WO2008108385A1 - 糖化ヘキサペプチドの測定方法 - Google Patents

糖化ヘキサペプチドの測定方法 Download PDF

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Publication number
WO2008108385A1
WO2008108385A1 PCT/JP2008/053907 JP2008053907W WO2008108385A1 WO 2008108385 A1 WO2008108385 A1 WO 2008108385A1 JP 2008053907 W JP2008053907 W JP 2008053907W WO 2008108385 A1 WO2008108385 A1 WO 2008108385A1
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WIPO (PCT)
Prior art keywords
glycosylated
hexapeptide
derived
measurement
protein
Prior art date
Application number
PCT/JP2008/053907
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English (en)
French (fr)
Inventor
Kozo Hirokawa
Kazuhiko Shimoji
Original Assignee
Kikkoman Corporation
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Publication date
Application filed by Kikkoman Corporation filed Critical Kikkoman Corporation
Priority to JP2009502596A priority Critical patent/JP5442432B2/ja
Publication of WO2008108385A1 publication Critical patent/WO2008108385A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

　糖化蛋白質由来の糖化ヘキサペプチドを簡便な操作で迅速に精度よく測定できる方法及び測定用試薬を提供する。 　糖化蛋白質由来の糖化ヘキサペプチドを含む試料に微生物由来の糖化ヘキサペプチドオキシダーゼを６０分間以下の時間作用させ、その生成物又は消費物を測定することにより、試料中の糖化ヘキサペプチドを測定する。この測定方法により、糖化ヘモグロビン等の糖化蛋白質からプロテアーゼ処理等により遊離させた糖化蛋白質由来の糖化ヘキサペプチドを簡便かつ精度よく測定することができる。
PCT/JP2008/053907 2007-03-05 2008-03-05 糖化ヘキサペプチドの測定方法 WO2008108385A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009502596A JP5442432B2 (ja) 2007-03-05 2008-03-05 糖化ヘキサペプチドの測定方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-054350 2007-03-05
JP2007054350 2007-03-05

Publications (1)

Publication Number Publication Date
WO2008108385A1 true WO2008108385A1 (ja) 2008-09-12

Family

ID=39738258

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/053907 WO2008108385A1 (ja) 2007-03-05 2008-03-05 糖化ヘキサペプチドの測定方法

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JP (1) JP5442432B2 (ja)
WO (1) WO2008108385A1 (ja)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011057809A1 (en) 2009-11-16 2011-05-19 Nobel Biocare Services Ag System and method for planning a first and second dental restoration
WO2011126067A1 (ja) * 2010-04-09 2011-10-13 東洋紡績株式会社 糖化ヘモグロビンの測定方法
EP2639586A1 (en) 2012-03-15 2013-09-18 ARKRAY, Inc. Measurement method using enzymes
WO2013162035A1 (ja) 2012-04-27 2013-10-31 キッコーマン株式会社 フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ
WO2015005257A1 (ja) 2013-07-09 2015-01-15 協和メデックス株式会社 糖化ヘモグロビンの測定方法
WO2015005258A1 (ja) 2013-07-09 2015-01-15 協和メデックス株式会社 糖化ヘキサペプチドオキシダーゼとその利用
WO2015060431A1 (ja) 2013-10-25 2015-04-30 キッコーマン株式会社 糖化ペプチドに作用するアマドリアーゼを用いたＨｂＡ１ｃ測定法
WO2015060429A1 (ja) 2013-10-25 2015-04-30 キッコーマン株式会社 ヘモグロビンＡ１ｃの測定方法および測定キット
WO2018101389A1 (ja) 2016-11-30 2018-06-07 東洋紡株式会社 ヘモグロビンの糖化率測定方法
WO2019045052A1 (ja) 2017-08-31 2019-03-07 キッコーマン株式会社 糖化ヘモグロビンオキシダーゼ改変体及び測定方法
US10934530B2 (en) 2015-04-03 2021-03-02 Kikkoman Corporation Amadoriase having improved specific activity
US11111517B2 (en) 2016-04-22 2021-09-07 Kikkoman Corporation HbA1c dehydrogenase
US11168349B2 (en) 2016-07-29 2021-11-09 Hitachi Chemical Diagnostics Systems Co., Ltd. Method for measuring glycated hemoglobin
US11384381B2 (en) 2016-07-13 2022-07-12 Kikkoman Corporation Reaction accelerating agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3949854B2 (ja) * 1999-10-01 2007-07-25 キッコーマン株式会社 糖化蛋白質の測定方法
JP4231668B2 (ja) * 2001-09-04 2009-03-04 キッコーマン株式会社 新規なフルクトシルペプチドオキシダーゼ
JP4227820B2 (ja) * 2003-03-12 2009-02-18 旭化成ファーマ株式会社 新規な酵素
JP2005110657A (ja) * 2003-09-18 2005-04-28 Kikkoman Corp α−糖化ジペプチドの製造法及びα−糖化ジペプチドの測定法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AKAZAWA, S. ET AL.: "Functional analysis of fructosyl-amino acid oxidases of Aspergillus oryzae.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 70, no. 10, 2004, pages 5882 - 5890, XP055352052 *
HIROKAWA, K. ET AL.: "An enzymatic method for the determination of hemoglobinAlC.", BIOTECHNOLOGY LETTERS, vol. 27, 2005, pages 963 - 968, XP019230894 *
HIROKAWA, K. ET AL.: "Enzymes used for the determination of HbA1C.", FEMS MICROBIOLOGY LETTERS, vol. 235, 2004, pages 157 - 162, XP003014720 *
HIROKAWA, K. ET AL.: "Molecular cloning and expression of novel fructosyl peptide oxidases and their application for the measurement of glycated protein.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 311, no. 1, 2003, pages 104 - 111, XP004465110 *

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011057809A1 (en) 2009-11-16 2011-05-19 Nobel Biocare Services Ag System and method for planning a first and second dental restoration
WO2011126067A1 (ja) * 2010-04-09 2011-10-13 東洋紡績株式会社 糖化ヘモグロビンの測定方法
EP2639586A1 (en) 2012-03-15 2013-09-18 ARKRAY, Inc. Measurement method using enzymes
US8802366B2 (en) 2012-03-15 2014-08-12 Arkray, Inc. Measurement method using enzyme
WO2013162035A1 (ja) 2012-04-27 2013-10-31 キッコーマン株式会社 フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ
US10767211B2 (en) 2012-04-27 2020-09-08 Kikkoman Corporation Modified amadoriase reacting with fructosyl hexapeptide
EP3508577A2 (en) 2012-04-27 2019-07-10 Kikkoman Corporation Modified amadoriase capable of acting on fructosyl hexapeptide
US9944970B2 (en) 2013-07-09 2018-04-17 Kyowa Medex Co., Ltd. Glycated hexapeptide oxidase and use thereof
WO2015005257A1 (ja) 2013-07-09 2015-01-15 協和メデックス株式会社 糖化ヘモグロビンの測定方法
WO2015005258A1 (ja) 2013-07-09 2015-01-15 協和メデックス株式会社 糖化ヘキサペプチドオキシダーゼとその利用
US10006923B2 (en) 2013-07-09 2018-06-26 Kyowa Medex Co., Ltd. Method for measuring glycated hemoglobin
JP2020141690A (ja) * 2013-10-25 2020-09-10 キッコーマン株式会社 糖化ペプチドに作用するアマドリアーゼを用いたＨｂＡ１ｃ測定法
US11078517B2 (en) 2013-10-25 2021-08-03 Kikkoman Corporation Hemoglobin A1c measurement method and measurement kit
US20160274129A1 (en) * 2013-10-25 2016-09-22 Kikkoman Corporation METHOD FOR MEASUREMENT OF HbA1c USING AMADORIASE THAT REACTS WITH GLYCATED PEPTIDE
KR102390400B1 (ko) * 2013-10-25 2022-04-25 기꼬만 가부시키가이샤 당화 펩티드에 작용하는 아마도리아제를 이용한 HbA1c 측정법
CN105683390A (zh) * 2013-10-25 2016-06-15 龟甲万株式会社 使用作用于糖基化肽的阿马多里酶的HbA1c测定方法
JP7043161B2 (ja) 2013-10-25 2022-03-29 キッコーマン株式会社 糖化ペプチドに作用するアマドリアーゼを用いたＨｂＡ１ｃ測定法
KR20160068966A (ko) * 2013-10-25 2016-06-15 기꼬만 가부시키가이샤 당화 펩티드에 작용하는 아마도리아제를 이용한 HbA1c 측정법
US10697979B2 (en) 2013-10-25 2020-06-30 Kikkoman Corporation Method for measurement of HbA1c using amadoriase that reacts with glycated peptide
JPWO2015060431A1 (ja) * 2013-10-25 2017-03-09 キッコーマン株式会社 糖化ペプチドに作用するアマドリアーゼを用いたＨｂＡ１ｃ測定法
WO2015060429A1 (ja) 2013-10-25 2015-04-30 キッコーマン株式会社 ヘモグロビンＡ１ｃの測定方法および測定キット
WO2015060431A1 (ja) 2013-10-25 2015-04-30 キッコーマン株式会社 糖化ペプチドに作用するアマドリアーゼを用いたＨｂＡ１ｃ測定法
CN105683390B (zh) * 2013-10-25 2021-02-26 龟甲万株式会社 使用作用于糖基化肽的阿马多里酶的HbA1c测定方法
US10934530B2 (en) 2015-04-03 2021-03-02 Kikkoman Corporation Amadoriase having improved specific activity
US11111517B2 (en) 2016-04-22 2021-09-07 Kikkoman Corporation HbA1c dehydrogenase
US11384381B2 (en) 2016-07-13 2022-07-12 Kikkoman Corporation Reaction accelerating agent
US11168349B2 (en) 2016-07-29 2021-11-09 Hitachi Chemical Diagnostics Systems Co., Ltd. Method for measuring glycated hemoglobin
EP3550030A4 (en) * 2016-11-30 2020-08-12 Toyobo Co., Ltd. METHOD OF MEASURING THE RATE OF GLYCATION OF HEMOGLOBIN
WO2018101389A1 (ja) 2016-11-30 2018-06-07 東洋紡株式会社 ヘモグロビンの糖化率測定方法
WO2019045052A1 (ja) 2017-08-31 2019-03-07 キッコーマン株式会社 糖化ヘモグロビンオキシダーゼ改変体及び測定方法

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Publication number Publication date
JP5442432B2 (ja) 2014-03-12
JPWO2008108385A1 (ja) 2010-06-17

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