WO2008105383A1 - Dérivé de pyrazole et son utilisation pour des objectifs médicaux - Google Patents
Dérivé de pyrazole et son utilisation pour des objectifs médicaux Download PDFInfo
- Publication number
- WO2008105383A1 WO2008105383A1 PCT/JP2008/053230 JP2008053230W WO2008105383A1 WO 2008105383 A1 WO2008105383 A1 WO 2008105383A1 JP 2008053230 W JP2008053230 W JP 2008053230W WO 2008105383 A1 WO2008105383 A1 WO 2008105383A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pyrazole derivative
- medical purposes
- disclosed
- pyrazole
- therapeutic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne un dérivé de pyrazole représenté par la formule (1) suivante. Cette invention concerne également l'utilisation du dérivé de pyrazole pour des objectifs médicaux. Le dérivé de pyrazole est efficace en tant qu'agent antalgique ou agent thérapeutique ou prophylactique pour une douleur neurogénique.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-045678 | 2007-02-26 | ||
JP2007045678 | 2007-02-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008105383A1 true WO2008105383A1 (fr) | 2008-09-04 |
Family
ID=39721215
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/053230 WO2008105383A1 (fr) | 2007-02-26 | 2008-02-26 | Dérivé de pyrazole et son utilisation pour des objectifs médicaux |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008105383A1 (fr) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010050577A1 (fr) | 2008-10-31 | 2010-05-06 | 東レ株式会社 | Dérivé du cyclohexane et son utilisation pharmaceutique |
WO2011125838A1 (fr) | 2010-03-31 | 2011-10-13 | 東レ株式会社 | Agent thérapeutique ou agent préventif pour les troubles de collecte de l'urine |
WO2011125836A1 (fr) | 2010-03-31 | 2011-10-13 | 東レ株式会社 | Agent thérapeutique ou agent prophylactique pour la fibromyalgie |
WO2011136318A1 (fr) | 2010-04-28 | 2011-11-03 | 東レ株式会社 | Agent thérapeutique et agent conservateur contre la maladie d'alzheimer |
JP2014172851A (ja) * | 2013-03-07 | 2014-09-22 | Chiba Univ | ピラゾール誘導体の製造方法およびイソオキサゾール誘導体の製造方法 |
WO2015115509A1 (fr) | 2014-01-29 | 2015-08-06 | 東レ株式会社 | Agent thérapeutique ou prophylactique pour la sclérose en plaques |
CN106674084A (zh) * | 2016-12-20 | 2017-05-17 | 山东轩德医药科技有限公司 | 一种2‑异丙基氧基‑5‑甲基‑4‑(哌啶‑4‑基)苯胺二盐酸盐的制备方法 |
US9951025B2 (en) | 2013-03-15 | 2018-04-24 | Verseon Corporation | Halogenopyrazoles as inhibitors of thrombin |
US9963440B2 (en) | 2010-03-30 | 2018-05-08 | Verseon Corporation | Multisubstituted aromatic compounds as inhibitors of thrombin |
US10058541B2 (en) | 2013-03-15 | 2018-08-28 | Verseon Corporation | Multisubstituted aromatic compounds as serine protease inhibitors |
CN108863803A (zh) * | 2018-06-15 | 2018-11-23 | 上海华堇生物技术有限责任公司 | 一种4-甲氧基-β-硝基苯乙烯的新制备方法 |
US10189810B2 (en) | 2014-09-17 | 2019-01-29 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
US10532995B2 (en) | 2015-02-27 | 2020-01-14 | Verseon Corporation | Substituted pyrazole compounds as serine protease inhibitors |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996038418A1 (fr) * | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Derives heterocyclo-substitues d'acide hydroxamique utilises comme inhibiteurs de la cyclo-oxygenase-2 et de la 5-lipoxygenase |
JP2006514095A (ja) * | 2002-12-02 | 2006-04-27 | アステラス製薬株式会社 | ピラゾール誘導体 |
WO2007111323A1 (fr) * | 2006-03-27 | 2007-10-04 | Toray Industries, Inc. | Dérivé d'uréide et son utilisation à des fins médicales |
-
2008
- 2008-02-26 WO PCT/JP2008/053230 patent/WO2008105383A1/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996038418A1 (fr) * | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Derives heterocyclo-substitues d'acide hydroxamique utilises comme inhibiteurs de la cyclo-oxygenase-2 et de la 5-lipoxygenase |
JP2006514095A (ja) * | 2002-12-02 | 2006-04-27 | アステラス製薬株式会社 | ピラゾール誘導体 |
WO2007111323A1 (fr) * | 2006-03-27 | 2007-10-04 | Toray Industries, Inc. | Dérivé d'uréide et son utilisation à des fins médicales |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8349874B2 (en) | 2008-10-31 | 2013-01-08 | Toray Industries, Inc. | Cyclohexane derivative and pharmaceutical use thereof |
JP5522031B2 (ja) * | 2008-10-31 | 2014-06-18 | 東レ株式会社 | シクロヘキサン誘導体及びその医薬用途 |
US8247569B2 (en) | 2008-10-31 | 2012-08-21 | Toray Industries, Inc. | Cyclohexane derivative and pharmaceutical use thereof |
WO2010050577A1 (fr) | 2008-10-31 | 2010-05-06 | 東レ株式会社 | Dérivé du cyclohexane et son utilisation pharmaceutique |
US10653674B2 (en) | 2010-03-30 | 2020-05-19 | Verseon Corporation | Multisubstituted aromatic compounds as inhibitors of thrombin |
US9963440B2 (en) | 2010-03-30 | 2018-05-08 | Verseon Corporation | Multisubstituted aromatic compounds as inhibitors of thrombin |
EP2554541A1 (fr) * | 2010-03-31 | 2013-02-06 | Toray Industries, Inc. | Agent thérapeutique ou agent prophylactique pour la fibromyalgie |
US8957094B2 (en) | 2010-03-31 | 2015-02-17 | Toray Industries, Inc. | Therapeutic agent or prophylactic agent for fibromyalgia |
CN102812008A (zh) * | 2010-03-31 | 2012-12-05 | 东丽株式会社 | 蓄尿障碍的治疗剂或预防剂 |
EP2554541A4 (fr) * | 2010-03-31 | 2013-10-09 | Toray Industries | Agent thérapeutique ou agent prophylactique pour la fibromyalgie |
KR101739879B1 (ko) | 2010-03-31 | 2017-05-25 | 도레이 카부시키가이샤 | 축뇨장해의 치료제 또는 예방제 |
US8642625B2 (en) | 2010-03-31 | 2014-02-04 | Toray Industries, Inc. | Therapeutic agent or preventive agent for urine collection disorder |
KR101738471B1 (ko) | 2010-03-31 | 2017-05-22 | 도레이 카부시키가이샤 | 섬유근 통증의 치료제 또는 예방제 |
CN102822148A (zh) * | 2010-03-31 | 2012-12-12 | 东丽株式会社 | 纤维肌痛综合征的治疗剂或预防剂 |
CN102812008B (zh) * | 2010-03-31 | 2015-01-07 | 东丽株式会社 | 蓄尿障碍的治疗剂或预防剂 |
WO2011125836A1 (fr) | 2010-03-31 | 2011-10-13 | 東レ株式会社 | Agent thérapeutique ou agent prophylactique pour la fibromyalgie |
JP5783042B2 (ja) * | 2010-03-31 | 2015-09-24 | 東レ株式会社 | 蓄尿障害の治療剤又は予防剤 |
WO2011125838A1 (fr) | 2010-03-31 | 2011-10-13 | 東レ株式会社 | Agent thérapeutique ou agent préventif pour les troubles de collecte de l'urine |
JP5682555B2 (ja) * | 2010-04-28 | 2015-03-11 | 東レ株式会社 | アルツハイマー病の治療剤又は予防剤 |
WO2011136318A1 (fr) | 2010-04-28 | 2011-11-03 | 東レ株式会社 | Agent thérapeutique et agent conservateur contre la maladie d'alzheimer |
KR101739881B1 (ko) | 2010-04-28 | 2017-05-25 | 도레이 카부시키가이샤 | 알츠하이머병의 치료제 또는 예방제 |
US8598212B2 (en) | 2010-04-28 | 2013-12-03 | Toray Industries, Inc. | Therapeutic agent and preventative agent for alzheimer's disease |
JP2014172851A (ja) * | 2013-03-07 | 2014-09-22 | Chiba Univ | ピラゾール誘導体の製造方法およびイソオキサゾール誘導体の製造方法 |
US10058541B2 (en) | 2013-03-15 | 2018-08-28 | Verseon Corporation | Multisubstituted aromatic compounds as serine protease inhibitors |
US9951025B2 (en) | 2013-03-15 | 2018-04-24 | Verseon Corporation | Halogenopyrazoles as inhibitors of thrombin |
US10251872B2 (en) | 2013-03-15 | 2019-04-09 | Verseon Corporation | Multisubstituted aromatic compounds as serine protease inhibitors |
WO2015115509A1 (fr) | 2014-01-29 | 2015-08-06 | 東レ株式会社 | Agent thérapeutique ou prophylactique pour la sclérose en plaques |
US10189810B2 (en) | 2014-09-17 | 2019-01-29 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
US10532995B2 (en) | 2015-02-27 | 2020-01-14 | Verseon Corporation | Substituted pyrazole compounds as serine protease inhibitors |
CN106674084A (zh) * | 2016-12-20 | 2017-05-17 | 山东轩德医药科技有限公司 | 一种2‑异丙基氧基‑5‑甲基‑4‑(哌啶‑4‑基)苯胺二盐酸盐的制备方法 |
CN106674084B (zh) * | 2016-12-20 | 2019-03-01 | 山东轩德医药科技有限公司 | 一种2-异丙基氧基-5-甲基-4-(哌啶-4-基)苯胺二盐酸盐的制备方法 |
CN108863803A (zh) * | 2018-06-15 | 2018-11-23 | 上海华堇生物技术有限责任公司 | 一种4-甲氧基-β-硝基苯乙烯的新制备方法 |
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