WO2008096868A1 - Skin disease model having inflammation and excessive proliferation - Google Patents

Skin disease model having inflammation and excessive proliferation Download PDF

Info

Publication number
WO2008096868A1
WO2008096868A1 PCT/JP2008/052185 JP2008052185W WO2008096868A1 WO 2008096868 A1 WO2008096868 A1 WO 2008096868A1 JP 2008052185 W JP2008052185 W JP 2008052185W WO 2008096868 A1 WO2008096868 A1 WO 2008096868A1
Authority
WO
WIPO (PCT)
Prior art keywords
inflammation
skin disease
disease model
excessive proliferation
proliferation
Prior art date
Application number
PCT/JP2008/052185
Other languages
French (fr)
Japanese (ja)
Inventor
Ritsuko Ehama
Toshihiko Hibino
Masakiyo Sakaguchi
Nam Ho Huh
Original Assignee
Shiseido Company, Ltd.
National University Corporation Okayama University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiseido Company, Ltd., National University Corporation Okayama University filed Critical Shiseido Company, Ltd.
Priority to JP2008557176A priority Critical patent/JP5366077B2/en
Publication of WO2008096868A1 publication Critical patent/WO2008096868A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/04—Screening or testing on artificial tissues
    • C12N2503/06—Screening or testing on artificial skin

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Disclosed is an in vitro model system for a skin disease having inflammation induction and excessive proliferation, which is characterized in that a keratinocyte in culture is reacted with at least one of S100A8 and S100A9 to induce an inflammatory cytokine and causes the increase in proliferation of the keratinocyte. Also disclosed is a method for producing the in vitro model system.
PCT/JP2008/052185 2007-02-09 2008-02-08 Skin disease model having inflammation and excessive proliferation WO2008096868A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008557176A JP5366077B2 (en) 2007-02-09 2008-02-08 A skin disease model with inflammation and hyperproliferation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007030383 2007-02-09
JP2007-030383 2007-02-09

Publications (1)

Publication Number Publication Date
WO2008096868A1 true WO2008096868A1 (en) 2008-08-14

Family

ID=39681768

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052185 WO2008096868A1 (en) 2007-02-09 2008-02-08 Skin disease model having inflammation and excessive proliferation

Country Status (2)

Country Link
JP (1) JP5366077B2 (en)
WO (1) WO2008096868A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018234430A1 (en) * 2017-06-22 2018-12-27 Laboratoires Expanscience Models of reconstructed sensitive skin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106519A2 (en) * 2003-06-03 2004-12-09 Switch Biotech Ag Mrp8/mrp14 inhibitors and the use thereof for preventing and/or treating hypertrophic scars and keloids
JP2006045168A (en) * 2004-08-09 2006-02-16 Kao Corp S100a8 expression regulator

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106519A2 (en) * 2003-06-03 2004-12-09 Switch Biotech Ag Mrp8/mrp14 inhibitors and the use thereof for preventing and/or treating hypertrophic scars and keloids
JP2006045168A (en) * 2004-08-09 2006-02-16 Kao Corp S100a8 expression regulator

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BENOIT S. ET AL.: "Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis", BRI. J., vol. 155, no. 1, 2006, pages 62 - 66 *
EHAMA R. ET AL.: "S100A8/A9 o Kaisuru ito Hyohi Kakuka Saibo no Zoshoku Sokushin Kiko", THE JOURNAL OF EXPERIMENTAL & APPLIED CELL CULTURE RESEARCH, vol. 26, no. 1, 31 March 2007 (2007-03-31), pages 73 *
EHAMA R. ET AL.: "S100A8/A9, a key mediator for positive feedback growth stimulation and inflammation of normal human keratinocytes", J. INV. DERMATOL., vol. 127, no. S1, April 2007 (2007-04-01), pages S98 *
MADSEN P. ET AL.: "Molecular cloning and expression of a novel keratinocytes protein (Psoriasis-associated fatty acid-binding protein[Pa-FABP]) that is highly up-regulated in psoriatic skin and that shared similarity to fatty acid-binding proteins", J. INVEST. DERMATOL., vol. 99, no. 3, 1992, pages 299 - 305, XP000645498 *
SEMPRINI S. ET AL.: "Evidence for differential S100 gene over-expression in psoriatic patients from genetically heterogeneous pedigrees", HUMAN GENETICS, vol. 111, no. 4-5, 2002, pages 310 - 313, XP002432877 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018234430A1 (en) * 2017-06-22 2018-12-27 Laboratoires Expanscience Models of reconstructed sensitive skin
FR3068045A1 (en) * 2017-06-22 2018-12-28 Laboratoires Expanscience SENSITIVE SKIN MODELS RECONSTITUTED
US12061189B2 (en) 2017-06-22 2024-08-13 Laboratoires Expanscience Models of reconstructed sensitive skin

Also Published As

Publication number Publication date
JP5366077B2 (en) 2013-12-11
JPWO2008096868A1 (en) 2010-05-27

Similar Documents

Publication Publication Date Title
EP2240317B8 (en) An engine with an honeycomb structure and corresponding method of producing the honeycomb
GB2477847B (en) Improvements in or relating to methods of manufacture
EP3664392A3 (en) Method and system for reducing feedback information in multicarrier-based communication systems based on tiers
PT2338008E (en) Solar collector system and method of making the same
EP2420658A4 (en) Engine combustion chamber structure and method for producing the same
PL2290051T3 (en) Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
EP2554706A4 (en) Hot-rolled steel sheet with high tensile strength and superior processability and method for producing same
EP2592647A4 (en) Manufacturing method for channel plate, channel plate, temperature adjustment plate, cold plate, and shower plate
EP2149307A4 (en) Fermented whey preparation and method for producing the same
IL199496A0 (en) In vitro methods for the induction and maintenance of plant cell lines as single suspension cells with intact cell walls, and transformation thereof
WO2010121074A8 (en) Modulation of inflammatory responses by factor xi
WO2008073446A3 (en) Methods and systems related to transmission of nutraceutical associated information
EP2587932A4 (en) Method and system for the continuous or semi-continuous production of flavored ice
EP2123824A4 (en) Stretchable sheet and method of producing the same
WO2008106134A3 (en) Engineered anti-il-23r antibodies
PL3269819T3 (en) Microorganism producing o-acetyl-homoserine and the method of producing o-acetyl-homoserine using the microorganism
EP2003194A4 (en) Biocompatible transparent sheet, method of producing the same and cell sheet
WO2011160827A3 (en) Novel jnk inhibitor molecules
EP2533895A4 (en) Catalyst for producing hydrogenated biodiesel and method of producing the same
WO2011121051A3 (en) Preparation created from an in vitro culture of dedifferentiated, non-elicited cells of the argania tree, use thereof for treating skin ageing, inflammation and scarring, and production thereof
EP1947532A3 (en) A control system
EP2176066A4 (en) Structural member and method of producing the structural member
EP3666900A3 (en) Cell-based production of nonulosonates
EP2153958A4 (en) Die for molding honeycomb segment and method of producing honeycomb structure
FR2956121B1 (en) BEER COMPOSITION AND METHOD FOR PRODUCING THE SAME

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08711064

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2008557176

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08711064

Country of ref document: EP

Kind code of ref document: A1