WO2008108284A1 - Rankl産生抑制剤 - Google Patents
Rankl産生抑制剤 Download PDFInfo
- Publication number
- WO2008108284A1 WO2008108284A1 PCT/JP2008/053595 JP2008053595W WO2008108284A1 WO 2008108284 A1 WO2008108284 A1 WO 2008108284A1 JP 2008053595 W JP2008053595 W JP 2008053595W WO 2008108284 A1 WO2008108284 A1 WO 2008108284A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- rankl
- production
- production inhibitor
- milk
- therapeutic agent
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 230000030432 tumor necrosis factor (ligand) superfamily member 11 production Effects 0.000 title abstract 4
- 102000014128 RANK Ligand Human genes 0.000 abstract 3
- 108010025832 RANK Ligand Proteins 0.000 abstract 3
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000008267 milk Substances 0.000 abstract 2
- 210000004080 milk Anatomy 0.000 abstract 2
- 235000013336 milk Nutrition 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- 208000030136 Marchiafava-Bignami Disease Diseases 0.000 abstract 1
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 235000013361 beverage Nutrition 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Mycology (AREA)
- Animal Husbandry (AREA)
- Nutrition Science (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fodder In General (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002679924A CA2679924A1 (en) | 2007-03-02 | 2008-02-29 | Milk-derived basic protein fraction for inhibiting rankl production |
EP08721043A EP2127662A4 (en) | 2007-03-02 | 2008-02-29 | INHIBITOR OF RANKL PRODUCTION |
CN2008800069226A CN101646446B (zh) | 2007-03-02 | 2008-02-29 | Rankl产生抑制剂 |
US12/529,660 US20100099848A1 (en) | 2007-03-02 | 2008-02-29 | Rankl production inhibitor |
AU2008221993A AU2008221993B2 (en) | 2007-03-02 | 2008-02-29 | RANKL production inhibitor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-052402 | 2007-03-02 | ||
JP2007052402A JP2008214237A (ja) | 2007-03-02 | 2007-03-02 | Rankl産生抑制剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008108284A1 true WO2008108284A1 (ja) | 2008-09-12 |
Family
ID=39738167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/053595 WO2008108284A1 (ja) | 2007-03-02 | 2008-02-29 | Rankl産生抑制剤 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20100099848A1 (ja) |
EP (1) | EP2127662A4 (ja) |
JP (1) | JP2008214237A (ja) |
KR (1) | KR20090119918A (ja) |
CN (1) | CN101646446B (ja) |
AU (1) | AU2008221993B2 (ja) |
CA (1) | CA2679924A1 (ja) |
WO (1) | WO2008108284A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2743406A1 (en) * | 2008-11-18 | 2010-05-27 | Kyushu University, National University Corporation | Fracture repair promoter |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61246198A (ja) | 1985-02-07 | 1986-11-01 | オレオフイナ・ソシエテ・アノニム | 蛋白の精製法 |
JPS63255300A (ja) | 1987-04-10 | 1988-10-21 | Snow Brand Milk Prod Co Ltd | 硫酸エステル化物を用いて乳からラクトフエリンを分離、精製する方法 |
JPH05202098A (ja) | 1992-01-29 | 1993-08-10 | Snow Brand Milk Prod Co Ltd | 乳質原料から生理活性物質の製造法 |
JPH08151331A (ja) | 1994-09-30 | 1996-06-11 | Snow Brand Milk Prod Co Ltd | 骨強化剤 |
JP2004115509A (ja) * | 2002-09-05 | 2004-04-15 | Snow Brand Milk Prod Co Ltd | 破骨細胞分化抑制因子産生促進剤 |
JP2006069995A (ja) * | 2004-09-06 | 2006-03-16 | Snow Brand Milk Prod Co Ltd | 炎症性サイトカイン産生抑制剤 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5230902A (en) * | 1988-04-29 | 1993-07-27 | Immunotec Research Corporation | Undenatured whey protein concentrate to improve active systemic humoral immune response |
JP2974604B2 (ja) * | 1996-01-23 | 1999-11-10 | 雪印乳業株式会社 | 塩基性タンパク質組成物、塩基性ペプチド組成物及びその利用 |
US6649590B2 (en) * | 2000-06-09 | 2003-11-18 | Snow Brand Milk Products Co., Ltd. | Method of producing fractions containing a high concentration of milk basic cystatin and decomposition products thereof |
JP4647750B2 (ja) * | 2000-06-20 | 2011-03-09 | 雪印乳業株式会社 | 乳塩基性シスタチン高含有画分及びその分解物の製造法 |
-
2007
- 2007-03-02 JP JP2007052402A patent/JP2008214237A/ja active Pending
-
2008
- 2008-02-29 AU AU2008221993A patent/AU2008221993B2/en not_active Ceased
- 2008-02-29 EP EP08721043A patent/EP2127662A4/en not_active Withdrawn
- 2008-02-29 US US12/529,660 patent/US20100099848A1/en not_active Abandoned
- 2008-02-29 CA CA002679924A patent/CA2679924A1/en active Pending
- 2008-02-29 KR KR1020097020047A patent/KR20090119918A/ko not_active Application Discontinuation
- 2008-02-29 CN CN2008800069226A patent/CN101646446B/zh not_active Expired - Fee Related
- 2008-02-29 WO PCT/JP2008/053595 patent/WO2008108284A1/ja active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61246198A (ja) | 1985-02-07 | 1986-11-01 | オレオフイナ・ソシエテ・アノニム | 蛋白の精製法 |
JPS63255300A (ja) | 1987-04-10 | 1988-10-21 | Snow Brand Milk Prod Co Ltd | 硫酸エステル化物を用いて乳からラクトフエリンを分離、精製する方法 |
JPH05202098A (ja) | 1992-01-29 | 1993-08-10 | Snow Brand Milk Prod Co Ltd | 乳質原料から生理活性物質の製造法 |
JPH08151331A (ja) | 1994-09-30 | 1996-06-11 | Snow Brand Milk Prod Co Ltd | 骨強化剤 |
JP2004115509A (ja) * | 2002-09-05 | 2004-04-15 | Snow Brand Milk Prod Co Ltd | 破骨細胞分化抑制因子産生促進剤 |
JP2006069995A (ja) * | 2004-09-06 | 2006-03-16 | Snow Brand Milk Prod Co Ltd | 炎症性サイトカイン産生抑制剤 |
Non-Patent Citations (11)
Title |
---|
CORNISH, J. ET AL.: "Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo", ENDOCRINOLOGY, vol. 145, no. 9, 2004, pages 4366 - 4374, XP003011980 * |
ETSUMORI HARADA ET AL.: "Milk Gan'yu Lactoferrin no Tainai Iko to Sono Shinki Tayo Kino no Hakken", SHUKAN IGAKU NO AYUMI, vol. 218, no. 5, 2006, pages 396 - 402, XP008142097 * |
HOCHWELLER ET AL., EUR. J. IMMUNOL., vol. 35, 2005, pages 1086 |
JOSIEN ET AL., J. EXP. MED., vol. 191, 2000, pages 495 |
JOSIENET, J. IMMUNOL., vol. 162, 1999, pages 2562 |
SUDA ET AL., ENDCR. REV., vol. 20, 1999, pages 345 |
THEIL ET AL., ANNU. REV. IMMUNOL., vol. 20, 2002, pages 795 |
WILLIAMSON ET AL., J IMMUNOL., vol. 169, 2002, pages 3606 |
WONG ET AL., J. BIOL. CHEM, vol. 272, 1997, pages 25190 - 25194 |
WONG ET AL., J. EXP. MED., vol. 186, 1997, pages 2075 |
WONG ET AL., J. LEUKOCYTE BIOL., vol. 65, 1999, pages 715 |
Also Published As
Publication number | Publication date |
---|---|
CA2679924A1 (en) | 2008-09-12 |
JP2008214237A (ja) | 2008-09-18 |
KR20090119918A (ko) | 2009-11-20 |
AU2008221993B2 (en) | 2014-02-27 |
EP2127662A1 (en) | 2009-12-02 |
US20100099848A1 (en) | 2010-04-22 |
CN101646446B (zh) | 2013-05-01 |
EP2127662A4 (en) | 2011-11-09 |
AU2008221993A1 (en) | 2008-09-12 |
CN101646446A (zh) | 2010-02-10 |
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