WO2008146917A1 - リンコマイシン誘導体及びこれを有効成分とする抗菌剤 - Google Patents

リンコマイシン誘導体及びこれを有効成分とする抗菌剤 Download PDF

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Publication number
WO2008146917A1
WO2008146917A1 PCT/JP2008/060042 JP2008060042W WO2008146917A1 WO 2008146917 A1 WO2008146917 A1 WO 2008146917A1 JP 2008060042 W JP2008060042 W JP 2008060042W WO 2008146917 A1 WO2008146917 A1 WO 2008146917A1
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WO
WIPO (PCT)
Prior art keywords
alkyl
optionally substituted
same
active ingredient
antibacterial agents
Prior art date
Application number
PCT/JP2008/060042
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English (en)
French (fr)
Inventor
Yoshinari Wakiyama
Kou Kumura
Satomi Masaki
Kazutaka Ueda
Yasuo Sato
Chika Kikuchi
Eijirou Umemura
Yoko Hirai
Hiroshi Kondo
Original Assignee
Meiji Seika Kaisha, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha, Ltd. filed Critical Meiji Seika Kaisha, Ltd.
Priority to JP2009516373A priority Critical patent/JP5356223B2/ja
Priority to EP08777053A priority patent/EP2151447A4/en
Priority to US12/451,744 priority patent/US7879808B2/en
Publication of WO2008146917A1 publication Critical patent/WO2008146917A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

　本発明によれば、式（Ｉ）［式中、Ａはアリール基を表し、Ｒ1はＮ－置換されていてもよいＣ１－６アルキル－Ｎ－置換されていてもよいＣ１－６アルキルアミノＣ１－６アルキル基を表し、Ｒ2は水素原子または、置換されていてもよいＣ１－6アルキル基を表し、Ｒ3は置換されていてもよいＣ１－６アルキル基またはＣ3－６シクロアルキル－Ｃ１－4アルキル基を表し、ｍは１～３を表し、ｎは０を表し、ｐは０～２を表す］の化合物またはその薬理学的に許容されうる塩もしくは溶媒和物が提供される。この化合物は、近年問題となっている感染症治療における、耐性肺炎球菌に強い活性を有する新規リンコマイシン誘導体である。またこの化合物は、抗菌剤として用いることができ、細菌性感染症の予防または治療に有用である。 　　【化１】
PCT/JP2008/060042 2007-05-31 2008-05-30 リンコマイシン誘導体及びこれを有効成分とする抗菌剤 WO2008146917A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009516373A JP5356223B2 (ja) 2007-05-31 2008-05-30 リンコマイシン誘導体及びこれを有効成分とする抗菌剤
EP08777053A EP2151447A4 (en) 2007-05-31 2008-05-30 LINCOMYCIN DERIVATIVES AND ANTIBACTERIAL AGENTS CONTAINING SAME AS ACTIVE INGREDIENTS
US12/451,744 US7879808B2 (en) 2007-05-31 2008-05-30 Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-146192 2007-05-31
JP2007146192 2007-05-31

Publications (1)

Publication Number Publication Date
WO2008146917A1 true WO2008146917A1 (ja) 2008-12-04

Family

ID=40075147

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/060042 WO2008146917A1 (ja) 2007-05-31 2008-05-30 リンコマイシン誘導体及びこれを有効成分とする抗菌剤

Country Status (4)

Country Link
US (1) US7879808B2 (ja)
EP (1) EP2151447A4 (ja)
JP (1) JP5356223B2 (ja)
WO (1) WO2008146917A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019032956A1 (en) * 2017-08-10 2019-02-14 President And Fellows Of Harvard College LINCONSAMIDE ANTIBIOTICS AND USES THEREOF
WO2019032941A1 (en) * 2017-08-10 2019-02-14 President And Fellows Of Harvard College NOVEL LINCOSAMIDE ANTIBIOTICS AND CORRESPONDING USES THEREOF
US11124534B2 (en) 2017-08-10 2021-09-21 President And Fellows Of Harvard College Lincosamide antibiotics and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007665A2 (en) * 2003-06-17 2005-01-27 Vicuron Pharmaceuticals Inc. Lincomycin derivatives possessing antibacterial activity
WO2005012320A2 (en) * 2003-06-17 2005-02-10 Vicuron Pharmaceuticals, Inc. Novel lincomycin derivatives possessing antimicrobial activity
JP2006504673A (ja) * 2002-08-15 2006-02-09 バイクロン ファーマシューティカルズ， インコーポレイテッド 抗菌活性を有するリンコマイシン誘導体
WO2006055070A2 (en) * 2004-11-17 2006-05-26 Vicuron Pharmaceuticals Inc. Novel lincomycin derivatives possessing antibacterial activity
WO2007066805A1 (ja) * 2005-12-09 2007-06-14 Meiji Seika Kaisha, Ltd. リンコマイシン誘導体およびこれを有効成分とする抗菌剤

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3418414A (en) 1966-08-31 1968-12-24 Upjohn Co Trimethylsilyl ethers of lincomycin and its compounds
US3544551A (en) 1968-04-30 1970-12-01 Upjohn Co 7-mercapto-7-deoxylincomycins and process for preparing the same
US3689474A (en) 1970-08-04 1972-09-05 Upjohn Co 7-mercapto-7-deoxylincomycins and process for preparing the same
SE384685B (sv) 1971-06-23 1976-05-17 Upjohn Co Forfarande for framstellning av linkomycinderivat
US3915954A (en) 1971-11-15 1975-10-28 Upjohn Co Derivatives of lincomycin and its analogs and process
US3767649A (en) 1971-11-15 1973-10-23 Upjohn Co Process for making derivatives of lincomycin and its analogs
US3870699A (en) 1973-03-06 1975-03-11 Upjohn Co Lincomycin analogs
US7199105B2 (en) * 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en) * 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
US7256177B2 (en) * 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006504673A (ja) * 2002-08-15 2006-02-09 バイクロン ファーマシューティカルズ， インコーポレイテッド 抗菌活性を有するリンコマイシン誘導体
WO2005007665A2 (en) * 2003-06-17 2005-01-27 Vicuron Pharmaceuticals Inc. Lincomycin derivatives possessing antibacterial activity
WO2005012320A2 (en) * 2003-06-17 2005-02-10 Vicuron Pharmaceuticals, Inc. Novel lincomycin derivatives possessing antimicrobial activity
WO2006055070A2 (en) * 2004-11-17 2006-05-26 Vicuron Pharmaceuticals Inc. Novel lincomycin derivatives possessing antibacterial activity
WO2007066805A1 (ja) * 2005-12-09 2007-06-14 Meiji Seika Kaisha, Ltd. リンコマイシン誘導体およびこれを有効成分とする抗菌剤

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIRKENMEYER R.D. ET AL.: "Synthesis and antimicrobial activity of clindamycin analogues: Prilimycin, a potent antibacterial agent", J. MED. CHEM., vol. 27, no. 2, 1984, pages 216 - 223, XP002174848 *
See also references of EP2151447A4 *
SZTARICSKAI F. ET AL.: "Semisynthetic modification of antibiotic lincomycin", J. ANTIBIOTICS, vol. 49, no. 9, 1996, pages 941 - 943, XP009044907 *

Also Published As

Publication number Publication date
US20100210570A1 (en) 2010-08-19
JP5356223B2 (ja) 2013-12-04
US7879808B2 (en) 2011-02-01
EP2151447A4 (en) 2012-09-05
JPWO2008146917A1 (ja) 2010-08-19
EP2151447A1 (en) 2010-02-10

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