WO2009019815A1 - 新規γセクレターゼ阻害剤 - Google Patents
新規γセクレターゼ阻害剤 Download PDFInfo
- Publication number
- WO2009019815A1 WO2009019815A1 PCT/JP2008/001728 JP2008001728W WO2009019815A1 WO 2009019815 A1 WO2009019815 A1 WO 2009019815A1 JP 2008001728 W JP2008001728 W JP 2008001728W WO 2009019815 A1 WO2009019815 A1 WO 2009019815A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- linear
- carbon atoms
- alkyl group
- branched alkyl
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008801027042A CN101970458B (zh) | 2007-08-09 | 2008-07-01 | 新型γ分泌酶抑制剂 |
US12/672,326 US8501813B2 (en) | 2007-08-09 | 2008-07-01 | γ-secretase inhibitor |
CA2695877A CA2695877A1 (en) | 2007-08-09 | 2008-07-01 | Novel .gamma.-secretase inhibitor |
EA201070245A EA017495B1 (ru) | 2007-08-09 | 2008-07-01 | ИНГИБИТОРЫ γ-СЕКРЕТАЗЫ |
EP08790127A EP2177529B1 (en) | 2007-08-09 | 2008-07-01 | Gamma-secretase inhibitor |
JP2009526326A JP5374370B2 (ja) | 2007-08-09 | 2008-07-01 | 新規γセクレターゼ阻害剤 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-207521 | 2007-08-09 | ||
JP2007207521 | 2007-08-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009019815A1 true WO2009019815A1 (ja) | 2009-02-12 |
Family
ID=40341060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/001728 WO2009019815A1 (ja) | 2007-08-09 | 2008-07-01 | 新規γセクレターゼ阻害剤 |
Country Status (8)
Country | Link |
---|---|
US (1) | US8501813B2 (ja) |
EP (1) | EP2177529B1 (ja) |
JP (1) | JP5374370B2 (ja) |
KR (1) | KR20100045458A (ja) |
CN (1) | CN101970458B (ja) |
CA (1) | CA2695877A1 (ja) |
EA (1) | EA017495B1 (ja) |
WO (1) | WO2009019815A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012520875A (ja) * | 2009-03-19 | 2012-09-10 | ブリストル−マイヤーズ スクイブ カンパニー | ベータアミロイドペプチド産生阻害剤としての新規アルファ−(n−スルホンアミド)アセトアミド化合物 |
JP2016204397A (ja) * | 2016-09-14 | 2016-12-08 | 国立大学法人京都大学 | アルツハイマー病予防薬 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102201638B1 (ko) | 2013-06-11 | 2021-01-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β 세포 및 조성물 그리고 그 생성 방법 |
CA3108275A1 (en) | 2018-08-10 | 2020-02-13 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
AU2022377078A1 (en) | 2021-11-01 | 2024-04-04 | Vertex Pharmaceuticals Incorporated | Stem cell derived pancreatic islet differentiation |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002053594A2 (en) * | 2000-12-28 | 2002-07-11 | Oklahoma Medical Research Foundation | Inhibitors of memapsin 2 and use thereof |
WO2003039454A2 (en) | 2001-10-23 | 2003-05-15 | Oklahoma Medical Research Foundation | Beta-secretase inhibitors and methods of use |
WO2003091278A1 (fr) | 2002-04-24 | 2003-11-06 | Hiroshi Mori | Inhibiteurs de gamma secretase |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040121947A1 (en) | 2000-12-28 | 2004-06-24 | Oklahoma Medical Research Foundation | Compounds which inhibit beta-secretase activity and methods of use thereof |
-
2008
- 2008-07-01 US US12/672,326 patent/US8501813B2/en not_active Expired - Fee Related
- 2008-07-01 WO PCT/JP2008/001728 patent/WO2009019815A1/ja active Application Filing
- 2008-07-01 EA EA201070245A patent/EA017495B1/ru not_active IP Right Cessation
- 2008-07-01 EP EP08790127A patent/EP2177529B1/en not_active Not-in-force
- 2008-07-01 CN CN2008801027042A patent/CN101970458B/zh not_active Expired - Fee Related
- 2008-07-01 KR KR1020107002512A patent/KR20100045458A/ko not_active Application Discontinuation
- 2008-07-01 JP JP2009526326A patent/JP5374370B2/ja not_active Expired - Fee Related
- 2008-07-01 CA CA2695877A patent/CA2695877A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002053594A2 (en) * | 2000-12-28 | 2002-07-11 | Oklahoma Medical Research Foundation | Inhibitors of memapsin 2 and use thereof |
WO2003039454A2 (en) | 2001-10-23 | 2003-05-15 | Oklahoma Medical Research Foundation | Beta-secretase inhibitors and methods of use |
WO2003091278A1 (fr) | 2002-04-24 | 2003-11-06 | Hiroshi Mori | Inhibiteurs de gamma secretase |
EP1498421A1 (en) | 2002-04-24 | 2005-01-19 | Hiroshi Mori | Gamma-secretase inhibitors |
Non-Patent Citations (4)
Title |
---|
BIOCHEMISTRY, vol. 39, no. 30, 2000, pages 8698 - 8704 |
J. BIOL. CHEM., vol. 254, no. 10, 1979, pages 4027 - 4032 |
J. MED. CHEM., vol. 41, no. 1, 1998, pages 6 - 9 |
See also references of EP2177529A4 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012520875A (ja) * | 2009-03-19 | 2012-09-10 | ブリストル−マイヤーズ スクイブ カンパニー | ベータアミロイドペプチド産生阻害剤としての新規アルファ−(n−スルホンアミド)アセトアミド化合物 |
JP2016204397A (ja) * | 2016-09-14 | 2016-12-08 | 国立大学法人京都大学 | アルツハイマー病予防薬 |
Also Published As
Publication number | Publication date |
---|---|
US20110071224A1 (en) | 2011-03-24 |
CN101970458B (zh) | 2013-08-28 |
JP5374370B2 (ja) | 2013-12-25 |
CA2695877A1 (en) | 2009-02-12 |
EP2177529A1 (en) | 2010-04-21 |
JPWO2009019815A1 (ja) | 2010-10-28 |
KR20100045458A (ko) | 2010-05-03 |
CN101970458A (zh) | 2011-02-09 |
EA017495B1 (ru) | 2012-12-28 |
EP2177529A4 (en) | 2011-04-20 |
EP2177529B1 (en) | 2013-03-27 |
EA201070245A1 (ru) | 2010-10-29 |
US8501813B2 (en) | 2013-08-06 |
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