WO2008123796A3 - Замещенные 2,3,4,5-tetpaгидpo-1h-пиpидo[4,3-b]иhдoлы, способ их получения и применения - Google Patents
Замещенные 2,3,4,5-tetpaгидpo-1h-пиpидo[4,3-b]иhдoлы, способ их получения и применения Download PDFInfo
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- WO2008123796A3 WO2008123796A3 PCT/RU2008/000196 RU2008000196W WO2008123796A3 WO 2008123796 A3 WO2008123796 A3 WO 2008123796A3 RU 2008000196 W RU2008000196 W RU 2008000196W WO 2008123796 A3 WO2008123796 A3 WO 2008123796A3
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- Prior art keywords
- substituted
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- alkyl
- indoles
- pyrido
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010502052A JP5580731B2 (ja) | 2007-04-05 | 2008-04-01 | 置換された2,3,4,5−テトラヒドロ−1h−ピリド[4,3−b]インドール、その製造のための方法及び使用 |
EA200901253A EA016234B1 (ru) | 2007-04-05 | 2008-04-01 | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
AU2008236872A AU2008236872B2 (en) | 2007-04-05 | 2008-04-01 | Substituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indoles, methods for the production and use thereof |
UAA200910930A UA98324C2 (ru) | 2007-04-05 | 2008-04-01 | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1H-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
EP08753899.7A EP2145887B1 (en) | 2007-04-05 | 2008-04-01 | Substituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indoles, methods for the production and use thereof |
US12/594,453 US8541437B2 (en) | 2007-04-05 | 2008-04-01 | Substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles, methods for the production and use thereof |
CA2683453A CA2683453C (en) | 2007-04-05 | 2008-04-01 | Substituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-.beta.]indoles, methods for the production and use thereof |
US13/844,825 US20130217703A1 (en) | 2007-04-05 | 2013-03-16 | Sustituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indoles, methods for use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2007112666A RU2334747C3 (ru) | 2007-04-05 | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ | |
RU2007112666 | 2007-04-05 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/844,825 Division US20130217703A1 (en) | 2007-04-05 | 2013-03-16 | Sustituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indoles, methods for use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008123796A2 WO2008123796A2 (ru) | 2008-10-16 |
WO2008123796A3 true WO2008123796A3 (ru) | 2008-12-31 |
Family
ID=39831503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/RU2008/000196 WO2008123796A2 (ru) | 2007-04-05 | 2008-04-01 | Замещенные 2,3,4,5-tetpaгидpo-1h-пиpидo[4,3-b]иhдoлы, способ их получения и применения |
Country Status (9)
Country | Link |
---|---|
US (3) | US8541437B2 (ru) |
EP (1) | EP2145887B1 (ru) |
JP (1) | JP5580731B2 (ru) |
KR (1) | KR20090130105A (ru) |
AU (1) | AU2008236872B2 (ru) |
CA (1) | CA2683453C (ru) |
EA (1) | EA016234B1 (ru) |
UA (1) | UA98324C2 (ru) |
WO (1) | WO2008123796A2 (ru) |
Cited By (20)
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US9006234B2 (en) | 2009-09-23 | 2015-04-14 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
US9034869B2 (en) | 2008-03-24 | 2015-05-19 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
US9034865B2 (en) | 2010-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9079904B2 (en) | 2009-09-23 | 2015-07-14 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9096591B2 (en) | 2007-10-25 | 2015-08-04 | Medivation Technologies, Inc. | Tetracyclic compounds |
US9115137B2 (en) | 2008-01-25 | 2015-08-25 | Medivation Technologies, Inc. | 2,3,4,5-tetrahydro-1H-pyrido[4,3-B]indole compounds and methods of use thereof |
US9187471B2 (en) | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9199996B2 (en) | 2009-09-23 | 2015-12-01 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9199985B2 (en) | 2011-02-18 | 2015-12-01 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
US9211287B2 (en) | 2011-02-18 | 2015-12-15 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
US9243281B2 (en) | 2013-11-11 | 2016-01-26 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
US9255094B2 (en) | 2009-04-29 | 2016-02-09 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9260429B2 (en) | 2008-03-24 | 2016-02-16 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9409910B2 (en) | 2008-10-31 | 2016-08-09 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
US9434747B2 (en) | 2011-02-18 | 2016-09-06 | Medivation Technologies, Inc. | Methods of treating diabetes |
US9446042B2 (en) | 2009-01-09 | 2016-09-20 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US9446022B2 (en) | 2009-01-09 | 2016-09-20 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US9458155B2 (en) | 2008-10-31 | 2016-10-04 | Medivation Technologies, Inc | Pyrido[4,3-b]indoles containing rigid moieties |
US9527854B2 (en) | 2011-02-18 | 2016-12-27 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
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JP2011507835A (ja) * | 2007-12-21 | 2011-03-10 | アンドレイ・アレクサンドロビッチ・イワシェンコ | α−アドレナリン受容体、ドーパミン、ヒスタミン、イミダゾリン及びセロトニン受容体のリガンド並びにその使用 |
US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
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US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
EP2396327A1 (en) | 2009-02-11 | 2011-12-21 | Sunovion Pharmaceuticals Inc. | Histamine h3 inverse agonists and antagonists and methods of use thereof |
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PE20160127A1 (es) | 2009-06-17 | 2016-02-24 | Vertex Pharma | COMPUESTO ACIDO (2S,3S)-3-((2-(5-FLUORO-1H-PIRROLO[2,3-B]PIRIDIN-3-IL)-5-FLUOROPIRIMIDIN-4-IL)AMINO)BICICLO[2.2.2]OCTANO-2-CARBOXILICO COMO INHIBIDOR DE LA REPLICACION DEL VIRUS DE LA GRIPE A H1N1, H2N2, H3N2 o H5N1 |
RU2009128817A (ru) * | 2009-07-28 | 2011-02-10 | Общество с ограниченной ответственностью "Инномед" (RU) | Производные гидрированных пиридо[4,3-b]индолов, фармацевтическая композиция, способы получения и применения |
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WO2011103448A1 (en) * | 2010-02-19 | 2011-08-25 | Medivation Technologies, Inc. | Methods and compositions for treating psychotic disorders using antipsychotic combination therapy |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
RU2490268C2 (ru) * | 2011-11-10 | 2013-08-20 | Федеральное Государственное Бюджетное Учреждение Науки Институт Физиологически Активных Веществ Российской Академии Наук (Ифав Ран) | ХЛОРГИДРАТЫ ФТОРСОДЕРЖАЩИХ ЗАМЕЩЕННЫХ 5-[2-(ПИРИД-3-ИЛ)-ЭТИЛ]-2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛОВ, В КАЧЕСТВЕ СРЕДСТВ СНИЖЕНИЯ НЕКОНТРОЛИРУЕМОЙ АГРЕГАЦИИ БЕЛКОВ В НЕРВНОЙ СИСТЕМЕ, ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ИХ ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
US9701676B2 (en) | 2012-08-24 | 2017-07-11 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US3484449A (en) * | 1966-05-12 | 1969-12-16 | Hoffmann La Roche | Certain substituted phenyl amino-ethylpyridine intermediates |
US3502688A (en) * | 1968-09-10 | 1970-03-24 | Hoffmann La Roche | 5-(4-pyridylethyl)-pyridoindole derivatives |
RU2106864C1 (ru) * | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
RU2283108C2 (ru) * | 2003-12-08 | 2006-09-10 | Сергей Олегович Бачурин | ГЕРОПРОТЕКТОР НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
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RU2140417C1 (ru) | 1995-10-17 | 1999-10-27 | Институт физиологически активных веществ РАН | Производные гидрированных пиридо(4,3-b)индолов, способы их получения, фармацевтическая композиция и способ лечения |
AU2007309390A1 (en) * | 2006-10-27 | 2008-05-02 | Medivation Neurology, Inc. | Methods and combination therapies for treating Alzheimer's disease |
RU2334514C1 (ru) * | 2006-12-01 | 2008-09-27 | Институт физиологически активных веществ Российской Академии наук | СРЕДСТВО ДЛЯ УЛУЧШЕНИЯ КОГНИТИВНЫХ ФУНКЦИЙ И ПАМЯТИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО (4,3-b) ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ |
CA2700160A1 (en) * | 2007-09-20 | 2009-03-26 | D2E, Llc | Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use |
RU2007139634A (ru) * | 2007-10-25 | 2009-04-27 | Сергей Олегович Бачурин (RU) | Новые тиазол-, триазол- или оксадиазол-содержащие тетрациклические соединения |
JP2011507835A (ja) * | 2007-12-21 | 2011-03-10 | アンドレイ・アレクサンドロビッチ・イワシェンコ | α−アドレナリン受容体、ドーパミン、ヒスタミン、イミダゾリン及びセロトニン受容体のリガンド並びにその使用 |
CN104387382A (zh) * | 2008-03-24 | 2015-03-04 | 梅迪维新技术公司 | 吡啶并[3,4-b]吲哚和应用方法 |
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2008
- 2008-04-01 WO PCT/RU2008/000196 patent/WO2008123796A2/ru active Application Filing
- 2008-04-01 US US12/594,453 patent/US8541437B2/en not_active Expired - Fee Related
- 2008-04-01 JP JP2010502052A patent/JP5580731B2/ja active Active
- 2008-04-01 AU AU2008236872A patent/AU2008236872B2/en not_active Ceased
- 2008-04-01 EP EP08753899.7A patent/EP2145887B1/en active Active
- 2008-04-01 KR KR1020097023171A patent/KR20090130105A/ko not_active Application Discontinuation
- 2008-04-01 EA EA200901253A patent/EA016234B1/ru not_active IP Right Cessation
- 2008-04-01 UA UAA200910930A patent/UA98324C2/ru unknown
- 2008-04-01 CA CA2683453A patent/CA2683453C/en active Active
-
2013
- 2013-03-16 US US13/844,825 patent/US20130217703A1/en not_active Abandoned
-
2015
- 2015-07-03 US US14/791,280 patent/US9655886B2/en active Active
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Also Published As
Publication number | Publication date |
---|---|
RU2334747C1 (ru) | 2008-09-27 |
EA016234B1 (ru) | 2012-03-30 |
EA200901253A1 (ru) | 2010-02-26 |
EP2145887B1 (en) | 2016-04-27 |
US20170000773A1 (en) | 2017-01-05 |
EP2145887A4 (en) | 2011-03-02 |
US9655886B2 (en) | 2017-05-23 |
EP2145887A2 (en) | 2010-01-20 |
KR20090130105A (ko) | 2009-12-17 |
CA2683453C (en) | 2013-06-11 |
US8541437B2 (en) | 2013-09-24 |
CA2683453A1 (en) | 2008-10-16 |
WO2008123796A2 (ru) | 2008-10-16 |
US20100120792A1 (en) | 2010-05-13 |
UA98324C2 (ru) | 2012-05-10 |
JP2010523556A (ja) | 2010-07-15 |
US20130217703A1 (en) | 2013-08-22 |
AU2008236872A1 (en) | 2008-10-16 |
JP5580731B2 (ja) | 2014-08-27 |
AU2008236872B2 (en) | 2013-01-17 |
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