WO2008081818A1 - 皮膚組織改善材およびその製造方法 - Google Patents

皮膚組織改善材およびその製造方法 Download PDF

Info

Publication number
WO2008081818A1
WO2008081818A1 PCT/JP2007/074962 JP2007074962W WO2008081818A1 WO 2008081818 A1 WO2008081818 A1 WO 2008081818A1 JP 2007074962 W JP2007074962 W JP 2007074962W WO 2008081818 A1 WO2008081818 A1 WO 2008081818A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin tissue
producing
same
ameliorating skin
growth factor
Prior art date
Application number
PCT/JP2007/074962
Other languages
English (en)
French (fr)
Inventor
Katsumi Ebisawa
Ryuji Kato
Hideaki Kagami
Minoru Ueda
Original Assignee
National University Corporation Nagoya University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39588501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008081818(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by National University Corporation Nagoya University filed Critical National University Corporation Nagoya University
Priority to JP2008528689A priority Critical patent/JP4247333B2/ja
Publication of WO2008081818A1 publication Critical patent/WO2008081818A1/ja
Priority to US12/490,764 priority patent/US8338174B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
    • C12N2533/92—Amnion; Decellularised dermis or mucosa

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

　本発明によって提供される皮膚組織改善材は、ヒト又は他の哺乳動物の歯槽粘膜由来の細胞又は組織片を培養して得られた培養物を主成分として構成される。典型的には、上記培養物に含まれる細胞の５０％以上が線維芽細胞であり、増殖速度が速く、血管内皮細胞増殖因子（ＶＥＧＦ）及び／又は角化細胞増殖因子（ＫＧＦ）の産生能に優れる。
PCT/JP2007/074962 2006-12-28 2007-12-26 皮膚組織改善材およびその製造方法 WO2008081818A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008528689A JP4247333B2 (ja) 2006-12-28 2007-12-26 皮膚組織改善材およびその製造方法
US12/490,764 US8338174B2 (en) 2006-12-28 2009-06-24 Material for ameliorating skin tissue and method for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006354259 2006-12-28
JP2006-354259 2006-12-28

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/490,764 Continuation US8338174B2 (en) 2006-12-28 2009-06-24 Material for ameliorating skin tissue and method for producing the same

Publications (1)

Publication Number Publication Date
WO2008081818A1 true WO2008081818A1 (ja) 2008-07-10

Family

ID=39588501

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/074962 WO2008081818A1 (ja) 2006-12-28 2007-12-26 皮膚組織改善材およびその製造方法

Country Status (4)

Country Link
US (1) US8338174B2 (ja)
JP (1) JP4247333B2 (ja)
KR (1) KR20090093792A (ja)
WO (1) WO2008081818A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011014883A2 (en) * 2009-07-31 2011-02-03 Chironcell Inc. Skin rejuvenation and wrinkle treatment by gingival fibroblast and its growth factor: activation of effect by hyluronic acid
KR20130060212A (ko) * 2010-05-07 2013-06-07 파이브로셀 테크놀로지스, 인코퍼레이티드 자가이식 피부 아섬유의 용량 단위 제형

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009231396B2 (en) * 2008-03-31 2015-05-07 Scarcell Therapeutics Method for the cosmetic treatment of skin ageing
US9881398B2 (en) * 2012-11-06 2018-01-30 Applied Materials, Inc. Trend dynamic sensor imaging using contour maps to visualize multiple trend data sets in a single view
US9370603B2 (en) * 2014-03-14 2016-06-21 Suneva Medical, Inc. Injectable alloplastic implants and methods of use thereof
US9370469B2 (en) * 2014-03-14 2016-06-21 Suneva Medical, Inc Injectable alloplastic implants and methods of use thereof
JP2020094925A (ja) * 2018-12-13 2020-06-18 住友電気工業株式会社 品質評価方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11510069A (ja) * 1995-07-28 1999-09-07 イソラゲン テクノロジーズ，インコーポレーテッド 皮膚および軟組織の欠損修復のための自己皮膚繊維芽細胞の使用
WO2007001016A1 (ja) * 2005-06-29 2007-01-04 National University Corporation Nagoya University 皮膚組織改善材及びその利用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284262B1 (en) * 1999-01-26 2001-09-04 Virgil A. Place Compact dosage unit for buccal administration of a pharmacologically active agent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11510069A (ja) * 1995-07-28 1999-09-07 イソラゲン テクノロジーズ，インコーポレーテッド 皮膚および軟組織の欠損修復のための自己皮膚繊維芽細胞の使用
WO2007001016A1 (ja) * 2005-06-29 2007-01-04 National University Corporation Nagoya University 皮膚組織改善材及びその利用

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BUURMA B. ET AL.: "Transplantation of human pulpal and gingival fibroblast attached to synthetic scaffolds", EUR. J. ORAL. SCI., vol. 107, 1999, pages 282 - 289, XP008019450, DOI: doi:10.1046/j.0909-8836.1999.eos107408.x *
KAGAMI H. ET AL.: "Hifu to Nenmaku no Soshiki Kogaku", SOSHIKI BAIYO KOGAKU, vol. 24, no. 4, 1998, pages 138 - 142 *
MACKENZIE I.C. ET AL.: "Keratinocyte growth factor expression in human gingival fibroblasts and stimulation of in vitro gene expressions by retinoic acid", J. PERIODONTOL., vol. 72, 2001, pages 445 - 453, XP003002694, DOI: doi:10.1902/jop.2001.72.4.445 *
ORTIZ-URDA S. ET AL.: "Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissue", J. CLIN. INVEST., vol. 111, 2003, pages 251 - 255, XP003002692, DOI: doi:10.1172/JCI200317193 *
SUTHIN K. ET AL.: "Enhanced expression of vascular endothelial growth factor by peridontal pathogens in gingival fibroblasts", J. PERIODONT. RES., vol. 38, 2003, pages 90 - 96, XP003002693, DOI: doi:10.1034/j.1600-0765.2003.01646.x *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011014883A2 (en) * 2009-07-31 2011-02-03 Chironcell Inc. Skin rejuvenation and wrinkle treatment by gingival fibroblast and its growth factor: activation of effect by hyluronic acid
WO2011014883A3 (en) * 2009-07-31 2011-07-14 Chironcell Inc. Skin rejuvenation and wrinkle treatment by gingival fibroblast and its growth factor: activation of effect by hyluronic acid
KR20130060212A (ko) * 2010-05-07 2013-06-07 파이브로셀 테크놀로지스, 인코퍼레이티드 자가이식 피부 아섬유의 용량 단위 제형
JP2013524856A (ja) * 2010-05-07 2013-06-20 ファイブロセル テクノロジーズ， インコーポレイテッド 自己真皮線維芽細胞の投与単位処方物
KR102001254B1 (ko) 2010-05-07 2019-07-17 파이브로셀 테크놀로지스, 인코퍼레이티드 자가이식 피부 아섬유의 용량 단위 제형
US11554142B2 (en) 2010-05-07 2023-01-17 Castle Creek Biosciences, Llc Dosage unit formulations of autologous dermal fibroblasts

Also Published As

Publication number Publication date
JPWO2008081818A1 (ja) 2010-04-30
US20100260722A1 (en) 2010-10-14
KR20090093792A (ko) 2009-09-02
JP4247333B2 (ja) 2009-04-02
US8338174B2 (en) 2012-12-25

Similar Documents

Publication Publication Date Title
WO2008081818A1 (ja) 皮膚組織改善材およびその製造方法
AU2003304250A1 (en) Method of isolating cells from umbilical cord
WO2007035363A3 (en) Compositions and methods for the augmentation and repair of defects in tissue
HK1156976A1 (en) Methods for producing hair microfollicles and de novo papillae and their use for in vitro tests and in vivo implantations
WO2006050330A3 (en) Platelets from stem cells
EP2420567A3 (en) Methods and compositions for treatment of bone defects with placental cell populations
WO2006093857A3 (en) Method of providing readily available cellular material derived from peripheral blood and a composition thereof
WO2006081435A3 (en) Method of providing readily available cellular material derived from cord blood, and a composition thereof
WO2006017134A3 (en) Preprimitive streak and mesendoderm cells
TW200503794A (en) Treatment of tissue with undifferentiated mesenchymal cells
GB2441718A (en) Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells
PT1428878E (pt) Processo para a produção e purificação de eritropoietina
UA92157C2 (ru) Способ продуцирования гормона роста
MY146352A (en) Adipose derived adult stem cells in hepatic regeneration
WO2007103379A3 (en) Method for endothelial cell extraction from adipose tissues
EP2641911A3 (en) Compositions and methods for re-programming cells without genetic modification
WO2004022696A3 (en) Fibrin cell supports and methods of use thereof
TW200736399A (en) Expansion and differentiation of neural stem cells under low oxygen conditions
WO2006093860A3 (en) Method and composition for repairing heart tissue
WO2006097701A3 (en) Skin equivalent culture
WO2006017176A3 (en) Scaffoldless constructs for tissue engineering of articular cartilage
WO2000034442A3 (en) Application of shear flow stress to smooth muscle cells for the production of implantable structures
WO2011105821A3 (ko) 무혈청 줄기 세포 배양 조성물, 이를 함유한 조직 재생용 조성물 및 이를 이용한 조직 재생 방법
EP2267114A3 (en) Tissue engineering using pure populations of isolated non-embryoblastic fetal cells
MX2012001004A (es) Proceso para la obtencion de miofibroblastos.

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 2008528689

Country of ref document: JP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07860191

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 1020087025295

Country of ref document: KR

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 07860191

Country of ref document: EP

Kind code of ref document: A1