WO2009031627A1 - Composé para-terphényle ou sel pharmacologiquement acceptable de ce composé, son procédé de production et son utilisation - Google Patents

Composé para-terphényle ou sel pharmacologiquement acceptable de ce composé, son procédé de production et son utilisation Download PDF

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Publication number
WO2009031627A1
WO2009031627A1 PCT/JP2008/065999 JP2008065999W WO2009031627A1 WO 2009031627 A1 WO2009031627 A1 WO 2009031627A1 JP 2008065999 W JP2008065999 W JP 2008065999W WO 2009031627 A1 WO2009031627 A1 WO 2009031627A1
Authority
WO
WIPO (PCT)
Prior art keywords
para
acceptable salt
pharmacologically acceptable
same
compound
Prior art date
Application number
PCT/JP2008/065999
Other languages
English (en)
Japanese (ja)
Inventor
Hiroyuki Koshino
Syunya Takahashi
Naoki Abe
Junichi Onose
Original Assignee
Riken
Tokyo University Of Agriculture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riken, Tokyo University Of Agriculture filed Critical Riken
Priority to JP2009531283A priority Critical patent/JP5408660B2/ja
Publication of WO2009031627A1 publication Critical patent/WO2009031627A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/24—Preparation of ethers by reactions not forming ether-oxygen bonds by elimination of halogens, e.g. elimination of HCl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un composé para-terphényle représenté par la formule (1) ou un sel pharmacologiquement acceptable de ce composé, un procédé de production du composé para-terphényle ou de son sel pharmacologiquement acceptable, ainsi que l'utilisation du composé para-terphényle ou de son sel pharmacologiquement acceptable. (1) [dans laquelle R1 et R2 désignent, indépendamment l'un de l'autre, un groupe alkyle, alkyle cyclique, alcoxyalkyle, siloxyalkyle ou phényle de 1 à 6 atomes de carbone, ou un groupe alkylène à 3 ou 4 atomes de carbone; et R3 et R4 désignent, indépendamment l'un de l'autre, un hydrogène ou un groupe protecteur pour un groupe hydroxyle]. Un composé ayant une activité inhibitrice sur la production du facteur de nécrose tumorale alpha, (TNF)-α, peut ainsi être produit par synthèse chimique. Le composé ne présente aucune activité toxique et est donc utilisé comme agent thérapeutique pour une maladie autoimmune, une maladie allergique ou analogue.
PCT/JP2008/065999 2007-09-04 2008-09-04 Composé para-terphényle ou sel pharmacologiquement acceptable de ce composé, son procédé de production et son utilisation WO2009031627A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009531283A JP5408660B2 (ja) 2007-09-04 2008-09-04 パラテルフェニル化合物、その薬理学的に許容される塩、その製造方法及び用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-229029 2007-09-04
JP2007229029 2007-09-04

Publications (1)

Publication Number Publication Date
WO2009031627A1 true WO2009031627A1 (fr) 2009-03-12

Family

ID=40428940

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065999 WO2009031627A1 (fr) 2007-09-04 2008-09-04 Composé para-terphényle ou sel pharmacologiquement acceptable de ce composé, son procédé de production et son utilisation

Country Status (2)

Country Link
JP (1) JP5408660B2 (fr)
WO (1) WO2009031627A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012094788A1 (fr) * 2011-01-13 2012-07-19 山东大学 Dérivé de paraterphényle et son utilisation dans l'élaboration de médicaments antitumoraux

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007070251A (ja) * 2005-09-05 2007-03-22 Tokyo Univ Of Agriculture 抗酸化活性及び抗アレルギー活性を有する化合物並びに該化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69726745T2 (de) * 1996-07-31 2004-09-30 Shionogi & Co., Ltd. NEUE p-TERPHENYL VERBINDUNGEN
HUP0203575A3 (en) * 1999-07-23 2003-11-28 Shionogi & Co Pharmaceutical compositions containing th2 differentiation inhibitors and their use
JP4094955B2 (ja) * 2001-01-18 2008-06-04 塩野義製薬株式会社 置換アミノ基を有するテルフェニル化合物
JP2008001675A (ja) * 2006-06-26 2008-01-10 Daiei Probis Kk 抗アレルギー剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007070251A (ja) * 2005-09-05 2007-03-22 Tokyo Univ Of Agriculture 抗酸化活性及び抗アレルギー活性を有する化合物並びに該化合物の製造方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHUN XIE ET AL: "Vialinin B, a novel potent inhibitor of TNF-α production, isolated from an edible mushroom, Thelephora vialis", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 20, 2006, pages 5424 - 5426, XP025107186 *
YE YUE QI ET AL: "First Total Synthesis of Vialinin A, a Novel and Extremely Potent Inhibitor of TNF-α Production", ORGANIC LETTERS, vol. 9, no. 21, 2007, pages 4131 - 4134, XP002552523 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012094788A1 (fr) * 2011-01-13 2012-07-19 山东大学 Dérivé de paraterphényle et son utilisation dans l'élaboration de médicaments antitumoraux

Also Published As

Publication number Publication date
JP5408660B2 (ja) 2014-02-05
JPWO2009031627A1 (ja) 2010-12-16

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