WO2008136457A1 - Dérivé aromatique contenant de l'azote - Google Patents
Dérivé aromatique contenant de l'azote Download PDFInfo
- Publication number
- WO2008136457A1 WO2008136457A1 PCT/JP2008/058192 JP2008058192W WO2008136457A1 WO 2008136457 A1 WO2008136457 A1 WO 2008136457A1 JP 2008058192 W JP2008058192 W JP 2008058192W WO 2008136457 A1 WO2008136457 A1 WO 2008136457A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydrogen atom
- formula
- optionally substituted
- independently represent
- different
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne un composé représenté par la formule (I) ci-après, qui est utile en tant qu'inhibiteur de la rénine, ou un sel pharmaceutiquement acceptable de celui-ci. (Dans la formule (I) ci-après, G représente un groupe représenté par la formule (a') ci-après ou similaire; R1a représente un groupe alcoxy en C1-6 facultativement substitué ou similaire; R1b et R1e peuvent être identiques ou différents et représentent indépendamment un atome d'hydrogène, un atome d'halogène ou similaire, R1c et R1d peuvent être identiques ou différents et représentent indépendamment un atome d'hydrogène, un atome d'halogène ou similaire; R1f représente un atome d'hydrogène ou similaire; R2 représente un groupe alkyle en C1-6 facultativement substitué ou similaire; R3a, R3b, R3c et R3d peuvent être identiques ou différents et représentent indépendamment un groupe exprimé comme de -A-B (où A représente une simple liaison ou similaire, et B représente un atome d'hydrogène, un groupe alkyle en C1-6 facultativement substitué ou similaire); et n représente 0 ou similaire.)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007120357A JP2010163361A (ja) | 2007-04-27 | 2007-04-27 | キノリン誘導体 |
JP2007-120357 | 2007-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008136457A1 true WO2008136457A1 (fr) | 2008-11-13 |
Family
ID=39943564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/058192 WO2008136457A1 (fr) | 2007-04-27 | 2008-04-28 | Dérivé aromatique contenant de l'azote |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP2010163361A (fr) |
WO (1) | WO2008136457A1 (fr) |
Cited By (42)
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---|---|---|---|---|
US20090156572A1 (en) * | 2007-12-03 | 2009-06-18 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound and use thereof |
WO2010150840A1 (fr) | 2009-06-24 | 2010-12-29 | 大日本住友製薬株式会社 | Dérivé amino cyclique n-substitué |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
US8389511B2 (en) | 2007-12-19 | 2013-03-05 | Dainippon Sumitomo Pharma Co., Ltd. | Bicyclic heterocyclic derivative |
US8466282B2 (en) | 2008-06-19 | 2013-06-18 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
WO2013088452A2 (fr) | 2011-11-11 | 2013-06-20 | Sun Pharma Advanced Research Company Ltd. | Dérivés de quinoléine utilisés en tant qu'inhibiteurs de la rénine |
US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
US8604032B2 (en) | 2010-05-21 | 2013-12-10 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
US8637542B2 (en) | 2008-03-14 | 2014-01-28 | Intellikine, Inc. | Kinase inhibitors and methods of use |
US8642604B2 (en) | 2006-04-04 | 2014-02-04 | The Regents Of The University Of California | Substituted pyrazolo[3,2-d]pyrimidines as anti-cancer agents |
US8697709B2 (en) | 2008-10-16 | 2014-04-15 | The Regents Of The University Of California | Fused ring heteroaryl kinase inhibitors |
US8703777B2 (en) | 2008-01-04 | 2014-04-22 | Intellikine Llc | Certain chemical entities, compositions and methods |
US8703778B2 (en) | 2008-09-26 | 2014-04-22 | Intellikine Llc | Heterocyclic kinase inhibitors |
US8785470B2 (en) | 2011-08-29 | 2014-07-22 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8785454B2 (en) | 2009-05-07 | 2014-07-22 | Intellikine Llc | Heterocyclic compounds and uses thereof |
US8809349B2 (en) | 2011-01-10 | 2014-08-19 | Infinity Pharmaceuticals, Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
US8901133B2 (en) | 2010-11-10 | 2014-12-02 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8980899B2 (en) | 2009-10-16 | 2015-03-17 | The Regents Of The University Of California | Methods of inhibiting Ire1 |
US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
US9056877B2 (en) | 2011-07-19 | 2015-06-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9096611B2 (en) | 2008-07-08 | 2015-08-04 | Intellikine Llc | Kinase inhibitors and methods of use |
US9295673B2 (en) | 2011-02-23 | 2016-03-29 | Intellikine Llc | Combination of mTOR inhibitors and P13-kinase inhibitors, and uses thereof |
US9321772B2 (en) | 2011-09-02 | 2016-04-26 | The Regents Of The University Of California | Substituted pyrazolo[3,4-D]pyrimidines and uses thereof |
US9359365B2 (en) | 2013-10-04 | 2016-06-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9359349B2 (en) | 2007-10-04 | 2016-06-07 | Intellikine Llc | Substituted quinazolines as kinase inhibitors |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
US9512125B2 (en) | 2004-11-19 | 2016-12-06 | The Regents Of The University Of California | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents |
US9629843B2 (en) | 2008-07-08 | 2017-04-25 | The Regents Of The University Of California | MTOR modulators and uses thereof |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US9775844B2 (en) | 2014-03-19 | 2017-10-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN108299397A (zh) * | 2018-03-21 | 2018-07-20 | 佳木斯大学附属第医院 | 一种用于降血压的活性药物及其制备方法 |
US10131668B2 (en) | 2012-09-26 | 2018-11-20 | The Regents Of The University Of California | Substituted imidazo[1,5-a]pYRAZINES for modulation of IRE1 |
US10160761B2 (en) | 2015-09-14 | 2018-12-25 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same |
US10759806B2 (en) | 2016-03-17 | 2020-09-01 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US11110096B2 (en) | 2014-04-16 | 2021-09-07 | Infinity Pharmaceuticals, Inc. | Combination therapies |
US11147818B2 (en) | 2016-06-24 | 2021-10-19 | Infinity Pharmaceuticals, Inc. | Combination therapies |
WO2022059779A1 (fr) | 2020-09-18 | 2022-03-24 | 大日本住友製薬株式会社 | Dérivé d'amine |
Families Citing this family (1)
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CN111138346B (zh) * | 2020-02-13 | 2022-11-08 | 上海大学 | 2-乙基-4,6-二取代吡啶类化合物及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2006522793A (ja) * | 2003-04-10 | 2006-10-05 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | 高血圧治療のためのレニン阻害剤としてのピペリジン誘導体 |
WO2006106963A1 (fr) * | 2005-03-31 | 2006-10-12 | Daiichi Sankyo Company, Limited | Dérivé de triamine |
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2007
- 2007-04-27 JP JP2007120357A patent/JP2010163361A/ja active Pending
-
2008
- 2008-04-28 WO PCT/JP2008/058192 patent/WO2008136457A1/fr active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2006522793A (ja) * | 2003-04-10 | 2006-10-05 | ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー | 高血圧治療のためのレニン阻害剤としてのピペリジン誘導体 |
WO2006106963A1 (fr) * | 2005-03-31 | 2006-10-12 | Daiichi Sankyo Company, Limited | Dérivé de triamine |
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US8389511B2 (en) | 2007-12-19 | 2013-03-05 | Dainippon Sumitomo Pharma Co., Ltd. | Bicyclic heterocyclic derivative |
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CN108299397A (zh) * | 2018-03-21 | 2018-07-20 | 佳木斯大学附属第医院 | 一种用于降血压的活性药物及其制备方法 |
CN108299397B (zh) * | 2018-03-21 | 2019-01-29 | 佳木斯大学附属第一医院 | 一种用于降血压的活性药物及其制备方法 |
WO2022059779A1 (fr) | 2020-09-18 | 2022-03-24 | 大日本住友製薬株式会社 | Dérivé d'amine |
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