WO2008156159A1 - ジアミン誘導体の製造法 - Google Patents
ジアミン誘導体の製造法 Download PDFInfo
- Publication number
- WO2008156159A1 WO2008156159A1 PCT/JP2008/061296 JP2008061296W WO2008156159A1 WO 2008156159 A1 WO2008156159 A1 WO 2008156159A1 JP 2008061296 W JP2008061296 W JP 2008061296W WO 2008156159 A1 WO2008156159 A1 WO 2008156159A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydrogen atom
- group
- ring
- production
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
活性化血液凝固第X因子の阻害剤として有用な化合物(1)及び(1a)の工業的な製造方法を提供する。 下記の[工程a]~[工程c] [式中、R1は水素原子、ハロゲノ基等;R2は水素原子、ハロゲノ基等;R3及びR4は、同一又は異なって、水素原子又はC1~4アルキル基;R5は、水素原子又はホルミル基;R6は、水素原子又はメチル基;R8及びR9は、同一又は異なって、メチル基又はエチル基;環Aはピリジン環等;環Bは、4,5,6,7-テトラヒドロチアゾロ[5,4-c]ピリジン環等を示す。]を特徴とする活性化血液凝固第X因子(FXa)の阻害剤として有用な化合物(1)及び(1a)の工業的な製造方法。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009520545A JPWO2008156159A1 (ja) | 2007-06-21 | 2008-06-20 | ジアミン誘導体の製造法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-164176 | 2007-06-21 | ||
JP2007164176 | 2007-06-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008156159A1 true WO2008156159A1 (ja) | 2008-12-24 |
Family
ID=40156317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/061296 WO2008156159A1 (ja) | 2007-06-21 | 2008-06-20 | ジアミン誘導体の製造法 |
Country Status (3)
Country | Link |
---|---|
JP (2) | JPWO2008156159A1 (ja) |
TW (1) | TW200909437A (ja) |
WO (1) | WO2008156159A1 (ja) |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010058751A1 (ja) * | 2008-11-18 | 2010-05-27 | 第一三共株式会社 | [1,3,4]オキサジアゾール化合物の薬理上許容される塩又はその水和物 |
WO2010071121A1 (ja) | 2008-12-17 | 2010-06-24 | 第一三共株式会社 | ジアミン誘導体の製造方法 |
WO2010082531A1 (ja) | 2009-01-13 | 2010-07-22 | 第一三共株式会社 | 活性化血液凝固因子阻害剤 |
WO2011115066A1 (ja) | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | ジアミン誘導体の結晶およびその製造方法 |
WO2011115067A1 (ja) | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | 抗凝固剤の溶出改善方法 |
US8258325B2 (en) | 2007-02-05 | 2012-09-04 | Evonik Oxeno Gmbh | Mixture of diesters of dianhydrohexitol derivatives with carboxylic acids of the empirical formula C8H17COOH, process for preparing these diesters, and use of these mixtures |
US8357808B2 (en) | 2009-03-10 | 2013-01-22 | Daiichi Sankyo Company, Limited | Process for producing diamine derivative |
US8449896B2 (en) | 2009-06-18 | 2013-05-28 | Daiichi Sankyo Company, Limited | Pharmaceutical composition having improved solubility |
US8901345B2 (en) | 2010-07-02 | 2014-12-02 | Daiichi Sankyo Company, Limited | Process for preparation of optically active diamine derivative salt |
US9175012B2 (en) | 2009-03-13 | 2015-11-03 | Daiichi Sankyo Company, Limited | Method for producing optically active diamine derivative |
US9402907B2 (en) | 2011-08-10 | 2016-08-02 | Daiichi Sankyo Company, Limited | Pharmaceutical composition containing diamine derivative |
US9707296B2 (en) | 2007-03-29 | 2017-07-18 | Daiichi Sankyo Company, Limited | Pharmaceutical composition |
CN109942600A (zh) * | 2019-04-15 | 2019-06-28 | 内蒙古京东药业有限公司 | 一种依度沙班的制备方法 |
WO2022129535A1 (en) | 2020-12-18 | 2022-06-23 | Krka, D.D., Novo Mesto | Edoxaban formulation containing no sugar alcohols |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110950886A (zh) * | 2019-12-13 | 2020-04-03 | 苏州莱克施德药业有限公司 | 一种合成1-甲基-咪唑-2-甲酸甲酯衍生物的方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001074774A1 (fr) * | 2000-04-05 | 2001-10-11 | Daiichi Pharmaceutical Co., Ltd. | Derives ethylenediamine |
JP2007070369A (ja) * | 2002-12-25 | 2007-03-22 | Dai Ichi Seiyaku Co Ltd | ジアミン誘導体 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11199586A (ja) * | 1997-10-23 | 1999-07-27 | Takeda Chem Ind Ltd | 縮合型イミダゾピリジン誘導体、その製造法及び剤 |
-
2008
- 2008-06-19 TW TW097122795A patent/TW200909437A/zh unknown
- 2008-06-20 WO PCT/JP2008/061296 patent/WO2008156159A1/ja active Application Filing
- 2008-06-20 JP JP2009520545A patent/JPWO2008156159A1/ja not_active Withdrawn
-
2013
- 2013-09-09 JP JP2013185829A patent/JP2014051492A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001074774A1 (fr) * | 2000-04-05 | 2001-10-11 | Daiichi Pharmaceutical Co., Ltd. | Derives ethylenediamine |
JP2007070369A (ja) * | 2002-12-25 | 2007-03-22 | Dai Ichi Seiyaku Co Ltd | ジアミン誘導体 |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8258325B2 (en) | 2007-02-05 | 2012-09-04 | Evonik Oxeno Gmbh | Mixture of diesters of dianhydrohexitol derivatives with carboxylic acids of the empirical formula C8H17COOH, process for preparing these diesters, and use of these mixtures |
US9707296B2 (en) | 2007-03-29 | 2017-07-18 | Daiichi Sankyo Company, Limited | Pharmaceutical composition |
WO2010058751A1 (ja) * | 2008-11-18 | 2010-05-27 | 第一三共株式会社 | [1,3,4]オキサジアゾール化合物の薬理上許容される塩又はその水和物 |
WO2010071121A1 (ja) | 2008-12-17 | 2010-06-24 | 第一三共株式会社 | ジアミン誘導体の製造方法 |
US8404847B2 (en) | 2008-12-17 | 2013-03-26 | Daiichi Sankyo Company, Limited | Method for producing diamine derivative |
US8394821B2 (en) | 2009-01-13 | 2013-03-12 | Daiichi Sankyo Company, Limited | Activated blood coagulation factor inhibitor |
WO2010082531A1 (ja) | 2009-01-13 | 2010-07-22 | 第一三共株式会社 | 活性化血液凝固因子阻害剤 |
US8357808B2 (en) | 2009-03-10 | 2013-01-22 | Daiichi Sankyo Company, Limited | Process for producing diamine derivative |
US9175012B2 (en) | 2009-03-13 | 2015-11-03 | Daiichi Sankyo Company, Limited | Method for producing optically active diamine derivative |
US8449896B2 (en) | 2009-06-18 | 2013-05-28 | Daiichi Sankyo Company, Limited | Pharmaceutical composition having improved solubility |
KR20130016225A (ko) | 2010-03-19 | 2013-02-14 | 다이이찌 산쿄 가부시키가이샤 | 디아민 유도체의 결정 및 그 제조 방법 |
US9918975B2 (en) | 2010-03-19 | 2018-03-20 | Daiichi Sankyo Company, Limited | Method for improving dissolution of anticoagulant agent |
WO2011115066A1 (ja) | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | ジアミン誘導体の結晶およびその製造方法 |
US8541443B2 (en) | 2010-03-19 | 2013-09-24 | Daiichi Sankyo Company, Limited | Crystal of diamine derivative and method of producing same |
WO2011115067A1 (ja) | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | 抗凝固剤の溶出改善方法 |
US8901345B2 (en) | 2010-07-02 | 2014-12-02 | Daiichi Sankyo Company, Limited | Process for preparation of optically active diamine derivative salt |
US9402907B2 (en) | 2011-08-10 | 2016-08-02 | Daiichi Sankyo Company, Limited | Pharmaceutical composition containing diamine derivative |
CN109942600A (zh) * | 2019-04-15 | 2019-06-28 | 内蒙古京东药业有限公司 | 一种依度沙班的制备方法 |
CN109942600B (zh) * | 2019-04-15 | 2021-08-20 | 内蒙古京东药业有限公司 | 一种依度沙班的制备方法 |
WO2022129535A1 (en) | 2020-12-18 | 2022-06-23 | Krka, D.D., Novo Mesto | Edoxaban formulation containing no sugar alcohols |
Also Published As
Publication number | Publication date |
---|---|
TW200909437A (en) | 2009-03-01 |
JPWO2008156159A1 (ja) | 2010-08-26 |
JP2014051492A (ja) | 2014-03-20 |
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