WO2008114736A1 - 生体組織補填材とその製造方法 - Google Patents

生体組織補填材とその製造方法 Download PDF

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Publication number
WO2008114736A1
WO2008114736A1 PCT/JP2008/054772 JP2008054772W WO2008114736A1 WO 2008114736 A1 WO2008114736 A1 WO 2008114736A1 JP 2008054772 W JP2008054772 W JP 2008054772W WO 2008114736 A1 WO2008114736 A1 WO 2008114736A1
Authority
WO
WIPO (PCT)
Prior art keywords
filling material
body tissue
porous carrier
tissue filling
hyaluronic acid
Prior art date
Application number
PCT/JP2008/054772
Other languages
English (en)
French (fr)
Inventor
Tomoaki Tamura
Yasuharu Hakamatsuka
Toshie Tsuchiya
Shigeyuki Wakitani
Original Assignee
Olympus Corporation
Japan As Represented By National Institute Of Health Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Corporation, Japan As Represented By National Institute Of Health Sciences filed Critical Olympus Corporation
Priority to US12/529,622 priority Critical patent/US20100278877A1/en
Priority to EP08722168A priority patent/EP2127688A4/en
Publication of WO2008114736A1 publication Critical patent/WO2008114736A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

　生着および修復能に優れた生体組織補填材を提供し、そのような生体組織補填材を簡易に製造することができる製造方法を提供する。ゼラチンからなる多孔質担体の表面に、硫酸化ヒアルロン酸からなるコーティングを施した生体組織補填材を提供する。また、ゼラチンからなる多孔質担体に硫酸化ヒアルロン酸溶液を滴下して含浸させるステップ（Ｓ３）と、硫酸化ヒアルロン酸溶液が含浸された多孔質担体を凍結させるステップ（Ｓ４）と、凍結した多孔質担体を乾燥させるステップ（Ｓ５）とを含む生体組織補填材の製造方法を提供する。
PCT/JP2008/054772 2007-03-16 2008-03-14 生体組織補填材とその製造方法 WO2008114736A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/529,622 US20100278877A1 (en) 2007-03-16 2008-03-14 Body tissue filling material and method for production thereof
EP08722168A EP2127688A4 (en) 2007-03-16 2008-03-14 BODY TISSUE FILLING MATERIAL AND METHOD OF MANUFACTURING THE SAME

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007069160A JP5088864B2 (ja) 2007-03-16 2007-03-16 生体組織補填材とその製造方法
JP2007-069160 2007-03-16

Publications (1)

Publication Number Publication Date
WO2008114736A1 true WO2008114736A1 (ja) 2008-09-25

Family

ID=39765844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/054772 WO2008114736A1 (ja) 2007-03-16 2008-03-14 生体組織補填材とその製造方法

Country Status (4)

Country Link
US (1) US20100278877A1 (ja)
EP (1) EP2127688A4 (ja)
JP (1) JP5088864B2 (ja)
WO (1) WO2008114736A1 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101594552B1 (ko) 2008-04-04 2016-02-17 유니버시티 오브 유타 리서치 파운데이션 알킬화된 반합성 글리코사미노글리코산 에테르 및 이의 제조 및 사용 방법
EP2688402B1 (en) 2011-03-23 2018-10-24 University of Utah Research Foundation Means for treating or preventing urological inflammation
US10000582B2 (en) 2013-04-02 2018-06-19 The Regents Of The University Of California Ethylsulfonated hyaluronic acid biopolymers and methods of use thereof
US11337994B2 (en) 2016-09-15 2022-05-24 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010426A1 (fr) 1994-09-30 1996-04-11 Yamanouchi Pharmaceutical Co., Ltd. Greffon osteoplastique
JPH09510493A (ja) * 1994-03-23 1997-10-21 フィディア・アドヴァンスト・バイオポリマーズ・ソシエタ・ア・レスポンサビリタ・リミタータ 新規なヘパリン様硫酸化多糖類
WO2003011353A1 (fr) 2001-07-30 2003-02-13 Japan Tissue Engineering Co., Ltd Materiau de base de regeneration de tissu, materiau implantaire et procede de production correspondant
JP2003245338A (ja) * 2002-02-26 2003-09-02 Kyocera Corp 関節軟骨修復材
WO2006037592A1 (en) * 2004-10-08 2006-04-13 Fidia Advanced Biopolymers S.R.L. Biomaterials consisting of sulphated hyaluronic acid and gellan to be used in the prevention of spinal adhesions
WO2007137674A1 (en) * 2006-05-31 2007-12-06 Fidia Farmaceutici S.P.A. Sulphated hyaluronic acid for treating degenerative osteoarthritis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2285542C (en) * 1997-04-04 2007-07-17 Fidia Advanced Biopolymers Srl N-sulphated hyaluronic acid compounds, derivatives thereof and a process for their preparation
ITPD980149A1 (it) * 1998-06-17 1999-12-17 Fidia Advanced Biopolymers Srl Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
JP3536295B2 (ja) * 1999-01-21 2004-06-07 ニプロ株式会社 縫合可能な組織再生誘導型癒着防止膜
DE10053053A1 (de) * 2000-10-19 2002-05-16 Knoell Hans Forschung Ev Pharmazeutische Formulierungen zur Hemmung von entzündlichen Arthritiden
ES2342070T3 (es) * 2003-09-12 2010-07-01 Seikagaku Corporation Pseudoesponja de polisacarido.
US20060154894A1 (en) * 2004-09-15 2006-07-13 Massachusetts Institute Of Technology Biologically active surfaces and methods of their use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09510493A (ja) * 1994-03-23 1997-10-21 フィディア・アドヴァンスト・バイオポリマーズ・ソシエタ・ア・レスポンサビリタ・リミタータ 新規なヘパリン様硫酸化多糖類
WO1996010426A1 (fr) 1994-09-30 1996-04-11 Yamanouchi Pharmaceutical Co., Ltd. Greffon osteoplastique
WO2003011353A1 (fr) 2001-07-30 2003-02-13 Japan Tissue Engineering Co., Ltd Materiau de base de regeneration de tissu, materiau implantaire et procede de production correspondant
JP2003245338A (ja) * 2002-02-26 2003-09-02 Kyocera Corp 関節軟骨修復材
WO2006037592A1 (en) * 2004-10-08 2006-04-13 Fidia Advanced Biopolymers S.R.L. Biomaterials consisting of sulphated hyaluronic acid and gellan to be used in the prevention of spinal adhesions
WO2007137674A1 (en) * 2006-05-31 2007-12-06 Fidia Farmaceutici S.P.A. Sulphated hyaluronic acid for treating degenerative osteoarthritis

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HAMILTON D.W. ET AL.: "The response of primary articular chondrocytes to micrometric surface topography and sulphated hyaluronic acid-based matrices", CELL BIOLOGY INTERNATIONAL, vol. 29, no. 8, 2005, pages 605 - 615, XP005012056 *
See also references of EP2127688A4 *

Also Published As

Publication number Publication date
US20100278877A1 (en) 2010-11-04
JP2008228812A (ja) 2008-10-02
EP2127688A1 (en) 2009-12-02
EP2127688A4 (en) 2013-01-02
JP5088864B2 (ja) 2012-12-05

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