BRPI0507960A - métodos terapêuticos empregando precursores de óxido nìtrico - Google Patents

métodos terapêuticos empregando precursores de óxido nìtrico

Info

Publication number
BRPI0507960A
BRPI0507960A BRPI0507960-8A BRPI0507960A BRPI0507960A BR PI0507960 A BRPI0507960 A BR PI0507960A BR PI0507960 A BRPI0507960 A BR PI0507960A BR PI0507960 A BRPI0507960 A BR PI0507960A
Authority
BR
Brazil
Prior art keywords
carbamyl phosphate
nitric oxide
therapeutic methods
oxide precursors
methods employing
Prior art date
Application number
BRPI0507960-8A
Other languages
English (en)
Inventor
Marshall L Summar
Brian Christman
Frederick E Barr
Original Assignee
Univ Vanderbilt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt
Publication of BRPI0507960A publication Critical patent/BRPI0507960A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

MéTODOS TERAPêUTICO EMPREGANDO PRECURSORES DE óXIDO NìTRICO Moléculas de polinucleotídeo isoladas e peptídeos codificados por essas moléculas são usados na análise de fenótipos de sintetase I de carbamil fosfato humano, bem como o diagnóstico e aplicações terapêutica referente a um polimorfismo da sintease I de carbamil fosfato humano. Através de análises do DNA genómico ou DNA genómico amplificado ou cDNA amplificado derivado de mRNA, é possível tipificar uma sintetase I de carbamil fosfato humano com relação ao polimorfismo de sintetase I de carbamil fosfato humano, por exemplo, no contexto de diagnóstico e tratamento de doença veno-oclusiva hepática (HVOD) associada a transplantes de medula óssea.
BRPI0507960-8A 2004-02-24 2005-02-24 métodos terapêuticos empregando precursores de óxido nìtrico BRPI0507960A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/785,374 US9486429B2 (en) 1999-06-01 2004-02-24 Therapeutic methods employing nitric oxide precursors
PCT/US2005/006081 WO2005082042A2 (en) 2004-02-24 2005-02-24 Therapeutic methods employing nitric oxide precursors

Publications (1)

Publication Number Publication Date
BRPI0507960A true BRPI0507960A (pt) 2007-07-17

Family

ID=34911448

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507960-8A BRPI0507960A (pt) 2004-02-24 2005-02-24 métodos terapêuticos empregando precursores de óxido nìtrico

Country Status (9)

Country Link
US (2) US9486429B2 (pt)
EP (3) EP3351241A1 (pt)
JP (5) JP2007524695A (pt)
CN (1) CN1946388B (pt)
AU (2) AU2005216270A1 (pt)
BR (1) BRPI0507960A (pt)
IL (4) IL177224A (pt)
WO (1) WO2005082042A2 (pt)
ZA (2) ZA200606575B (pt)

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Also Published As

Publication number Publication date
CN1946388A (zh) 2007-04-11
EP2319507A1 (en) 2011-05-11
IL177224A0 (en) 2006-12-10
WO2005082042A2 (en) 2005-09-09
AU2005216270A1 (en) 2005-09-09
CN1946388B (zh) 2012-03-07
JP2018024665A (ja) 2018-02-15
EP1718289A2 (en) 2006-11-08
US20170119715A1 (en) 2017-05-04
IL177224A (en) 2014-05-28
AU2009203177A1 (en) 2009-08-20
IL225912A0 (en) 2013-06-27
JP2013040176A (ja) 2013-02-28
EP3351241A1 (en) 2018-07-25
JP2015007090A (ja) 2015-01-15
ZA200606575B (en) 2012-10-31
IL225911A0 (en) 2013-06-27
EP1718289A4 (en) 2007-04-11
AU2009203177B2 (en) 2012-03-22
ZA200806276B (en) 2012-12-27
JP2016074709A (ja) 2016-05-12
IL225912A (en) 2015-07-30
WO2005082042A3 (en) 2006-05-04
JP2007524695A (ja) 2007-08-30
JP6239571B2 (ja) 2017-11-29
IL232265A0 (en) 2014-06-30
IL225911A (en) 2015-05-31
US20040235953A1 (en) 2004-11-25
JP6395912B2 (ja) 2018-09-26
US9486429B2 (en) 2016-11-08

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Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL