WO2008116977A1 - Tube de conditionnement d'un volume prédéterminé de substance biologique à conserver à basse température et système le comportant - Google Patents
Tube de conditionnement d'un volume prédéterminé de substance biologique à conserver à basse température et système le comportant Download PDFInfo
- Publication number
- WO2008116977A1 WO2008116977A1 PCT/FR2008/000158 FR2008000158W WO2008116977A1 WO 2008116977 A1 WO2008116977 A1 WO 2008116977A1 FR 2008000158 W FR2008000158 W FR 2008000158W WO 2008116977 A1 WO2008116977 A1 WO 2008116977A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tube
- tube according
- annular
- receiving portion
- biological substance
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
Definitions
- Tube for conditioning a predetermined volume of biological substance to be kept at low temperature and system comprising same
- the present invention relates to the packaging of biological substances to be kept at low temperature.
- Biological substance conditioning tubes are already known to be stored at freezing temperatures (between -20 ° C. and -40 ° C.) or even at cryogenic temperatures (between -180 ° C. and -196 ° C.) such that for example, capillary tubes also called "flakes" intended to receive small volumes of biological substances.
- the flakes initially open at both ends, are sealed at these ends by thermal welding after filling.
- relatively rigid plastics material such as polycarbonate or polypropylene
- Such a tube is in particular known from French Patent 2,865,190 which describes such a tube provided with a threaded portion and whose plug is of the screw type.
- the aim of the invention is to improve the performance of such a tube, in particular with regard to safety against contaminations.
- said predetermined volume, said tube comprising a receiving portion of said volume, characterized in that said tube also comprises an annular end portion adapted to be more easily squeezed by clamping said receiving portion and to take a flattened position where two lips are in contact with each other, said annular end portion being adapted to be secured to said lips one to the another to form a hermetic seal of said tube.
- the plugs known in the state of the art are likely to have a sealing defect (potential source of contamination) in the face of the significant stresses they undergo due to the pressure difference between inside and outside of the tube generated by the cooling.
- packaging tube according to the invention is thus shaped to effectively achieve hermetic sealing, although it has larger dimensions than those of flakes.
- said annular portion has on at least part of its length a thickness smaller than the thickness of said receiving portion; the thickness of said annular portion decreases regularly in the direction from said receiving portion to said opening for introducing said volume; and or
- said sealing is a thermal weld
- sealing is a seal that can be activated by UV. Sealing by welding, by permanent bonding, or by any other means requiring cutting to access the contents of the tube thus ensures in a simple way the inviolability of the contents of the tube.
- said tube also comprises at least one localized sampling zone that is more easily perforable than its environment
- said receiving portion has, on the opposite side to said annular end portion, a housing for receiving an identification element of said substance; said housing is occupied by a resin adapted to retain said identification element;
- said receiving portion comprises an identification sleeve of said biological substance
- said sleeve has at least one viewing window of the inside of said tube;
- said tube is made of plastics molded by two-material injection.
- the invention also aims, in a second aspect, at a system for conditioning a predetermined volume of biological substance to be conserved at low temperature, characterized in that it comprises at least one tube as set out above and a jaw welding device. adapted to cause said annular portion to assume said flattened position and to weld said lips together to form said hermetic seal.
- FIG. 1 is an elevational view of a packaging tube according to the invention
- FIG. 2 is a sectional view of this tube taken along the line M-II of Figure 1;
- FIG. 3 is an elevational sectional view of this tube taken along the line MI-III of FIG. 1;
- - Figures 4 and 5 are two views similar to Figure 3 but taken in two transverse planes and after being fixed to the bottom of the tube RFID chip and after this tube has been sealed.
- Figures 6 and 7 are two views similar to Figures 1 and 3 but for a second embodiment of the tube;
- Figures 8 and 9 are two views similar to Figure 3 respectively showing a third and a fourth embodiment of the tube;
- FIG. 10 is an elevational view of a welding device in which is arranged a plate provided with a row of tubes according to the invention; and FIG. 11 is an elevational view of this row of tubes and this plate after two tubes of this plate have been welded.
- the conditioning tube 1 illustrated in FIGS. 1 to 3 comprises a receiving portion 2 of a biological substance and an annular end portion 3. Such a tube is intended to receive samples of large volume or relatively large size such as for example tissue samples.
- the receiving portion 2 has a tubular portion 9 and a sleeve 4 partially covering the tubular portion 9.
- the portions 3 and 9 are made of Surlyn ® low density polyethylene and the sleeve 4 of SEBS Santoprene ® .
- Portions 3 and 9 with the sleeve 4 are made of plastics molded by two-material injection.
- the tube 1 has an opening 8 at the edge of the annular portion 3 while it is closed near the opposite end by a transverse bottom wall 5.
- This wall 5 is slightly set back from the end opposite the opening 8, so that this recessed wall delimits with the rest of the receiving portion 2, on the side of the portion 3, a receiving housing 6 of the biological substance and, on the other side, a housing 7, which as will be seen below is adapted to receive an identification element of the biological substance.
- the annular end portion 3 is a tubular portion of smaller thickness than that of the receiving portion 2 so that the tube has at the junction of the portion 2 and the portion 3, a shoulder surface 12.
- the sleeve 4 is embedded in the portion 9 so that the receiving portion 2 (the sleeve 4 and the portion 9) has a constant thickness (in the portions of the portion 9 covered or not by the sleeve 4) greater than that of the annular portion 3.
- This sleeve has two rings 13 and 14 connected to one another by two strips 15 and 16 so that this sleeve has two windows 17 and 18 for viewing the contents of the tube 1.
- the tube 1 has a height of 48 mm, for an internal diameter of 9.8 mm.
- the sleeve 4 has a thickness of 0.3 mm.
- the receiving portion 2 has a wall thickness equal to 1.0 mm (1 mm Surlyn ® for the portion 9 in the areas not covered by the sleeve and 0.7 mm Surlyn ® for the portion 9 which s' adds 0.3 mm of Santoprene ® for the sleeve 4 in the areas of the portion 9 covered by the sleeve) while the annular end portion 3 has a wall of thickness equal to 0.6 mm.
- the dimensions of the tube 1 are chosen according to market standards so that this tube is in particular adapted to be placed in the conventional boxes for storing screw-type packaging tubes.
- Two other conventional height values for these tubes are 70 and 92 mm.
- the housing 7 of the tube 1 is designed to receive an identification element 21 (shown only in FIGS. 4 and 5) of the biological substance such as an RFID chip or else a mono or two-dimensional bar code (also called Datamatrix).
- the identification element 21 is held in position in this housing by a transparent resin 22 cast in this housing to freeze the position of this identification element. It is also possible to stick a label (not shown) provided with a flexible chip on this tube.
- the conditioning tube 1 is associated with a welding machine 24 illustrated in FIGS. 10 and 11.
- This machine comprises a frame 25, a mobile welding module 26, and a movable plate 27.
- the module 26 comprises two jaws 28 movable and adapted to perform reciprocating movements coordinated with the transverse displacement of the plate 27 carrying the filled tubes 1 so as to crush by pinching the annular portion 3 of each of the tubes 1.
- the module 26 is adjustable along the frame 25 by means of the wheels 29.
- the tubes previously filled with biological substance (using a pipette for example), are arranged in a row on the plate 27 and this plate is disposed in the welding machine 24 on a mechanism (not shown) adapted to translate the tray in the direction of alignment of the tubes.
- the plate is then moved so that the first tube of the row is disposed between the heating jaws 28.
- the welding machine 24 is then controlled to cause the heating jaws 28 to move so that they come closer to one another. another in the direction of the portion 3 of the tube 1 so as to crush by pressing this annular portion 3 of the tube so that the portion thus crushed takes a flattened position forming two lips 30 brought into contact with one another.
- the crushing of the annular portion 3 causes a deformation of this portion under the weld zone and possibly a slight deformation (not shown) of the receiving portion 2 (although the wall of this portion is thicker and therefore less easily deformable ).
- the crushing of the portion 3 causes a slight reflux of material so that the weld 31 extends slightly beyond the initial contour of the portion 3 ( Figure 4).
- the wall of the portion 3 being of small thickness this reflux is limited, this reduced thickness also ensuring a rapid warming and uniform welding lips.
- Such a weld would be particularly difficult to form on unconformed tubes such as the tubes according to the invention and the thickness of the walls in the weld zone is too large, such walls when they come together forming at the ends of the beads relatively difficult to crush against each other and thus adversely affect the quality of the weld especially in terms of sealing.
- These tubes can then be stored for example in a conventional storage box.
- the welds 31 being arranged offset relative to each other so that two neighboring tubes are not hindered by their respective weld.
- the operator cuts the tube in a zone of the annular portion 3 located under the weld 31, for example using a hot wire, a laser or some other accessory (sterile scissors, a scalpel, or a tube cutter for example) in order to separate the portion of the tube having the weld 31 of the rest of the tube and thus have access to the biological substance.
- a hot wire a laser or some other accessory (sterile scissors, a scalpel, or a tube cutter for example) in order to separate the portion of the tube having the weld 31 of the rest of the tube and thus have access to the biological substance.
- the cutting of the annular portion 3 is facilitated by the fact that the latter has a reduced thickness which makes it not only more easily deformable and weldable, but also easier to cut than the rest of the tube.
- the tube 101 is similar to the tube 1 except that it has no sleeve 4 and that it has in the receiving portion 102, at the edge of the annular portion 103, a sampling zone 119 of the same thickness as the annular portion 103 and which is thus made more easily perforable than its immediate environment (here portion 102).
- This zone thus makes it possible to easily take the liquid by the tip of a syringe introduced into the tube through this zone.
- FIG. 1 Another embodiment of the tube is shown in FIG. 1
- the same references have been used but the number 200 has been added.
- the receiving portion 202 and the annular portion 203 are no longer distinct, the shoulder 12 having disappeared, the thickness of the tube decreasing regularly in the direction from the bottom wall 205 towards the opening 208.
- the end portion 203 thus has a relatively small average thickness so that this portion is made more easily deformable, weldable and cuttable than the rest of the tube.
- FIG. 1 Another embodiment of the tube is shown in FIG. 1
- the annular end portion 303 has at the junction with the receiving portion 302, a groove 310 for locally reducing the thickness of this portion, the surface 311 of the portion 303 located at the bottom of this portion. groove constituting a sampling zone or a weakening zone that is even more easily perforable and cut-off than the rest of the annular portion 303.
- such a groove is formed in the annular portion 103 or 203 .
- the annular portion 103 or 303 has a thickness that decreases regularly in the direction from the receiving portion 102 or 302 to the introduction opening 108 or 308.
- the weld formed in the annular end portion has a particular pattern adapted to identify which type of machine has made it possible to produce this weld so as to reinforce the inviolability character. of the tube.
- the bottom of the receiving portion is tapered to facilitate the recovery of the liquid.
- the sealing of the lips of the tube is obtained not with the aid of a thermal welding but by activation of an adhesive (sensitive to UV for example).
- an adhesive sensitive to UV for example
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- Sampling And Sample Adjustment (AREA)
- Packging For Living Organisms, Food Or Medicinal Products That Are Sensitive To Environmental Conditiond (AREA)
- Lining Or Joining Of Plastics Or The Like (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Packages (AREA)
- Devices For Use In Laboratory Experiments (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200880005417XA CN101678357B (zh) | 2007-02-19 | 2008-02-08 | 包装低温保存的预定量生物制剂的管及具有该管的系统 |
EP08761859.1A EP2114572B1 (fr) | 2007-02-19 | 2008-02-08 | Tube de conditionnement d'un volume prédéterminé de substance biologique à conserver à basse température et système le comportant |
US12/527,737 US8266872B2 (en) | 2007-02-19 | 2008-02-08 | Packaging tube for a predetermined volume of a biological substance to be stored at a low temperature and system including same |
MX2009008814A MX2009008814A (es) | 2007-02-19 | 2008-02-08 | Tubo de acondicionamiento de un volumen predeterminado de sustancia biologica para almacenarse a baja temperatura y sistema que incluye el mismo. |
DK08761859.1T DK2114572T3 (da) | 2007-02-19 | 2008-02-08 | Rør til emballering af et forudbestemt volumen af biologisk substans, der skal opbevares ved en lav temperatur, og et system dertil |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0753346 | 2007-02-19 | ||
FR0753346A FR2912727B1 (fr) | 2007-02-19 | 2007-02-19 | Tube de conditionnement d'un volume predetermine de substance biologique a conserver a basse temperature et systeme le comportant |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008116977A1 true WO2008116977A1 (fr) | 2008-10-02 |
WO2008116977A8 WO2008116977A8 (fr) | 2009-09-17 |
Family
ID=38740281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2008/000158 WO2008116977A1 (fr) | 2007-02-19 | 2008-02-08 | Tube de conditionnement d'un volume prédéterminé de substance biologique à conserver à basse température et système le comportant |
Country Status (8)
Country | Link |
---|---|
US (1) | US8266872B2 (fr) |
EP (1) | EP2114572B1 (fr) |
CN (1) | CN101678357B (fr) |
DK (1) | DK2114572T3 (fr) |
FR (1) | FR2912727B1 (fr) |
MX (1) | MX2009008814A (fr) |
RU (1) | RU2457032C2 (fr) |
WO (1) | WO2008116977A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105964319A (zh) * | 2016-06-29 | 2016-09-28 | 江阴市正中科教器材有限公司 | 一种快速加热试管 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101869855B (zh) * | 2010-05-31 | 2013-04-03 | 嘉兴凯实生物科技有限公司 | 核酸分离和检测方法 |
GB201211766D0 (en) * | 2012-06-29 | 2012-08-15 | Cryogatt Systems Ltd | RFID tag for cryogenic straws |
JP6823074B2 (ja) | 2015-12-07 | 2021-01-27 | クーパーサージカル・インコーポレイテッドCooperSurgical, Inc. | 低温検体キャリヤおよび関連する方法 |
FR3046715B1 (fr) * | 2016-01-19 | 2018-02-16 | Imv Technologies | Dispositif pour la conservation d'une dose predeterminee de substance a base liquide et gamme de tels dispositifs |
US10569939B1 (en) | 2016-03-21 | 2020-02-25 | United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Axially sealing plug |
RU185691U1 (ru) * | 2018-10-10 | 2018-12-13 | Общество с ограниченной ответственностью "ТЗК Техоснастка" | Пробирка |
CN114929460A (zh) * | 2019-12-31 | 2022-08-19 | 费森尤斯医疗护理德国有限责任公司 | 剥离密封管封闭结构 |
RU203230U1 (ru) * | 2020-12-26 | 2021-03-29 | Общество с ограниченной ответственностью "Гранат Био Тех" (ООО "Гранат Био Тех") | Устройство для забора и исследования биоматериала |
Citations (5)
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US829178A (en) * | 1905-06-27 | 1906-08-21 | Otto Stegmaier | Antirefilling-bottle. |
GB722969A (en) * | 1952-08-21 | 1955-02-02 | Svenska Kapsylfabriken Ab | Automatically sealable paste tube of plastic or similar material |
EP0635305A1 (fr) * | 1993-07-22 | 1995-01-25 | Societe D'etudes, De Gestion, D'engineering | Dispositif en forme de paillette pour la conservation d'un produit liquide ou pulvérulent |
WO2001068166A1 (fr) * | 2000-03-13 | 2001-09-20 | Barry Farris | Procede et appareil pour le stockage et le transfert d'un lyophilisat |
WO2003022435A2 (fr) * | 2001-09-11 | 2003-03-20 | Iquum, Inc. | Tubes echantillons |
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US3862684A (en) * | 1971-04-26 | 1975-01-28 | Karlsruhe Augsburg Iweka | Aseptic packing container and method of making and filling it |
US3993223A (en) * | 1974-07-25 | 1976-11-23 | American Home Products Corporation | Dispensing container |
FR2465190A1 (fr) | 1979-09-17 | 1981-03-20 | Ruggieri Ets | Bouchon allumeur pour grenade comportant une chaine pyrotechnique |
ATE9185T1 (de) * | 1979-11-19 | 1984-09-15 | Robert Charles Turner | Fluessigkeitsprobensammler. |
US4415393A (en) * | 1981-10-22 | 1983-11-15 | Baxter Travenol Laboratories, Inc. | Method of making a frangible port protector |
US4502616A (en) * | 1982-01-04 | 1985-03-05 | Health Care Concepts, Inc. | Single use vial |
FR2653746A1 (fr) * | 1989-10-26 | 1991-05-03 | Merck Sharp & Dohme | Ensemble de conditionnement sterile permettant de distribuer un liquide par gouttage, et procede de fabrication d'un tel ensemble. |
US5047271A (en) * | 1990-06-21 | 1991-09-10 | Fmt Holdings, Inc. | Apparatus and process relating to a preform and a container with geodesic reinforcement |
US5203379A (en) * | 1990-09-12 | 1993-04-20 | Courtaulds Packaging Inc. | Headed thermoplastic tube |
JPH0774772B2 (ja) * | 1990-12-31 | 1995-08-09 | エイ. レビン ロバート | 血液サンプリング組立体、ターゲット細胞の採取方法およびターゲット成分の採取方法 |
DE29502783U1 (de) * | 1995-02-20 | 1996-06-20 | Thera Ges Fuer Patente | Behälter zum Lagern und Ausbringen einer Dentalmasse |
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US6101791A (en) * | 1998-04-03 | 2000-08-15 | Louviere; Kent A. | Method of making a plurality of interconnected vials |
AR034176A1 (es) * | 2000-11-08 | 2004-02-04 | Graham Packaging Pet Tech | Metodo de produccion de un envase plastico de forma en tubo comprimible, articulo intermedio para utilizacion en la formacion de un envase plastico de forma en tubo comprimible, y envase plastico de forma en tubo comprimible |
FR2865190B1 (fr) | 2004-01-15 | 2006-03-10 | Nicolas Bara | Dispositif de securisation de tubes |
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CN2838744Y (zh) | 2005-10-12 | 2006-11-22 | 北京大学 | 一种用于生物实验的暴露试验管 |
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2007
- 2007-02-19 FR FR0753346A patent/FR2912727B1/fr active Active
-
2008
- 2008-02-08 CN CN200880005417XA patent/CN101678357B/zh active Active
- 2008-02-08 WO PCT/FR2008/000158 patent/WO2008116977A1/fr active Application Filing
- 2008-02-08 DK DK08761859.1T patent/DK2114572T3/da active
- 2008-02-08 EP EP08761859.1A patent/EP2114572B1/fr active Active
- 2008-02-08 MX MX2009008814A patent/MX2009008814A/es active IP Right Grant
- 2008-02-08 US US12/527,737 patent/US8266872B2/en active Active
- 2008-02-08 RU RU2009135002/05A patent/RU2457032C2/ru not_active IP Right Cessation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US829178A (en) * | 1905-06-27 | 1906-08-21 | Otto Stegmaier | Antirefilling-bottle. |
GB722969A (en) * | 1952-08-21 | 1955-02-02 | Svenska Kapsylfabriken Ab | Automatically sealable paste tube of plastic or similar material |
EP0635305A1 (fr) * | 1993-07-22 | 1995-01-25 | Societe D'etudes, De Gestion, D'engineering | Dispositif en forme de paillette pour la conservation d'un produit liquide ou pulvérulent |
WO2001068166A1 (fr) * | 2000-03-13 | 2001-09-20 | Barry Farris | Procede et appareil pour le stockage et le transfert d'un lyophilisat |
WO2003022435A2 (fr) * | 2001-09-11 | 2003-03-20 | Iquum, Inc. | Tubes echantillons |
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CN105964319A (zh) * | 2016-06-29 | 2016-09-28 | 江阴市正中科教器材有限公司 | 一种快速加热试管 |
Also Published As
Publication number | Publication date |
---|---|
CN101678357A (zh) | 2010-03-24 |
EP2114572A1 (fr) | 2009-11-11 |
MX2009008814A (es) | 2009-12-14 |
DK2114572T3 (da) | 2021-03-01 |
EP2114572B1 (fr) | 2020-12-09 |
WO2008116977A8 (fr) | 2009-09-17 |
US8266872B2 (en) | 2012-09-18 |
US20100107560A1 (en) | 2010-05-06 |
CN101678357B (zh) | 2012-07-04 |
FR2912727A1 (fr) | 2008-08-22 |
FR2912727B1 (fr) | 2013-07-19 |
RU2009135002A (ru) | 2011-03-27 |
RU2457032C2 (ru) | 2012-07-27 |
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