WO2008150981A2 - Nouveaux peptides courts inhibant l'ouverture de jonctions serrées mammaliennes - Google Patents

Nouveaux peptides courts inhibant l'ouverture de jonctions serrées mammaliennes Download PDF

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Publication number
WO2008150981A2
WO2008150981A2 PCT/US2008/065268 US2008065268W WO2008150981A2 WO 2008150981 A2 WO2008150981 A2 WO 2008150981A2 US 2008065268 W US2008065268 W US 2008065268W WO 2008150981 A2 WO2008150981 A2 WO 2008150981A2
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
seq
tight junctions
antagonist
acid sequence
Prior art date
Application number
PCT/US2008/065268
Other languages
English (en)
Other versions
WO2008150981A3 (fr
Inventor
Amir Tamiz
Original Assignee
Alba Therapeutics Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alba Therapeutics Corporation filed Critical Alba Therapeutics Corporation
Publication of WO2008150981A2 publication Critical patent/WO2008150981A2/fr
Publication of WO2008150981A3 publication Critical patent/WO2008150981A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La présente invention concerne de nouveaux antagonistes de peptide de jonctions serrées qui inhibent et/ou réduisent l'ouverture de jonctions serrées mammaliennes. Les peptides comprennent de préférence 7 acides aminés ou moins en longueur. La présente invention propose également des procédés pour le traitement d'une perméabilité excessive ou non souhaitable d'un tissu par l'administration à un sujet souffrant d'une telle affection d'une composition comprenant un antagoniste de jonction serrée de peptide de l'invention.
PCT/US2008/065268 2007-05-30 2008-05-30 Nouveaux peptides courts inhibant l'ouverture de jonctions serrées mammaliennes WO2008150981A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94077307P 2007-05-30 2007-05-30
US60/940,773 2007-05-30

Publications (2)

Publication Number Publication Date
WO2008150981A2 true WO2008150981A2 (fr) 2008-12-11
WO2008150981A3 WO2008150981A3 (fr) 2009-02-12

Family

ID=40094366

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/065268 WO2008150981A2 (fr) 2007-05-30 2008-05-30 Nouveaux peptides courts inhibant l'ouverture de jonctions serrées mammaliennes

Country Status (1)

Country Link
WO (1) WO2008150981A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200231626A1 (en) * 2008-05-06 2020-07-23 Alba Therapeutics Corporation Inhibition of gliadin peptides
US11608359B2 (en) 2018-02-23 2023-03-21 9 Meters Biopharma, Inc. Compounds and methods for treating tight junction permeabtility

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050209161A1 (en) * 1998-08-03 2005-09-22 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
US20060127320A1 (en) * 2004-05-10 2006-06-15 Nastech Pharmaceutical Company Inc. Method of delivering parathyroid hormone to a human

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050209161A1 (en) * 1998-08-03 2005-09-22 University Of Maryland, Baltimore Peptide antagonists of zonulin and methods for use of the same
US20060127320A1 (en) * 2004-05-10 2006-06-15 Nastech Pharmaceutical Company Inc. Method of delivering parathyroid hormone to a human

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200231626A1 (en) * 2008-05-06 2020-07-23 Alba Therapeutics Corporation Inhibition of gliadin peptides
US11149063B2 (en) 2008-05-06 2021-10-19 Alba Therapeutics Corporation Peptide inhibitors of tight junction permeability
US11608359B2 (en) 2018-02-23 2023-03-21 9 Meters Biopharma, Inc. Compounds and methods for treating tight junction permeabtility

Also Published As

Publication number Publication date
WO2008150981A3 (fr) 2009-02-12

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