WO2008115098A3 - 2,3,4,5-tétrahydro-1h-pyrido[4,3-b]indoles substitués ainsi que procédés de leur fabrication et leur utilisation - Google Patents
2,3,4,5-tétrahydro-1h-pyrido[4,3-b]indoles substitués ainsi que procédés de leur fabrication et leur utilisation Download PDFInfo
- Publication number
- WO2008115098A3 WO2008115098A3 PCT/RU2008/000169 RU2008000169W WO2008115098A3 WO 2008115098 A3 WO2008115098 A3 WO 2008115098A3 RU 2008000169 W RU2008000169 W RU 2008000169W WO 2008115098 A3 WO2008115098 A3 WO 2008115098A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- hydrogen
- indoles
- pyrido
- tetrahydro
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2007110379 | 2007-03-21 | ||
RU2007110379/04A RU2338745C1 (ru) | 2007-03-21 | 2007-03-21 | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008115098A2 WO2008115098A2 (fr) | 2008-09-25 |
WO2008115098A3 true WO2008115098A3 (fr) | 2008-11-13 |
Family
ID=39766609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/RU2008/000169 WO2008115098A2 (fr) | 2007-03-21 | 2008-03-21 | 2,3,4,5-tétrahydro-1h-pyrido[4,3-b]indoles substitués ainsi que procédés de leur fabrication et leur utilisation |
Country Status (2)
Country | Link |
---|---|
RU (1) | RU2338745C1 (ru) |
WO (1) | WO2008115098A2 (ru) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9006234B2 (en) | 2009-09-23 | 2015-04-14 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
US9034869B2 (en) | 2008-03-24 | 2015-05-19 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
US9034865B2 (en) | 2010-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9040519B2 (en) | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9079904B2 (en) | 2009-09-23 | 2015-07-14 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9096591B2 (en) | 2007-10-25 | 2015-08-04 | Medivation Technologies, Inc. | Tetracyclic compounds |
US9115137B2 (en) | 2008-01-25 | 2015-08-25 | Medivation Technologies, Inc. | 2,3,4,5-tetrahydro-1H-pyrido[4,3-B]indole compounds and methods of use thereof |
US9187471B2 (en) | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9199985B2 (en) | 2011-02-18 | 2015-12-01 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
US9199996B2 (en) | 2009-09-23 | 2015-12-01 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9211287B2 (en) | 2011-02-18 | 2015-12-15 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
US9255094B2 (en) | 2009-04-29 | 2016-02-09 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9260429B2 (en) | 2008-03-24 | 2016-02-16 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9409910B2 (en) | 2008-10-31 | 2016-08-09 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
US9434747B2 (en) | 2011-02-18 | 2016-09-06 | Medivation Technologies, Inc. | Methods of treating diabetes |
US9527854B2 (en) | 2011-02-18 | 2016-12-27 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
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---|---|---|---|---|
EP2236511A4 (en) * | 2007-12-21 | 2011-04-13 | Alla Chem Llc | LIGANDS OF ALPHA ADRENOCEPTORS AND OF DOPAMINE, HISTAMIN, IMIDAZOLIN AND SEROTONIN RECEPTORS AND THEIR APPLICATION THEREOF |
HK1150388A1 (en) * | 2008-01-25 | 2011-12-23 | Medivation Technologies Inc | New 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indole compounds and methods of use thereof 2345--1h-[43-b] |
US8604074B2 (en) | 2009-01-09 | 2013-12-10 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
US8362277B2 (en) | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
AU2010282990B2 (en) | 2009-04-29 | 2015-11-05 | Medivation Technologies, Inc. | Pyrido [4, 3-b] indoles and methods of use |
EP2590647B1 (en) | 2010-07-07 | 2017-11-08 | Board of Regents of the University of Texas System | Pro-neurogenic compounds |
US9701676B2 (en) | 2012-08-24 | 2017-07-11 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
EP3068388A4 (en) | 2013-11-11 | 2017-04-12 | Board of Regents of the University of Texas System | Neuroprotective compounds and use thereof |
KR101694753B1 (ko) | 2015-08-28 | 2017-01-11 | 주식회사 온코크로스 | 크로몰린 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 간질환 예방 및 치료용 약학적 조성물 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US5817756A (en) * | 1993-09-09 | 1998-10-06 | Scios Inc. | Pseudo- and non-peptide bradykinin receptor antagonists |
RU2140417C1 (ru) * | 1995-10-17 | 1999-10-27 | Институт физиологически активных веществ РАН | Производные гидрированных пиридо(4,3-b)индолов, способы их получения, фармацевтическая композиция и способ лечения |
RU2157803C2 (ru) * | 1994-10-04 | 2000-10-20 | Байер Аг | Производные циклоалкано-индола и азаиндола, смесь их изомеров или отдельные изомеры и их фармацевтически приемлемые соли, производные карбоновой кислоты в качестве исходных соединений и фармацевтическая композиция, ингибирующая высвобождение ассоциированных с аполипопротеином в-100 липопротеинов |
WO2004056324A2 (en) * | 2002-12-19 | 2004-07-08 | Bristol-Myers Squibb Company | Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists |
WO2005095397A1 (en) * | 2004-03-11 | 2005-10-13 | Actelion Pharmaceuticals Ltd | Tetrahydropyridoindole derivatives |
-
2007
- 2007-03-21 RU RU2007110379/04A patent/RU2338745C1/ru not_active IP Right Cessation
-
2008
- 2008-03-21 WO PCT/RU2008/000169 patent/WO2008115098A2/ru active Search and Examination
Patent Citations (5)
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US5817756A (en) * | 1993-09-09 | 1998-10-06 | Scios Inc. | Pseudo- and non-peptide bradykinin receptor antagonists |
RU2157803C2 (ru) * | 1994-10-04 | 2000-10-20 | Байер Аг | Производные циклоалкано-индола и азаиндола, смесь их изомеров или отдельные изомеры и их фармацевтически приемлемые соли, производные карбоновой кислоты в качестве исходных соединений и фармацевтическая композиция, ингибирующая высвобождение ассоциированных с аполипопротеином в-100 липопротеинов |
RU2140417C1 (ru) * | 1995-10-17 | 1999-10-27 | Институт физиологически активных веществ РАН | Производные гидрированных пиридо(4,3-b)индолов, способы их получения, фармацевтическая композиция и способ лечения |
WO2004056324A2 (en) * | 2002-12-19 | 2004-07-08 | Bristol-Myers Squibb Company | Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists |
WO2005095397A1 (en) * | 2004-03-11 | 2005-10-13 | Actelion Pharmaceuticals Ltd | Tetrahydropyridoindole derivatives |
Non-Patent Citations (1)
Title |
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NANTAKA KHORANA ET AL.: "gamma-Carbolines: Binding at 5-HT5A Serotonin Receptors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, 2003, pages 717 - 722, XP002290954 * |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9096591B2 (en) | 2007-10-25 | 2015-08-04 | Medivation Technologies, Inc. | Tetracyclic compounds |
US9181240B2 (en) | 2007-10-25 | 2015-11-10 | Medivation Technologies, Inc. | Tetracyclic compounds |
US9115137B2 (en) | 2008-01-25 | 2015-08-25 | Medivation Technologies, Inc. | 2,3,4,5-tetrahydro-1H-pyrido[4,3-B]indole compounds and methods of use thereof |
US9034869B2 (en) | 2008-03-24 | 2015-05-19 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
US9469641B2 (en) | 2008-03-24 | 2016-10-18 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9260429B2 (en) | 2008-03-24 | 2016-02-16 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9481676B2 (en) | 2008-10-31 | 2016-11-01 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
US9409910B2 (en) | 2008-10-31 | 2016-08-09 | Medivation Technologies, Inc. | Azepino[4,5-B]indoles and methods of use |
US9255094B2 (en) | 2009-04-29 | 2016-02-09 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9199996B2 (en) | 2009-09-23 | 2015-12-01 | Medivation Technologies, Inc. | Pyrido[4,3-B]indoles and methods of use |
US9085580B2 (en) | 2009-09-23 | 2015-07-21 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9580425B2 (en) | 2009-09-23 | 2017-02-28 | Medivation Technologies, Inc. | Pyrido[3,4-b] indoles and methods of use |
US9006234B2 (en) | 2009-09-23 | 2015-04-14 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
US9079904B2 (en) | 2009-09-23 | 2015-07-14 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9271971B2 (en) | 2009-09-23 | 2016-03-01 | Medivation Technologies, Inc. | Pyrido[3,4-B]indoles and methods of use |
US9433626B2 (en) | 2010-02-18 | 2016-09-06 | Medivation Technologies, Inc. | Pyrido[4,3-B]indole and pyrido[3,4-B]indole derivatives and methods of use |
US9193728B2 (en) | 2010-02-18 | 2015-11-24 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9040519B2 (en) | 2010-02-18 | 2015-05-26 | Medivation Technologies, Inc. | Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9034865B2 (en) | 2010-02-18 | 2015-05-19 | Medivation Technologies, Inc. | Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use |
US9187471B2 (en) | 2010-02-19 | 2015-11-17 | Medivation Technologies, Inc. | Pyrido [4,3-b] indole and pyrido [3,4-b] indole derivatives and methods of use |
US9211287B2 (en) | 2011-02-18 | 2015-12-15 | Medivation Technologies, Inc. | Pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use |
US9434747B2 (en) | 2011-02-18 | 2016-09-06 | Medivation Technologies, Inc. | Methods of treating diabetes |
US9527854B2 (en) | 2011-02-18 | 2016-12-27 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
US9550782B2 (en) | 2011-02-18 | 2017-01-24 | Medivation Technologies, Inc. | Compounds and methods for treating diabetes |
US9199985B2 (en) | 2011-02-18 | 2015-12-01 | Medivation Technologies, Inc. | Compounds and methods for treatment of hypertension |
Also Published As
Publication number | Publication date |
---|---|
WO2008115098A2 (fr) | 2008-09-25 |
RU2338745C1 (ru) | 2008-11-20 |
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