WO2008096868A1 - Modèle de maladie de peau présentant une inflammation et une prolifération excessive - Google Patents

Modèle de maladie de peau présentant une inflammation et une prolifération excessive Download PDF

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Publication number
WO2008096868A1
WO2008096868A1 PCT/JP2008/052185 JP2008052185W WO2008096868A1 WO 2008096868 A1 WO2008096868 A1 WO 2008096868A1 JP 2008052185 W JP2008052185 W JP 2008052185W WO 2008096868 A1 WO2008096868 A1 WO 2008096868A1
Authority
WO
WIPO (PCT)
Prior art keywords
inflammation
skin disease
disease model
excessive proliferation
proliferation
Prior art date
Application number
PCT/JP2008/052185
Other languages
English (en)
Japanese (ja)
Inventor
Ritsuko Ehama
Toshihiko Hibino
Masakiyo Sakaguchi
Nam Ho Huh
Original Assignee
Shiseido Company, Ltd.
National University Corporation Okayama University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiseido Company, Ltd., National University Corporation Okayama University filed Critical Shiseido Company, Ltd.
Priority to JP2008557176A priority Critical patent/JP5366077B2/ja
Publication of WO2008096868A1 publication Critical patent/WO2008096868A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/04—Screening or testing on artificial tissues
    • C12N2503/06—Screening or testing on artificial skin

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur un système de modèle in vitro pour une maladie de peau ayant une induction d'inflammation et une prolifération excessive, caractérisé en ce que des kératinocytes en culture sont mis à réagir avec au moins du S100A8 ou du S100A9 pour induire une cytokine inflammatoire et provoquer l'augmentation de la prolifération des kératinocytes. L'invention porte également sur un procédé de fabrication du système modèle in vitro.
PCT/JP2008/052185 2007-02-09 2008-02-08 Modèle de maladie de peau présentant une inflammation et une prolifération excessive WO2008096868A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008557176A JP5366077B2 (ja) 2007-02-09 2008-02-08 炎症および過剰増殖を伴う皮膚疾患モデル

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007030383 2007-02-09
JP2007-030383 2007-02-09

Publications (1)

Publication Number Publication Date
WO2008096868A1 true WO2008096868A1 (fr) 2008-08-14

Family

ID=39681768

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/052185 WO2008096868A1 (fr) 2007-02-09 2008-02-08 Modèle de maladie de peau présentant une inflammation et une prolifération excessive

Country Status (2)

Country Link
JP (1) JP5366077B2 (fr)
WO (1) WO2008096868A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018234430A1 (fr) * 2017-06-22 2018-12-27 Laboratoires Expanscience Modeles de peau sensible reconstituee

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106519A2 (fr) * 2003-06-03 2004-12-09 Switch Biotech Ag Inhibiteurs de mrp8/mrp14 et leur utilisation pour prevenir et/ou traiter des cicatrices et des cheloides hypertrophiees
JP2006045168A (ja) * 2004-08-09 2006-02-16 Kao Corp Ｓ１００ａ８発現調節剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004106519A2 (fr) * 2003-06-03 2004-12-09 Switch Biotech Ag Inhibiteurs de mrp8/mrp14 et leur utilisation pour prevenir et/ou traiter des cicatrices et des cheloides hypertrophiees
JP2006045168A (ja) * 2004-08-09 2006-02-16 Kao Corp Ｓ１００ａ８発現調節剤

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BENOIT S. ET AL.: "Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis", BRI. J., vol. 155, no. 1, 2006, pages 62 - 66 *
EHAMA R. ET AL.: "S100A8/A9 o Kaisuru ito Hyohi Kakuka Saibo no Zoshoku Sokushin Kiko", THE JOURNAL OF EXPERIMENTAL & APPLIED CELL CULTURE RESEARCH, vol. 26, no. 1, 31 March 2007 (2007-03-31), pages 73 *
EHAMA R. ET AL.: "S100A8/A9, a key mediator for positive feedback growth stimulation and inflammation of normal human keratinocytes", J. INV. DERMATOL., vol. 127, no. S1, April 2007 (2007-04-01), pages S98 *
MADSEN P. ET AL.: "Molecular cloning and expression of a novel keratinocytes protein (Psoriasis-associated fatty acid-binding protein[Pa-FABP]) that is highly up-regulated in psoriatic skin and that shared similarity to fatty acid-binding proteins", J. INVEST. DERMATOL., vol. 99, no. 3, 1992, pages 299 - 305, XP000645498 *
SEMPRINI S. ET AL.: "Evidence for differential S100 gene over-expression in psoriatic patients from genetically heterogeneous pedigrees", HUMAN GENETICS, vol. 111, no. 4-5, 2002, pages 310 - 313, XP002432877 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018234430A1 (fr) * 2017-06-22 2018-12-27 Laboratoires Expanscience Modeles de peau sensible reconstituee
FR3068045A1 (fr) * 2017-06-22 2018-12-28 Laboratoires Expanscience Modeles de peau sensible reconstituee

Also Published As

Publication number Publication date
JPWO2008096868A1 (ja) 2010-05-27
JP5366077B2 (ja) 2013-12-11

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