WO2008099580A1 - 細胞特徴量算出装置および細胞特徴量算出方法 - Google Patents

細胞特徴量算出装置および細胞特徴量算出方法 Download PDF

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Publication number
WO2008099580A1
WO2008099580A1 PCT/JP2008/000138 JP2008000138W WO2008099580A1 WO 2008099580 A1 WO2008099580 A1 WO 2008099580A1 JP 2008000138 W JP2008000138 W JP 2008000138W WO 2008099580 A1 WO2008099580 A1 WO 2008099580A1
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WIPO (PCT)
Prior art keywords
cell
calculating
feature quantity
outline length
outline
Prior art date
Application number
PCT/JP2008/000138
Other languages
English (en)
French (fr)
Inventor
Tomoharu Kiyuna
Original Assignee
Nec Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nec Corporation filed Critical Nec Corporation
Priority to US12/449,515 priority Critical patent/US8280139B2/en
Priority to JP2008557998A priority patent/JP5088329B2/ja
Publication of WO2008099580A1 publication Critical patent/WO2008099580A1/ja

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    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/12—Edge-based segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/149—Segmentation; Edge detection involving deformable models, e.g. active contour models
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/60—Analysis of geometric attributes
    • G06T7/62—Analysis of geometric attributes of area, perimeter, diameter or volume
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/40—Extraction of image or video features
    • G06V10/46—Descriptors for shape, contour or point-related descriptors, e.g. scale invariant feature transform [SIFT] or bags of words [BoW]; Salient regional features
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Multimedia (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Quality & Reliability (AREA)
  • Geometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Software Systems (AREA)
  • Image Analysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Image Processing (AREA)

Abstract

　核内ＤＮＡの状態を捉えることを可能にする細胞特徴量算出装置を提供する。この細胞特徴量算出装置は、細胞の画像を入力する画像入力部と、上記細胞の細胞核領域を上記画像から抽出する細胞核領域抽出部と、上記細胞核領域の標準輪郭長を算出する標準輪郭長算出部と、相異なる複数の閾値の各々について、上記閾値以上の画素値を持つ領域である特定領域を上記細胞核領域から抽出し、当該特定領域の輪郭長を算出することにより、輪郭長系列を算出する輪郭長系列算出部と、上記標準輪郭長および上記輪郭長系列に基づいて、上記細胞の特徴量を算出する輪郭複雑度算出部と、を備えている。
PCT/JP2008/000138 2007-02-13 2008-02-05 細胞特徴量算出装置および細胞特徴量算出方法 WO2008099580A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/449,515 US8280139B2 (en) 2007-02-13 2008-02-05 Cell feature amount calculating apparatus and cell feature amount calculating method
JP2008557998A JP5088329B2 (ja) 2007-02-13 2008-02-05 細胞特徴量算出装置および細胞特徴量算出方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007032490 2007-02-13
JP2007-032490 2007-02-13

Publications (1)

Publication Number Publication Date
WO2008099580A1 true WO2008099580A1 (ja) 2008-08-21

Family

ID=39689829

Family Applications (1)

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PCT/JP2008/000138 WO2008099580A1 (ja) 2007-02-13 2008-02-05 細胞特徴量算出装置および細胞特徴量算出方法

Country Status (3)

Country Link
US (1) US8280139B2 (ja)
JP (1) JP5088329B2 (ja)
WO (1) WO2008099580A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016194338A1 (ja) * 2015-06-04 2016-12-08 パナソニック株式会社 画像処理方法および画像処理装置
CN114418994A (zh) * 2022-01-19 2022-04-29 生态环境部长江流域生态环境监督管理局生态环境监测与科学研究中心 一种基于显微镜图像的脆杆群体藻类细胞统计方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2633678A4 (en) * 2010-10-29 2015-05-20 Univ California CELLSCOPE DEVICE AND IMAGING METHOD THEREFOR
US8494284B2 (en) * 2011-11-21 2013-07-23 Nokia Corporation Methods and apparatuses for facilitating detection of text within an image
JP5941674B2 (ja) * 2011-12-28 2016-06-29 オリンパス株式会社 細胞輪郭線形成装置及びその方法、細胞輪郭線形成プログラム
JP6070420B2 (ja) 2013-05-31 2017-02-01 富士ゼロックス株式会社 画像処理装置及びプログラム
TWI594207B (zh) * 2016-04-26 2017-08-01 財團法人金屬工業研究發展中心 細胞核影像輪廓擷取裝置及其方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2000331143A (ja) * 1999-05-14 2000-11-30 Mitsubishi Electric Corp 画像処理方法
JP2002142800A (ja) * 2000-11-13 2002-05-21 Olympus Optical Co Ltd 細胞の形態解析方法および記憶媒体

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US20040071328A1 (en) * 2001-09-07 2004-04-15 Vaisberg Eugeni A. Classifying cells based on information contained in cell images
JP3649328B2 (ja) * 2002-04-10 2005-05-18 日本電気株式会社 画像領域抽出方法および装置
SE0302114D0 (sv) * 2003-07-21 2003-07-21 Cellavision Ab Sätt att urskilja en objektkontur
JP4271054B2 (ja) 2004-02-12 2009-06-03 オリンパス株式会社 細胞画像解析装置
US7689038B2 (en) * 2005-01-10 2010-03-30 Cytyc Corporation Method for improved image segmentation
WO2007042553A1 (de) * 2005-10-13 2007-04-19 Evotec Technologies Gmbh Verfahren zur detektion von konturen in bildern biologischer zellen

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
JP2000331143A (ja) * 1999-05-14 2000-11-30 Mitsubishi Electric Corp 画像処理方法
JP2002142800A (ja) * 2000-11-13 2002-05-21 Olympus Optical Co Ltd 細胞の形態解析方法および記憶媒体

Non-Patent Citations (2)

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Title
HIROSE Y. ET AL.: "Electron Microscopic Morphometry of Chronic Type Lymphoid Leukemias", MEDICAL ELECTRON MICROSCOPY, vol. 26, no. 1, 1993, pages 2 - 39 *
PERNER P.: "Classification of HEp-2 Cells Using Fluorescent Image Analysis and Data Mining", LECTURE NOTES IN COMPUTER SCIENCE, vol. 2199, 2001, pages 219 - 224 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016194338A1 (ja) * 2015-06-04 2016-12-08 パナソニック株式会社 画像処理方法および画像処理装置
CN114418994A (zh) * 2022-01-19 2022-04-29 生态环境部长江流域生态环境监督管理局生态环境监测与科学研究中心 一种基于显微镜图像的脆杆群体藻类细胞统计方法

Also Published As

Publication number Publication date
US8280139B2 (en) 2012-10-02
JP5088329B2 (ja) 2012-12-05
US20100098317A1 (en) 2010-04-22
JPWO2008099580A1 (ja) 2010-05-27

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