WO2008084028A3 - Beschichtete bariumsulfatnanopartikel als kontrastmittel - Google Patents

Beschichtete bariumsulfatnanopartikel als kontrastmittel Download PDF

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Publication number
WO2008084028A3
WO2008084028A3 PCT/EP2008/050094 EP2008050094W WO2008084028A3 WO 2008084028 A3 WO2008084028 A3 WO 2008084028A3 EP 2008050094 W EP2008050094 W EP 2008050094W WO 2008084028 A3 WO2008084028 A3 WO 2008084028A3
Authority
WO
WIPO (PCT)
Prior art keywords
contrast agent
barium sulphate
coated barium
sulphate nanoparticles
nanoparticles
Prior art date
Application number
PCT/EP2008/050094
Other languages
English (en)
French (fr)
Other versions
WO2008084028A2 (de
Inventor
Juergen Sander
Rolf Danzebrink
Soenke Bartling
Fabian Kiessling
Bernd Morgenstern
Wolfhardt Semmler
Jochen Huppert
Original Assignee
Nanogate Ag
Deutsches Krebsforsch
Juergen Sander
Rolf Danzebrink
Soenke Bartling
Fabian Kiessling
Bernd Morgenstern
Wolfhardt Semmler
Jochen Huppert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanogate Ag, Deutsches Krebsforsch, Juergen Sander, Rolf Danzebrink, Soenke Bartling, Fabian Kiessling, Bernd Morgenstern, Wolfhardt Semmler, Jochen Huppert filed Critical Nanogate Ag
Publication of WO2008084028A2 publication Critical patent/WO2008084028A2/de
Publication of WO2008084028A3 publication Critical patent/WO2008084028A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0404—X-ray contrast preparations containing barium sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/0428—Surface-modified nanoparticles, e.g. immuno-nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Gegenstand der Erfindung ist ein Blood-pool Kontrastmittel und ein Röntgenkontrastmittel für die Röntgendiagnostik auf der Basis von oberflächenbeschichteten Nanopartikeln aus Bariumsulfat.
PCT/EP2008/050094 2007-01-09 2008-01-07 Beschichtete bariumsulfatnanopartikel als kontrastmittel WO2008084028A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007001393.2 2007-01-09
DE200710001393 DE102007001393A1 (de) 2007-01-09 2007-01-09 Beschichtete Bariumsulfatnanopartikel als Kontrastmittel

Publications (2)

Publication Number Publication Date
WO2008084028A2 WO2008084028A2 (de) 2008-07-17
WO2008084028A3 true WO2008084028A3 (de) 2009-03-05

Family

ID=39252744

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/050094 WO2008084028A2 (de) 2007-01-09 2008-01-07 Beschichtete bariumsulfatnanopartikel als kontrastmittel

Country Status (2)

Country Link
DE (1) DE102007001393A1 (de)
WO (1) WO2008084028A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11672875B2 (en) * 2021-03-17 2023-06-13 Saint Louis University Nanoparticle-alginate gels for X-ray imaging of the vasculature

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174031A (en) * 1967-02-17 1969-12-10 Laboratoirers Labaz Peroral Contrast Medium for use in Radiological Examination of the Digestive Tract
WO2004046035A2 (de) * 2002-11-21 2004-06-03 Nanosolutions Gmbh Verfahren zur herstellung von erdalkalisulfatnanopartikeln
WO2005105933A1 (en) * 2004-05-04 2005-11-10 Centrum Für Angewandte Nanotechnologie (Can) Gmbh Process for preparing dispersible sulfate, preferably barium sulfate nanoparticles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5037255B1 (de) 1969-07-26 1975-12-01
US5593657A (en) * 1995-02-09 1997-01-14 Nanosystems L.L.C. Barium salt formulations stabilized by non-ionic and anionic stabilizers
US20030152519A1 (en) * 2001-11-07 2003-08-14 Reinhard Koenig Methods for vascular imaging using nanoparticulate contrast agents
CN1232587C (zh) 2003-02-28 2005-12-21 山东大学 衰减x射线的树脂纳米硫酸钡复合材料
DE102005047807A1 (de) * 2005-06-04 2006-12-07 Solvay Infra Bad Hönningen GmbH Modifizierte Nanopartikel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174031A (en) * 1967-02-17 1969-12-10 Laboratoirers Labaz Peroral Contrast Medium for use in Radiological Examination of the Digestive Tract
WO2004046035A2 (de) * 2002-11-21 2004-06-03 Nanosolutions Gmbh Verfahren zur herstellung von erdalkalisulfatnanopartikeln
WO2005105933A1 (en) * 2004-05-04 2005-11-10 Centrum Für Angewandte Nanotechnologie (Can) Gmbh Process for preparing dispersible sulfate, preferably barium sulfate nanoparticles

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BALA ET AL: "In situ preparation and surface modification of barium sulfate nanoparticles", COLLOIDS AND SURFACES. A, PHYSICACHEMICAL AND ENGINEERING ASPECTS, ELSEVIER, AMSTERDAM, NL, vol. 274, no. 1-3, 15 February 2006 (2006-02-15), pages 71 - 76, XP005259101, ISSN: 0927-7757 *
KONDO SHUNZO: "Microinjection methods for visualization of the vascular architecture of the mouse embryo for light and scanning electron microscopy", JOURNAL OF ELECTRON MICROSCOPY, JAPANESE SOCIETY FOR ELECTRON MICROSCOPY. TOKYO, JP, vol. 47, no. 2, 1 January 1998 (1998-01-01), pages 101 - 113, XP008099279, ISSN: 0022-0744 *
QUINODOZ ET AL: "Barium sulphate and soft-tissue radiology: allying the old and the new for the investigation of animal cutaneous microcirculation", BRITISH JOURNAL OF PLASTIC SURGERY, CHURCHILL LIVINGSTONE, GB, vol. 55, no. 8, 1 December 2002 (2002-12-01), pages 664 - 667, XP005315308, ISSN: 0007-1226 *

Also Published As

Publication number Publication date
WO2008084028A2 (de) 2008-07-17
DE102007001393A1 (de) 2008-07-10

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