WO2009028487A1 - 結晶セルロース及び顆粒含有錠の製造方法 - Google Patents

結晶セルロース及び顆粒含有錠の製造方法 Download PDF

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Publication number
WO2009028487A1
WO2009028487A1 PCT/JP2008/065170 JP2008065170W WO2009028487A1 WO 2009028487 A1 WO2009028487 A1 WO 2009028487A1 JP 2008065170 W JP2008065170 W JP 2008065170W WO 2009028487 A1 WO2009028487 A1 WO 2009028487A1
Authority
WO
WIPO (PCT)
Prior art keywords
production
crystalline cellulose
granules
mass
tablets containing
Prior art date
Application number
PCT/JP2008/065170
Other languages
English (en)
French (fr)
Inventor
Yoshihito Yaginuma
Naoya Yoshida
Original Assignee
Asahi Kasei Chemicals Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Chemicals Corporation filed Critical Asahi Kasei Chemicals Corporation
Priority to EP08828249.6A priority Critical patent/EP2184056B1/en
Priority to US12/675,215 priority patent/US8367115B2/en
Priority to JP2009530121A priority patent/JP5242576B2/ja
Publication of WO2009028487A1 publication Critical patent/WO2009028487A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B1/00—Preparatory treatment of cellulose for making derivatives thereof, e.g. pre-treatment, pre-soaking, activation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/02—Cellulose; Modified cellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

　引張破断変位が２５～８０μｍ、かつ最大圧密応力１５ｋＰａにおける相対流動性指数が２．１５～２．８０である結晶セルロース２５質量％を超え８９質量％以下と、球形顆粒１０～７０質量％と、崩壊剤２０質量％以下とを混合し、次いで圧縮成形することを含む顆粒含有錠の製造方法。
PCT/JP2008/065170 2007-08-27 2008-08-26 結晶セルロース及び顆粒含有錠の製造方法 WO2009028487A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08828249.6A EP2184056B1 (en) 2007-08-27 2008-08-26 Process for production of tablets containing both crystalline cellulose and granules
US12/675,215 US8367115B2 (en) 2007-08-27 2008-08-26 Process for production of crystalline cellulose and tablets containing granules
JP2009530121A JP5242576B2 (ja) 2007-08-27 2008-08-26 結晶セルロース及び顆粒含有錠の製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-219299 2007-08-27
JP2007219299 2007-08-27

Publications (1)

Publication Number Publication Date
WO2009028487A1 true WO2009028487A1 (ja) 2009-03-05

Family

ID=40387207

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/065170 WO2009028487A1 (ja) 2007-08-27 2008-08-26 結晶セルロース及び顆粒含有錠の製造方法

Country Status (4)

Country Link
US (1) US8367115B2 (ja)
EP (1) EP2184056B1 (ja)
JP (1) JP5242576B2 (ja)
WO (1) WO2009028487A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8992988B2 (en) 2009-10-09 2015-03-31 Asahi Kasei Chemicals Corporation Coating film, and granules and tablets each utilizing same

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8268356B2 (en) * 2007-11-16 2012-09-18 Asahi Kasei Chemicals Corporation Aqueous film coating solution, film coated granule and tablet using the same
CN102056977B (zh) * 2008-06-09 2013-06-26 旭化成化学株式会社 含结晶性纤维素复合体的组合物

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53127553A (en) * 1977-04-13 1978-11-07 Asahi Chem Ind Co Ltd Vehicle
JPH07173050A (ja) * 1990-04-18 1995-07-11 Asahi Chem Ind Co Ltd 球状核、球形顆粒およびその製造方法
WO2002002613A1 (fr) * 2000-06-14 2002-01-10 Biowindow Gene Development Inc. Shanghai Nouveau polypeptide, proteine humaine de liaison 38.72 au sterol de type oxygene, et polynucleotide codant ce polypeptide
WO2004106416A1 (ja) * 2003-05-30 2004-12-09 Asahi Kasei Chemicals Corporation セルロース粉末
WO2006074185A2 (en) * 2005-01-06 2006-07-13 Cima Labs Inc. Taste masking system for non-plasticizing drugs
WO2007066646A1 (ja) * 2005-12-06 2007-06-14 Asahi Kasei Chemicals Corporation 高速直接打錠による錠剤の製造方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU508480B2 (en) * 1977-04-13 1980-03-20 Asahi Kasei Kogyo Kabushiki Kaisha Microcrystalline cellulose excipient and pharmaceutical composition containing thesame
JP2856485B2 (ja) 1990-03-07 1999-02-10 旭化成工業株式会社 顆粒含有錠
EP0452862B1 (en) * 1990-04-18 1995-07-19 Asahi Kasei Kogyo Kabushiki Kaisha Spherical seed cores, spherical granules and process for production thereof
JP2517155B2 (ja) 1990-05-16 1996-07-24 松下電器産業株式会社 Ｇｐｓ受信機の疑似雑音符号測定方法
JP3258730B2 (ja) 1992-10-29 2002-02-18 日本電産コパル株式会社 ステップモータを駆動源としたシャッタ機構
KR100496749B1 (ko) * 2000-07-05 2005-06-22 아사히 가세이 가부시키가이샤 셀룰로스 분말
AU2004285284B2 (en) 2003-10-31 2010-03-25 Hexal Ag A process for the preparation of an active-ingredient-containing formulation with a coating
WO2005084636A2 (en) 2004-02-27 2005-09-15 Ranbaxy Laboratories Limited A process for the preparation of controlled-release pharmaceutical composition of metoprolol
EP1873196B1 (en) * 2005-04-22 2016-04-13 Asahi Kasei Chemicals Corporation Porous cellulose aggregate and molding composition thereof
PE20110019A1 (es) * 2005-12-22 2011-01-27 Takeda Pharmaceutical Composicion farmaceutica que contiene un sensibilizante de insulina y un secretagogo de insulina
SG184754A1 (en) * 2005-12-28 2012-10-30 Takeda Pharmaceutical Controlled release solid preparation
WO2007074856A1 (ja) * 2005-12-28 2007-07-05 Takeda Pharmaceutical Company Limited 口腔内崩壊性固形製剤の製造法
KR100753480B1 (ko) * 2006-01-27 2007-08-31 씨제이 주식회사 잘토프로펜 함유 서방성 정제 및 그 제조방법

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53127553A (en) * 1977-04-13 1978-11-07 Asahi Chem Ind Co Ltd Vehicle
JPH07173050A (ja) * 1990-04-18 1995-07-11 Asahi Chem Ind Co Ltd 球状核、球形顆粒およびその製造方法
WO2002002613A1 (fr) * 2000-06-14 2002-01-10 Biowindow Gene Development Inc. Shanghai Nouveau polypeptide, proteine humaine de liaison 38.72 au sterol de type oxygene, et polynucleotide codant ce polypeptide
WO2004106416A1 (ja) * 2003-05-30 2004-12-09 Asahi Kasei Chemicals Corporation セルロース粉末
WO2006074185A2 (en) * 2005-01-06 2006-07-13 Cima Labs Inc. Taste masking system for non-plasticizing drugs
WO2007066646A1 (ja) * 2005-12-06 2007-06-14 Asahi Kasei Chemicals Corporation 高速直接打錠による錠剤の製造方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8992988B2 (en) 2009-10-09 2015-03-31 Asahi Kasei Chemicals Corporation Coating film, and granules and tablets each utilizing same
EP2486917A4 (en) * 2009-10-09 2016-04-13 Asahi Kasei Chemicals Corp COATING FILM, AND PELLETS AND TABLETS USING THE SAME
US9439865B2 (en) 2009-10-09 2016-09-13 Asahi Kasei Chemicals Corporation Coating film, and granules and tablets each utilizing same

Also Published As

Publication number Publication date
US8367115B2 (en) 2013-02-05
EP2184056A1 (en) 2010-05-12
US20100209504A1 (en) 2010-08-19
JPWO2009028487A1 (ja) 2010-12-02
EP2184056B1 (en) 2019-04-24
EP2184056A4 (en) 2013-06-05
JP5242576B2 (ja) 2013-07-24

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