WO2008093767A1 - ベンジルアミン誘導体またはその薬学的に許容される酸付加塩、およびその医薬用途 - Google Patents

ベンジルアミン誘導体またはその薬学的に許容される酸付加塩、およびその医薬用途 Download PDF

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Publication number
WO2008093767A1
WO2008093767A1 PCT/JP2008/051479 JP2008051479W WO2008093767A1 WO 2008093767 A1 WO2008093767 A1 WO 2008093767A1 JP 2008051479 W JP2008051479 W JP 2008051479W WO 2008093767 A1 WO2008093767 A1 WO 2008093767A1
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutically acceptable
acid addition
addition salt
acceptable acid
derivative
Prior art date
Application number
PCT/JP2008/051479
Other languages
English (en)
French (fr)
Inventor
Ryoji Hayashi
Tsukasa Kikuchi
Masaki Arai
Satoshi Kurosawa
Ko Hasebe
Sayoko Kanie
Seiichiro Ozono
Atsushi Otsuka
Original Assignee
Toray Industries, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries, Inc. filed Critical Toray Industries, Inc.
Priority to CN2008800036203A priority Critical patent/CN101595088B/zh
Priority to AU2008210637A priority patent/AU2008210637B2/en
Priority to DK08704230.5T priority patent/DK2119700T3/da
Priority to CA2677061A priority patent/CA2677061C/en
Priority to KR1020097013383A priority patent/KR101479048B1/ko
Priority to EP08704230A priority patent/EP2119700B1/en
Priority to US12/525,364 priority patent/US8148427B2/en
Priority to JP2008556166A priority patent/JP4720909B2/ja
Priority to ES08704230T priority patent/ES2387586T3/es
Priority to PL08704230T priority patent/PL2119700T3/pl
Publication of WO2008093767A1 publication Critical patent/WO2008093767A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers

Abstract

下式に代表されるベンジルアミン誘導体およびその薬学的に許容される酸付加塩、並びに当該誘導体またはその薬学的に許容される酸付加塩を含有する医薬、並びに当該誘導体またはその薬学的に許容される酸付加塩を含有する頻尿もしくは尿失禁の治療または予防剤を提供する。本発明のベンジルアミン誘導体およびその薬学的に許容される酸付加塩は、従来の化合物よりも副作用の懸念が低く、かつ、頻尿もしくは尿失禁に対し高い治療効果を有するため、優れた頻尿もしくは尿失禁の治療または予防剤として利用できる。
PCT/JP2008/051479 2007-01-31 2008-01-31 ベンジルアミン誘導体またはその薬学的に許容される酸付加塩、およびその医薬用途 WO2008093767A1 (ja)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CN2008800036203A CN101595088B (zh) 2007-01-31 2008-01-31 苯甲胺衍生物或其药学上允许的酸加成盐及其医药用途
AU2008210637A AU2008210637B2 (en) 2007-01-31 2008-01-31 Benzylamine derivative or pharmaceutically acceptable acid addition salt thereof, and use thereof for medical purposes
DK08704230.5T DK2119700T3 (da) 2007-01-31 2008-01-31 Benzylaminderivat eller farmaceutisk acceptabelt syreadditionssalt heraf og anvendelse heraf til medicinske formål
CA2677061A CA2677061C (en) 2007-01-31 2008-01-31 Benzylamine derivative or pharmaceutically acceptable acid addition salt thereof, and use thereof for medical purposes
KR1020097013383A KR101479048B1 (ko) 2007-01-31 2008-01-31 벤질아민 유도체 또는 그 약학적으로 허용되는 산부가염, 및 그 의약 용도
EP08704230A EP2119700B1 (en) 2007-01-31 2008-01-31 Benzylamine derivative or pharmaceutically acceptable acid addition salt thereof, and use thereof for medical purposes
US12/525,364 US8148427B2 (en) 2007-01-31 2008-01-31 Benzylamine derivative or pharmaceutically acceptable acid addition salt thereof, and use thereof for medical purposes
JP2008556166A JP4720909B2 (ja) 2007-01-31 2008-01-31 ベンジルアミン誘導体またはその薬学的に許容される酸付加塩、およびその医薬用途
ES08704230T ES2387586T3 (es) 2007-01-31 2008-01-31 Derivado de bencilamina o sal de adición de ácido del mismo farmacéuticamente aceptable y utilización del mismo para fines médicos
PL08704230T PL2119700T3 (pl) 2007-01-31 2008-01-31 Pochodna benzyloaminy lub jej farmaceutycznie dopuszczalna sól addycyjna z kwasem oraz ich zastosowanie do celów medycznych

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-020582 2007-01-31
JP2007020582 2007-01-31

Publications (1)

Publication Number Publication Date
WO2008093767A1 true WO2008093767A1 (ja) 2008-08-07

Family

ID=39674074

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051479 WO2008093767A1 (ja) 2007-01-31 2008-01-31 ベンジルアミン誘導体またはその薬学的に許容される酸付加塩、およびその医薬用途

Country Status (12)

Country Link
US (1) US8148427B2 (ja)
EP (1) EP2119700B1 (ja)
JP (1) JP4720909B2 (ja)
KR (1) KR101479048B1 (ja)
CN (1) CN101595088B (ja)
AU (1) AU2008210637B2 (ja)
CA (1) CA2677061C (ja)
DK (1) DK2119700T3 (ja)
ES (1) ES2387586T3 (ja)
PL (1) PL2119700T3 (ja)
PT (1) PT2119700E (ja)
WO (1) WO2008093767A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010013798A1 (ja) 2008-07-31 2010-02-04 東レ株式会社 ベンジルアミン誘導体又はその薬学的に許容される酸付加塩を含有する糖尿病、肥満症、脂質異常症若しくはメタボリックシンドロームの治療剤又は予防剤

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3341584A (en) 1962-01-24 1967-09-12 Mead Johnson & Co Anilides
JPH07206806A (ja) 1993-12-21 1995-08-08 Bristol Myers Squibb Co β３アゴニストとして有用なカテコールアミン代用物
WO1999020607A1 (fr) 1997-10-17 1999-04-29 Yamanouchi Pharmaceutical Co., Ltd. Derives amides ou sels desdits derives
WO2000059885A1 (fr) * 1999-04-01 2000-10-12 Asahi Kasei Kabushiki Kaisha Procede de preparation de derives d'alcools amines tricycliques avec des azides
JP2002512639A (ja) 1998-04-06 2002-04-23 藤沢薬品工業株式会社 プロパノールアミン誘導体
US20020068751A1 (en) * 2000-07-17 2002-06-06 American Home Products Corporation Phenyl-oxo-tetrahydroquinolin-3-yl beta-3 adrenergic receptor agonists
WO2005040093A1 (ja) 2003-10-24 2005-05-06 Kissei Pharmaceutical Co., Ltd. アミノアルコール誘導体、それを含有する医薬組成物およびそれらの用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436914B1 (en) * 1998-06-30 2002-08-20 Bristol-Myers Squibb Company 2-hydroxy-3—(4-hydroxy-3-sulfonamidophenyl)—propylamines useful as beta 3 adrenergic agonists
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3341584A (en) 1962-01-24 1967-09-12 Mead Johnson & Co Anilides
JPH07206806A (ja) 1993-12-21 1995-08-08 Bristol Myers Squibb Co β３アゴニストとして有用なカテコールアミン代用物
WO1999020607A1 (fr) 1997-10-17 1999-04-29 Yamanouchi Pharmaceutical Co., Ltd. Derives amides ou sels desdits derives
JP2002512639A (ja) 1998-04-06 2002-04-23 藤沢薬品工業株式会社 プロパノールアミン誘導体
WO2000059885A1 (fr) * 1999-04-01 2000-10-12 Asahi Kasei Kabushiki Kaisha Procede de preparation de derives d'alcools amines tricycliques avec des azides
US20020068751A1 (en) * 2000-07-17 2002-06-06 American Home Products Corporation Phenyl-oxo-tetrahydroquinolin-3-yl beta-3 adrenergic receptor agonists
WO2005040093A1 (ja) 2003-10-24 2005-05-06 Kissei Pharmaceutical Co., Ltd. アミノアルコール誘導体、それを含有する医薬組成物およびそれらの用途

Non-Patent Citations (12)

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Title
"Experimental Methods in Pharmacology", KYODO ISHO SHUPPAN CO., LTD, pages: 168
"Experimental Methods in Pharmacology", KYODO ISHO SHUPPAN CO., LTD., pages: 166
"Experimental Methods in Pharmacology", KYODO ISHO SHUPPAN CO., LTD., pages: 168
"Fieser and Fieser's Reagent for Organic Synthesis", WILEY & SONS
"Organic Reaction", WILEY & SONS
J. PHARMACOL. EXP. THER., vol. 271, 1994, pages 1253
J. PHARMACOL. EXP. THER., vol. 293, 2000, pages 939
J.UROLOGY, vol. 165, 2001, pages 240
JPN. J. PHARMACOL., vol. 87, 2001, pages 27
NAUNYN-SCHMIEDEBERG'S ARCH. PHARMACOL., vol. 369, 2004, pages 151
See also references of EP2119700A4 *
SUM F.-W. ET AL.: "Cyclic amine sulfonamides as linkers in the design and synthesis of novel human beta3 adrenergic receptor agonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 13, 2003, pages 2191 - 2194, XP002282659 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010013798A1 (ja) 2008-07-31 2010-02-04 東レ株式会社 ベンジルアミン誘導体又はその薬学的に許容される酸付加塩を含有する糖尿病、肥満症、脂質異常症若しくはメタボリックシンドロームの治療剤又は予防剤
EP2311447A4 (en) * 2008-07-31 2012-04-18 Toray Industries THERAPEUTIC OR PROPHYLACTIC AGENT FOR DIABETES, ADIPOSITAS, DYSLIPIDEMIA OR METABOLIC SYNDROME WITH A BENZYLAMINE DERIVATIVE OR A PHARMACEUTIC ACCEPTIC ACID SALT OTHER THEREOF
US8198330B2 (en) 2008-07-31 2012-06-12 Toray Industries, Inc. Therapeutic or prophylactic agent for diabetes, obesity, dyslipidemia or metabolic syndrome comprising benzylamine derivative or pharmaceutically acceptable acid addition salt thereof
JP5597992B2 (ja) * 2008-07-31 2014-10-01 東レ株式会社 ベンジルアミン誘導体又はその薬学的に許容される酸付加塩を含有する糖尿病、肥満症、脂質異常症若しくはメタボリックシンドロームの治療剤又は予防剤

Also Published As

Publication number Publication date
CA2677061C (en) 2014-07-29
JPWO2008093767A1 (ja) 2010-05-20
EP2119700B1 (en) 2012-08-01
US20100099769A1 (en) 2010-04-22
EP2119700A1 (en) 2009-11-18
DK2119700T3 (da) 2012-10-22
US8148427B2 (en) 2012-04-03
AU2008210637B2 (en) 2012-08-16
CN101595088B (zh) 2013-06-19
PT2119700E (pt) 2012-10-02
ES2387586T3 (es) 2012-09-26
KR20090104815A (ko) 2009-10-06
CA2677061A1 (en) 2008-08-07
EP2119700A4 (en) 2011-06-08
CN101595088A (zh) 2009-12-02
AU2008210637A1 (en) 2008-08-07
JP4720909B2 (ja) 2011-07-13
KR101479048B1 (ko) 2015-01-05
PL2119700T3 (pl) 2013-01-31

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