WO2008099730A1 - 光学活性な２－（アロイルオキシ）プロピオン酸を用いたアミン化合物の製造方法 - Google Patents

光学活性な２－（アロイルオキシ）プロピオン酸を用いたアミン化合物の製造方法 Download PDF

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Publication number
WO2008099730A1
WO2008099730A1 PCT/JP2008/051926 JP2008051926W WO2008099730A1 WO 2008099730 A1 WO2008099730 A1 WO 2008099730A1 JP 2008051926 W JP2008051926 W JP 2008051926W WO 2008099730 A1 WO2008099730 A1 WO 2008099730A1
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WO
WIPO (PCT)
Prior art keywords
optically active
aroyloxy
propionic acid
amine compound
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/051926
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English (en)
French (fr)
Inventor
Akira Nishiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Priority to JP2008558056A priority Critical patent/JP5031778B2/ja
Publication of WO2008099730A1 publication Critical patent/WO2008099730A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

　本願は、工業的規模で簡便かつ安価に製造可能な新規なアミン化合物の光学分割剤を提供することを課題とする。この課題は、光学活性な２－（アロイルオキシ）プロピオン酸をアミン化合物の光学分割剤として使用することにより解決される。光学活性な２－（アロイルオキシ）プロピオン酸は、光学活性な乳酸又はそのエステルから製造することが可能である。このため、工業的規模で簡便かつ安価な光学分割剤を提供することができる。また、アロイル基の置換基としては種々のものが容易に製造可能であるため、種々のアミン化合物の光学分割に適用できる確率を飛躍的に向上させることが可能である。                                                                               
PCT/JP2008/051926 2007-02-14 2008-02-06 光学活性な２－（アロイルオキシ）プロピオン酸を用いたアミン化合物の製造方法 Ceased WO2008099730A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008558056A JP5031778B2 (ja) 2007-02-14 2008-02-06 光学活性な２−（アロイルオキシ）プロピオン酸を用いたアミン化合物の製造方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-033942 2007-02-14
JP2007033942 2007-02-14
JP2007191235 2007-07-23
JP2007-191235 2007-07-23

Publications (1)

Publication Number Publication Date
WO2008099730A1 true WO2008099730A1 (ja) 2008-08-21

Family

ID=39689968

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051926 Ceased WO2008099730A1 (ja) 2007-02-14 2008-02-06 光学活性な２－（アロイルオキシ）プロピオン酸を用いたアミン化合物の製造方法

Country Status (2)

Country Link
JP (1) JP5031778B2 (ja)
WO (1) WO2008099730A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011010579A1 (ja) * 2009-07-21 2011-01-27 住友化学株式会社 光学活性ニペコタミドの製造方法
WO2011158720A1 (ja) * 2010-06-15 2011-12-22 株式会社カネカ 光学純度が高められた（１ｒ，２ｓ）－１－アミノ－２－ビニルシクロプロパンカルボン酸エステルの製造法
WO2019225267A1 (ja) * 2018-05-22 2019-11-28 株式会社カネカ 光学活性－ｃｉｓ－アミノピペリジンの製造方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2180534A (en) * 1985-09-19 1987-04-01 Gen Foods Corp Benzoyloxyacetic acid derivatives useful as sweetness inhibitors
JPH0525100A (ja) * 1990-12-11 1993-02-02 Bayer Ag １−（４−クロロフエニル）−エチルアミンのラセミ体を分割した結晶母液の回収方法
JPH06256227A (ja) * 1993-03-04 1994-09-13 Japan Energy Corp 光学活性な化合物の光学分割法及び光学純度測定方法
JPH0710813A (ja) * 1993-06-28 1995-01-13 Nissan Chem Ind Ltd α−フェネチルアミン化合物の光学分割法
JPH0867655A (ja) * 1993-12-22 1996-03-12 Fuso Kagaku Kogyo Kk 新規なｐ−ｔｅｒｔ−ブチル安息香酸エステル
JPH11511477A (ja) * 1995-09-26 1999-10-05 ビーエーエスエフ アクチェンゲゼルシャフト ラセミ体分割のための方法
JP2001527517A (ja) * 1996-07-26 2001-12-25 スーザン・ピー・ペリーネ 血液、ウイルス性および細胞性疾患の治療組成物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2180534A (en) * 1985-09-19 1987-04-01 Gen Foods Corp Benzoyloxyacetic acid derivatives useful as sweetness inhibitors
JPH0525100A (ja) * 1990-12-11 1993-02-02 Bayer Ag １−（４−クロロフエニル）−エチルアミンのラセミ体を分割した結晶母液の回収方法
JPH06256227A (ja) * 1993-03-04 1994-09-13 Japan Energy Corp 光学活性な化合物の光学分割法及び光学純度測定方法
JPH0710813A (ja) * 1993-06-28 1995-01-13 Nissan Chem Ind Ltd α−フェネチルアミン化合物の光学分割法
JPH0867655A (ja) * 1993-12-22 1996-03-12 Fuso Kagaku Kogyo Kk 新規なｐ−ｔｅｒｔ−ブチル安息香酸エステル
JPH11511477A (ja) * 1995-09-26 1999-10-05 ビーエーエスエフ アクチェンゲゼルシャフト ラセミ体分割のための方法
JP2001527517A (ja) * 1996-07-26 2001-12-25 スーザン・ピー・ペリーネ 血液、ウイルス性および細胞性疾患の治療組成物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BUNTING J.W. ET AL.: "Nonspecific Esterase Activity of Carboxypeptidase A. Specificity for the Alcohol Moeity of p-Nitrobenzoate Esters", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 99, no. 8, 1997, pages 2775 - 2780 *
SANIERE M. ET AL.: "SYNTHESIS OF THE ENANTIOMERS OF 3-DEUTERIUM LABELED LACTIC ACID", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 29, no. 3, 1991, pages 305 - 312 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011010579A1 (ja) * 2009-07-21 2011-01-27 住友化学株式会社 光学活性ニペコタミドの製造方法
WO2011158720A1 (ja) * 2010-06-15 2011-12-22 株式会社カネカ 光学純度が高められた（１ｒ，２ｓ）－１－アミノ－２－ビニルシクロプロパンカルボン酸エステルの製造法
CN102906064A (zh) * 2010-06-15 2013-01-30 株式会社钟化 光学纯度得以提高了的(1r,2s)-1-氨基-2-乙烯基环丙烷羧酸酯的制造方法
CN102906064B (zh) * 2010-06-15 2015-07-29 株式会社钟化 光学纯度得以提高了的(1r,2s)-1-氨基-2-乙烯基环丙烷羧酸酯的制造方法
EP2586769A4 (en) * 2010-06-15 2015-11-04 Kaneka Corp PROCESS FOR THE PRODUCTION OF ENHANCED (1R, 2S) -1-AMINO-2-VINYL-CYCLOPROPANE CARBOXYLIC ACID ESTER WITH ENHANCED OPTICAL PURITY
WO2019225267A1 (ja) * 2018-05-22 2019-11-28 株式会社カネカ 光学活性－ｃｉｓ－アミノピペリジンの製造方法

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Publication number Publication date
JPWO2008099730A1 (ja) 2010-05-27
JP5031778B2 (ja) 2012-09-26

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