WO2009049574A1 - Coated granules for new formation of bone material - Google Patents

Coated granules for new formation of bone material Download PDF

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Publication number
WO2009049574A1
WO2009049574A1 PCT/DE2008/000101 DE2008000101W WO2009049574A1 WO 2009049574 A1 WO2009049574 A1 WO 2009049574A1 DE 2008000101 W DE2008000101 W DE 2008000101W WO 2009049574 A1 WO2009049574 A1 WO 2009049574A1
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WIPO (PCT)
Prior art keywords
granules
collagen
bone
human
jaw
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PCT/DE2008/000101
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German (de)
French (fr)
Inventor
Antonis Alexakis
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Antonis Alexakis
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Publication date
Application filed by Antonis Alexakis filed Critical Antonis Alexakis
Priority to EP08715436A priority Critical patent/EP2211782A1/en
Publication of WO2009049574A1 publication Critical patent/WO2009049574A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003—Not used, see subgroups
    • A61C8/0004—Consolidating natural teeth
    • A61C8/0006—Periodontal tissue or bone regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2803—Bones for mandibular reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A61F2002/30064—Coating or prosthesis-covering structure made of biodegradable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00347—Nacre or mother-of-pearl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
    • A61F2310/00982—Coating made of collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

The invention relates to coated granules (3) for promoting new bone formation, particularly in the jaw. It comprises a material resorbable by the human or animal body, wherein the granules (3) have a cavity-filling granule shape on a human or animal bone substrate (1).

Description

Dr.med.dent. Antonis Alexakis 21.01.2008 Dr.med.dent. Antonis Alexakis 21.01.2008
78337 Öhningen78337 Ohningen
Beschichtetes Granulat zur Neubildung von KnochenmaterialCoated granules for the regeneration of bone material
Die Erfindung betrifft ein beschichtetes Granulat zur Förderung der Knochenbildung gemäß dem Oberbegriff des Anspruchs 1.The invention relates to a coated granule for promoting bone formation according to the preamble of claim 1.
In der Medizin gibt es eine Vielzahl von Anwendungsfallen, in denen es wünschenswert ist, dass Knochenmaterial vom menschlichen oder tierischen Patienten selbst neu gebildet wird. Es ist bekannt, dass Osteoblasten bestrebt sind, in Hohlräume hineinzuwachsen. Diese Erkenntnis macht man sich beispielsweise in der Zahnmedizin zunutze, wenn der Kieferknochen z. B. durch Parodontitis angegriffen und teilweise zerstört ist.In medicine, there are a variety of use cases in which it is desirable that bone material be re-formed by the human or animal patient himself. It is known that osteoblasts endeavor to grow into cavities. This knowledge makes you, for example, in dentistry advantage if the jaw bone z. B. attacked by periodontitis and is partially destroyed.
Es ist bekannt, den für das gezielte Wachstum der Osteoblasten am menschlichen oder tierischen Kieferknochen benötigten Hohlraum durch resorbierbare Granulate gebildet wird.It is known that the cavity required for the targeted growth of the osteoblasts on the human or animal jawbone is formed by resorbable granules.
Es gibt einige Materialien, die in Granulatform als Füllkörper zur Verfügung stehen um Knochendefekte zu füllen oder zum Kieferaufbau in Höhe und/oder Breite.There are some materials that are available in granular form as filler to fill bone defects or for the construction of jaws in height and / or width.
Manche dieser Materialien resorbieren sich sehr schnell, so dass das Ziel derSome of these materials absorb very quickly, so the goal of the
Auffüllung oder des Aufbaues nicht erreicht werden kann. Andere wiederum, die sich zwar sehr langsam resorbieren, lassen in den höheren Schichten keine Osteoblasten wachsen, da dort kein Nährboden vorhanden ist.Filling or the structure can not be achieved. Others, however, who reabsorb very slowly, do not allow osteoblasts to grow in the higher layers, as there is no breeding ground there.
Auf diese Weise kann das Ziel nicht vollständig erreicht werden.In this way, the goal can not be fully achieved.
Der Erfindung liegt die Aufgabe zugrunde, ein grundsätzlich neuartiges Granulat vorzuschlagen. Diese Aufgabe wird mit den Merkmalen des Anspruchs 1 gelöst. Vorteilhafte Weiterbildungen der Erfindung sind in den Unteransprüchen angegeben.The invention has for its object to propose a fundamentally novel granules. This object is achieved with the features of claim 1. Advantageous developments of the invention are specified in the subclaims.
Der Erfindung liegt der Gedanke zugrunde, das vom Körper vollständig resorbierbare Granulat dauerhaft formstabil auszubilden. Bevorzugt wird das erfindungsgemäße Granulat als Massenprodukt in unterschiedlichen Körnungsgrößen hergestellt. Dabei sind die Körner derart ausgeformt, das sie, ohne Veränderungen verwenden zu müssen, an die entsprechenden Körperteile aufgebracht werden können.The invention is based on the idea to form the body completely resorbable granules permanently dimensionally stable. The granulate according to the invention is preferably produced as a mass product in different grain sizes. The grains are formed in such a way that they can be applied to the corresponding body parts without having to use changes.
Ein weiterer Vorteil des erfindungsgemäßen Granulates ist die Beschichtung. Vorteil 1: Die Beschichtung saugt das Blut des Patienten auf und so sind Körperzellen an jeder Höhe und Tiefe verfügbar. Auf diese Art können im gesamten Hohlraum gleichzeitig Gefäße wachsen, die wichtig sind, damit die Osteoblasten sich ernähren können und neue Knochen bilden können.Another advantage of the granules according to the invention is the coating. Advantage 1: The coating absorbs the patient's blood and thus body cells are available at any height and depth. In this way, vessels can grow at the same time in the entire cavity, which are important for the osteoblasts to be able to feed themselves and to form new bones.
Vorteil 2: Durch die Beschichtung kleben die mit Blut getränkten Partikel zusammen und so bildet sich eine homogene Masse ohne Hohlräume. So ist das neue Knochenwachstum am Schnellsten zu gewährleisten.Advantage 2: Due to the coating, the blood-soaked particles stick together, forming a homogeneous mass without cavities. Thus, the new bone growth is the fastest to ensure.
Vorteil 3: Die aufgefüllte oder aufgebaute Granulatmenge klebt an der vorhandenen Knochenunterlage oder Zahnwurzel und das erleichtert ebenfalls die Regeneration. Bevorzugt weist das Beschichtungsmaterial eineAdvantage 3: The filled-up or built-up granules stick to the existing bone backing or tooth root, which also facilitates regeneration. Preferably, the coating material has a
Klebeeigenschaft auf, durch das das eingebrachte Granulat an einer vorgegebenen Position am Körper fixierbar ist.Adhesive property, by which the introduced granules can be fixed at a predetermined position on the body.
Gemäß einer vorteilhaften Weiterbildung der Erfindung ist vorgesehen, das als Beschichtungsmaterial Collagen verwendet wird, insbesondere eine Mischung aus Collagen 1 und Collagen 3. Es ist jedoch auch denkbar, lediglich Collagen 1 oder ausschließlich Collagen 3 zu verwenden. Collagen hat nicht nur Dichtungseigenschaften, sondern fixiert den Formkörper zumindest vorläufig durch seine Klebewirkung.According to an advantageous development of the invention, it is provided that collagen is used as the coating material, in particular a mixture of collagen 1 and collagen 3. However, it is also conceivable to use only collagen 1 or exclusively collagen 3. Collagen not only has sealing properties, but fixes the molding at least temporarily by its adhesive effect.
Gemäß einer bevorzugten Ausführangsform enthält das Granulat allogenes Material oder besteht vollständig aus allogenem Material. Insbesondere ist es denkbar, das Granulat aus Spenderknochen oder aus Knochen von Knochenbanken auszubilden. Auch ist die Verwendung von FDBA ( freeze dried bone allacrafts) oder von DFDBA ( decalcifϊed freeze dried bone allocrafts) von Vorteil. Durch die Ausbildung des Granulates aus einem Material von einem genetisch differenten Individuum derselben Spezies kann das Knochenwachstum optimal verlaufen. Die Wahrscheinlichkeit entzündlicher Reaktionen wird vorteilhaft reduziert.According to a preferred embodiment, the granules contain allogeneic material or consist entirely of allogenic material. In particular, it is conceivable to form the granules from donor bone or bone from bone banks. Also, the use of FDBA (freeze-dried bone allacrafts) or of DFDBA (decalcified freeze-dried bone allocrafts) is advantageous. By forming the granules from a material from a genetically different individual of the same species, bone growth can be optimal. The likelihood of inflammatory reactions is advantageously reduced.
Auch die Verwendung von xenogenen Materialien zur Herstellung des Granulates hat sich als vorteilhaft erwiesen. Zur Herstellung von Formteilen, die für den Menschen geeignet sind, eignen sich insbesondere Knochen von Rind, Schwein, und Pferd. Es ist jedoch auch möglich, das Granulat aus Algen, insbesondere Algenextrakten, Korallen oder Muscheln herzustellen.The use of xenogenic materials for the production of granules has proven to be advantageous. Bones of beef, pork, and horse are particularly suitable for the production of moldings which are suitable for humans. However, it is also possible to produce the granules from algae, in particular algae extracts, corals or mussels.
Die Schale von Muscheln eignen sich besonders zur Herstellung von Granulaten, da sie aus einem Calcium-Protein-Gemisch besteht und besonders gut vom Körper resorbiert werden kann. Daneben ist es auch möglich, das Granulat aus autogenem Material herzustellen. Hierbei ist die Wahrscheinlichkeit des Auftretens von entzündlichen Reaktionen des Körpers des Patienten am geringsten.The shell of mussels are particularly suitable for the production of granules, since it consists of a calcium-protein mixture and can be absorbed particularly well by the body. In addition, it is also possible to produce the granules of autogenous material. Here, the likelihood of occurrence of inflammatory reactions of the body of the patient is the lowest.
Weiterhin ist es möglich, alloplastische Materialien wie Calciumphosphate, Keramiken oder Biogläser zur Herstellung des erfindungsgemäßen formstabilen Granulates zu verwenden.Furthermore, it is possible to use alloplastic materials such as calcium phosphates, ceramics or bioglasses for the production of the dimensionally stable granules according to the invention.
Weitere Vorteile und zweckmäßige Ausführungen sind den weiteren Ansprüchen, der Figurenbeschreibung und der Zeichnung zu entnehmen.Further advantages and expedient embodiments can be found in the further claims, the description of the figures and the drawing.
Die Fig. 1 zeigt einen Knochendefekt, der mit dem beschichteten Granulat aufgefüllt ist.Fig. 1 shows a bone defect which is filled with the coated granules.
Es ist ein von Parodontitis teilweise zerstörter Kieferknochen. Wird der Kieferknochen 1 nicht wieder hergestellt, kann es zum Ausfallen des in dem Kieferknochen 1 gehaltenen Zahns 2 kommen. Zum Zwecke der Knochenneubildung ist auf den Kieferknochen 1 ein beschichtetes Granulat 3 eingesetzt.It is a jawbone partially destroyed by periodontitis. If the jawbone 1 is not restored, the tooth 2 held in the jawbone 1 may fail. For the purpose of bone regeneration a coated granules 3 is used on the jaw bone 1.
In Fig.l ist das Granulat 3 geschnitten dargestellt. Es bildet oberhalb des Kieferknochens 1 einen Hohlraum 4 aus, in den zunächst Fibroblasten und dann die Osteoblasten des Kieferknochens 1 in Pfeilrichtung 5 hineinwachsen können. Um zu verhindern, dass Zellen der Knochenhaut 6 oder Zellen des Zahnfleisches 7 in den Hohlraum 4 eindringen können, ist das Granulat 3 gegenüber dem Zahn 2 sowie gegenüber dem Kieferknochen 1 mithilfe von Collagen 8 abgedichtet.In Fig.l the granules 3 is shown in section. It forms above the jaw bone 1 from a cavity 4, in the first fibroblasts and then the osteoblasts of the jawbone 1 in the direction of arrow 5 can grow. To prevent cells of the periosteum 6 or cells of the gum 7 from penetrating into the cavity 4, the granules 3 are sealed against the tooth 2 and against the jawbone 1 by means of collagen 8.
Das Granulat 3 besteht in dem gezeigten Ausführungsbeispiel aus einem Muschelgranulat, das über die Collagenbeschichtung an die spezielle Situation am Körper des Patienten angepasst werden kann.In the exemplary embodiment shown, the granulate 3 consists of a shell granulate which can be adapted via the collagen coating to the special situation on the body of the patient.
Um das Granulat 3 in die dargestellte Position einbringen zu können, wird zunächst der obere Zahnfleischlappen 7 aufgeklappt. Gegebenenfalls wird die Oberfläche des Kieferknochens aufgeraut, um das Wachstum des Knochens 1 zu fördern. Daraufhin wird das Granulat 3 mit seiner Collagenbeschichtung 8 an die entsprechende Stelle aufgebracht am Kieferknochen 1 und/oder Zahn 2 fixiert. Daraufhin wird der Zahnfleischlappen 7 wieder in die in Fig. 1 dargestellte Position geklappt und an der Außenseite des Granulates 3 fixiert. An der Außenseite des Granulates 3 wächst die Knochenhaut 6 entlang in Pfeilrichtung 10, so dass nach einiger Zeit die ursprüngliche KiefersituationIn order to bring the granules 3 in the position shown, the upper gingival flap 7 is first opened. Optionally, the surface of the jawbone is roughened to promote the growth of the bone 1. Thereafter, the granules 3 with its collagen coating 8 applied to the appropriate place on the jaw bone 1 and / or 2 tooth fixed. The gingival flap 7 is then folded back into the position shown in FIG. 1 and fixed on the outside of the granulate 3. On the outside of the granules 3, the periosteum 6 grows along in the direction of the arrow 10, so that after some time the original jaw situation
mit vollständigem Kieferknochen 1 , Knochenhaut 6 und Zahnfleisch 7 wiederhergestellt ist. Eine zweite Operation zur Entfernung des Granulates 1 nach erfolgter Knochenneubildung ist nicht erforderlich, da das Granulat 1 mit Collagen 8 vom Körper vollständig abgebaut wird. with complete jawbone 1, periosteum 6 and gum 7 is restored. A second operation to remove the granules 1 after the formation of new bone is not required because the granules 1 with collagen 8 is completely degraded by the body.
Dr. Antonis Alexakis 21.01.2008Dr. Antonis Alexakis 21.01.2008
Rielasingen-WorblingenRielasingen-Worblingen
BezugszeichenlisteLIST OF REFERENCE NUMBERS
1 Kieferknochen1 jawbone
2 Zahn2 tooth
3 Granulat3 granules
4 Hohlraum4 cavity
5 Pfeilrichtung5 arrow direction
6 Knochenhaut6 periosteum
7 Zahnfleisch7 gums
8 Collagen8 collages
9 Pfeilrichtung 9 arrow direction

Claims

Dr. Antonis Alexakis 21.01.20008Rielasingen-WorblingenPatentansprüche Dr. Antonis Alexakis 21.01.20008Rielasingen-WorblingenPatentansprüche
1. Granulat (3) zur Förderung der Knochenneubildung, insbesondere im Kiefer, bestehend aus einem vom menschlichen oder tierischem Körper resorbierbaren Material, wobei das Granulat (3) eine auf einer menschlichen oder tierischen Knochenunterlage (1) Hohlräume auffüllt.1. granules (3) to promote the formation of new bone, especially in the jaw, consisting of a resorbable material from the human or animal body, wherein the granules (3) one on a human or animal bone pad (1) fills cavities.
2. Granulat nach Anspruch 1, dadurch gekennzeichnet, dass das Granulat (3) beschichtet ist, mit vom menschlichen oder tierischem Körper resorbierbarem Material.2. Granules according to claim 1, characterized in that the granules (3) is coated with resorbable material from the human or animal body.
3. Granulat nach Anspruch 3, dadurch gekennzeichnet, dass das Dichtungsmaterial ( 8 ) aus Collagen besteht, oder zumindest Collagen enthält, vorzugsweise Collagen 1 und/oder Collagen 3.3. Granules according to claim 3, characterized in that the sealing material (8) consists of collagen, or at least contains collagen, preferably collagen 1 and / or collagen third
4. Granulat nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass das Granulat (3) allogenes Material enthält oder vollständig aus allogenem Material besteht.4. Granules according to one of the preceding claims, characterized in that the granules (3) contains allogeneic material or consists entirely of allogenic material.
5. Granulat nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, das dass Granulat (3) xenogenes Material, insbesondere Muschelschalen, enthält oder vollständig aus xenogenem Material besteht. 5. Granules according to one of the preceding claims, characterized in that the granules (3) xenogeneic material, in particular mussel shells, contains or consists entirely of xenogeneic material.
6. Granulat nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet,6. Granules according to one of the preceding claims, characterized
das dass Granulat (3) autogenes Material enthält oder vollständig aus autogenem Material besteht.that granules (3) contains autogenous material or consists entirely of autogenous material.
7. Granulat nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, das dass Granulat (3) alloplastisches Material enthält oder vollständig aus alloplastischem Material besteht.7. Granules according to one of the preceding claims, characterized in that the granules (3) contains alloplastic material or consists entirely of alloplastic material.
8. Verwendung des Granulates (3) nach einem der Ansprüche 1 bis 7 oder eines Granulates (3) bei einer medizinischen Operation, insbesondere bei einer Kieferoperation. 8. Use of the granules (3) according to any one of claims 1 to 7 or of a granulate (3) in a medical operation, in particular in a jaw operation.
PCT/DE2008/000101 2007-10-18 2008-01-22 Coated granules for new formation of bone material WO2009049574A1 (en)

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WO2010130409A3 (en) * 2009-05-11 2011-05-05 Antonis Alexakis Granulate for the new formation of bone material

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