WO2009028411A1 - 腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤 - Google Patents

腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤 Download PDF

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WO2009028411A1
WO2009028411A1 PCT/JP2008/064987 JP2008064987W WO2009028411A1 WO 2009028411 A1 WO2009028411 A1 WO 2009028411A1 JP 2008064987 W JP2008064987 W JP 2008064987W WO 2009028411 A1 WO2009028411 A1 WO 2009028411A1
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protein
agent
cell
immunosuppression
gene expression
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Chie Kudo
Yutaka Kawakami
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Keio University
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Priority to US12/674,881 priority Critical patent/US20100291677A1/en
Priority to CN200880110043A priority patent/CN101808664A/zh
Priority to JP2009530080A priority patent/JP5641599B2/ja
Priority to EP08792646.5A priority patent/EP2193805A4/en
Publication of WO2009028411A1 publication Critical patent/WO2009028411A1/ja
Priority to US13/627,655 priority patent/US9169324B2/en

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Abstract

【課題】細胞においてFoxP3遺伝子の発現を増強させるFoxP3遺伝子発現増強剤、細胞を制御性Ｔ細胞に分化誘導する細胞分化誘導剤、それらの作用から免疫を抑制する免疫抑制剤及び過剰免疫疾患治療剤、細胞においてFoxP3遺伝子の発現増強を阻害する遺伝子発現増強阻害剤、細胞の制御性Ｔ細胞への分化誘導を阻害する細胞分化誘導阻害剤、それらの作用から免疫抑制を解除する免疫抑制解除剤、腫瘍免疫賦活剤、及び抗腫瘍剤、などを提供すること。 【解決手段】例えば、Snailタンパク質、MCP1タンパク質、FSTL1タンパク質、膜型IL-13Ra2タンパク質または分泌型IL-13Ra2タンパク質を発現する細胞、あるいは、MCP1タンパク質、FSTL1タンパク質、または分泌型IL-13Ra2タンパク質、の少なくともいずれか一つを含有する薬剤をFoxP3遺伝子発現増強剤、制御性Ｔ細胞分化誘導剤、免疫抑制剤及び過剰免疫疾患治療剤として用い、抗MCP1抗体、抗FSTL1抗体、抗IL-13Ra2抗体を含有する薬剤をFoxP3遺伝子発現増強阻害剤、免疫抑制解除剤、腫瘍免疫賦活剤、及び抗腫瘍剤などとして用いる。
PCT/JP2008/064987 2007-08-24 2008-08-22 腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤 WO2009028411A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/674,881 US20100291677A1 (en) 2007-08-24 2008-08-22 Reducer of immunosuppression by tumor cell and antitumor agent using the same
CN200880110043A CN101808664A (zh) 2007-08-24 2008-08-22 肿瘤细胞所导致的免疫抑制的解除剂及使用该解除剂的抗肿瘤剂
JP2009530080A JP5641599B2 (ja) 2007-08-24 2008-08-22 腫瘍細胞による免疫抑制の解除剤とそれを用いた抗腫瘍剤
EP08792646.5A EP2193805A4 (en) 2007-08-24 2008-08-22 IMMUNOSUPPRESSION WEANING AGENT COMPRISING A TUMOR CELL AND ANTI-TUMOR AGENT USING THE SAME
US13/627,655 US9169324B2 (en) 2007-08-24 2012-09-26 Reducer of immunosuppression by tumor cell and antitumor agent using the same

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JP2007218977 2007-08-24
JP2007-218977 2007-08-24

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US12/674,881 A-371-Of-International US20100291677A1 (en) 2007-08-24 2008-08-22 Reducer of immunosuppression by tumor cell and antitumor agent using the same
US13/627,655 Continuation US9169324B2 (en) 2007-08-24 2012-09-26 Reducer of immunosuppression by tumor cell and antitumor agent using the same

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WO2009028411A1 true WO2009028411A1 (ja) 2009-03-05

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US (2) US20100291677A1 (ja)
EP (2) EP2193805A4 (ja)
JP (1) JP5641599B2 (ja)
CN (2) CN103223165B (ja)
WO (1) WO2009028411A1 (ja)

Cited By (7)

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WO2011122611A1 (ja) * 2010-03-30 2011-10-06 学校法人慶應義塾 がんワクチン
WO2016133059A1 (ja) * 2015-02-16 2016-08-25 株式会社ファーマフーズ Ｆｓｔｌ１を利用した抗がん剤・転移抑制剤およびその併用剤
JP2016529892A (ja) * 2013-08-01 2016-09-29 ユニベルシテ カソリク デ ロウバイン 抗ｇａｒｐタンパク質及びその使用
JP2017079741A (ja) * 2016-11-15 2017-05-18 国立大学法人三重大学 線維症予防又は治療剤
WO2018025869A1 (ja) * 2016-08-01 2018-02-08 株式会社ファーマフーズ がん患者におけるｆｓｔｌ１阻害剤による治療効果を予測するためのバイオマーカー
WO2018186032A1 (ja) * 2017-04-05 2018-10-11 国立大学法人千葉大学 Ｓｗｉ／ｓｎｆ複合体の機能阻害剤
JP2019112363A (ja) * 2017-12-25 2019-07-11 小林製薬株式会社 制御性ｔ細胞分化抑制剤、及び免疫調節用組成物

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PT2981822T (pt) 2013-05-06 2020-12-07 Scholar Rock Inc Composições e métodos para modulação do fator de crescimento
WO2015171691A2 (en) * 2014-05-06 2015-11-12 Scholar Rock, Inc. Compositions and methods for growth factor modulation
JP2020518569A (ja) * 2017-04-28 2020-06-25 リサーチ アンド ビジネス ファウンデーション ソンギュンクァン ユニバーシティ Ｆｏｘｐ３を発現する樹状細胞の癌の診断または治療のための用途
CN116870167A (zh) * 2023-08-24 2023-10-13 四川大学 一种用于治疗实体肿瘤的联合用药物和药物组合物

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