WO2008126837A1 - 標識可能な核酸、標識核酸及びその用途 - Google Patents

標識可能な核酸、標識核酸及びその用途 Download PDF

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Publication number
WO2008126837A1
WO2008126837A1 PCT/JP2008/056926 JP2008056926W WO2008126837A1 WO 2008126837 A1 WO2008126837 A1 WO 2008126837A1 JP 2008056926 W JP2008056926 W JP 2008056926W WO 2008126837 A1 WO2008126837 A1 WO 2008126837A1
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WO
WIPO (PCT)
Prior art keywords
nucleic acid
labeled
labeling
labelable
imaging
Prior art date
Application number
PCT/JP2008/056926
Other languages
English (en)
French (fr)
Inventor
Yoshihiro Nakagami
Tomio Inoue
Original Assignee
Yokohama City University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Yokohama City University filed Critical Yokohama City University
Priority to JP2009509346A priority Critical patent/JPWO2008126837A1/ja
Publication of WO2008126837A1 publication Critical patent/WO2008126837A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

　核酸の標識方法、例えば、イメージングに適した核種によりsiRNAを標識することが可能な二本鎖RNAの標識方法を提供する。 　キレート化剤がプリン塩基又はピリミジン塩基にコンジュゲートしている少なくとも１個のヌクレオシド一リン酸が付加されている核酸。この核酸は、キレート化剤を介して67Ga、68Ga、99mTc、111In、201Tlなどの金属で標識可能である。標識された核酸は、核酸の体内動態評価、核酸のターゲット臓器への到達の有無の確認、遺伝子発現のイメージング、疾病の予防及び／又は治療などに利用することができる。
PCT/JP2008/056926 2007-04-10 2008-04-08 標識可能な核酸、標識核酸及びその用途 WO2008126837A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009509346A JPWO2008126837A1 (ja) 2007-04-10 2008-04-08 標識可能な核酸、標識核酸及びその用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-102283 2007-04-10
JP2007102283 2007-04-10

Publications (1)

Publication Number Publication Date
WO2008126837A1 true WO2008126837A1 (ja) 2008-10-23

Family

ID=39863934

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056926 WO2008126837A1 (ja) 2007-04-10 2008-04-08 標識可能な核酸、標識核酸及びその用途

Country Status (2)

Country Link
JP (1) JPWO2008126837A1 (ja)
WO (1) WO2008126837A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012039908A3 (en) * 2010-09-20 2012-07-05 Kong Yanping M D Method and compound for treatment of cancer using phosphorous-32 labeled dna
JP2017114841A (ja) * 2015-12-25 2017-06-29 行政院原子能委員會核能研究所 リボ核酸及びジエチレントリアミン五酢酸の高収量の迅速な結合方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEWANJEE M.K. ET AL.: "Noninvasive imaging of c-myc oncogene messenger RNA with indium-111-antisense probes in a mammary tumor-bearing mouse model", J. NUCL. MED., vol. 35, no. 6, June 1994 (1994-06-01), pages 1054 - 1063, XP002121053 *
LIU N. ET AL.: "Radiolabeling small RNA with technetium-99m for visualizing cellular delivery and mouse biodistribution", NUCL. MED. BIOL., vol. 34, no. 4, May 2007 (2007-05-01), pages 399 - 404, XP022069557 *
VAN DE WATER F.M. ET AL.: "Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules", DRUG METAB. DISPOS., vol. 34, no. 8, August 2006 (2006-08-01), pages 1393 - 1397, XP002450241 *
ZHANG Y.M. ET AL.: "Influence of different chelators (HYNIC, MAG3 and DTPA) on tumor cell accumulation and mouse biodistribution of technetium-99m labeled to antisense DNA", EUR. J. NUCL. MED., vol. 27, no. 11, November 2000 (2000-11-01), pages 1700 - 1707 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012039908A3 (en) * 2010-09-20 2012-07-05 Kong Yanping M D Method and compound for treatment of cancer using phosphorous-32 labeled dna
US8642007B2 (en) 2010-09-20 2014-02-04 Yanping Kong Method and compound for treatment of cancer using phosphorous-32 labeled DNA
JP2017114841A (ja) * 2015-12-25 2017-06-29 行政院原子能委員會核能研究所 リボ核酸及びジエチレントリアミン五酢酸の高収量の迅速な結合方法

Also Published As

Publication number Publication date
JPWO2008126837A1 (ja) 2010-07-22

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