WO2008093060A3 - Peptides et leur utilisation - Google Patents

Peptides et leur utilisation Download PDF

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Publication number
WO2008093060A3
WO2008093060A3 PCT/GB2008/000283 GB2008000283W WO2008093060A3 WO 2008093060 A3 WO2008093060 A3 WO 2008093060A3 GB 2008000283 W GB2008000283 W GB 2008000283W WO 2008093060 A3 WO2008093060 A3 WO 2008093060A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
sequence
amino acids
same
antifungal agents
Prior art date
Application number
PCT/GB2008/000283
Other languages
English (en)
Other versions
WO2008093060A2 (fr
Inventor
Deborah O'neil
Original Assignee
Novabiotics Ltd
Deborah O'neil
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novabiotics Ltd, Deborah O'neil filed Critical Novabiotics Ltd
Priority to EP08701955A priority Critical patent/EP2114988A2/fr
Priority to CA2706744A priority patent/CA2706744C/fr
Priority to US12/525,523 priority patent/US9169290B2/en
Priority to AU2008211789A priority patent/AU2008211789B2/en
Priority to JP2009547750A priority patent/JP2010517988A/ja
Priority to NZ578970A priority patent/NZ578970A/en
Priority to CN200880009167.7A priority patent/CN101679487B/zh
Publication of WO2008093060A2 publication Critical patent/WO2008093060A2/fr
Publication of WO2008093060A3 publication Critical patent/WO2008093060A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des peptides à utiliser en tant qu'agents antifongique. Ces peptides comprennent une séquence comprenant 5 à 15 acides aminés basiques. Dans la séquence d'acides aminés d'un peptide de l'invention, sensiblement tous les acides aminés sont identiques.
PCT/GB2008/000283 2007-02-02 2008-01-28 Peptides et leur utilisation WO2008093060A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP08701955A EP2114988A2 (fr) 2007-02-02 2008-01-28 Peptides et leur utilisation
CA2706744A CA2706744C (fr) 2007-02-02 2008-01-28 Peptides antifongiques et leur utilisation
US12/525,523 US9169290B2 (en) 2007-02-02 2008-01-28 Peptides and their use
AU2008211789A AU2008211789B2 (en) 2007-02-02 2008-01-28 Peptides and their use
JP2009547750A JP2010517988A (ja) 2007-02-02 2008-01-28 ペプチドおよびその使用
NZ578970A NZ578970A (en) 2007-02-02 2008-01-28 Antimicrobial peptides comprising one basic amino acid
CN200880009167.7A CN101679487B (zh) 2007-02-02 2008-01-28 肽及其用途

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89928307P 2007-02-02 2007-02-02
GB0702020.9 2007-02-02
US60/899,283 2007-02-02
GBGB0702020.9A GB0702020D0 (en) 2007-02-02 2007-02-02 Peptides and their use

Publications (2)

Publication Number Publication Date
WO2008093060A2 WO2008093060A2 (fr) 2008-08-07
WO2008093060A3 true WO2008093060A3 (fr) 2008-10-23

Family

ID=37891189

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/000283 WO2008093060A2 (fr) 2007-02-02 2008-01-28 Peptides et leur utilisation

Country Status (17)

Country Link
US (1) US9169290B2 (fr)
EP (2) EP2251348B1 (fr)
JP (2) JP2010517988A (fr)
CN (1) CN101679487B (fr)
AU (1) AU2008211789B2 (fr)
CA (1) CA2706744C (fr)
CY (1) CY1115140T1 (fr)
DK (1) DK2251348T3 (fr)
ES (1) ES2449615T3 (fr)
GB (1) GB0702020D0 (fr)
HK (1) HK1145506A1 (fr)
HR (1) HRP20140185T1 (fr)
NZ (1) NZ578970A (fr)
PL (1) PL2251348T3 (fr)
PT (1) PT2251348E (fr)
SI (1) SI2251348T1 (fr)
WO (1) WO2008093060A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0702021D0 (en) 2007-02-02 2007-03-14 Novabiotics Ltd Peptides and their use
WO2009153418A1 (fr) * 2008-06-16 2009-12-23 Centre National De La Recherche Scientifique (C.N.R.S) Peptides harp inhibant la croissance tumorale
FR2941231B1 (fr) 2009-01-16 2016-04-01 Sederma Sa Nouveaux peptides, compositions les comprenant et utilisations cosmetiques et dermo-pharmaceutiques.
CN102432672A (zh) * 2011-12-13 2012-05-02 重庆理工大学 一组新型合成抗菌肽及其应用
GB201204457D0 (en) * 2012-03-14 2012-04-25 Novabiotics Ltd Polypeptides and their use
HRP20231151T1 (hr) 2012-03-19 2024-01-05 Cidara Therapeutics, Inc. Režimi za doziranje spojeva iz klase ehinokandina
US20160250285A1 (en) * 2013-10-30 2016-09-01 University Of Western Australia Neuroprotective peptides
GB201405891D0 (en) * 2014-04-02 2014-05-14 Novabiotics Ltd Modified antimicrobial peptides
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
HUE045872T2 (hu) 2014-05-21 2020-01-28 Entrada Therapeutics Inc Sejteket penetráló peptidek és ezek elõállítására és alkalmazására szolgáló eljárások
EP3185880B1 (fr) 2014-08-27 2020-02-12 Ohio State Innovation Foundation Inhibiteurs améliorés de la peptidyl-calcineurine
WO2017034961A1 (fr) * 2015-08-21 2017-03-02 Trilogy Therapeutics, Inc. Procédés de traitement d'une infection pulmonaire avec la caspofungine
WO2017120471A1 (fr) 2016-01-08 2017-07-13 Cidara Therapeutics, Inc. Procédés de prévention et de traitement d'infections à pneumocystis
WO2017161016A1 (fr) 2016-03-16 2017-09-21 Cidara Therapeutics, Inc. Schémas posologiques pour le traitement d'infections fongiques
GB201609925D0 (en) * 2016-06-07 2016-07-20 Novabiotics Ltd Formulation
WO2018191692A1 (fr) * 2017-04-14 2018-10-18 Cidara Therapeutics, Inc. Procédés de traitement d'infections fongiques
WO2019014333A1 (fr) 2017-07-12 2019-01-17 Cidara Therapeutics, Inc. Compositions et méthodes pour le traitement d'infections fongiques
US11576946B2 (en) 2018-01-29 2023-02-14 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-NFAT interaction
TW201945014A (zh) 2018-02-22 2019-12-01 美商安卓達治療股份有限公司 用於治療粒線體性神經胃腸腦病變之組合物及方法
US11344614B2 (en) * 2018-09-29 2022-05-31 Emergex Vaccines Holding Ltd. Pharmaceutical compositions comprising dengue virus-specific multiple HLA-binding T cell epitopes
KR102429281B1 (ko) * 2020-05-25 2022-08-05 (주)노바셀테크놀로지 신규 안구건조증 치료용 약학적 조성물
CN113336824A (zh) * 2021-04-30 2021-09-03 重庆理工大学 一种多肽在作为pd-1/pd-l1蛋白-蛋白相互作用(ppi)调节剂中的应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0149254A2 (fr) * 1983-12-29 1985-07-24 The Research Foundation Of State University Of New York Compositions fongicides contenant des polypeptides renfermant de la L-histidine
WO2004050685A2 (fr) * 2002-11-29 2004-06-17 Adaptive Therapeutics, Inc. Agents therapeutiques antifongiques
US20040229801A1 (en) * 2003-04-07 2004-11-18 Takumi Kawabe Anti-fungal compounds and methods of use
WO2007072037A1 (fr) * 2005-12-22 2007-06-28 Novabiotics Limited Peptides cycliques antimicrobiens

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646120A (en) * 1990-10-24 1997-07-08 Allelix Biopharmaceuticals, Inc. Peptide-based inhibitors of HIV replication
BR9809138A (pt) * 1997-05-21 2001-08-28 Trustees For The Leland Stanfo Conjugado e método para aumentar o transporte de um composto selecionado atravessando uma membrana biológica
US8038984B2 (en) * 1998-06-20 2011-10-18 Washington University Membrane-permeant peptide complexes for treatment of sepsis
US7049395B2 (en) * 2000-05-02 2006-05-23 Yale University Anti-inflammatory compounds and uses thereof
US20040142892A1 (en) * 2001-04-30 2004-07-22 The University Of British Columbia Autogene nucleic acids encoding a secretable RNA polymerase
US7033991B2 (en) * 2001-07-16 2006-04-25 Board Of Supervisors Of Louisiana State University And Agriculture And Mechanical College Inhibiting furin with polybasic peptides
WO2003020213A2 (fr) * 2001-08-30 2003-03-13 Praecis Pharmaceuticals Incorporated Procedes et compositions pour le traitement de troubles inflammatoires
US20050203892A1 (en) * 2004-03-02 2005-09-15 Jonathan Wesley Dynamically integrating disparate systems and providing secure data sharing
CN101031583B (zh) 2004-08-18 2013-06-05 诺瓦生命科学有限公司 包含含有精氨酸和/或赖氨酸的基序的抗微生物肽
JP4520477B2 (ja) * 2006-10-31 2010-08-04 株式会社マルハニチロ食品 抗真菌ペプチドまたはそれを含有するペプチド組成物とその製造方法
GB0702021D0 (en) 2007-02-02 2007-03-14 Novabiotics Ltd Peptides and their use
GB0702022D0 (en) 2007-02-02 2007-03-14 Novabiotics Ltd Peptides and their use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0149254A2 (fr) * 1983-12-29 1985-07-24 The Research Foundation Of State University Of New York Compositions fongicides contenant des polypeptides renfermant de la L-histidine
WO2004050685A2 (fr) * 2002-11-29 2004-06-17 Adaptive Therapeutics, Inc. Agents therapeutiques antifongiques
US20040229801A1 (en) * 2003-04-07 2004-11-18 Takumi Kawabe Anti-fungal compounds and methods of use
WO2007072037A1 (fr) * 2005-12-22 2007-06-28 Novabiotics Limited Peptides cycliques antimicrobiens

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HONG S Y ET AL: "The effect of charge increased on the specifity and activity of a short antimicrobial peptide", PEPTIDES, ELSEVIER, AMSTERDAM, vol. 22, no. 10, 1 January 2001 (2001-01-01), pages 1669 - 1674, XP002989856, ISSN: 0196-9781 *
LEHRER RI ET AL.: "Modulation of the In Vitro Candidacial Activity of Human Neutrophil Defensins by Target Cell Metabolism and Divalent Cations", JOURNAL OF CLINICAL INVESTIGATION, vol. 81, June 1988 (1988-06-01), pages 1829 - 1835, XP002482896 *
PARK Y ET AL: "A Leu-Lys-rich antimicrobial peptide: activity and mechanism", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS & PROTEOMICS, ELSEVIER, vol. 1645, no. 2, 21 February 2003 (2003-02-21), pages 172 - 182, XP004405445, ISSN: 1570-9639 *
POLLOCK JJ ET AL.: "Fungistatic and Fungicidal Activity of Human Parotid Salivary Histidine-Rich Polypeptides on Candida albicans", INFECTION AND IMMUNITY, vol. 44, no. 3, June 1984 (1984-06-01), pages 702 - 707, XP002482895 *
ZHU J ET AL.: "Synthetic Histidine-Rich Peptides Inhibit Candida Species and Other Fungi In Vitro: Role of Endocytosis and Treatment Implications", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 50, no. 8, August 2006 (2006-08-01), pages 2797 - 2805, XP002482897 *

Also Published As

Publication number Publication date
GB0702020D0 (en) 2007-03-14
EP2251348A2 (fr) 2010-11-17
DK2251348T3 (en) 2014-03-03
CN101679487A (zh) 2010-03-24
PL2251348T3 (pl) 2014-05-30
CN101679487B (zh) 2018-04-03
SI2251348T1 (sl) 2014-05-30
EP2114988A2 (fr) 2009-11-11
HRP20140185T1 (hr) 2014-05-09
US9169290B2 (en) 2015-10-27
AU2008211789A1 (en) 2008-08-07
CY1115140T1 (el) 2016-12-14
ES2449615T3 (es) 2014-03-20
JP2014012667A (ja) 2014-01-23
NZ578970A (en) 2012-04-27
US20100184696A1 (en) 2010-07-22
HK1145506A1 (en) 2011-04-21
PT2251348E (pt) 2014-03-06
EP2251348A3 (fr) 2011-03-02
JP2010517988A (ja) 2010-05-27
CA2706744A1 (fr) 2008-08-07
WO2008093060A2 (fr) 2008-08-07
CA2706744C (fr) 2017-12-05
EP2251348B1 (fr) 2014-01-15
JP5882260B2 (ja) 2016-03-09
AU2008211789B2 (en) 2013-11-14

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