WO2008126785A1 - 有用物質の製造法 - Google Patents

有用物質の製造法 Download PDF

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Publication number
WO2008126785A1
WO2008126785A1 PCT/JP2008/056760 JP2008056760W WO2008126785A1 WO 2008126785 A1 WO2008126785 A1 WO 2008126785A1 JP 2008056760 W JP2008056760 W JP 2008056760W WO 2008126785 A1 WO2008126785 A1 WO 2008126785A1
Authority
WO
WIPO (PCT)
Prior art keywords
useful substance
culture medium
medium
protein
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/056760
Other languages
English (en)
French (fr)
Inventor
Kiyotaka Hara
Hideo Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Kyowa Kirin Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Kyowa Hakko Kirin Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd, Kyowa Hakko Kirin Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP2009509319A priority Critical patent/JPWO2008126785A1/ja
Publication of WO2008126785A1 publication Critical patent/WO2008126785A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

　本発明により、配列番号１で表されるアミノ酸配列を有する蛋白質、または該蛋白質のホモログの活性が親株より低下、または喪失している微生物を培地中で培養し、培養物中に有用物質を生成、蓄積させ、該培養物中より該有用物質を採取することを特徴とする有用物質の製造法、および配列番号１で表されるアミノ酸配列を有する蛋白質、または該蛋白質のホモログの活性が親株より低下、または喪失している微生物の培養物または該培養物の処理物、ATPをエネルギー源として有用物質を生成する活性を有する酵素または該活性を有する細胞の培養物または該培養物の処理物、炭素源、および該有用物質の前駆物質を媒体中に共存せしめ、該媒体中に有用物質を生成、蓄積させ、該媒体中より該有用物質を採取することを特徴とする有用物質の製造法が提供される。
PCT/JP2008/056760 2007-04-06 2008-04-04 有用物質の製造法 Ceased WO2008126785A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009509319A JPWO2008126785A1 (ja) 2007-04-06 2008-04-04 有用物質の製造法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-099955 2007-04-06
JP2007099955 2007-04-06

Publications (1)

Publication Number Publication Date
WO2008126785A1 true WO2008126785A1 (ja) 2008-10-23

Family

ID=39863884

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056760 Ceased WO2008126785A1 (ja) 2007-04-06 2008-04-04 有用物質の製造法

Country Status (2)

Country Link
JP (1) JPWO2008126785A1 (ja)
WO (1) WO2008126785A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013505714A (ja) * 2009-09-24 2013-02-21 ユセベ ファルマ ソシエテ アノニム シャペロン活性を保持するプロテアーゼ欠損ＤｅｇＰ並びにノックアウトＴｓｐ及びｐｔｒ遺伝子を持つ、組換えタンパク質発現のための細菌株

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007037301A1 (ja) * 2005-09-29 2007-04-05 Kyowa Hakko Kogyo Co., Ltd. 有用物質の製造法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007037301A1 (ja) * 2005-09-29 2007-04-05 Kyowa Hakko Kogyo Co., Ltd. 有用物質の製造法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JONES W.R. ET AL.: "Altered growth-rate-dependent regulation of 6-phosphogluconate dehydrogenase level in hisT mutants of Salmonella typhimurium and Escherichia coli", J. BACTERIOL., vol. 172, no. 3, 1990, pages 1197 - 1205 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013505714A (ja) * 2009-09-24 2013-02-21 ユセベ ファルマ ソシエテ アノニム シャペロン活性を保持するプロテアーゼ欠損ＤｅｇＰ並びにノックアウトＴｓｐ及びｐｔｒ遺伝子を持つ、組換えタンパク質発現のための細菌株
JP2016116517A (ja) * 2009-09-24 2016-06-30 ユセベ ファルマ ソシエテ アノニム シャペロン活性を保持するプロテアーゼ欠損ＤｅｇＰ並びにノックアウトＴｓｐ及びｐｔｒ遺伝子を持つ、組換えタンパク質発現のための細菌株

Also Published As

Publication number Publication date
JPWO2008126785A1 (ja) 2010-07-22

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