WO2009037225A2 - Herstellung von blattextrakten von pittosporum phillyraeoides und deren verwendung in der medizin - Google Patents
Herstellung von blattextrakten von pittosporum phillyraeoides und deren verwendung in der medizin Download PDFInfo
- Publication number
- WO2009037225A2 WO2009037225A2 PCT/EP2008/062239 EP2008062239W WO2009037225A2 WO 2009037225 A2 WO2009037225 A2 WO 2009037225A2 EP 2008062239 W EP2008062239 W EP 2008062239W WO 2009037225 A2 WO2009037225 A2 WO 2009037225A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- extract
- pittosporum
- phillyraeoides
- extract according
- leaves
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Definitions
- the present invention relates to extracts of leaves of a subspecies of the tree or shrub Pittosporum phillyraeoides, in particular Pittosporum phillyraeoides DC, subspecies microcarpa S.Moore, methods of their preparation and the use of the extracts themselves or of their pharmaceutical compositions for prophylactic and therapeutic purposes, especially in malignant diseases.
- plants or their constituents such as leaves, bark, flowers, seeds, fruits and roots are an important source of medically usable defined substances or also undefined substance mixtures.
- Original or chemically modified natural substances are used as remedies worldwide or regionally limited.
- the spectrum of indications ranges from the treatment of chronic and acute inflammations, infections, circulatory disorders to cancers.
- pharmacological agents of plant origin are hydrolases such as bromelain and papain, ganomycins, ginkgolides and taxol.
- the medicinally used active substances from plants can be processed in various forms. They range from aqueous extracts prepared from dried plant parts to elaborately isolated active substances, which can additionally be chemically modified.
- the chemical processes used depend on the chemical or physicochemical properties of the active substances or substance groups.
- For the digestion of the plant components is usually a mechanical and possibly enzymatic pretreatment. Even microwaves or ultrasound are now common methods. All methods can also be used in combination.
- the aim of the extraction of plant components is as far as possible the active substances gentle treatment with simultaneous depletion of non-effective or interfering substances. This task is successful in leaves of Pittosporum phillyraeoides, in particular by the use of aqueous and / or alcoholic solvents.
- aqueous and organic solvents of different polarity, ion concentration and temperature are used for the extraction.
- Mixtures of various solvents are also common, as are extraction times of different lengths, e.g. by using Soxhlet equipment.
- the extractions applied over several hours are intensified by the use of shaking apparatus.
- oral dosage forms for the extracts obtained are drops, capsules, dragees or tablets in question, optionally in gastric juice-resistant version.
- ointments, suspensions or sprays prepared for topical use are customary.
- injectable fluids intravenous, intraperitoneal, intramuscular, intratumoral plant extracts are therapeutically applicable. Additions of excipients which improve the solubility of the extracts, their stability and their bioavailability are usual.
- Object of the present invention are methods for the preparation of extracts of leaves of Pittosporum phillyraeoides DC, subspecies microcarpa S.Moore and their provision, including in pharmaceutical preparation, for the prophylaxis and treatment of malignant diseases.
- special preparation forms of leaf extracts are particularly medically effective in cancers such as prostate carcinoma, lung carcinoma or mammary carcinoma.
- the evergreen trees or shrubs of the genus Pittosporum are used by humans worldwide in tropical areas, eg as ornamental plants, fish poison or hop substitutes. Their use for medical purposes is known by the natives.
- the leaves are mechanically crushed by the medicine women by chewing and saliva-fermented.
- the peppery porridge is then collected and heated by exposure to the sun.
- they are administered orally to wounds or painful body parts.
- the leaf extracts can be prepared by various methods known from phytopharmacy. Subsequent to the extraction of extracts from leaves of Pittosporum phillyraeoides DC, subspecies microcarpa S.Moore, subsequent aqueous, enzymatic or alcoholic extraction methods have been found.
- the invention therefore also provides an extract of leaves of Pittosporum phillyraeoides DC, in particular var. Microcarpa S.Moore.
- the leaves may have different ages and also a different degree of dryness.
- the extract according to the invention is obtainable by extraction with water, methanol, ethanol or combinations thereof, optionally with the addition of amylase.
- the extract is recovered by treatment with the said extender, water, methanol and / or ethanol at elevated temperatures. Is extractions have proven especially at temperatures up to the boiling point of the alcoholic extractants used in each case, with water up to 80 0 C. Typically, but temperature ranges between 10 0 C and 80 0 C are contemplated.
- the liquid extract After obtaining the liquid extract, it can be solidified by evaporation of the solvent, in particular by freeze-drying.
- the extract can be administered according to the invention in a pharmaceutical formulation for oral and extracorporeal topical application as well as for intravenous, intramuscular or intracutaneous application and for application as a klyma.
- the extract according to the invention is suitable for the prophylaxis and therapy of malignant diseases.
- stabilizing pharmaceutical, chemical or biological adjuvants can be added to the extract.
- the extract may also be administered in combination with other pharmacologically or medically active substances or mixtures of substances.
- the invention likewise relates to the use of the extract according to the invention for the treatment of malignant diseases.
- Amylase of commercial origin is introduced in physiological saline solution in a suitable concentration in the ratio 20: 80 (gram: Volume) and shaking 1 - incubated for 24 hours or several days, wherein the temperature is 37 ° C h and then room temperature (20 ⁇ 4 0 C 1 Thereafter, the liquid was filtered and the filtrate was reduced by lyophilization.
- Example 3 Preparation of the extract by hot ethanol.
- the extract is recovered by 70 0 C hot ethanol, which is incubated in a mixing ratio of 1:10 (grams shredded leaves: ml of ethanol) with shaking for 24 h. After filtration, the ethanol is distilled off, leaving the extract.
- composition of the extraction mixture wherein the extractant is a mixture of 80% methanol with water.
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2008300612A AU2008300612B2 (en) | 2007-09-14 | 2008-09-15 | Production of leaf extracts of Pittosporum phillyraeoides and the use thereof in medicine |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007044094A DE102007044094A1 (de) | 2007-09-14 | 2007-09-14 | Herstellung von Blattextrakten von Pittosporum phillyraeoides und deren Verwendung in der Medizin |
DE102007044094.6 | 2007-09-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009037225A2 true WO2009037225A2 (de) | 2009-03-26 |
WO2009037225A3 WO2009037225A3 (de) | 2009-09-17 |
Family
ID=40384057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/062239 WO2009037225A2 (de) | 2007-09-14 | 2008-09-15 | Herstellung von blattextrakten von pittosporum phillyraeoides und deren verwendung in der medizin |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2008300612B2 (de) |
DE (1) | DE102007044094A1 (de) |
WO (1) | WO2009037225A2 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102604418A (zh) * | 2012-01-19 | 2012-07-25 | 常州美胜生物材料有限公司 | 天然染料的提取、分离及染色应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060122129A1 (en) * | 2003-10-09 | 2006-06-08 | Chan Pui-Kwong | Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof |
-
2007
- 2007-09-14 DE DE102007044094A patent/DE102007044094A1/de not_active Ceased
-
2008
- 2008-09-15 AU AU2008300612A patent/AU2008300612B2/en active Active
- 2008-09-15 WO PCT/EP2008/062239 patent/WO2009037225A2/de active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060122129A1 (en) * | 2003-10-09 | 2006-06-08 | Chan Pui-Kwong | Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof |
Non-Patent Citations (3)
Title |
---|
ERRINGTON ET AL: "Triterpenoid sapogenins of Pittosporum phillyraeoides" PHYTOCHEMISTRY, PERGAMON PRESS, GB, Bd. 27, Nr. 2, 1. Januar 1988 (1988-01-01), Seiten 543-545, XP022478176 ISSN: 0031-9422 * |
L. J. WEBB: "The Use of Plant Medicines and Poisons by Australian Aborigines" MANKIND, Bd. 7, 1959, Seiten 137-146, XP002537569 in der Anmeldung erwähnt * |
SEMPLE S J ET AL: "Screening of Australian medicinal plants for antiviral activity." JOURNAL OF ETHNOPHARMACOLOGY MAR 1998, Bd. 60, Nr. 2, März 1998 (1998-03), Seiten 163-172, XP002537570 ISSN: 0378-8741 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102604418A (zh) * | 2012-01-19 | 2012-07-25 | 常州美胜生物材料有限公司 | 天然染料的提取、分离及染色应用 |
CN102604418B (zh) * | 2012-01-19 | 2013-11-13 | 常州美胜生物材料有限公司 | 天然染料的提取、分离及染色应用 |
Also Published As
Publication number | Publication date |
---|---|
DE102007044094A1 (de) | 2009-04-02 |
WO2009037225A3 (de) | 2009-09-17 |
AU2008300612A1 (en) | 2009-03-26 |
AU2008300612B2 (en) | 2013-03-28 |
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