WO2008090884A1 - 新規トリフルオロメチルフェニルテトラヒドロシンノリン誘導体及びその医薬用途 - Google Patents

新規トリフルオロメチルフェニルテトラヒドロシンノリン誘導体及びその医薬用途 Download PDF

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Publication number
WO2008090884A1
WO2008090884A1 PCT/JP2008/050809 JP2008050809W WO2008090884A1 WO 2008090884 A1 WO2008090884 A1 WO 2008090884A1 JP 2008050809 W JP2008050809 W JP 2008050809W WO 2008090884 A1 WO2008090884 A1 WO 2008090884A1
Authority
WO
WIPO (PCT)
Prior art keywords
trifluoromethylphenyltetrahydrocinnoline
derivative
novel
hydroxy group
pharmaceutical use
Prior art date
Application number
PCT/JP2008/050809
Other languages
English (en)
French (fr)
Inventor
Takahiro Watanabe
Yoshitaka Sato
Seiichi Saito
Original Assignee
Nippon Kayaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Kabushiki Kaisha filed Critical Nippon Kayaku Kabushiki Kaisha
Publication of WO2008090884A1 publication Critical patent/WO2008090884A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/28—Cinnolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　下記一般式（１） ［式中、Ｘ１からＸ５は各々独立に水素原子若しくは水酸基を示し、且つ、少なくとも一つの基は水酸基を示し、Ｘ６は水素原子若しくは水酸基を示す］ で表されるトリフルオロメチルフェニルテトラヒドロシンノリン誘導体又はその生理学的に許容される塩は、悪性腫瘍に対して広い抗癌スペクトルを持ち、優れた抗腫瘍剤として有用である。
PCT/JP2008/050809 2007-01-23 2008-01-22 新規トリフルオロメチルフェニルテトラヒドロシンノリン誘導体及びその医薬用途 WO2008090884A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007012118A JP2010070452A (ja) 2007-01-23 2007-01-23 新規トリフルオロメチルフェニルテトラヒドロシンノリン誘導体とその用途
JP2007-012118 2007-01-23

Publications (1)

Publication Number Publication Date
WO2008090884A1 true WO2008090884A1 (ja) 2008-07-31

Family

ID=39644460

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/050809 WO2008090884A1 (ja) 2007-01-23 2008-01-22 新規トリフルオロメチルフェニルテトラヒドロシンノリン誘導体及びその医薬用途

Country Status (3)

Country Link
JP (1) JP2010070452A (ja)
TW (1) TW200845993A (ja)
WO (1) WO2008090884A1 (ja)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052866A1 (ja) * 2002-12-10 2004-06-24 Nippon Kayaku Kabushiki Kaisha ３−フェニル−シンノリン類縁体とそれを用いた抗腫瘍剤
WO2005121105A1 (ja) * 2004-06-09 2005-12-22 Nippon Kayaku Kabushiki Kaisha 新規３－フェニルテトラヒドロシンノリン－5－オール誘導体及びその医薬用途
JP2006225333A (ja) * 2005-02-18 2006-08-31 Nippon Kayaku Co Ltd 新規ピラノピリダジン誘導体とその用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052866A1 (ja) * 2002-12-10 2004-06-24 Nippon Kayaku Kabushiki Kaisha ３−フェニル−シンノリン類縁体とそれを用いた抗腫瘍剤
WO2005121105A1 (ja) * 2004-06-09 2005-12-22 Nippon Kayaku Kabushiki Kaisha 新規３－フェニルテトラヒドロシンノリン－5－オール誘導体及びその医薬用途
JP2006225333A (ja) * 2005-02-18 2006-08-31 Nippon Kayaku Co Ltd 新規ピラノピリダジン誘導体とその用途

Also Published As

Publication number Publication date
TW200845993A (en) 2008-12-01
JP2010070452A (ja) 2010-04-02

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