WO2008114516A1 - リポソームおよびこれを含む免疫賦活活性用組成物。 - Google Patents

リポソームおよびこれを含む免疫賦活活性用組成物。 Download PDF

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Publication number
WO2008114516A1
WO2008114516A1 PCT/JP2008/000692 JP2008000692W WO2008114516A1 WO 2008114516 A1 WO2008114516 A1 WO 2008114516A1 JP 2008000692 W JP2008000692 W JP 2008000692W WO 2008114516 A1 WO2008114516 A1 WO 2008114516A1
Authority
WO
WIPO (PCT)
Prior art keywords
liposome
same
immunostimulating composition
lipid membrane
immunostimulating
Prior art date
Application number
PCT/JP2008/000692
Other languages
English (en)
French (fr)
Inventor
Yoshio Kumazawa
Hiroaki Takimoto
Joe Inoue
Masahiro Kubota
Takashi Nozawa
Katsumi Murata
Original Assignee
Kibun Food Chemifa Co., Ltd.
Kitasato Gakuen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kibun Food Chemifa Co., Ltd., Kitasato Gakuen filed Critical Kibun Food Chemifa Co., Ltd.
Priority to CA002653226A priority Critical patent/CA2653226A1/en
Priority to EP08720571A priority patent/EP2060271A4/en
Priority to US12/301,965 priority patent/US20110104248A1/en
Publication of WO2008114516A1 publication Critical patent/WO2008114516A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

スフィンゴ糖脂質の免疫賦活活性をより高めることを目的とする。 脂質膜内外に下記式（１）で表されるスフィンゴ糖脂質の少なくとも１種を含有するリポソーム。
PCT/JP2008/000692 2007-03-22 2008-03-24 リポソームおよびこれを含む免疫賦活活性用組成物。 WO2008114516A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002653226A CA2653226A1 (en) 2007-03-22 2008-03-24 Liposomes and immunopotentiating compositions containing the same
EP08720571A EP2060271A4 (en) 2007-03-22 2008-03-24 LIPOSOME AND IMMUNOSTIMULATING COMPOSITION COMPRISING THE SAME
US12/301,965 US20110104248A1 (en) 2007-03-22 2008-03-24 Liposomes and immunopotentiating compositions containing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007075615 2007-03-22
JP2007-075615 2007-03-22

Publications (1)

Publication Number Publication Date
WO2008114516A1 true WO2008114516A1 (ja) 2008-09-25

Family

ID=39765634

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/000692 WO2008114516A1 (ja) 2007-03-22 2008-03-24 リポソームおよびこれを含む免疫賦活活性用組成物。

Country Status (4)

Country Link
US (1) US20110104248A1 (ja)
EP (1) EP2060271A4 (ja)
CA (1) CA2653226A1 (ja)
WO (1) WO2008114516A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112316132B (zh) * 2020-07-28 2021-09-03 江苏飞阳益科生物科技有限公司 一种姜黄素纳米脂质体佐剂及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012986A1 (en) 1991-01-23 1992-08-06 Kabushikikaisha Kibun Shokuhin Sphingoglycolipid
JPH1143437A (ja) 1997-05-30 1999-02-16 Kibun Food Chemifa Co Ltd 皮膚外用剤
JP2000051676A (ja) 1998-08-07 2000-02-22 Kibun Food Chemifa Co Ltd 乳化剤および乳化組成物
JP2002010797A (ja) 2000-06-29 2002-01-15 Kibun Food Chemifa Co Ltd スフィンゴ糖脂質
JP2005263797A (ja) 2004-02-19 2005-09-29 Kibun Food Chemifa Co Ltd ＮＫＴ細胞活性化用組成物、ＩＬ−４産生促進用組成物、ＩＦＮ−γ産生促進用組成物、樹状細胞活性化用組成物、ＩＬ−１２産生促進用組成物、ＩＬ−１０産生促進用組成物、ＮＫ細胞活性化用組成物、抗腫瘍作用組成物、抗アレルギー作用組成物、感染抵抗性増強用組成物、抗ウイルス作用組成物、ＩＬ−６産生促進用組成物、ＮＯ産出促進用組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030104044A1 (en) * 1997-05-14 2003-06-05 Semple Sean C. Compositions for stimulating cytokine secretion and inducing an immune response
CA2526905A1 (en) * 2004-02-19 2005-09-01 Kibun Food Chemifa Co., Ltd. Composition for nkt cell activation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012986A1 (en) 1991-01-23 1992-08-06 Kabushikikaisha Kibun Shokuhin Sphingoglycolipid
JPH1143437A (ja) 1997-05-30 1999-02-16 Kibun Food Chemifa Co Ltd 皮膚外用剤
JP2000051676A (ja) 1998-08-07 2000-02-22 Kibun Food Chemifa Co Ltd 乳化剤および乳化組成物
JP2002010797A (ja) 2000-06-29 2002-01-15 Kibun Food Chemifa Co Ltd スフィンゴ糖脂質
JP2005263797A (ja) 2004-02-19 2005-09-29 Kibun Food Chemifa Co Ltd ＮＫＴ細胞活性化用組成物、ＩＬ−４産生促進用組成物、ＩＦＮ−γ産生促進用組成物、樹状細胞活性化用組成物、ＩＬ−１２産生促進用組成物、ＩＬ−１０産生促進用組成物、ＮＫ細胞活性化用組成物、抗腫瘍作用組成物、抗アレルギー作用組成物、感染抵抗性増強用組成物、抗ウイルス作用組成物、ＩＬ−６産生促進用組成物、ＮＯ産出促進用組成物

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BANGHAM, A.D.; STANDISH, M.M.; WATKINS, J.C.: "Diffusion of univalent ions across the lamellae of swollen phospholipids", J. MOL. BIOL., vol. 13, 1965, pages 238 - 252, XP008039387, DOI: doi:10.1016/S0022-2836(65)80093-6
D. D. LASIC: "liposomes: from basic to applications", 1993, ELSEVIER SCIENCE PUBLISHERS, pages: 1 - 171
MICROBIOL. IMMUNOL., vol. 44, 2000, pages 563 - 575
See also references of EP2060271A4 *
WIESE A. ET AL.: "Planar asymmetric lipid bilayers of glycosphingolipid or lipopolysaccharide on one sideand phospholipids on the other: membrane potential, porin function, and complement activation", BIOPHYSICAL JOURNAL, vol. 70, no. 1, 1996, pages 321 - 329, XP008131915 *
ZANIN M.H.A. ET AL.: "Physical characterization of surface-modified liposomes by incorporation of gangliosides designed for immunotherapies", COLLOIDS AND SURFACES A, vol. 251, no. 1/3, 2004, pages 175 - 182, XP004664092 *

Also Published As

Publication number Publication date
CA2653226A1 (en) 2008-09-25
US20110104248A1 (en) 2011-05-05
EP2060271A4 (en) 2011-07-06
EP2060271A1 (en) 2009-05-20

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