WO2008099730A1 - 光学活性な2-(アロイルオキシ)プロピオン酸を用いたアミン化合物の製造方法 - Google Patents
光学活性な2-(アロイルオキシ)プロピオン酸を用いたアミン化合物の製造方法 Download PDFInfo
- Publication number
- WO2008099730A1 WO2008099730A1 PCT/JP2008/051926 JP2008051926W WO2008099730A1 WO 2008099730 A1 WO2008099730 A1 WO 2008099730A1 JP 2008051926 W JP2008051926 W JP 2008051926W WO 2008099730 A1 WO2008099730 A1 WO 2008099730A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optically active
- aroyloxy
- propionic acid
- amine compound
- production
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/86—Separation
- C07C209/88—Separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
本願は、工業的規模で簡便かつ安価に製造可能な新規なアミン化合物の光学分割剤を提供することを課題とする。この課題は、光学活性な2-(アロイルオキシ)プロピオン酸をアミン化合物の光学分割剤として使用することにより解決される。光学活性な2-(アロイルオキシ)プロピオン酸は、光学活性な乳酸又はそのエステルから製造することが可能である。このため、工業的規模で簡便かつ安価な光学分割剤を提供することができる。また、アロイル基の置換基としては種々のものが容易に製造可能であるため、種々のアミン化合物の光学分割に適用できる確率を飛躍的に向上させることが可能である。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008558056A JP5031778B2 (ja) | 2007-02-14 | 2008-02-06 | 光学活性な2−(アロイルオキシ)プロピオン酸を用いたアミン化合物の製造方法 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007033942 | 2007-02-14 | ||
JP2007-033942 | 2007-02-14 | ||
JP2007-191235 | 2007-07-23 | ||
JP2007191235 | 2007-07-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008099730A1 true WO2008099730A1 (ja) | 2008-08-21 |
Family
ID=39689968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/JP2008/051926 WO2008099730A1 (ja) | 2007-02-14 | 2008-02-06 | 光学活性な2-(アロイルオキシ)プロピオン酸を用いたアミン化合物の製造方法 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP5031778B2 (ja) |
WO (1) | WO2008099730A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011010579A1 (ja) * | 2009-07-21 | 2011-01-27 | 住友化学株式会社 | 光学活性ニペコタミドの製造方法 |
WO2011158720A1 (ja) * | 2010-06-15 | 2011-12-22 | 株式会社カネカ | 光学純度が高められた(1r,2s)-1-アミノ-2-ビニルシクロプロパンカルボン酸エステルの製造法 |
WO2019225267A1 (ja) * | 2018-05-22 | 2019-11-28 | 株式会社カネカ | 光学活性-cis-アミノピペリジンの製造方法 |
Citations (7)
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GB2180534A (en) * | 1985-09-19 | 1987-04-01 | Gen Foods Corp | Benzoyloxyacetic acid derivatives useful as sweetness inhibitors |
JPH0525100A (ja) * | 1990-12-11 | 1993-02-02 | Bayer Ag | 1−(4−クロロフエニル)−エチルアミンのラセミ体を分割した結晶母液の回収方法 |
JPH06256227A (ja) * | 1993-03-04 | 1994-09-13 | Japan Energy Corp | 光学活性な化合物の光学分割法及び光学純度測定方法 |
JPH0710813A (ja) * | 1993-06-28 | 1995-01-13 | Nissan Chem Ind Ltd | α−フェネチルアミン化合物の光学分割法 |
JPH0867655A (ja) * | 1993-12-22 | 1996-03-12 | Fuso Kagaku Kogyo Kk | 新規なp−tert−ブチル安息香酸エステル |
JPH11511477A (ja) * | 1995-09-26 | 1999-10-05 | ビーエーエスエフ アクチェンゲゼルシャフト | ラセミ体分割のための方法 |
JP2001527517A (ja) * | 1996-07-26 | 2001-12-25 | スーザン・ピー・ペリーネ | 血液、ウイルス性および細胞性疾患の治療組成物 |
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2008
- 2008-02-06 JP JP2008558056A patent/JP5031778B2/ja active Active
- 2008-02-06 WO PCT/JP2008/051926 patent/WO2008099730A1/ja active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2180534A (en) * | 1985-09-19 | 1987-04-01 | Gen Foods Corp | Benzoyloxyacetic acid derivatives useful as sweetness inhibitors |
JPH0525100A (ja) * | 1990-12-11 | 1993-02-02 | Bayer Ag | 1−(4−クロロフエニル)−エチルアミンのラセミ体を分割した結晶母液の回収方法 |
JPH06256227A (ja) * | 1993-03-04 | 1994-09-13 | Japan Energy Corp | 光学活性な化合物の光学分割法及び光学純度測定方法 |
JPH0710813A (ja) * | 1993-06-28 | 1995-01-13 | Nissan Chem Ind Ltd | α−フェネチルアミン化合物の光学分割法 |
JPH0867655A (ja) * | 1993-12-22 | 1996-03-12 | Fuso Kagaku Kogyo Kk | 新規なp−tert−ブチル安息香酸エステル |
JPH11511477A (ja) * | 1995-09-26 | 1999-10-05 | ビーエーエスエフ アクチェンゲゼルシャフト | ラセミ体分割のための方法 |
JP2001527517A (ja) * | 1996-07-26 | 2001-12-25 | スーザン・ピー・ペリーネ | 血液、ウイルス性および細胞性疾患の治療組成物 |
Non-Patent Citations (2)
Title |
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BUNTING J.W. ET AL.: "Nonspecific Esterase Activity of Carboxypeptidase A. Specificity for the Alcohol Moeity of p-Nitrobenzoate Esters", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 99, no. 8, 1997, pages 2775 - 2780 * |
SANIERE M. ET AL.: "SYNTHESIS OF THE ENANTIOMERS OF 3-DEUTERIUM LABELED LACTIC ACID", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 29, no. 3, 1991, pages 305 - 312 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011010579A1 (ja) * | 2009-07-21 | 2011-01-27 | 住友化学株式会社 | 光学活性ニペコタミドの製造方法 |
WO2011158720A1 (ja) * | 2010-06-15 | 2011-12-22 | 株式会社カネカ | 光学純度が高められた(1r,2s)-1-アミノ-2-ビニルシクロプロパンカルボン酸エステルの製造法 |
CN102906064A (zh) * | 2010-06-15 | 2013-01-30 | 株式会社钟化 | 光学纯度得以提高了的(1r,2s)-1-氨基-2-乙烯基环丙烷羧酸酯的制造方法 |
CN102906064B (zh) * | 2010-06-15 | 2015-07-29 | 株式会社钟化 | 光学纯度得以提高了的(1r,2s)-1-氨基-2-乙烯基环丙烷羧酸酯的制造方法 |
EP2586769A4 (en) * | 2010-06-15 | 2015-11-04 | Kaneka Corp | PROCESS FOR THE PRODUCTION OF ENHANCED (1R, 2S) -1-AMINO-2-VINYL-CYCLOPROPANE CARBOXYLIC ACID ESTER WITH ENHANCED OPTICAL PURITY |
WO2019225267A1 (ja) * | 2018-05-22 | 2019-11-28 | 株式会社カネカ | 光学活性-cis-アミノピペリジンの製造方法 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2008099730A1 (ja) | 2010-05-27 |
JP5031778B2 (ja) | 2012-09-26 |
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