WO2008150001A1 - Amas adipeux - Google Patents

Amas adipeux Download PDF

Info

Publication number
WO2008150001A1
WO2008150001A1 PCT/JP2008/060501 JP2008060501W WO2008150001A1 WO 2008150001 A1 WO2008150001 A1 WO 2008150001A1 JP 2008060501 W JP2008060501 W JP 2008060501W WO 2008150001 A1 WO2008150001 A1 WO 2008150001A1
Authority
WO
WIPO (PCT)
Prior art keywords
cell
adipose tissue
preparation
neural stem
stem cell
Prior art date
Application number
PCT/JP2008/060501
Other languages
English (en)
Japanese (ja)
Inventor
Takashi Nagase
Toshiyuki Kikuchi
Yuko Fujita
Shoko Murase
Original Assignee
Biomaster, Inc.
National Hospital Organization
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomaster, Inc., National Hospital Organization filed Critical Biomaster, Inc.
Priority to JP2009517921A priority Critical patent/JP5388297B2/ja
Publication of WO2008150001A1 publication Critical patent/WO2008150001A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells

Abstract

Un objectif est d'examiner si l'exigence d'une propriété de clone est ou non nécessaire dans l'obtention d'une préparation de cellules souches neurales. Un autre objectif est de proposer un procédé de préparation de cellules souches neurales d'une manière simple. Ainsi, l'invention porte sur un procédé de production de cellules contenant un dérivé de cellules provenant d'un tissu adipeux Musashi positif, qui comprend les étapes consistant à : se procurer des cellules provenant d'un tissu adipeux ; et soumettre les cellules à la culture flottante pendant un laps de temps suffisant pour produire un agrégat.
PCT/JP2008/060501 2007-06-08 2008-06-06 Amas adipeux WO2008150001A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009517921A JP5388297B2 (ja) 2007-06-08 2008-06-06 アディポクラスター

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007153424 2007-06-08
JP2007-153424 2007-06-08

Publications (1)

Publication Number Publication Date
WO2008150001A1 true WO2008150001A1 (fr) 2008-12-11

Family

ID=40093805

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060501 WO2008150001A1 (fr) 2007-06-08 2008-06-06 Amas adipeux

Country Status (2)

Country Link
JP (1) JP5388297B2 (fr)
WO (1) WO2008150001A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015033558A1 (fr) * 2013-09-04 2015-03-12 株式会社大塚製薬工場 Procédé de préparation de cellules souches pluripotentes
JP2015511487A (ja) * 2012-03-13 2015-04-20 インスティテュート オブ ジェネティックス アンド ディベロップメンタル バイオロジー，チャイニーズ アカデミー オブ サイエンシズ ３次元培養による細胞の再プログラミング
WO2016013352A1 (fr) * 2014-07-23 2016-01-28 学校法人日本大学 Procédé de production d'une cellule adipeuse dédifférenciée
JP2019503474A (ja) * 2015-11-06 2019-02-07 ヴェンタナ メディカル システムズ， インク． 代表診断法
CN115501393A (zh) * 2022-09-21 2022-12-23 中国人民解放军总医院第一医学中心 用于修复神经缺损的水凝胶及其制备方法和用途
CN115697347A (zh) * 2020-07-08 2023-02-03 北京荣祥再生医学研究所有限公司 一种调节musashi1在细胞中表达水平的方法
WO2023159019A1 (fr) * 2022-02-15 2023-08-24 The General Hospital Corporation Compositions à base de cellules progénitrices neurales et leurs procédés d'utilisation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537849A (ja) * 1999-03-10 2002-11-12 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 脂肪由来の幹細胞および格子
WO2003008592A1 (fr) * 2001-07-19 2003-01-30 Yasuhiko Tabata Cellules embryonnaires polyfonctionnelles provenant de tissus adipeux
WO2003045137A1 (fr) * 2001-11-29 2003-06-05 Japan Science And Technology Agency Procede de construction d'un modele simien de lesion spinale et son utilisation
WO2008018190A1 (fr) * 2006-08-09 2008-02-14 Biomaster, Inc. Cellules de la crête neurale dérivées de tissu adipeux

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537849A (ja) * 1999-03-10 2002-11-12 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 脂肪由来の幹細胞および格子
WO2003008592A1 (fr) * 2001-07-19 2003-01-30 Yasuhiko Tabata Cellules embryonnaires polyfonctionnelles provenant de tissus adipeux
WO2003045137A1 (fr) * 2001-11-29 2003-06-05 Japan Science And Technology Agency Procede de construction d'un modele simien de lesion spinale et son utilisation
WO2008018190A1 (fr) * 2006-08-09 2008-02-14 Biomaster, Inc. Cellules de la crête neurale dérivées de tissu adipeux

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
BUNNELL B.A. ET AL.: "Common transcriptional gene profile in neurospheres-derived from pATSCs, pBMSCs, and pNSCs", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 343, 2006, pages 762 - 771, XP024924774 *
CRANE J.F. AND TRAINOR P.A.: "Neural crest stem and progenitor cells", ANN. REV. CELL DEVELOP. BIOL., vol. 22, 2006, pages 267 - 286 *
DICKER A. ET AL.: "Functional studies of mesenchymal stem cells derived from adult human adipose tissue", EXP. CELL RES., vol. 308, 2005, pages 283 - 290, XP004997316 *
FERNANDES K.J.L. ET AL.: "A dermal niche for multipotent adult skin-derived precursor cells", NATURE CELL BIOL., vol. 6, no. 11, November 2004 (2004-11-01), pages 1082 - 1093, XP002494290 *
HARRISON J. ET AL.: "Colonization and maintenance of murine embryonic stem cells on poly (alpha-hydroxy esters)", BIOMATERIALS, vol. 25, 2004, pages 4963 - 4970, XP004504183 *
KANG S.K. ET AL.: "Neurogenesis of Rhesus adipose stromal cells", J. CELL SCI., vol. 117, no. 18, 2004, pages 4289 - 4299 *
KOIKE M. ET AL.: "A round-bottom 96-well polystyrene plate coated with 2-methacryloyloxyethyl phosphorylcholine as an effective tool for embryoid body formation", CYTOTECHNOLOGY, vol. 47, 2005, pages 3 - 10, XP019236867 *
NAGASE T. ET AL.: "Adipocluster: Mouse, Rat Hikashibo karano Jinsoku na Shinkei Zenkusaibo Kaishuho no Kaihatsu", DAI 16 KAI JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY KISO GAKUJUTSU SHUKAI PROGRAM.YOKOSHU, October 2007 (2007-10-01), pages 96 *
NAGASE T. ET AL.: "Hito Shibo Soshiki Yurai neurosphere Saibo no Mouse Hai eno Ishoku no Kokoromi", DAI 15 KAI JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY KISO GAKUJUTSU SHUKAI PROGRAM.YOKOSHU, December 2006 (2006-12-01), pages 108 *
NAGASE T. ET AL.: "Neurospheres from human adipose tissue transplanted into cultured mouse embryos can contribute to craniofacial morphogenesis: A preliminary report", J. CRANIOFACIAL SURGERY, vol. 18, no. 1, January 2007 (2007-01-01), pages 49 - 53, XP003020988 *
NAGASE T. ET AL.: "Shibo Soshiki Yurai neurosphere no Mouse Taiji Ishoku", REGENERATIVE MEDICINE, vol. 6, 19 February 2007 (2007-02-19), pages 297 *
NAGASE T. ET AL.: "Shibo Yurai Shinkei Zenkusaibo no Jinsoku Kaishuho no Kaihatsu", DAI 61 KAI JAPANESE SOCIETY OF NATIONAL MEDICAL SERVICES KOEN SHOROKUSHU, 22 November 2007 (2007-11-22), pages 481 *
NING H. ET AL.: "Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells", DIFFERENTIATION, vol. 74, 2006, pages 510 - 518, XP026770202, DOI: doi:10.1111/j.1432-0436.2006.00081.x *
SCHAUB G.A. ET AL.: "Hydrophobic attachment of trypanosoma cruzi to the rectal cuticle of Triatoma infestans and its influence on methacyclogenesis-A review", TOKAI J. EXP. CLIN. MED., vol. 23, no. 6, 1999, pages 321 - 327 *
SINGEC I. ET AL.: "Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology", NATURE METHODS, vol. 3, no. 10, October 2006 (2006-10-01), pages 801 - 806 *
WEI L. ET AL.: "Embryonic stem cell survival, migration and differentiation after transplantation into rats subjected to barrel cortex ischemia", ABSTRACT VIEW, 31ST ANNUAL MEETING, SOCIETY FOR NEUROSCIENCE'S, 2001, Retrieved from the Internet <URL:http://www.sfn.scholarone.com/itin2001> *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015511487A (ja) * 2012-03-13 2015-04-20 インスティテュート オブ ジェネティックス アンド ディベロップメンタル バイオロジー，チャイニーズ アカデミー オブ サイエンシズ ３次元培養による細胞の再プログラミング
US9650602B2 (en) 2012-03-13 2017-05-16 Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences Reprogramming cells by three-dimensional cultivation
US11155782B2 (en) 2013-09-04 2021-10-26 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
JPWO2015033558A1 (ja) * 2013-09-04 2017-03-02 株式会社大塚製薬工場 多能性幹細胞の調製方法
US9765296B2 (en) 2013-09-04 2017-09-19 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
JP2018023401A (ja) * 2013-09-04 2018-02-15 株式会社大塚製薬工場 多能性幹細胞の調製方法
WO2015033558A1 (fr) * 2013-09-04 2015-03-12 株式会社大塚製薬工場 Procédé de préparation de cellules souches pluripotentes
US10370639B2 (en) 2013-09-04 2019-08-06 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
WO2016013352A1 (fr) * 2014-07-23 2016-01-28 学校法人日本大学 Procédé de production d'une cellule adipeuse dédifférenciée
JP5991687B2 (ja) * 2014-07-23 2016-09-14 学校法人日本大学 脱分化脂肪細胞の製造方法
JP2019503474A (ja) * 2015-11-06 2019-02-07 ヴェンタナ メディカル システムズ， インク． 代表診断法
JP7094880B2 (ja) 2015-11-06 2022-07-04 ヴェンタナ メディカル システムズ， インク． 代表診断法
US11959838B2 (en) 2015-11-06 2024-04-16 Ventana Medical Systems, Inc. Representative diagnostics
CN115697347A (zh) * 2020-07-08 2023-02-03 北京荣祥再生医学研究所有限公司 一种调节musashi1在细胞中表达水平的方法
CN115697347B (zh) * 2020-07-08 2024-04-19 北京荣祥再生医学研究所有限公司 一种调节musashi1在细胞中表达水平的方法
WO2023159019A1 (fr) * 2022-02-15 2023-08-24 The General Hospital Corporation Compositions à base de cellules progénitrices neurales et leurs procédés d'utilisation
CN115501393A (zh) * 2022-09-21 2022-12-23 中国人民解放军总医院第一医学中心 用于修复神经缺损的水凝胶及其制备方法和用途
CN115501393B (zh) * 2022-09-21 2023-10-24 中国人民解放军总医院第一医学中心 用于修复神经缺损的水凝胶及其制备方法和用途

Also Published As

Publication number Publication date
JP5388297B2 (ja) 2014-01-15
JPWO2008150001A1 (ja) 2010-08-26

Similar Documents

Publication Publication Date Title
WO2008150001A1 (fr) Amas adipeux
WO2006070370A3 (fr) Systemes de culture de cellules souches
WO2005080551A3 (fr) Cellules souches
WO2009061442A8 (fr) Procédé de production de cellules souches pluripotentes induites (ips) à partir de cellules humaines non embryonnaires
WO2010026575A3 (fr) Cellules adhérentes provenant d&#39;un tissu placentaire et leur utilisation en thérapie
WO2007127927A3 (fr) Différentiation de cellules souches embryonnaires humaines
WO2009012428A3 (fr) Différenciation de cellules souches embryonnaires humaines
WO2011011302A3 (fr) Différenciation de cellules souches embryonnaires humaines
WO2010059565A3 (fr) Allogreffes combinées avec des cellules souches dérivées de tissu pour la cicatrisation osseuse
MX356756B (es) Células madre pluripotentes en microportadores.
WO2010026574A3 (fr) Cellules adhérentes provenant d&#39;un tissu placentaire et leur utilisation en thérapie
WO2006136953A3 (fr) Procede
MX2010001335A (es) Diferenciacion de celulas madre embrionarias humanas.
WO2006017134A3 (fr) Cellules mesendodermiques et cellules de ligne pre-primitive
WO2008153179A1 (fr) Cellule souche multipotentielle issue de tissu adipeux
WO2009007852A3 (fr) Cellules multipotentes/pluripotentes et procédés s&#39;y rapportant
WO2007008722A3 (fr) Procede permettant d&#39;isoler l&#39;arn de sources biologiques
WO2009132083A3 (fr) Compositions et méthodes permettant de favoriser la production de cellules pancréatiques pdx1+
WO2011011300A3 (fr) Différentiation de cellules souches embryonnaires humaines
WO2009081012A3 (fr) Procedes de production d&#39;acide succinique
WO2010128024A3 (fr) Cellules immortalisees de façon reversible et procedes s&#39;y rapportant
WO2008086296A3 (fr) Céramidase acide et survie de cellules
SG10201803982TA (en) Antibodies and processes for preparing the same
WO2007143117A3 (fr) Différentiation de cellules pluripotentes de primates en cellules de lignées hépatocytaires
WO2010020876A3 (fr) Procédé de culture cellulaire

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08777120

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009517921

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08777120

Country of ref document: EP

Kind code of ref document: A1