WO2008148473A3 - Verfahren zur herstellung von 17 alpha-acetoxy-6-methylenpregn-4-en-3, 20-dion, medroxyprogesteronacetat und megestrolacetat - Google Patents

Verfahren zur herstellung von 17 alpha-acetoxy-6-methylenpregn-4-en-3, 20-dion, medroxyprogesteronacetat und megestrolacetat Download PDF

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Publication number
WO2008148473A3
WO2008148473A3 PCT/EP2008/004156 EP2008004156W WO2008148473A3 WO 2008148473 A3 WO2008148473 A3 WO 2008148473A3 EP 2008004156 W EP2008004156 W EP 2008004156W WO 2008148473 A3 WO2008148473 A3 WO 2008148473A3
Authority
WO
WIPO (PCT)
Prior art keywords
acetoxy
dione
acetate
ene
methylenepregn
Prior art date
Application number
PCT/EP2008/004156
Other languages
English (en)
French (fr)
Other versions
WO2008148473A2 (de
Inventor
Klaus Annen
Thomas Linz
Karl-Heinz Neff
Rolf Bohlmann
Henry Laurent
Original Assignee
Bayer Schering Pharma Ag
Klaus Annen
Thomas Linz
Karl-Heinz Neff
Rolf Bohlmann
Henry Laurent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag, Klaus Annen, Thomas Linz, Karl-Heinz Neff, Rolf Bohlmann, Henry Laurent filed Critical Bayer Schering Pharma Ag
Publication of WO2008148473A2 publication Critical patent/WO2008148473A2/de
Publication of WO2008148473A3 publication Critical patent/WO2008148473A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von 17α-Acetoxy-6- methylenpregn-4-en-3,20-dion (4) als Zwischenstufe, sowie Verfahren zur Herstellung von Medroxyprogesteronacetat (1) (17α-Acetoxy-6α-methylpregn-4-en- 3,20-dion) und Megestrolacetat (2) (17α-Acetoxy-6-methylpregna-4,6-dien-3,20-dion) über diese Zwischenstufe (4).
PCT/EP2008/004156 2007-06-06 2008-05-24 Verfahren zur herstellung von 17 alpha-acetoxy-6-methylenpregn-4-en-3, 20-dion, medroxyprogesteronacetat und megestrolacetat WO2008148473A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007026636.9 2007-06-06
DE102007026636A DE102007026636A1 (de) 2007-06-06 2007-06-06 Verfahren zur Herstellung von 17α-Acetoxy-6-methylenpregn-4-en-3,20-dion, Medroxyprogesteronacetat und Megestrolacetat

Publications (2)

Publication Number Publication Date
WO2008148473A2 WO2008148473A2 (de) 2008-12-11
WO2008148473A3 true WO2008148473A3 (de) 2009-06-04

Family

ID=39942161

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/004156 WO2008148473A2 (de) 2007-06-06 2008-05-24 Verfahren zur herstellung von 17 alpha-acetoxy-6-methylenpregn-4-en-3, 20-dion, medroxyprogesteronacetat und megestrolacetat

Country Status (2)

Country Link
DE (1) DE102007026636A1 (de)
WO (1) WO2008148473A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014067127A1 (zh) * 2012-11-02 2014-05-08 Huang Yunsheng 一种合成6-甲基-17α-乙酰氧基-19-去甲孕甾-4,6-二烯-3,20-二酮的方法
CN106810585B (zh) * 2016-12-03 2019-03-05 丽江映华生物药业有限公司 一种6α-甲基-17α-乙酰氧基-19-去甲孕甾-4-烯-3,20-二酮的合成方法
CN106866766B (zh) * 2017-02-14 2018-03-20 岳阳环宇药业有限公司 一种醋酸甲羟孕酮的制备方法及制备系统
RU2664101C1 (ru) * 2017-06-30 2018-08-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения 6-метиленгидрокортизона или его эфиров из 21-ацетата гидрокортизона
RU2663893C1 (ru) * 2017-07-14 2018-08-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения 6-дегидро-6-метилгидрокортизона или его эфиров из 21-ацетата гидрокортизона
RU2663483C1 (ru) * 2017-12-29 2018-08-06 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения 6-(n-метил-n-фенил)аминометил-гидрокортизона или его эфиров из 21-ацетата гидрокортизона
CN110655548B (zh) * 2018-06-29 2022-05-17 天津药业研究院股份有限公司 一种6β-甲基甾体化合物的制备方法
CN109627277A (zh) * 2018-12-19 2019-04-16 上海新华联制药有限公司 一种醋酸甲羟孕酮的制备方法
CN110590890A (zh) * 2019-09-27 2019-12-20 台州仙琚药业有限公司 17α-乙酰氧基-6-亚甲基孕甾-4-烯-3,20-二酮的制备方法
CN111187326B (zh) * 2020-01-14 2022-04-19 上海灏翔生物科技有限公司 一种醋酸诺美孕酮的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3004508A1 (de) * 1980-02-05 1981-08-06 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur herstellung von 6-methylensterioden
US4544555A (en) * 1974-05-21 1985-10-01 Gastaud Jean M 3,20-Diketo, 6-methyl, 17-alpha-hydroxy 19-norpregna 4,6-diene, its esters and the uses thereof
EP0326340A2 (de) * 1988-01-26 1989-08-02 FARMITALIA CARLO ERBA S.r.l. Synthese von 6-Methylenandrosta-1,4-dien-3,17-dion-Derivate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544555A (en) * 1974-05-21 1985-10-01 Gastaud Jean M 3,20-Diketo, 6-methyl, 17-alpha-hydroxy 19-norpregna 4,6-diene, its esters and the uses thereof
DE3004508A1 (de) * 1980-02-05 1981-08-06 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur herstellung von 6-methylensterioden
EP0326340A2 (de) * 1988-01-26 1989-08-02 FARMITALIA CARLO ERBA S.r.l. Synthese von 6-Methylenandrosta-1,4-dien-3,17-dion-Derivate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BURN, D. ET AL., TETRAHEDRON, vol. 21, 1965, pages 1619 - 1624, XP002513719 *
SCHNEIDER, F. ET AL., HELVETICA CHIMICA ACTA, vol. 56, no. 7, 1973, pages 2396 - 2404, XP002513720 *

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Publication number Publication date
DE102007026636A1 (de) 2008-12-11
WO2008148473A2 (de) 2008-12-11

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