WO2008081937A1 - 蛋白質毒素の分泌阻害剤 - Google Patents

蛋白質毒素の分泌阻害剤 Download PDF

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Publication number
WO2008081937A1
WO2008081937A1 PCT/JP2007/075295 JP2007075295W WO2008081937A1 WO 2008081937 A1 WO2008081937 A1 WO 2008081937A1 JP 2007075295 W JP2007075295 W JP 2007075295W WO 2008081937 A1 WO2008081937 A1 WO 2008081937A1
Authority
WO
WIPO (PCT)
Prior art keywords
secretion inhibitor
protein toxin
toxin
toxin secretion
effect
Prior art date
Application number
PCT/JP2007/075295
Other languages
English (en)
French (fr)
Inventor
Hirofumi Shibata
Tomihiko Higuchi
Original Assignee
Microbiotech Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbiotech Inc. filed Critical Microbiotech Inc.
Publication of WO2008081937A1 publication Critical patent/WO2008081937A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

【課題】　毒素産生病原菌に対して、高い毒素分泌抑制効果、結果として感染予防効果を 有する組成物および医薬を提供する。 【解決手段】　ガロイルエステル類を有効成分として含有する細菌による蛋白質毒素の分 泌阻害剤とする。
PCT/JP2007/075295 2006-12-28 2007-12-28 蛋白質毒素の分泌阻害剤 WO2008081937A1 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2006-356663 2006-12-28
JP2006356663 2006-12-28
JP2007-044783 2007-02-24
JP2007044783A JP2010059057A (ja) 2006-12-28 2007-02-24 蛋白質毒素の分泌阻害剤

Publications (1)

Publication Number Publication Date
WO2008081937A1 true WO2008081937A1 (ja) 2008-07-10

Family

ID=39588617

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/075295 WO2008081937A1 (ja) 2006-12-28 2007-12-28 蛋白質毒素の分泌阻害剤

Country Status (2)

Country Link
JP (1) JP2010059057A (ja)
WO (1) WO2008081937A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110151752A (zh) * 2019-06-03 2019-08-23 湖北省农业科学院畜牧兽医研究所 一种茶多酚类组合物及其在制备抗猪链球菌药物中的应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02306915A (ja) * 1989-05-19 1990-12-20 Mitsui Norin Kk 細菌性外毒素に対する抗毒素剤
JPH03246227A (ja) * 1990-02-23 1991-11-01 Mitsui Norin Kk 抗生物質耐性ブドウ球菌感染予防剤
JPH10273495A (ja) * 1997-03-31 1998-10-13 Nippon Koutai Kenkyusho:Kk ガリック酸エステル誘導体及びこれを有効成分とする医薬
JP2005232115A (ja) * 2004-02-23 2005-09-02 Mitsui Norin Co Ltd 茶由来の抗体産生誘導剤
JP2005314275A (ja) * 2004-04-28 2005-11-10 Japan Science & Technology Agency モノテルペンを含む細菌毒性物質分泌阻害剤、及び該阻害剤を用いる保存処理方法
JP2006306836A (ja) * 2005-01-11 2006-11-09 Microbiotech:Kk 抗ウイルス・抗炎症作用薬剤組成物
JP2007084477A (ja) * 2005-09-21 2007-04-05 Institute Of National Colleges Of Technology Japan 抗菌性組成物及びそれを含有する抗菌剤並びにガロイルグルコースの抽出方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02306915A (ja) * 1989-05-19 1990-12-20 Mitsui Norin Kk 細菌性外毒素に対する抗毒素剤
JPH03246227A (ja) * 1990-02-23 1991-11-01 Mitsui Norin Kk 抗生物質耐性ブドウ球菌感染予防剤
JPH10273495A (ja) * 1997-03-31 1998-10-13 Nippon Koutai Kenkyusho:Kk ガリック酸エステル誘導体及びこれを有効成分とする医薬
JP2005232115A (ja) * 2004-02-23 2005-09-02 Mitsui Norin Co Ltd 茶由来の抗体産生誘導剤
JP2005314275A (ja) * 2004-04-28 2005-11-10 Japan Science & Technology Agency モノテルペンを含む細菌毒性物質分泌阻害剤、及び該阻害剤を用いる保存処理方法
JP2006306836A (ja) * 2005-01-11 2006-11-09 Microbiotech:Kk 抗ウイルス・抗炎症作用薬剤組成物
JP2007084477A (ja) * 2005-09-21 2007-04-05 Institute Of National Colleges Of Technology Japan 抗菌性組成物及びそれを含有する抗菌剤並びにガロイルグルコースの抽出方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110151752A (zh) * 2019-06-03 2019-08-23 湖北省农业科学院畜牧兽医研究所 一种茶多酚类组合物及其在制备抗猪链球菌药物中的应用
CN110151752B (zh) * 2019-06-03 2021-12-31 湖北省农业科学院畜牧兽医研究所 一种茶多酚类组合物及其在制备抗猪链球菌药物中的应用

Also Published As

Publication number Publication date
JP2010059057A (ja) 2010-03-18

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