WO2008123291A1 - 蛍光体標識化合物 - Google Patents

蛍光体標識化合物 Download PDF

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Publication number
WO2008123291A1
WO2008123291A1 PCT/JP2008/055682 JP2008055682W WO2008123291A1 WO 2008123291 A1 WO2008123291 A1 WO 2008123291A1 JP 2008055682 W JP2008055682 W JP 2008055682W WO 2008123291 A1 WO2008123291 A1 WO 2008123291A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
labeling
inorganic fluorescent
surface modification
fluorescent nanoparticles
Prior art date
Application number
PCT/JP2008/055682
Other languages
English (en)
French (fr)
Inventor
Kazuya Tsukada
Kazuyoshi Goan
Hisatake Okada
Original Assignee
Konica Minolta Medical & Graphic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Konica Minolta Medical & Graphic, Inc. filed Critical Konica Minolta Medical & Graphic, Inc.
Priority to US12/531,092 priority Critical patent/US20100044673A1/en
Priority to JP2009509135A priority patent/JP5136548B2/ja
Publication of WO2008123291A1 publication Critical patent/WO2008123291A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K9/00—Tenebrescent materials, i.e. materials for which the range of wavelengths for energy absorption is changed as a result of excitation by some form of energy
    • C09K9/02—Organic tenebrescent materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Materials Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

　本発明は、生体標識への検出性が非常に安定で感度も高い蛍光体標識化合物を提供する。蛍光体標識化合物は、表面に表面修飾化合物が配置されており、かつ平均粒径が１．０～２０ｎｍである無機蛍光体ナノ粒子からなり、該無機蛍光体ナノ粒子の粒径に対する、該表面修飾化合物の該無機蛍光体ナノ粒子の表面からの長さの比率が０．１０～０．５０であり、かつ該表面修飾化合物がついていない無機蛍光体ナノ粒子の比重に対する、該表面修飾化合物がついた無機蛍光体ナノ粒子の比重の比率が０．８０～０．４０であることを特徴とする。
PCT/JP2008/055682 2007-03-29 2008-03-26 蛍光体標識化合物 WO2008123291A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/531,092 US20100044673A1 (en) 2007-03-29 2008-03-26 Labeling fluorescent compound
JP2009509135A JP5136548B2 (ja) 2007-03-29 2008-03-26 蛍光体標識化合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-087254 2007-03-29
JP2007087254 2007-03-29

Publications (1)

Publication Number Publication Date
WO2008123291A1 true WO2008123291A1 (ja) 2008-10-16

Family

ID=39830779

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/055682 WO2008123291A1 (ja) 2007-03-29 2008-03-26 蛍光体標識化合物

Country Status (3)

Country Link
US (1) US20100044673A1 (ja)
JP (1) JP5136548B2 (ja)
WO (1) WO2008123291A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014501919A (ja) * 2010-12-13 2014-01-23 アレバ 発光性ナノ粒子によるマーキングを備えた原子力発電所コンポーネント、対応する読み取りプロセス、およびアセンブリ

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10371633B2 (en) * 2017-10-30 2019-08-06 Saudi Arabian Oil Company Determining a specific gravity of a sample
US11662288B2 (en) 2020-09-24 2023-05-30 Saudi Arabian Oil Company Method for measuring API gravity of petroleum crude oils using angle-resolved fluorescence spectra

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002056020A1 (fr) * 2001-01-12 2002-07-18 Kazunori Kataoka Complexes d'un solide et de polymeres utilises dans un dosage biologique
WO2005071039A1 (ja) * 2004-01-26 2005-08-04 Kyocera Corporation 波長変換器、発光装置、波長変換器の製造方法および発光装置の製造方法
JP2006515418A (ja) * 2002-08-27 2006-05-25 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 規定された数のリガンドを有するナノ粒子の製造
JP2006143526A (ja) * 2004-11-19 2006-06-08 National Institute Of Advanced Industrial & Technology ナノ粒子の低温合成法
WO2007086189A1 (ja) * 2006-01-30 2007-08-02 Konica Minolta Medical & Graphic, Inc. ナノ粒子またはナノロッドからなる蛍光標識物質
WO2008032535A1 (fr) * 2006-09-15 2008-03-20 Konica Minolta Medical & Graphic, Inc. Microparticule semi-conductrice fluorescente, procédé de production de cette microparticule, agent de marquage fluorescent pour substances biologiques comportant cette microparticule, et procédé de bio-imagerie faisant intervenir cette microparticule
WO2008032599A1 (fr) * 2006-09-14 2008-03-20 Konica Minolta Medical & Graphic, Inc. agrégat de nanoparticules semi-conductrices, processus de fabrication de l'agrégat de nanoparticules semi-conductrices, et agent de marquage de substance biologique utilisant l'agrégat de nanoparticules semi-conductrices

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251303B1 (en) * 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002056020A1 (fr) * 2001-01-12 2002-07-18 Kazunori Kataoka Complexes d'un solide et de polymeres utilises dans un dosage biologique
JP2006515418A (ja) * 2002-08-27 2006-05-25 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 規定された数のリガンドを有するナノ粒子の製造
WO2005071039A1 (ja) * 2004-01-26 2005-08-04 Kyocera Corporation 波長変換器、発光装置、波長変換器の製造方法および発光装置の製造方法
JP2006143526A (ja) * 2004-11-19 2006-06-08 National Institute Of Advanced Industrial & Technology ナノ粒子の低温合成法
WO2007086189A1 (ja) * 2006-01-30 2007-08-02 Konica Minolta Medical & Graphic, Inc. ナノ粒子またはナノロッドからなる蛍光標識物質
WO2008032599A1 (fr) * 2006-09-14 2008-03-20 Konica Minolta Medical & Graphic, Inc. agrégat de nanoparticules semi-conductrices, processus de fabrication de l'agrégat de nanoparticules semi-conductrices, et agent de marquage de substance biologique utilisant l'agrégat de nanoparticules semi-conductrices
WO2008032535A1 (fr) * 2006-09-15 2008-03-20 Konica Minolta Medical & Graphic, Inc. Microparticule semi-conductrice fluorescente, procédé de production de cette microparticule, agent de marquage fluorescent pour substances biologiques comportant cette microparticule, et procédé de bio-imagerie faisant intervenir cette microparticule

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014501919A (ja) * 2010-12-13 2014-01-23 アレバ 発光性ナノ粒子によるマーキングを備えた原子力発電所コンポーネント、対応する読み取りプロセス、およびアセンブリ

Also Published As

Publication number Publication date
JPWO2008123291A1 (ja) 2010-07-15
US20100044673A1 (en) 2010-02-25
JP5136548B2 (ja) 2013-02-06

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