WO2008123641A1 - Élément de fixation pour implant comprenant un composite hydroxyapatite/alumine/silice - Google Patents

Élément de fixation pour implant comprenant un composite hydroxyapatite/alumine/silice Download PDF

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Publication number
WO2008123641A1
WO2008123641A1 PCT/KR2007/003685 KR2007003685W WO2008123641A1 WO 2008123641 A1 WO2008123641 A1 WO 2008123641A1 KR 2007003685 W KR2007003685 W KR 2007003685W WO 2008123641 A1 WO2008123641 A1 WO 2008123641A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxyapatite
alumina
implant fixture
fixture
silica
Prior art date
Application number
PCT/KR2007/003685
Other languages
English (en)
Inventor
Young Min Park
Sang Ho Min
Su Chak Ryu
Original Assignee
Dio Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dio Corporation filed Critical Dio Corporation
Publication of WO2008123641A1 publication Critical patent/WO2008123641A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A61L27/105—Ceramics or glasses containing Al2O3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body

Definitions

  • the present invention relates to an implant fixture, in which small amounts of alumina and silica are added to hydroxyapatite, which is biocompatible and shows excellent bioactivity, such that the mechanical strength of hydroxyapatite is increased without reducing the biocompatibility and bioactivity, and to a preparation method thereof.
  • the term “dental implants” refers to replacements themselves for lost natural teeth or refers to dental surgery of restoring the original function of teeth by inserting a screw-shaped implant fixture into the jawbone, allowing the inserted fixture to be fused with the bone for a given period of time, and then fixing prostheses such as an abutment and an artificial tooth crown on the fixture.
  • Implants can exhibit a chewing force approximately similar to that of normal teeth, compared to the existing false teeth having a chewing force of only about 30% of natural teeth, and are very superior to the existing other prostheses in terms of the restoration of chewing functions, and aesthetic properties, because teeth on both sides of a missing tooth are not ground, unlike artificial teeth.
  • Dental implant fixtures which are currently frequently used to firmly anchor an implant to the jawbone, are unalloyed titanium (Ti) materials, including ASTM grades 3 and 4, and Ti-6A1-4V (ELI). Titanium (Ti) is very easy to use, because it is light, has excellent strength and an elastic modulus similar to that of natural teeth and, at the same time, is biocompatible. However, it was recently found that human beings having genes showing a rejection reaction to titanium exist and the long-term use of titanium shows an erosion phenomenon.
  • Another object of the present invention is to provide an implant fixture for use in dental surgery, orthopedic surgery, otorhinolaryngology, oral and maxillofacial surgery, plastic surgery and the like, which has osseoinductive surface properties and excellent mechanical strength, such that it can be successfully osseointegrated into a patient in a short period of time.
  • the present invention provides an implant fixture comprising a hy- droxyapatite/alumina/silica composite.
  • Hydroxyapatite which is used in the present invention, is the same component as that of the enamel of human bones and teeth and may have the following formula 1 : [10] ⁇ foraiula 1>
  • hydroxyapatite has a great effect on the restoration of loss of dental enamel and has recently received attention as a tooth whitening agent, because it restores the original color of teeth.
  • hydroxyapatite is intended to be used as a raw material for the implant fixture composite.
  • Alumina which is used in the present invention, is also called "aluminum oxide" as a compound of aluminum and oxygen, and is represented by a chemical formula of Al O . It has a molecular weight of 101.96 and is present in various forms, ⁇ -alumina, which is produced by heating aluminum hydroxide to a temperature lower than 300 0 C, is in a pure and stable form. In addition, there is ⁇ -alumina having low crystallinity, which is produced by dehydrating ⁇ -alumina hydrate containing little alkali, and alumina types such as ⁇ , ⁇ , ⁇ , ⁇ , K ⁇ or p-alumina are also known. In the present invention, all forms of silica, which are represented by a chemical formula of Al O , may be used without a particular limitation.
  • Silica which is used in the present invention, is also called "silicon dioxide" as a compound of silicon and oxygen and is represented by a chemical formula of SiO . It is a component in various naturally occurring silicates. Also, it naturally occurs as crystalline or amorphous silica in quartz, cryolite, chalcedony, agate, flint, tridymite cristobalite and the like. In the present invention, all forms of silica, which are represented by a chemical formula of SiO , may be used.
  • implant fixture refers to a fixture, at least a portion of which is brought into contact with bone tissue or implanted into bone tissue.
  • This implant fixture is used for in vivo implantation in medical fields, including dental surgery, orthopedic surgery, otorhinolaryngology, oral and maxillofacial surgery, plastic surgery and the like, and the implant fixture is not limited only to dental applications as long as it is an implant fixture for in vivo implantation in medical fields.
  • bioglass is formed due to the reaction between the Ca and P components of hydroxyapatite and the Si and Al components of silica and alumina.
  • Such bioglass surrounds hydroxyapatite particles, is distributed uniformly throughout the fixture, and thus acts like a binder. Accordingly, the fixture of the present invention has high bioactivity and excellent stability compared to the prior fixtures, because the mechanical strength of hydroxyapatite in the inventive fixture is increased due to the addition of silica and alumina (see Example 3).
  • the present invention provides a method for preparing said implant fixture, the method comprising the steps of: 1) preparing each of hydroxyapatite, alumina and silica powders as raw materials; 2) ball-milling the raw material powders to regrind and mix them; 3) drying the mixed powders; 4) press-molding the dried powders; and 5) thermally treating the press-molded body, thereby preparing a fixture.
  • the inventive implant fixture comprising the hydroxyapatite/alumina/silica complex is aesthetic and biologically safe, compared to the prior implant fixture made of titanium. Also, it increases the activity of osteoblasts to induce rapid osseointegration by binding to bone tissues.
  • the inventive implant fixture provides an effect of increasing the functionality and success rate of implants, which are implanted into patients in medical fields, including dental surgery, orthopedic surgery, otorhino- laryngology, oral and maxillofacial surgery, plastic surgery and the like.
  • FIG. 1 is a flowchart showing a process for preparing an implant fixture comprising a hydroxyapatite/alumina/silica composite according to one embodiment of the present invention
  • FIG. 2 is an SEM (scanning electron microscope) photograph of raw material powders for preparing the hydroxyapatite/alumina/silica composite implant fixture comprising a according to one embodiment of the present invention
  • FIG. 3 shows the results of XRD analysis conducted in Example 2 for the hydroxyapatite/alumina/silica composite implant fixture sintered at 145O 0 C;
  • FIG. 4 is an optical microscope photograph showing the osseointegration of fixtures, measured at 3 days and 2 weeks after implanting each of the hydroxyapatite/ alumina/silica composite implant fixture according to one embodiment of the present invention and a titanium fixture into a rabbit's hind leg; and
  • FIG. 5 shows several colors of the inventive implant fixture comprising the hydroxyapatite/alumina/silica composite. Best Mode for Carrying Out the Invention
  • the volume ratio of hydroxyapatite: alumina: silica is preferably 50-90: 0.5-49.5: 0.5-49.5.
  • hydroxyapatite, silica and alumina were used in amounts of 90 vol%, 2 vol% and 8 vol%, respectively (see Example 1).
  • the volume ratio of alumina: silica is preferably 7-9: 1-3.
  • the compressive strength, bending strength and micro Vickers hardness of the implant fixture were significantly increased (see Example 3, Table 2).
  • the shape of hydroxyapatite powder which is used in the present invention, is not specifically limited, it is preferable to use a combination of spherical powder and a second shape.
  • the volume ratio of spherical hydroxyapatite: Whisker hydroxyapatite powder is preferably 50-85: 5-40.
  • spherical hydroxyapatite and Whisker hydroxyapatite were used in amounts of 80 vol% and 10 vol%, respectively (Example 1).
  • the aspect ratio of Whisker hydroxyapatite powder which isi used in the present invention, is in the range of 3-15, and preferably 10-15.
  • the average particle size of each of hydroxyapatite, silica and alumina raw material powders is in the range of 0.1-lOOQ, and preferably 0.8-3D.
  • the raw material powders are re-ground and mixed with each other.
  • ball milling is performed.
  • the powders can be ball-milled in water (wet process) or air (dry process) for 6-48 hours.
  • the powders were ball-milled in water for 24 hours (S20 of FIG. 1).
  • the dried powders are prepared as mono-dispersed fine spherical particles.
  • the drying of the powders can be carried out in a dryer at a temperature of 80 to 13O 0 C, and preferably 100 0 C.
  • the powders may also be freeze-dried at a temperature of -30 to -8O 0 C, and preferably -5O 0 C.
  • the powders were freeze-dried to prepare mono-dispersed fine spherical particles (S30 of FIG. 1).
  • the particle size distribution of the prepared fine spherical particles is 0.1-lOOD, and preferably 0.8-3D.
  • the dried powders are pressed and molded.
  • the dried powders are molded under a pressure of 1-100 Ton/D.
  • the powders were molded under 20 Ton/D (S40 of FIG. 1).
  • the molding process can be carried out using one or more selected from among biaxial pressing, injection molding, hot isostatic pressing (HIP) or cold isostatic pressing (CIP).
  • HIP hot isostatic pressing
  • CIP cold isostatic pressing
  • the powders were molded by biaxial pressing, and then cold isotatic pressing (S40 of FIG. 1).
  • the press-molded body is thermally treated to prepare an implant fixture.
  • the press-molded body can be thermally treated in an electric furnace at 1200-1500 0 C to prepare an implant fixture. More specifically, the press-molded body can be thermally treated at 600 0 C for 2 hour to burn-out a small amount of organic materials, can be compacted at 1200 0 C for 3 hours, and then can be sintered at 1450 0 C, thus preparing an implant fixture. In a specific example of the present invention, the press-molded body was thermally treated at 1450 0 C to prepare an implant fixture (S50 of FIG. 1).
  • the inventive implant fixture prepared according to the above-described method can be prepared in various colors.
  • the present invention provides implant fixtures having various colors.
  • light blue, light yellow, beige and pure white fixtures were prepared (see FIG. 5).
  • the implant fixture is used in dental applications, it is preferably prepare to have a color similar to the color of teeth.
  • Example 1 Preparation of implant fixture comprising hydroxyapatite/ alumina/silica composite
  • Example 2 X-ray diffraction (XRD) analysis of hydroxyapatite/alumina/silica composite
  • FIG. 3 shows the results of XRD analysis of an implant fixture comprising a hydroxyapatite/alumina/silica composite, sintered at 145O 0 C.
  • the main peaks of alumina and silica did not appear, even though the composite containing silica and alumina was sintered. This is thought to be because the Ca and P components of hydroxyapatite reacted with Si and Al to form bioglass, and thus Si and Al were not detected in the XRD analysis.
  • the bioglass surrounds the HAp particles, is distributed uniformly throughout the fixture, and thus acts like as a binder. Such bioglass is formed by the reaction between the Ca and P components of hydroxyapatite and the Si and Al components of silica and alumina.
  • Example 3 Compressive strength, bending strength and micro-hardness according to composition ratio of implant fixture
  • the binding force of bioglass to hy- droxyapatite started to increase from a composition ratio of HAp:A12O3:SiO2 of 90:5:5 and reached the highest at a composition ratio of HAp:A12O3:SiO2 of 90:8:2.
  • the amount of bioglass formed was decreased, so that the binding force of bioglass to hydroxyapatite was reduced, thus reducing the compressive strength, bending strength and micro- Vickers hardness of the fixtures.
  • FIG. 5 shows cylinder-type or screw-type implant fixtures comprising a hy- droxyapatite/alumina/silica composite, which have various colors.
  • the implant fixtures could be prepared to have various colors, such as light blue, light yellow, beige and pure white colors.
  • Hydroxyapatite powder has a white, light yellow or light blue color; the use of blue color hydroxyapatite can prepare a blue color implant fixture.
  • a pure white, beige or light yellow fixture can be obtained by controlling the amounts of alumina and silica added.
  • silica is added in an amount larger than alumina
  • silica is added in an amount larger than alumina
  • Test Example Tissue reaction of implant fixture comprising hydroxyapatite/ alumina/silica composite, implanted into rabbit's hind leg
  • the implant fixture comprising the hydroxyapatite/alumina/silica composite, prepared in Example 1 was implanted into a rabbit's hind leg, and after 3 days and 2 weeks, the degree of osseointegration of the fixture was observed.
  • FIG. 4 shows an optical microscope photograph showing the osseointegration of fixtures, measured at 3 days and 2 weeks after implanting each of the hydroxyapatite/ alumina/silica composite implant fixture and a titanium fixture into a rabbit's hind leg.
  • Ti titanium
  • the implant fixture comprising the hydroxyapatite/alumina/silica was implanted, with the passage of time from 3 days to 2 weeks, not only the periosteum was formed around the fixture, but also osteoblasts, fibrous tissues and cementums were produced, and thus the osseointegration of the fixture rapidly occurred.
  • the implant fixture prepared according to the present invention showed a high degree of osseointegration compared to the prior implant fixture made of pure titanium (Ti).
  • the inventive implant fixture comprising the hydroxyapatite/ alumina/silica complex is aesthetic and biologically safe, compared to the prior implant fixture made of titanium. Also, it increases the activity of osteoblasts to induce rapid osseointegration by binding to bone tissues.
  • the inventive implant fixture provides an effect of increasing the functionality and success rate of implants, which are implanted into patients in medical fields, including dental surgery, orthopedic surgery, otorhinolaryngology, oral and maxillofacial surgery, plastic surgery and the like.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Ceramic Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dentistry (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un élément de fixation pour implant qui comprend un composite hydroxyapatite (Ca10 (PO4)6(OH)2)/alumine (Al2O3)/silice (SiO2), à utiliser pour une implantation in vivo dans les domaines médicaux, notamment la chirurgie dentaire, la chirurgie orthopédique, l'oto-rhino-laryngologie, la chirurgie buccale et maxillo-faciale, la chirurgie plastique; ainsi qu'un procédé de préparation de celui-ci. Par comparaison avec un élément de fixation de l'art antérieur composé de titane, ledit élément de fixation pour implant présente une excellente biocompatibilité et se lie rapidement à un os pendant la phase initiale d'implantation de manière à améliorer la fixation d'implants pendant la phase initiale. Ledit élément de fixation est très utile en raison de sa capacité à améliorer la fixation d'implants et leur stabilité.
PCT/KR2007/003685 2007-04-06 2007-07-31 Élément de fixation pour implant comprenant un composite hydroxyapatite/alumine/silice WO2008123641A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2007-0034123 2007-04-06
KR1020070034123A KR100733726B1 (ko) 2007-04-06 2007-04-06 수산화인회석/알루미나/실리카 복합체를 이용한 임플란트용매식체

Publications (1)

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WO2008123641A1 true WO2008123641A1 (fr) 2008-10-16

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109528499A (zh) * 2018-10-04 2019-03-29 南京航空航天大学溧水仿生产业研究院有限公司 仿生二氧化硅牙齿贴面及其制备方法
CN117205360A (zh) * 2023-09-20 2023-12-12 中南大学湘雅二医院 一种人造生物陶瓷骨骼材料及其制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60026286T2 (de) * 1999-05-28 2006-11-09 Shin-Etsu Handotai Co., Ltd. MIT Ga DOTIERTER CZOCHRALSKI-EINKRISTALL UND WAFER UND VERFAHREN ZU DEREN HERSTELLUNG
KR100936489B1 (ko) 2007-12-17 2010-01-13 이소현 치과용 임시 임플란트 제조방법
KR101840267B1 (ko) * 2015-03-10 2018-03-22 서울대학교 산학협력단 폴리에테르에테르케톤-금속 복합체의 제조방법 및 이를 포함하는 생체 이식용 임플란트

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5772439A (en) * 1995-03-28 1998-06-30 Kanebo Limited Hybrid dental implant
KR20040001325A (ko) * 2002-06-27 2004-01-07 김현이 생체 이식용 세라믹 복합체 및 그 제조방법
KR20040084184A (ko) * 2003-03-27 2004-10-06 주식회사 에이치티 치열교정용 도제 브라켓 및 그 제조방법
KR20060052140A (ko) * 2004-10-11 2006-05-19 주식회사 엘지화학 임플란트용 생체활성 세라믹 소결 복합체 및 그 제조 방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5772439A (en) * 1995-03-28 1998-06-30 Kanebo Limited Hybrid dental implant
KR20040001325A (ko) * 2002-06-27 2004-01-07 김현이 생체 이식용 세라믹 복합체 및 그 제조방법
KR20040084184A (ko) * 2003-03-27 2004-10-06 주식회사 에이치티 치열교정용 도제 브라켓 및 그 제조방법
KR20060052140A (ko) * 2004-10-11 2006-05-19 주식회사 엘지화학 임플란트용 생체활성 세라믹 소결 복합체 및 그 제조 방법

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109528499A (zh) * 2018-10-04 2019-03-29 南京航空航天大学溧水仿生产业研究院有限公司 仿生二氧化硅牙齿贴面及其制备方法
CN117205360A (zh) * 2023-09-20 2023-12-12 中南大学湘雅二医院 一种人造生物陶瓷骨骼材料及其制备方法

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