UA86441C2 - (2-hydroxyethyl)trimethylammonium thiooctate (choline thioctate), having hepatoprotective, hypoamoniemic and detoxic action, method for production thereof and pharmaceutical compositions based on it - Google Patents

(2-hydroxyethyl)trimethylammonium thiooctate (choline thioctate), having hepatoprotective, hypoamoniemic and detoxic action, method for production thereof and pharmaceutical compositions based on it

Info

Publication number
UA86441C2
UA86441C2 UAA200703481A UAA200703481A UA86441C2 UA 86441 C2 UA86441 C2 UA 86441C2 UA A200703481 A UAA200703481 A UA A200703481A UA A200703481 A UAA200703481 A UA A200703481A UA 86441 C2 UA86441 C2 UA 86441C2
Authority
UA
Ukraine
Prior art keywords
thiooctate
trimethylammonium
hydroxyethyl
hepatoprotective
hypoamoniemic
Prior art date
Application number
UAA200703481A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Иван Иванович Новик
Original Assignee
Акционерное Общество Открытого Типа "Галичфарм"
Иван Иванович Новик
Открытое Акционерное Общество "Киевмедпрепарат"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Акционерное Общество Открытого Типа "Галичфарм", Иван Иванович Новик, Открытое Акционерное Общество "Киевмедпрепарат" filed Critical Акционерное Общество Открытого Типа "Галичфарм"
Priority to UAA200703481A priority Critical patent/UA86441C2/en
Priority to PCT/IB2008/000727 priority patent/WO2008120070A2/en
Publication of UA86441C2 publication Critical patent/UA86441C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to medicine and chemical and pharmaceutical industry, in particular, to the obtaining of new physiologically active compound (2-hydroxyethyl)trimethylammonium thiooctate (choline thioctate), having hepatoprotective, hypoamoniemic and detoxic action, to the development of method for production thereof and pharmaceutical compositions containing based on it.The technical result, which is obtained at implementation of the invention, consists in the obtaining of new physiologically active chemical compound (2-hydroxyethyl)trimethylammonium thiooctate (choline thioctate), having hepatoprotective, hypoamoniemic and detoxic action, to the development of method for production thereof, which provides higher level and larger region of specific activity with simultaneous simplification of reducing of duration of the technological process, as well as in development of pharmaceutical compositions based on new physiologically active chemical compound (2-hydroxyethyl)trimethylammonium thiooctate (choline thioctate) in different medicinal forms, use of which leads to the diversification of hepatoprotective agents.
UAA200703481A 2007-03-30 2007-03-30 (2-hydroxyethyl)trimethylammonium thiooctate (choline thioctate), having hepatoprotective, hypoamoniemic and detoxic action, method for production thereof and pharmaceutical compositions based on it UA86441C2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
UAA200703481A UA86441C2 (en) 2007-03-30 2007-03-30 (2-hydroxyethyl)trimethylammonium thiooctate (choline thioctate), having hepatoprotective, hypoamoniemic and detoxic action, method for production thereof and pharmaceutical compositions based on it
PCT/IB2008/000727 WO2008120070A2 (en) 2007-03-30 2008-03-17 2(hydroxyethyl)trimethylammonium thioctate (choline thioctate) displaying hepatoprotective, hypoammoniemic and detoxic action, a method for its production and a pharmaceutical composition based thereon

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UAA200703481A UA86441C2 (en) 2007-03-30 2007-03-30 (2-hydroxyethyl)trimethylammonium thiooctate (choline thioctate), having hepatoprotective, hypoamoniemic and detoxic action, method for production thereof and pharmaceutical compositions based on it

Publications (1)

Publication Number Publication Date
UA86441C2 true UA86441C2 (en) 2009-04-27

Family

ID=39808755

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200703481A UA86441C2 (en) 2007-03-30 2007-03-30 (2-hydroxyethyl)trimethylammonium thiooctate (choline thioctate), having hepatoprotective, hypoamoniemic and detoxic action, method for production thereof and pharmaceutical compositions based on it

Country Status (2)

Country Link
UA (1) UA86441C2 (en)
WO (1) WO2008120070A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7914815B2 (en) 2000-08-16 2011-03-29 Encore Health, Llc Method for delivery of pharmaceuticals for treating or preventing presbyopia
US7935332B2 (en) 2000-08-16 2011-05-03 Encore Health, Llc Presbyopia treatment by lens alteration
US8647612B2 (en) 2008-03-05 2014-02-11 Encore Health, Llc Dithiol compounds, derivatives, and treatment of presbyopia
US8697109B2 (en) 2000-08-16 2014-04-15 Encore Health, Llc Caged mercaptan and seleno-mercaptan compounds and methods of using them
WO2008067403A2 (en) 2006-11-28 2008-06-05 Encore Health Llc Presbyopia treatment by lens alteration
WO2009111635A2 (en) 2008-03-05 2009-09-11 Encore Health, Llc Dithiol compounds, derivatives, and uses therefor
US9044439B2 (en) 2008-03-05 2015-06-02 Encore Health, Llc Low dose lipoic and pharmaceutical compositions and methods
EP2442645B1 (en) 2009-06-15 2014-08-27 Encore Health, Llc Choline esters
DK2442647T3 (en) 2009-06-15 2016-05-30 Encore Health Llc Dithiolforbindelser, derivatives thereof, and the uses of these
CN106455563A (en) 2014-03-03 2017-02-22 安可视觉公司 Lipoic acid choline ester compositions and methods of use
JP2021512876A (en) * 2018-02-05 2021-05-20 セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ Combinations of antimuscarinic drugs or anticholinergic drugs and lipoic acid and their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR4864M (en) * 1965-10-21 1967-02-27
DE19818563C2 (en) * 1998-04-25 2003-04-17 Sueddeutsche Kalkstickstoff Use of alpha lipoic acid to reduce appetite and / or to reduce body weight

Also Published As

Publication number Publication date
WO2008120070A2 (en) 2008-10-09
WO2008120070A3 (en) 2008-12-31

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