WO2008153135A1 - Dérivé de naphtalène - Google Patents

Dérivé de naphtalène Download PDF

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Publication number
WO2008153135A1
WO2008153135A1 PCT/JP2008/060865 JP2008060865W WO2008153135A1 WO 2008153135 A1 WO2008153135 A1 WO 2008153135A1 JP 2008060865 W JP2008060865 W JP 2008060865W WO 2008153135 A1 WO2008153135 A1 WO 2008153135A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogen atom
optionally substituted
independently represent
different
same
Prior art date
Application number
PCT/JP2008/060865
Other languages
English (en)
Japanese (ja)
Inventor
Hiroyuki Nakahira
Hitoshi Hochigai
Yohei Ikuma
Atsushi Suwa
Junya Ikeda
Original Assignee
Dainippon Sumitomo Pharma Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Sumitomo Pharma Co., Ltd. filed Critical Dainippon Sumitomo Pharma Co., Ltd.
Publication of WO2008153135A1 publication Critical patent/WO2008153135A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur un composé représenté par la formule (I) ci-après ou sur un sel acceptable du point de vue pharmaceutique de celui-ci, qui s'utilise comme inhibiteur de la rénine. (I) (Dans la formule, R1a représente un groupe alcoxy en C1-6 facultativement substitué ou similaire ; R1b et R1e peuvent être identiques ou différents et représentent indépendamment un atome d'hydrogène, un atome d'halogène ou similaire ; R1c et R1d peuvent être identiques ou différents et représentent indépendamment un atome d'hydrogène, un atome d'halogène ou similaire ; R1f et R1g peuvent être identiques ou différents et représentent indépendamment un atome d'hydrogène, un atome d'halogène ou similaire ; R2 représente un groupe alkyle en C1-6 facultativement substitué ou similaire ; R3a, R3b, R3c et R3d peuvent être identiques ou différents et représentent indépendamment un groupe -A-B (dans lequel A représente une simple liaison, un groupe -(CH2)sO ou similaire, et B représente un atome d'hydrogène, un groupe alkyle en C1-6 facultativement substitué ou similaire) ; R4 représente un atome d'hydrogène, un groupe alkyle en C1-6 facultativement substitué ou similaire ; s représente 0 ou similaire ; et n représente 1 ou similaire).
PCT/JP2008/060865 2007-06-14 2008-06-13 Dérivé de naphtalène WO2008153135A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-158075 2007-06-14
JP2007158075A JP2010189275A (ja) 2007-06-14 2007-06-14 ナフタレン誘導体

Publications (1)

Publication Number Publication Date
WO2008153135A1 true WO2008153135A1 (fr) 2008-12-18

Family

ID=40129738

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060865 WO2008153135A1 (fr) 2007-06-14 2008-06-13 Dérivé de naphtalène

Country Status (2)

Country Link
JP (1) JP2010189275A (fr)
WO (1) WO2008153135A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010150840A1 (fr) 2009-06-24 2010-12-29 大日本住友製薬株式会社 Dérivé amino cyclique n-substitué
US8389511B2 (en) 2007-12-19 2013-03-05 Dainippon Sumitomo Pharma Co., Ltd. Bicyclic heterocyclic derivative
US8466282B2 (en) 2008-06-19 2013-06-18 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004111003A1 (fr) * 2003-06-17 2004-12-23 Pfizer Limited Derives d'amide en tant qu'inhibiteurs selectifs du recaptage de la serotonine
WO2006066896A2 (fr) * 2004-12-23 2006-06-29 Novartis Ag Composes organiques
JP2006522793A (ja) * 2003-04-10 2006-10-05 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー 高血圧治療のためのレニン阻害剤としてのピペリジン誘導体
JP2006527758A (ja) * 2003-06-17 2006-12-07 ファイザー インコーポレイテッド セロトニン及びノルアドレナリン再取り込み阻害薬としてのｎ−ピロリジン−３−イル−アミド誘導体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522793A (ja) * 2003-04-10 2006-10-05 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー 高血圧治療のためのレニン阻害剤としてのピペリジン誘導体
WO2004111003A1 (fr) * 2003-06-17 2004-12-23 Pfizer Limited Derives d'amide en tant qu'inhibiteurs selectifs du recaptage de la serotonine
JP2006527758A (ja) * 2003-06-17 2006-12-07 ファイザー インコーポレイテッド セロトニン及びノルアドレナリン再取り込み阻害薬としてのｎ−ピロリジン−３−イル−アミド誘導体
WO2006066896A2 (fr) * 2004-12-23 2006-06-29 Novartis Ag Composes organiques

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8389511B2 (en) 2007-12-19 2013-03-05 Dainippon Sumitomo Pharma Co., Ltd. Bicyclic heterocyclic derivative
US8466282B2 (en) 2008-06-19 2013-06-18 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US8664380B2 (en) 2008-06-19 2014-03-04 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US9045436B2 (en) 2008-06-19 2015-06-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US9221836B2 (en) 2008-06-19 2015-12-29 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
WO2010150840A1 (fr) 2009-06-24 2010-12-29 大日本住友製薬株式会社 Dérivé amino cyclique n-substitué
US8658639B2 (en) 2009-06-24 2014-02-25 Dainippon Sumitomo Pharma Co., Ltd N-substituted-cyclic amino derivative

Also Published As

Publication number Publication date
JP2010189275A (ja) 2010-09-02

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