WO2008111668A1 - 神経因性疼痛新規予防剤及び／又は治療剤 - Google Patents

神経因性疼痛新規予防剤及び／又は治療剤 Download PDF

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Publication number
WO2008111668A1
WO2008111668A1 PCT/JP2008/054709 JP2008054709W WO2008111668A1 WO 2008111668 A1 WO2008111668 A1 WO 2008111668A1 JP 2008054709 W JP2008054709 W JP 2008054709W WO 2008111668 A1 WO2008111668 A1 WO 2008111668A1
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WO
WIPO (PCT)
Prior art keywords
pain
therapeutic agent
prophylactic
neuropathy
pain associated
Prior art date
Application number
PCT/JP2008/054709
Other languages
English (en)
French (fr)
Inventor
Toshiaki Aoki
Seiji Tamura
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Priority to AU2008225378A priority Critical patent/AU2008225378A1/en
Priority to CN2008800084601A priority patent/CN101636391B/zh
Priority to JP2009504091A priority patent/JP5223859B2/ja
Priority to CA002680935A priority patent/CA2680935A1/en
Priority to MX2009009702A priority patent/MX2009009702A/es
Priority to EP08722105A priority patent/EP2123642A4/en
Priority to BRPI0808809-8A priority patent/BRPI0808809A2/pt
Publication of WO2008111668A1 publication Critical patent/WO2008111668A1/ja
Priority to IL200668A priority patent/IL200668A0/en
Priority to US12/557,164 priority patent/US20100087439A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

　本発明は、式（Ｉ）の２‐［（置換インデン‐７‐イルオキシ）メチル］モルホリン又はその薬学的に許容される塩を有効成分として含有する神経因性疼痛の予防剤及び／又は治療剤に関する。本発明は，優れた神経因性疼痛の予防剤及び／又は治療剤を提供するものとして有用であり、アロディニア、痛覚過敏、知覚過敏、自発痛、癌性疼痛、三叉神経痛、幻肢痛、帯状疱疹後疼痛、線維筋痛症、腰下肢痛症、視床痛、絞扼性（圧迫性）末梢神経障害、非定形性顔面痛、脊髄損傷に伴う痛み、多発性硬化症に伴う痛み、化学療法誘発ニューロパチーに伴う痛み、モルヒネなどの麻薬性鎮痛薬による鎮痛効果が不十分な癌性疼痛、糖尿病性神経障害に伴う疼痛などの予防剤及び／又は治療剤を提供するものとして特に有用である。
PCT/JP2008/054709 2007-03-15 2008-03-14 神経因性疼痛新規予防剤及び／又は治療剤 WO2008111668A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2008225378A AU2008225378A1 (en) 2007-03-15 2008-03-14 Novel preventive and/or therapeutic agent for neuropathic pain
CN2008800084601A CN101636391B (zh) 2007-03-15 2008-03-14 神经病理性疼痛的预防剂和/或治疗剂
JP2009504091A JP5223859B2 (ja) 2007-03-15 2008-03-14 神経因性疼痛新規予防剤及び／又は治療剤
CA002680935A CA2680935A1 (en) 2007-03-15 2008-03-14 Novel preventive and/or therapeutic agent for neuropathic pain
MX2009009702A MX2009009702A (es) 2007-03-15 2008-03-14 Agente profilactico y/o terapeutico para el dolor neurogenico.
EP08722105A EP2123642A4 (en) 2007-03-15 2008-03-14 NEW PROPHYLACTIC AND / OR THERAPEUTIC AGENT AGAINST NEUROGENIC PAIN
BRPI0808809-8A BRPI0808809A2 (pt) 2007-03-15 2008-03-14 Agente preventivo e/ou terapêutico para dor neuropática
IL200668A IL200668A0 (en) 2007-03-15 2009-09-01 Novel preventive and/or therapeutic agent for neuropathic pain
US12/557,164 US20100087439A1 (en) 2007-03-15 2009-09-10 Novel preventive and/or therapeutic agent for neuropathic pain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007066727 2007-03-15
JP2007-066727 2007-03-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/557,164 Continuation US20100087439A1 (en) 2007-03-15 2009-09-10 Novel preventive and/or therapeutic agent for neuropathic pain

Publications (1)

Publication Number Publication Date
WO2008111668A1 true WO2008111668A1 (ja) 2008-09-18

Family

ID=39759596

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/054709 WO2008111668A1 (ja) 2007-03-15 2008-03-14 神経因性疼痛新規予防剤及び／又は治療剤

Country Status (13)

Country Link
US (1) US20100087439A1 (ja)
EP (1) EP2123642A4 (ja)
JP (1) JP5223859B2 (ja)
KR (1) KR20090130050A (ja)
CN (2) CN101646662B (ja)
AU (1) AU2008225378A1 (ja)
BR (1) BRPI0808809A2 (ja)
CA (1) CA2680935A1 (ja)
IL (1) IL200668A0 (ja)
MX (1) MX2009009702A (ja)
RU (1) RU2462459C2 (ja)
TW (1) TW200846002A (ja)
WO (1) WO2008111668A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010029959A1 (ja) 2008-09-11 2010-03-18 アステラス製薬株式会社 モルホリン誘導体の新規な塩
WO2010029958A1 (ja) 2008-09-11 2010-03-18 アステラス製薬株式会社 侵害受容性疼痛の新規治療用医薬組成物

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140287021A1 (en) * 2013-03-21 2014-09-25 Panacea Pharmaceuticals Treatment of chemotherapy-induced peripheral neuropathy
TW202203929A (zh) * 2020-04-03 2022-02-01 日商塩野義製藥股份有限公司 疼痛治療用醫藥

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4109088A (en) 1975-01-29 1978-08-22 Yamanouchi Pharmaceutical Co., Ltd. 2-(indenyloxymethyl) morpholine derivatives
US5521180A (en) 1993-02-10 1996-05-28 Yamanouchi Pharmaceutical Co., Ltd. Morpholine derivative
WO2005051488A1 (en) * 2003-11-26 2005-06-09 Pfizer Products Inc. Combination of dopamine agonists and monoamine reuptake inhibitors
WO2007017764A2 (en) * 2005-05-18 2007-02-15 Neuraxon, Inc. Substituted benzimidazole compounds with dual nos inhibitory activity and muopioid agonist activity
US20070259865A1 (en) 2004-07-14 2007-11-08 Astellas Pharma Inc. Agent for Promoting the Recovery from Dysfunction After the Onset of Central Neurological Disease

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US5735817A (en) * 1995-05-19 1998-04-07 Shantha; T. R. Apparatus for transsphenoidal stimulation of the pituitary gland and adjoining brain structures
US6673832B1 (en) * 1998-05-04 2004-01-06 Gudarz Davar Methods for identifying compounds for treating pain
WO2004054511A2 (en) * 2002-12-13 2004-07-01 The Regents Of The University Of California Analgesic combination comprising nalbuphine
US20070042969A1 (en) * 2004-03-26 2007-02-22 Srz Properties, Inc. Combination therapy for pain in painful diabetic neuropathy
AP2006003771A0 (en) * 2004-04-30 2006-10-31 Warner Lambert Co Substituted morpholine compounds for the treatmentof central nervous system disorders
WO2007141018A1 (en) * 2006-06-08 2007-12-13 Schwarz Pharma Ag Therapeutic combination for painful medical conditions

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
US4109088A (en) 1975-01-29 1978-08-22 Yamanouchi Pharmaceutical Co., Ltd. 2-(indenyloxymethyl) morpholine derivatives
US5521180A (en) 1993-02-10 1996-05-28 Yamanouchi Pharmaceutical Co., Ltd. Morpholine derivative
WO2005051488A1 (en) * 2003-11-26 2005-06-09 Pfizer Products Inc. Combination of dopamine agonists and monoamine reuptake inhibitors
US20070259865A1 (en) 2004-07-14 2007-11-08 Astellas Pharma Inc. Agent for Promoting the Recovery from Dysfunction After the Onset of Central Neurological Disease
WO2007017764A2 (en) * 2005-05-18 2007-02-15 Neuraxon, Inc. Substituted benzimidazole compounds with dual nos inhibitory activity and muopioid agonist activity

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"International Association for the Study of Pain (IASP)", 1994, TASK FORCE ON TAXONOMY IASP PRESS, article "Classification of Chronic Pain", pages: 209 - 214
"Saishin Nou to Shinkeikagaku Series", ITAMI NO SHINKEIKAGAKU, MEDICAL VIEW, vol. 6, 1997, pages 97
BOMHOLT S.F. ET AL.: "Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain", NEUROPHARMACOLOGY, vol. 48, no. 2, 2005, pages 252 - 263, XP002460895 *
CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 33, no. 9, 1985, pages 3766 - 3774
CLINICAL THERAPUTICS, vol. 25, 2003, pages 2506 - 2538
EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 395, no. 1, 2000, pages 31 - 36
HUMAN PSYCOPHARMACOLOGY, vol. 19, 2004, pages 21 - 525
IGAKU NO AYUMI, JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 203, no. 1, 2002, pages 65 - 69
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IGAKU NO AYUMI, vol. 189, no. 10, 1999, pages 757 - 762
INTERNATIONAL ASSOCIATION OF THE STUDY OF PAIN, vol. 21, 2001, pages 169 - 183
KOJIMA T. ET AL.: "Synthesis of (plus or minus)-2-[(Inden-7-yloxy)methyl]morpholine Hydrochloride (YM-08054, Indeloxazine Hydrocholiride) and Its Derivatives with Potential Cerebral-Activating and Antidepressive Properties", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 33, no. 9, 1985, pages 3766 - 3774, XP008112250 *
LYENGAR S. ET AL.: "Efficacy of Duloxetine, a Potent and Balanced Serotonin-Norepinephrine Reuptake Inhibitor in Persistent Pain Models in Rats", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 311, no. 2, 2004, pages 576 - 584, XP008112279 *
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See also references of EP2123642A4
SUMPTON J.E. ET AL.: "Treatment of Neuropathic Pain with Venlafaxine", THE ANNALS OF PHARMACOTHERAPY, vol. 35, no. 5, 2001, pages 557 - 559, XP008112382 *
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010029959A1 (ja) 2008-09-11 2010-03-18 アステラス製薬株式会社 モルホリン誘導体の新規な塩
WO2010029958A1 (ja) 2008-09-11 2010-03-18 アステラス製薬株式会社 侵害受容性疼痛の新規治療用医薬組成物

Also Published As

Publication number Publication date
CN101646662A (zh) 2010-02-10
TW200846002A (en) 2008-12-01
RU2462459C2 (ru) 2012-09-27
CN101636391B (zh) 2012-11-28
JPWO2008111668A1 (ja) 2010-06-24
CN101646662B (zh) 2012-07-11
CA2680935A1 (en) 2008-09-18
CN101636391A (zh) 2010-01-27
AU2008225378A1 (en) 2008-09-18
MX2009009702A (es) 2009-10-07
US20100087439A1 (en) 2010-04-08
JP5223859B2 (ja) 2013-06-26
EP2123642A1 (en) 2009-11-25
KR20090130050A (ko) 2009-12-17
IL200668A0 (en) 2010-05-17
EP2123642A4 (en) 2011-12-07
RU2009138028A (ru) 2011-04-20
BRPI0808809A2 (pt) 2014-08-19

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