WO2009031627A1 - Para-terphenyl compound or pharmacologically acceptable salt thereof, method for production of the same, and use of the same - Google Patents

Para-terphenyl compound or pharmacologically acceptable salt thereof, method for production of the same, and use of the same Download PDF

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Publication number
WO2009031627A1
WO2009031627A1 PCT/JP2008/065999 JP2008065999W WO2009031627A1 WO 2009031627 A1 WO2009031627 A1 WO 2009031627A1 JP 2008065999 W JP2008065999 W JP 2008065999W WO 2009031627 A1 WO2009031627 A1 WO 2009031627A1
Authority
WO
WIPO (PCT)
Prior art keywords
para
acceptable salt
pharmacologically acceptable
same
compound
Prior art date
Application number
PCT/JP2008/065999
Other languages
French (fr)
Japanese (ja)
Inventor
Hiroyuki Koshino
Syunya Takahashi
Naoki Abe
Junichi Onose
Original Assignee
Riken
Tokyo University Of Agriculture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riken, Tokyo University Of Agriculture filed Critical Riken
Priority to JP2009531283A priority Critical patent/JP5408660B2/en
Publication of WO2009031627A1 publication Critical patent/WO2009031627A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/24—Preparation of ethers by reactions not forming ether-oxygen bonds by elimination of halogens, e.g. elimination of HCl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed are: a para-terphenyl compound represented by the formula (1) or a pharmacologically acceptable salt thereof; a method for producing the para-terphenyl compound or the pharmacologically acceptable salt thereof; and use of the para-terphenyl compound or the pharmacologically acceptable salt thereof. (1) [wherein R1 and R2 independently represent an alkyl, cyclic alkyl, alkoxyalkyl, siloxyalkyl or phenyl group having 1 to 6 carbon atoms or an alkylene group having 3 or 4 carbon atoms; and R3 and R4 independently represent a hydrogen or a protective group for a hydroxyl group.] Thus, a compound having an inhibitory activity on the production of tumor necrosis factor (TNF)-α can be produced by a chemical synthesis. The compound has no toxic activity, and is therefore useful as a therapeutic agent for an autoimmune disease, an allergic disease or the like.
PCT/JP2008/065999 2007-09-04 2008-09-04 Para-terphenyl compound or pharmacologically acceptable salt thereof, method for production of the same, and use of the same WO2009031627A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009531283A JP5408660B2 (en) 2007-09-04 2008-09-04 Paraterphenyl compound, pharmacologically acceptable salt thereof, production method and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007229029 2007-09-04
JP2007-229029 2007-09-04

Publications (1)

Publication Number Publication Date
WO2009031627A1 true WO2009031627A1 (en) 2009-03-12

Family

ID=40428940

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065999 WO2009031627A1 (en) 2007-09-04 2008-09-04 Para-terphenyl compound or pharmacologically acceptable salt thereof, method for production of the same, and use of the same

Country Status (2)

Country Link
JP (1) JP5408660B2 (en)
WO (1) WO2009031627A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012094788A1 (en) * 2011-01-13 2012-07-19 山东大学 Paraterphenyl derivative and use thereof for preparing antitumor medicaments

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007070251A (en) * 2005-09-05 2007-03-22 Tokyo Univ Of Agriculture Compound exhibiting antioxidant activity and antiallergic activity, and manufacturing method of the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1232443A (en) * 1996-07-31 1999-10-20 盐野义制药株式会社 Novel p-terphenyl compounds
US7008954B1 (en) * 1999-07-23 2006-03-07 Shionogi & Co., Ltd. Th2 differentiation inhibitors
WO2002057216A1 (en) * 2001-01-18 2002-07-25 Shionogi & Co., Ltd. Terphenyl compounds bearing substituted amino groups
JP2008001675A (en) * 2006-06-26 2008-01-10 Daiei Probis Kk Antiallergic agent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007070251A (en) * 2005-09-05 2007-03-22 Tokyo Univ Of Agriculture Compound exhibiting antioxidant activity and antiallergic activity, and manufacturing method of the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHUN XIE ET AL: "Vialinin B, a novel potent inhibitor of TNF-α production, isolated from an edible mushroom, Thelephora vialis", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 16, no. 20, 2006, pages 5424 - 5426, XP025107186 *
YE YUE QI ET AL: "First Total Synthesis of Vialinin A, a Novel and Extremely Potent Inhibitor of TNF-α Production", ORGANIC LETTERS, vol. 9, no. 21, 2007, pages 4131 - 4134, XP002552523 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012094788A1 (en) * 2011-01-13 2012-07-19 山东大学 Paraterphenyl derivative and use thereof for preparing antitumor medicaments

Also Published As

Publication number Publication date
JPWO2009031627A1 (en) 2010-12-16
JP5408660B2 (en) 2014-02-05

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