔内速崩壊性医薬組成物およびその製造方法 WO2009054432A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009538242A JPWO2009054432A1 (ja) 2007-10-26 2008-10-23 口腔内速崩壊性医薬組成物およびその製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007278532 2007-10-26
JP2007-278532 2007-10-26

Publications (1)

Publication Number Publication Date
WO2009054432A1 true WO2009054432A1 (ja) 2009-04-30

Family

ID=40579534

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069183 WO2009054432A1 (ja) 2007-10-26 2008-10-23 口腔内速崩壊性医薬組成物およびその製造方法

Country Status (2)

Country Link
JP (1) JPWO2009054432A1 (ja)
WO (1) WO2009054432A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010134540A1 (ja) * 2009-05-20 2010-11-25 大日本住友製薬株式会社 有核型の口腔内崩壊錠
WO2012147660A1 (ja) 2011-04-28 2012-11-01 田辺三菱製薬株式会社 口腔内速崩壊性錠
JP2015034132A (ja) * 2013-08-07 2015-02-19 大同化成工業株式会社 外用剤用組成物
JP2016094364A (ja) * 2014-11-14 2016-05-26 ニプロ株式会社 安定化および苦味抑制された口腔内崩壊製剤
JP2019001730A (ja) * 2017-06-13 2019-01-10 武田テバファーマ株式会社 安定な経口医薬組成物

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002185A1 (fr) * 1996-07-12 1998-01-22 Daiichi Pharmaceutical Co., Ltd. Materiaux moules par compression, a desagregation rapide, et leur procede de production
JP2001058944A (ja) * 1999-06-18 2001-03-06 Takeda Chem Ind Ltd 速崩壊性固形製剤
JP2001122785A (ja) * 1999-10-22 2001-05-08 Nippon Boehringer Ingelheim Co Ltd ブロチゾラムを含有する錠剤
JP2002508773A (ja) * 1997-07-03 2002-03-19 ユセベ，ソシエテ アノニム 活性物質及びシクロデキストリンを含有する経口投与用医薬剤
CN1660098A (zh) * 2004-12-09 2005-08-31 鲁南制药股份有限公司 含有盐酸西替利嗪的口服药物组合物
WO2006011051A1 (en) * 2004-07-22 2006-02-02 Pfizer Products Inc. Taste masking formulation comprising the drug in a dissolution-retarded form and/or cyclodextrin in a dissolution-enhanced form
JP2007269716A (ja) * 2006-03-31 2007-10-18 Sato Pharmaceutical Co Ltd 塩酸セチリジン含有粒子

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998002185A1 (fr) * 1996-07-12 1998-01-22 Daiichi Pharmaceutical Co., Ltd. Materiaux moules par compression, a desagregation rapide, et leur procede de production
JP2002508773A (ja) * 1997-07-03 2002-03-19 ユセベ，ソシエテ アノニム 活性物質及びシクロデキストリンを含有する経口投与用医薬剤
JP2001058944A (ja) * 1999-06-18 2001-03-06 Takeda Chem Ind Ltd 速崩壊性固形製剤
JP2001122785A (ja) * 1999-10-22 2001-05-08 Nippon Boehringer Ingelheim Co Ltd ブロチゾラムを含有する錠剤
WO2006011051A1 (en) * 2004-07-22 2006-02-02 Pfizer Products Inc. Taste masking formulation comprising the drug in a dissolution-retarded form and/or cyclodextrin in a dissolution-enhanced form
CN1660098A (zh) * 2004-12-09 2005-08-31 鲁南制药股份有限公司 含有盐酸西替利嗪的口服药物组合物
JP2007269716A (ja) * 2006-03-31 2007-10-18 Sato Pharmaceutical Co Ltd 塩酸セチリジン含有粒子

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHAO, L. ET AL.: "Preparation of fast dissolving tablet containing cetirizine-beta-CD inclusion complex", ZHONGGUO YIYUAN YAOXUE ZAZHI, vol. 24, no. 7, 2004, pages 417 - 419 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010134540A1 (ja) * 2009-05-20 2010-11-25 大日本住友製薬株式会社 有核型の口腔内崩壊錠
JP5458096B2 (ja) * 2009-05-20 2014-04-02 大日本住友製薬株式会社 有核型の口腔内崩壊錠
US8920839B2 (en) 2009-05-20 2014-12-30 Sumitomo Dainippon Pharma Co., Ltd. Dry-coated orally-disintegrating tablet
WO2012147660A1 (ja) 2011-04-28 2012-11-01 田辺三菱製薬株式会社 口腔内速崩壊性錠
JP2015034132A (ja) * 2013-08-07 2015-02-19 大同化成工業株式会社 外用剤用組成物
JP2016094364A (ja) * 2014-11-14 2016-05-26 ニプロ株式会社 安定化および苦味抑制された口腔内崩壊製剤
JP2019001730A (ja) * 2017-06-13 2019-01-10 武田テバファーマ株式会社 安定な経口医薬組成物

Also Published As

Publication number Publication date
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