WO2009025159A1 - Detection and treatment of schizophrenia - Google Patents

Detection and treatment of schizophrenia Download PDF

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Publication number
WO2009025159A1
WO2009025159A1 PCT/JP2008/063803 JP2008063803W WO2009025159A1 WO 2009025159 A1 WO2009025159 A1 WO 2009025159A1 JP 2008063803 W JP2008063803 W JP 2008063803W WO 2009025159 A1 WO2009025159 A1 WO 2009025159A1
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WO
WIPO (PCT)
Prior art keywords
schizophrenia
disclosed
detection
treatment
glyoxalase
Prior art date
Application number
PCT/JP2008/063803
Other languages
French (fr)
Japanese (ja)
Inventor
Masanari Itokawa
Toshio Miyata
Makoto Arai
Original Assignee
Tokai University Educational System
Tokyo Metropolitan Organization For Medical Research
Renascience Co., Ltd.
Medical & Biological Laboratories Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokai University Educational System, Tokyo Metropolitan Organization For Medical Research, Renascience Co., Ltd., Medical & Biological Laboratories Co., Ltd. filed Critical Tokai University Educational System
Priority to PL08792016T priority Critical patent/PL2189537T3/en
Priority to SI200831305T priority patent/SI2189537T1/en
Priority to EP08792016.1A priority patent/EP2189537B1/en
Priority to ES08792016.1T priority patent/ES2515168T3/en
Priority to DK08792016.1T priority patent/DK2189537T3/en
Priority to US12/674,018 priority patent/US8809329B2/en
Publication of WO2009025159A1 publication Critical patent/WO2009025159A1/en
Priority to US14/325,808 priority patent/US20140335517A1/en
Priority to HRP20140993AT priority patent/HRP20140993T1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase

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  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

Disclosed is a schizophrenia detection method. Also disclosed is a schizophrenia detection reagent or apparatus for use in the method. Further disclosed is a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia comprises a carbonyl scavenger or an inhibitor of the production of a protein-modified product of a carbonyl compound as an active ingredient. The schizophrenia detection method is achieved by the step of measuring at least one item selected from the group consisting of the following items (1) to (4) in a subject: (1) the genetic abnormality of glyoxalase-I gene; (2) the expression level or activity of glyoxalase-I in a biological sample; (3) the quantity of a carbonyl compound or a protein-modified product thereof; and (4) and the quantity of pyridoxal in a biological sample.
PCT/JP2008/063803 2007-08-20 2008-07-31 Detection and treatment of schizophrenia WO2009025159A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
PL08792016T PL2189537T3 (en) 2007-08-20 2008-07-31 Detection and treatment of schizophrenia
SI200831305T SI2189537T1 (en) 2007-08-20 2008-07-31 Detection and treatment of schizophrenia
EP08792016.1A EP2189537B1 (en) 2007-08-20 2008-07-31 Detection and treatment of schizophrenia
ES08792016.1T ES2515168T3 (en) 2007-08-20 2008-07-31 Detection and treatment of schizophrenia
DK08792016.1T DK2189537T3 (en) 2007-08-20 2008-07-31 Detection and treatment of schizophrenia
US12/674,018 US8809329B2 (en) 2007-08-20 2008-07-31 Detection and treatment of schizophrenia
US14/325,808 US20140335517A1 (en) 2007-08-20 2014-07-08 Detection and treatment of schizophrenia
HRP20140993AT HRP20140993T1 (en) 2007-08-20 2014-10-16 Detection and treatment of schizophrenia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-214047 2007-08-20
JP2007214047A JP5288365B2 (en) 2007-07-17 2007-08-20 Examination and treatment of schizophrenia

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/674,018 A-371-Of-International US8809329B2 (en) 2007-08-20 2008-07-31 Detection and treatment of schizophrenia
US14/325,808 Division US20140335517A1 (en) 2007-08-20 2014-07-08 Detection and treatment of schizophrenia

Publications (1)

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WO2009025159A1 true WO2009025159A1 (en) 2009-02-26

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PCT/JP2008/063803 WO2009025159A1 (en) 2007-08-20 2008-07-31 Detection and treatment of schizophrenia

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US (2) US8809329B2 (en)
EP (2) EP2662453A3 (en)
JP (1) JP5288365B2 (en)
CY (1) CY1115640T1 (en)
DK (1) DK2189537T3 (en)
ES (1) ES2515168T3 (en)
HR (1) HRP20140993T1 (en)
PL (1) PL2189537T3 (en)
PT (1) PT2189537E (en)
SI (1) SI2189537T1 (en)
WO (1) WO2009025159A1 (en)

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CN102993191B (en) * 2012-12-18 2015-05-27 苏州大学 Heterocyclic chiral compound containing azlactone and pyrazolone, and derivative, synthetic method and use thereof
WO2016031839A1 (en) 2014-08-29 2016-03-03 株式会社プロジェクトＰｍ Pharmaceutical composition formed by combining pyridoxamine compound and thiamine compound
KR101796390B1 (en) * 2015-07-24 2017-11-09 동국대학교 산학협력단 Novel compound having BLT-inhibitory activity and composition for preventing or treating inflammatory diseases comprising the same as an active ingredient
JP6105111B1 (en) 2016-03-02 2017-03-29 国立大学法人東北大学 Composition for improving autism spectrum disorder
CN109982639A (en) * 2017-07-07 2019-07-05 松下知识产权经营株式会社 Information providing method, information processing system, information terminal and information processing method
JP6643747B2 (en) * 2017-07-07 2020-02-12 パナソニックＩｐマネジメント株式会社 Information providing method, information processing system, and information processing method
JP6924964B2 (en) * 2017-07-07 2021-08-25 パナソニックＩｐマネジメント株式会社 Information provision method, information processing system, information terminal, and information processing method
US11932880B2 (en) 2018-02-27 2024-03-19 Kikkoman Corporation Enzyme and method for assaying pentosidine using same
WO2021039611A1 (en) * 2019-08-27 2021-03-04 キッコーマン株式会社 Method for measuring pentosidine and measurement kit

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WO2010143762A1 (en) * 2009-06-12 2010-12-16 (주)바이오니아 Compound for inhibiting activity of ribonuclease, and container for storing nucleic acid containing the same
US8551426B2 (en) 2009-06-12 2013-10-08 Bioneer Corporation Compound for inhibiting activity of ribonuclease, and container for storing nucleic acid containing the same

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EP2662453A3 (en) 2014-02-26
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DK2189537T3 (en) 2014-10-27
US20140335517A1 (en) 2014-11-13
EP2189537B1 (en) 2014-10-08
US20110028470A1 (en) 2011-02-03
HRP20140993T1 (en) 2014-12-19
EP2189537A4 (en) 2010-08-11
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US20120065198A2 (en) 2012-03-15

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