WO2008136378A1 - 新規なスルホンアミド誘導体またはその塩 - Google Patents

新規なスルホンアミド誘導体またはその塩 Download PDF

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WO2008136378A1
WO2008136378A1 PCT/JP2008/058015 JP2008058015W WO2008136378A1 WO 2008136378 A1 WO2008136378 A1 WO 2008136378A1 JP 2008058015 W JP2008058015 W JP 2008058015W WO 2008136378 A1 WO2008136378 A1 WO 2008136378A1
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Prior art keywords
salt
bonding hand
sulfonamide derivative
hydrogen atom
aryl group
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PCT/JP2008/058015
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English (en)
French (fr)
Inventor
Junichi Yokotani
Yoichi Taniguchi
Yoshitake Konishi
Yukie Tada
Minori Yanai
Masaki Katai
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Toyama Chemical Co., Ltd.
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Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Priority to JP2009512960A priority Critical patent/JP5443975B2/ja
Publication of WO2008136378A1 publication Critical patent/WO2008136378A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/09—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by at least two halogen atoms
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    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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Abstract

一般式 「式中、Ｒ１は、水素原子などを；Ｒ２は、置換されていてもよいアルキルまたはアリール基などを；Ｒ３およびＲ４は、同一または異なって、アリール基などを；Ｒ５は、水素原子などを；Ｘ１は、アルキレン基または結合手などを；Ｘ２は、結合手などを；Ｙ１は、結合手などを；Ｚ１およびＺ２は、ＣＨなどを示す。」で表される化合物またはその塩は、強いＰＧＥ２産生阻害作用を有することから、ＰＧＥ２の関与する疾患または状態の治療あるいは予防に有用である。
PCT/JP2008/058015 2007-04-27 2008-04-25 新規なスルホンアミド誘導体またはその塩 WO2008136378A1 (ja)

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Cited By (8)

* Cited by examiner, † Cited by third party
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WO2012015723A1 (en) 2010-07-26 2012-02-02 Bristol-Myers Squibb Company Sulfonamide compounds useful as cyp17 inhibitors
US8748615B2 (en) 2010-03-05 2014-06-10 Sanofi Process for the preparation of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
US20160168144A1 (en) * 2011-05-24 2016-06-16 The Wistar Institute Compositions and methods for modulating the activity of epstein-barr nuclear antigen 1
JP2016523974A (ja) * 2013-07-11 2016-08-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｉｄｏ阻害剤
WO2019219689A1 (en) 2018-05-18 2019-11-21 Syngenta Participations Ag Pesticidally active heterocyclic derivatives with sulfoximine containing substituents
WO2022050385A1 (ja) * 2020-09-07 2022-03-10 大日本住友製薬株式会社 フェノール誘導体
CN114262293A (zh) * 2022-01-10 2022-04-01 安徽有吉医药科技有限公司 2-氨基-3-溴吡啶的制备方法
CN114957132A (zh) * 2021-02-20 2022-08-30 中国科学院上海药物研究所 含s构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用

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US8748615B2 (en) 2010-03-05 2014-06-10 Sanofi Process for the preparation of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
WO2012015723A1 (en) 2010-07-26 2012-02-02 Bristol-Myers Squibb Company Sulfonamide compounds useful as cyp17 inhibitors
US8916553B2 (en) 2010-07-26 2014-12-23 Bristol-Myers Squibb Company Sulfonamide compounds useful as CYP17 inhibitors
US20160168144A1 (en) * 2011-05-24 2016-06-16 The Wistar Institute Compositions and methods for modulating the activity of epstein-barr nuclear antigen 1
JP2016523974A (ja) * 2013-07-11 2016-08-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｉｄｏ阻害剤
WO2019219689A1 (en) 2018-05-18 2019-11-21 Syngenta Participations Ag Pesticidally active heterocyclic derivatives with sulfoximine containing substituents
WO2022050385A1 (ja) * 2020-09-07 2022-03-10 大日本住友製薬株式会社 フェノール誘導体
CN114957132A (zh) * 2021-02-20 2022-08-30 中国科学院上海药物研究所 含s构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用
CN114262293A (zh) * 2022-01-10 2022-04-01 安徽有吉医药科技有限公司 2-氨基-3-溴吡啶的制备方法
CN114262293B (zh) * 2022-01-10 2023-09-22 上海有吉医药化工有限公司 2-氨基-3-溴吡啶的制备方法

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