WO2009014201A1 - 表面被覆無機物粒子の製造方法 - Google Patents

表面被覆無機物粒子の製造方法 Download PDF

Info

Publication number
WO2009014201A1
WO2009014201A1 PCT/JP2008/063361 JP2008063361W WO2009014201A1 WO 2009014201 A1 WO2009014201 A1 WO 2009014201A1 JP 2008063361 W JP2008063361 W JP 2008063361W WO 2009014201 A1 WO2009014201 A1 WO 2009014201A1
Authority
WO
WIPO (PCT)
Prior art keywords
inorganic particles
coating substance
fatty acid
polar solvent
dispersible
Prior art date
Application number
PCT/JP2008/063361
Other languages
English (en)
French (fr)
Inventor
Hiroshi Handa
Mamoru Hatakeyama
Masanori Abe
Satoshi Sakamoto
Yuka Masaike
Kosuke Nishio
Yoshinori Kita
Hiroshi Kishi
Original Assignee
Tokyo Institute Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Institute Of Technology filed Critical Tokyo Institute Of Technology
Priority to EP08791605A priority Critical patent/EP2184262B1/en
Priority to CA2694536A priority patent/CA2694536A1/en
Priority to US12/670,807 priority patent/US8852555B2/en
Priority to CN2008801006563A priority patent/CN101765562B/zh
Priority to JP2009524516A priority patent/JP5569837B2/ja
Publication of WO2009014201A1 publication Critical patent/WO2009014201A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/183—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an inorganic material or being composed of an inorganic material entrapping the MRI-active nucleus, e.g. silica core doped with a MRI-active nucleus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
    • A61K49/1836—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a carboxylic acid having less than 8 carbon atoms in the main chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1854—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly(meth)acrylate, polyacrylamide, polyvinylpyrrolidone, polyvinylalcohol
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/05—Metallic powder characterised by the size or surface area of the particles
    • B22F1/054—Nanosized particles
    • B22F1/0545—Dispersions or suspensions of nanosized particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/10—Metallic powder containing lubricating or binding agents; Metallic powder containing organic material
    • B22F1/102—Metallic powder coated with organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G49/00—Compounds of iron
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
    • C09C1/22—Compounds of iron
    • C09C1/24—Oxides of iron
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C3/00—Treatment in general of inorganic materials, other than fibrous fillers, to enhance their pigmenting or filling properties
    • C09C3/08—Treatment with low-molecular-weight non-polymer organic compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C3/00—Treatment in general of inorganic materials, other than fibrous fillers, to enhance their pigmenting or filling properties
    • C09C3/10—Treatment with macromolecular organic compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C3/00—Treatment in general of inorganic materials, other than fibrous fillers, to enhance their pigmenting or filling properties
    • C09C3/12—Treatment with organosilicon compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/42—Magnetic properties

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Power Engineering (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Compounds Of Iron (AREA)
  • Powder Metallurgy (AREA)

Abstract

　粒子サイズがよく揃い粒径が精密に制御されたナノサイズの無機物粒子が有機溶媒中での合成によって得られるようになったものの、その無機物粒子には長鎖の脂肪酸が粒子表面に吸着しているため極性溶媒中での分散が阻害されており、しかもこの表面被覆を置換して極性溶媒中で分散するナノサイズの無機物粒子を得ることが困難であった。脂肪酸で被覆された無機物粒子が分散している非極性溶媒中に、チオリンゴ酸などの一時被覆物質を添加して粒子の脂肪酸被覆をまずこの一時被覆物質被覆で置換し、次にこの一時被覆物質で被覆された無機物粒子を極性溶媒に分散し、この分散液にクエン酸などの極性溶媒分散性被覆物質を添加し、無機物粒子を被覆している一時被覆物質被覆をこの極性溶媒分散性被覆物質で置換することによって、脂肪酸で被覆された無機物粒子から極性溶媒中で分散するさまざまな表面被覆無機物粒子を得ることができるようになった。
PCT/JP2008/063361 2007-07-26 2008-07-25 表面被覆無機物粒子の製造方法 WO2009014201A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08791605A EP2184262B1 (en) 2007-07-26 2008-07-25 Process for production of surface-coated inorganic particles
CA2694536A CA2694536A1 (en) 2007-07-26 2008-07-25 Process for production of surface-coated inorganic particles
US12/670,807 US8852555B2 (en) 2007-07-26 2008-07-25 Process for production of surface-coated inorganic particles
CN2008801006563A CN101765562B (zh) 2007-07-26 2008-07-25 表面被覆无机物粒子的制造方法
JP2009524516A JP5569837B2 (ja) 2007-07-26 2008-07-25 表面被覆無機物粒子の製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007194233 2007-07-26
JP2007-194233 2007-07-26

Publications (1)

Publication Number Publication Date
WO2009014201A1 true WO2009014201A1 (ja) 2009-01-29

Family

ID=40281448

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/063361 WO2009014201A1 (ja) 2007-07-26 2008-07-25 表面被覆無機物粒子の製造方法

Country Status (7)

Country Link
US (1) US8852555B2 (ja)
EP (1) EP2184262B1 (ja)
JP (1) JP5569837B2 (ja)
KR (1) KR20100046182A (ja)
CN (1) CN101765562B (ja)
CA (1) CA2694536A1 (ja)
WO (1) WO2009014201A1 (ja)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010208875A (ja) * 2009-03-09 2010-09-24 Tokyo Institute Of Technology 磁性中空粒子およびその製造方法
WO2012063659A1 (ja) * 2010-11-10 2012-05-18 Ｄｏｗａエレクトロニクス株式会社 銀粒子含有組成物、分散液ならびにペーストおよびそれぞれの製造方法
JP2013505569A (ja) * 2009-09-21 2013-02-14 ビーエーエスエフ ソシエタス・ヨーロピア 切換え可能な強磁性ナノ粒子を含む基板
JP2013087308A (ja) * 2011-10-14 2013-05-13 Nippon Steel & Sumikin Chemical Co Ltd 金属ナノ粒子及びその製造方法
JP2013535991A (ja) * 2010-06-21 2013-09-19 ユニバーシティ オブ ワシントン センター フォー コマーシャライゼーション 生物医学向けにチューニングされた多機能性磁性ナノ粒子
JP2014088603A (ja) * 2012-10-31 2014-05-15 Nippon Steel & Sumikin Chemical Co Ltd 分散性ニッケル微粒子スラリーの製造方法
JP2014511324A (ja) * 2011-02-09 2014-05-15 ハンファ ケミカル コーポレーション 親水性物質でコーティングされた酸化鉄ナノ粒子の調製方法、及び酸化鉄ナノ粒子を含む磁気共鳴画像造影剤
JP2014517764A (ja) * 2011-04-11 2014-07-24 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ 金属クラスターおよびナノ粒子が封入された安定酸化物
JP7522606B2 (ja) 2020-08-17 2024-07-25 株式会社日本触媒 金属酸化物ナノ粒子、金属酸化物ナノ粒子を含む組成物及びその硬化物

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010519354A (ja) * 2007-02-15 2010-06-03 アイソトロン コーポレイション 無機有機ハイブリッド耐薬品性塗料
US20110220837A1 (en) * 2007-09-07 2011-09-15 Hoya Corporation Solvent-dispersible particle
WO2012050616A1 (en) * 2010-10-15 2012-04-19 Los Alamos National Security, Llc Composite materials with metal oxide attached to lead chalcogenide nanocrystal quantum dots with linkers
DE102012201774A1 (de) * 2012-02-07 2013-08-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Magnetisch abtrennbare Mikropartikel mit einer silikatischen Hülle, Verfahren zu ihrer Herstellung sowie ihre Verwendung
EP2647389A1 (en) * 2012-04-04 2013-10-09 Charité - Universitätsmedizin Berlin Magnetic nanoparticle dispersion, its preparation and diagnostic and therapeutic use
CN102863026A (zh) * 2012-09-18 2013-01-09 首都医科大学 一种水分散的锰掺杂磁性纳米簇及制备方法和应用
RU2614005C1 (ru) * 2015-12-29 2017-03-22 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский технологический университет "МИСиС" Способ измельчения смеси карбоната бария и оксида железа в производстве гексаферритов бария
KR101884380B1 (ko) * 2016-09-29 2018-08-01 동우 화인켐 주식회사 양자점 분산체, 이의 제조 방법, 컬러필터 및 화상표시장치
US10774218B2 (en) * 2017-11-03 2020-09-15 The Boeing Company Iron particle passivation
CN110292632A (zh) * 2019-07-03 2019-10-01 北京大学第三医院（北京大学第三临床医学院） 一种肿瘤热疗粒子
WO2021067537A1 (en) * 2019-10-02 2021-04-08 The Regents Of The University Of California Hydrophobically modified pigment composition
CN114558165A (zh) * 2022-03-09 2022-05-31 环心医疗科技(苏州)有限公司 一种磁性显影栓塞微球及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10503281A (ja) 1994-07-27 1998-03-24 シリカ ゲル ゲス．エム．ビー．エイチ 超常磁性粒子、それらの製造法および使用法
JP2000507197A (ja) 1996-03-18 2000-06-13 ピルグリム，ヘルベルト Ｒ▲下１▼緩和性を増加した超常磁性体粒子、前記粒子の製造方法およびその使用
JP2004075530A (ja) * 2002-07-31 2004-03-11 General Electric Co <Ge> 無機コアを有するナノ粒子
JP2006502572A (ja) 2002-10-09 2006-01-19 フェロファーマ ゲーエムベーハー フォルシュングスラボア 安定化超常磁性粒子
JP2006025627A (ja) * 2004-07-13 2006-02-02 Nichimo Co Ltd 水産用資材
JP2006282582A (ja) 2005-03-31 2006-10-19 Tokyo Institute Of Technology 表面修飾無機微粒子の製造方法および表面修飾無機微粒子

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6361944B1 (en) * 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6083484A (en) * 1996-10-17 2000-07-04 Molecular Biosystems, Inc. Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents
CN1646549A (zh) * 2002-02-04 2005-07-27 财团法人理工学振兴会 结合铁氧体的有机物及其制备方法
US7541509B2 (en) * 2004-08-31 2009-06-02 University Of Florida Research Foundation, Inc. Photocatalytic nanocomposites and applications thereof
KR100604976B1 (ko) * 2004-09-03 2006-07-28 학교법인연세대학교 다작용기 리간드로 안정화된 수용성 나노입자

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10503281A (ja) 1994-07-27 1998-03-24 シリカ ゲル ゲス．エム．ビー．エイチ 超常磁性粒子、それらの製造法および使用法
JP2000507197A (ja) 1996-03-18 2000-06-13 ピルグリム，ヘルベルト Ｒ▲下１▼緩和性を増加した超常磁性体粒子、前記粒子の製造方法およびその使用
JP2004075530A (ja) * 2002-07-31 2004-03-11 General Electric Co <Ge> 無機コアを有するナノ粒子
JP2006502572A (ja) 2002-10-09 2006-01-19 フェロファーマ ゲーエムベーハー フォルシュングスラボア 安定化超常磁性粒子
JP2006025627A (ja) * 2004-07-13 2006-02-02 Nichimo Co Ltd 水産用資材
JP2006282582A (ja) 2005-03-31 2006-10-19 Tokyo Institute Of Technology 表面修飾無機微粒子の製造方法および表面修飾無機微粒子

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
J. AM. CHEM. SOC., vol. 126, 2004, pages 273 - 279
J. AM. CHEM. SOC., vol. 127, 2005, pages 2732 - 5733
J. AM. CHEM. SOC., vol. 127, 2005, pages 5732 - 5733
JIANG W. ET AL.: "Preparation and properties of superparamagnetic nanoparticles with narrow size distribution and biocompatible", JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, vol. 283, 2004, pages 210 - 214, XP004629551 *
JUN Y.-W. ET AL.: "Nanoscale Size Effect of Magnetic Nanocrystals and Their Utilization for Cancer Diagnosis via Magnetic Resonance Imaging", J. AM. CHEM. SOC., vol. 127, no. 16, 2005, pages 5732 - 5733, XP008129911 *
LATTUADA M. ET AL.: "Functionalization of Monodisperse Magnetic Nanoparticles", LANGMUIR, vol. 23, 13 February 2007 (2007-02-13), pages 2158 - 2168, XP008129912 *
NAT. MATER., vol. 3, 2004, pages 891 - 895
See also references of EP2184262A4
SUN Y. ET AL.: "An improved may to prepara superparamagnetic magnetite-silica core-shell nanoparitcles for possible biological application", JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, vol. 285, 2005, pages 65 - 70, XP004659948 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010208875A (ja) * 2009-03-09 2010-09-24 Tokyo Institute Of Technology 磁性中空粒子およびその製造方法
JP2013505569A (ja) * 2009-09-21 2013-02-14 ビーエーエスエフ ソシエタス・ヨーロピア 切換え可能な強磁性ナノ粒子を含む基板
JP2013535991A (ja) * 2010-06-21 2013-09-19 ユニバーシティ オブ ワシントン センター フォー コマーシャライゼーション 生物医学向けにチューニングされた多機能性磁性ナノ粒子
WO2012063659A1 (ja) * 2010-11-10 2012-05-18 Ｄｏｗａエレクトロニクス株式会社 銀粒子含有組成物、分散液ならびにペーストおよびそれぞれの製造方法
US9255205B2 (en) 2010-11-10 2016-02-09 Dowa Electronics Materials Co., Ltd. Silver particle-containing composition, dispersion solution, and paste and method for manufacturing the same
JP2014511324A (ja) * 2011-02-09 2014-05-15 ハンファ ケミカル コーポレーション 親水性物質でコーティングされた酸化鉄ナノ粒子の調製方法、及び酸化鉄ナノ粒子を含む磁気共鳴画像造影剤
US9352058B2 (en) 2011-02-09 2016-05-31 Hanwha Chemical Corporation Method of preparing iron oxide nanoparticles coated with hydrophilic material, and magnetic resonance imaging contrast agent using the same
JP2014517764A (ja) * 2011-04-11 2014-07-24 カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ 金属クラスターおよびナノ粒子が封入された安定酸化物
JP2013087308A (ja) * 2011-10-14 2013-05-13 Nippon Steel & Sumikin Chemical Co Ltd 金属ナノ粒子及びその製造方法
JP2014088603A (ja) * 2012-10-31 2014-05-15 Nippon Steel & Sumikin Chemical Co Ltd 分散性ニッケル微粒子スラリーの製造方法
JP7522606B2 (ja) 2020-08-17 2024-07-25 株式会社日本触媒 金属酸化物ナノ粒子、金属酸化物ナノ粒子を含む組成物及びその硬化物

Also Published As

Publication number Publication date
EP2184262A4 (en) 2011-12-14
EP2184262B1 (en) 2012-12-26
KR20100046182A (ko) 2010-05-06
US20100254908A1 (en) 2010-10-07
JP5569837B2 (ja) 2014-08-13
CA2694536A1 (en) 2009-01-29
CN101765562B (zh) 2013-05-29
CN101765562A (zh) 2010-06-30
US8852555B2 (en) 2014-10-07
EP2184262A1 (en) 2010-05-12
JPWO2009014201A1 (ja) 2010-10-07

Similar Documents

Publication Publication Date Title
WO2009014201A1 (ja) 表面被覆無機物粒子の製造方法
Uddin et al. Effects of various surfactants on the dispersion stability and electrical conductivity of surface modified graphene
ES2882949T3 (es) Procedimiento para preparar nanoplaquetas de grafeno
Yun et al. Difference of dispersion behavior between graphene oxide and oxidized carbon nanotubes in polar organic solvents
Li et al. Fabrication of carbon nanotube/SiO 2 and carbon nanotube/SiO 2/Ag nanoparticles hybrids by using plasma treatment
US20090226684A1 (en) Printable Composition Containing Carbon Nanotubes, Processes for Their Preparation and Electrically Conductive Coating Prepared Therefrom
WO2018002607A3 (en) Formation of 2d flakes from chemical cutting of prefabricated nanoparticles and van der waals heterostructure devices made using the same
Liu et al. Layer-by-layer assembly and tribological property of multilayer ultrathin films constructed by modified graphene sheets and polyethyleneimine
MY185109A (en) Composition and process for making a porous inorganic oxide coating
Rani et al. Multilayer films of cationic graphene-polyelectrolytes and anionic graphene-polyelectrolytes fabricated using layer-by-layer self-assembly
WO2009014200A1 (ja) ハニカム構造体用コーティング材
TW200719993A (en) Metal nanoparticle, metal nanoparticle colloid, method for storing metal nanoparticle colloid, and metal coating film
WO2007112805A3 (de) Herstellung von nanopartikeln, insbesondere nanopartikelkompositen, ausgehend von pulveragglomeraten
WO2006094808A3 (de) Verfahren zur herstellung ultrafeiner submicron-suspensionen
WO2009060613A1 (ja) ナノダイヤモンド有機溶媒分散体およびその製造法
WO2008114866A1 (ja) 金属微粒子及びその製造方法、並びに金属微粒子分散液及びその製造方法
WO2009037717A3 (en) Nanocomposite material useful for the preparation superhydrophobic coating and a process for the preparation thereof
WO2008017364A3 (de) Mit polysiloxan oberflächenmodifizierte partikel und herstellungsverfahren
WO2010041834A3 (ko) 광결정으로 이루어진 페인트 조성물용 안료 및 이의 제조 방법
WO2009142852A3 (en) Process for manufacturing flowable powder drug compositions
Azani et al. Highly concentrated and stable few-layers graphene suspensions in pure and volatile organic solvents
Modesto-López et al. Direct deposition of graphene nanomaterial films on polymer-coated glass by ultrasonic spraying
WO2008034856A3 (de) Wässrige siliciumdioxid dispersionen für dicht- und klebstoffformulierungen
Nasiri et al. Carbonaceous sorbents alongside an optimized magnetic solid phase extraction (MSPE) towards enrichment of crude Paclitaxel extracts from callus cultures of Taxus baccata
Zhang et al. Layer-by-layer assembled gold nanoparticle films on amine-terminated substrates

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880100656.3

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08791605

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
ENP Entry into the national phase

Ref document number: 2009524516

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2694536

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 456/KOLNP/2010

Country of ref document: IN

ENP Entry into the national phase

Ref document number: 20107002865

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2008791605

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 12670807

Country of ref document: US