WO2008081580A1 - 環状ホスファチジン酸誘導体を含む鎮痛剤 - Google Patents

環状ホスファチジン酸誘導体を含む鎮痛剤 Download PDF

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Publication number
WO2008081580A1
WO2008081580A1 PCT/JP2007/001463 JP2007001463W WO2008081580A1 WO 2008081580 A1 WO2008081580 A1 WO 2008081580A1 JP 2007001463 W JP2007001463 W JP 2007001463W WO 2008081580 A1 WO2008081580 A1 WO 2008081580A1
Authority
WO
WIPO (PCT)
Prior art keywords
analgesic agent
acid derivative
phosphatidic acid
cyclic phosphatidic
analgesic
Prior art date
Application number
PCT/JP2007/001463
Other languages
English (en)
French (fr)
Inventor
Kimiko Murofushi
Harumi Kanashiki
Original Assignee
Ochanomizu University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ochanomizu University filed Critical Ochanomizu University
Priority to JP2008552022A priority Critical patent/JP5077893B2/ja
Priority to CA002672534A priority patent/CA2672534A1/en
Priority to US12/447,566 priority patent/US20090326256A1/en
Priority to CN200780045798XA priority patent/CN101610775B/zh
Priority to EP07849882A priority patent/EP2098237B1/en
Publication of WO2008081580A1 publication Critical patent/WO2008081580A1/ja
Priority to US12/907,666 priority patent/US8017597B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　本発明の目的は、cPAの新しい生理活性の一つとして鎮痛作用を解明し、新規な鎮痛剤を提供することである。本発明によれば、リン脂質の1種である環状ホスファチジン酸誘導体を含む鎮痛剤が提供される。
PCT/JP2007/001463 2006-12-28 2007-12-25 環状ホスファチジン酸誘導体を含む鎮痛剤 WO2008081580A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2008552022A JP5077893B2 (ja) 2006-12-28 2007-12-25 環状ホスファチジン酸誘導体を含む鎮痛剤
CA002672534A CA2672534A1 (en) 2006-12-28 2007-12-25 Analgesic agent comprising cyclic phosphatidic acid derivative
US12/447,566 US20090326256A1 (en) 2006-12-28 2007-12-25 Analgesic agent comprising cyclic phosphatidic acid derivative
CN200780045798XA CN101610775B (zh) 2006-12-28 2007-12-25 含有环状磷脂酸衍生物的镇痛剂
EP07849882A EP2098237B1 (en) 2006-12-28 2007-12-25 Analgesic agent comprising cyclic phosphatidic acid derivative
US12/907,666 US8017597B2 (en) 2006-12-28 2010-10-19 Analgesic agent comprising cyclic phosphatidic acid derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-353642 2006-12-28
JP2006353642 2006-12-28

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/447,566 A-371-Of-International US20090326256A1 (en) 2006-12-28 2007-12-25 Analgesic agent comprising cyclic phosphatidic acid derivative
US12/907,666 Division US8017597B2 (en) 2006-12-28 2010-10-19 Analgesic agent comprising cyclic phosphatidic acid derivative

Publications (1)

Publication Number Publication Date
WO2008081580A1 true WO2008081580A1 (ja) 2008-07-10

Family

ID=39588269

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/001463 WO2008081580A1 (ja) 2006-12-28 2007-12-25 環状ホスファチジン酸誘導体を含む鎮痛剤

Country Status (7)

Country Link
US (2) US20090326256A1 (ja)
EP (1) EP2098237B1 (ja)
JP (1) JP5077893B2 (ja)
KR (1) KR20090097943A (ja)
CN (1) CN101610775B (ja)
CA (1) CA2672534A1 (ja)
WO (1) WO2008081580A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014115885A1 (ja) 2013-01-28 2014-07-31 国立大学法人お茶の水女子大学 脱髄疾患治療薬
WO2021100847A1 (ja) 2019-11-22 2021-05-27 国立大学法人お茶の水女子大学 カルバリゾホスファチジン酸
US11958876B2 (en) 2019-12-23 2024-04-16 Otsuka Chemical Co., Ltd. Carbacyclic phosphatidic acid compound

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090326256A1 (en) 2006-12-28 2009-12-31 Ochanomizu University Analgesic agent comprising cyclic phosphatidic acid derivative
CA2855660C (en) * 2011-11-11 2019-04-16 Sansho Co. Ltd. Therapeutic agent for arthrosis
SG11201406911RA (en) * 2012-04-27 2014-11-27 Sansho Co Hair-growing agent
EP3483169B1 (en) 2014-08-12 2021-05-26 Otsuka Chemical Co., Ltd. Crystal of cyclic phosphonic acid sodium salt and method for manufacturing same

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05230088A (ja) 1991-09-30 1993-09-07 Mitsubishi Kasei Corp 新規生理活性物質及びその製造法
JPH07149772A (ja) 1993-11-26 1995-06-13 Sagami Chem Res Center タンパク質リン酸化酵素ｃの活性促進剤
JPH07258278A (ja) 1994-03-18 1995-10-09 Sagami Chem Res Center １−Ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするＤＮＡポリメラーゼαの阻害剤
JPH0925235A (ja) 1995-07-13 1997-01-28 Sagami Chem Res Center １−ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするがん転移抑制剤
JP2001178489A (ja) 1999-12-24 2001-07-03 Kimiko Murofushi 環状ホスファチジン酸の製造法
JP2002308778A (ja) * 2001-04-13 2002-10-23 Gencom Co 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤
JP2002308779A (ja) * 2001-04-13 2002-10-23 Gencom Co 環状ホスファチジン酸を含むグリア細胞の増殖、分化及び／又は生存の促進のための薬剤
JP2002540146A (ja) * 1999-03-25 2002-11-26 イエダ リサーチ アンド デベロップメント カンパニー リミテッド 神経細胞分化を促進するための環状グリセロリン酸とその類似体を含む医薬組成物
WO2002094286A1 (fr) 2001-05-21 2002-11-28 Gencom Corporation Inhibiteurs de metastases cancereuses contenant des derives d'acide phosphatidique carbacycliques
JP2004010582A (ja) 2002-06-11 2004-01-15 Gencom Co カルバ環状ホスファチジン酸誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1613298A4 (en) * 2003-04-11 2007-10-03 Univ Tennessee Res Foundation LYSOPHOSPHATIDE ACID ANALOGUES AND INHIBITION OF NEOINTIMA FORMATION
US20090326256A1 (en) 2006-12-28 2009-12-31 Ochanomizu University Analgesic agent comprising cyclic phosphatidic acid derivative

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05230088A (ja) 1991-09-30 1993-09-07 Mitsubishi Kasei Corp 新規生理活性物質及びその製造法
JPH07149772A (ja) 1993-11-26 1995-06-13 Sagami Chem Res Center タンパク質リン酸化酵素ｃの活性促進剤
JPH07258278A (ja) 1994-03-18 1995-10-09 Sagami Chem Res Center １−Ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするＤＮＡポリメラーゼαの阻害剤
JPH0925235A (ja) 1995-07-13 1997-01-28 Sagami Chem Res Center １−ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするがん転移抑制剤
JP2002540146A (ja) * 1999-03-25 2002-11-26 イエダ リサーチ アンド デベロップメント カンパニー リミテッド 神経細胞分化を促進するための環状グリセロリン酸とその類似体を含む医薬組成物
JP2001178489A (ja) 1999-12-24 2001-07-03 Kimiko Murofushi 環状ホスファチジン酸の製造法
JP2002308778A (ja) * 2001-04-13 2002-10-23 Gencom Co 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤
JP2002308779A (ja) * 2001-04-13 2002-10-23 Gencom Co 環状ホスファチジン酸を含むグリア細胞の増殖、分化及び／又は生存の促進のための薬剤
WO2002094286A1 (fr) 2001-05-21 2002-11-28 Gencom Corporation Inhibiteurs de metastases cancereuses contenant des derives d'acide phosphatidique carbacycliques
JP2004010582A (ja) 2002-06-11 2004-01-15 Gencom Co カルバ環状ホスファチジン酸誘導体

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* Cited by examiner, † Cited by third party
Title
"The Pharmaceutical Society of Japan, The 23rd Symposium of Advancement of Reaction and Synthesis", SYNTHESIS AND PHYSIOLOGICAL EFFECTS OF CYCLIC PHOSPHATIDIC ACID AND CARBA DERIVATIVE, 17 November 1997 (1997-11-17), pages 101 - 104
KOBAYASHI, S. ET AL., TETRAHEDRON LETT., vol. 34, 1993, pages 4047 - 4050
KOBAYASHI, S. ET AL., TETRAHEDRON LETTERS, vol. 34, 1993, pages 4047 - 4050
KOBAYASHI, T. ET AL., LIFE SCI., vol. 65, 1999, pages 2185 - 2191
MURAKAMI-MUROFUSHI, K. ET AL., BIOCHEM. BIOPHYS. ACTA, vol. 1258, 1995, pages 57 - 60
MURAKAMI-MUROFUSHI, K. ET AL., J. BIOL. CHEM., vol. 267, 1992, pages 21512 - 21517
SATO ET AL., J AUTON NERV SYST, vol. 4, 1981, pages 231
See also references of EP2098237A4
UCHIDA ET AL., NEUROSCI LETT, vol. 269, 1999, pages 161

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014115885A1 (ja) 2013-01-28 2014-07-31 国立大学法人お茶の水女子大学 脱髄疾患治療薬
US10413559B2 (en) 2013-01-28 2019-09-17 Ochanomizu University Method for treating demyelinating disease
WO2021100847A1 (ja) 2019-11-22 2021-05-27 国立大学法人お茶の水女子大学 カルバリゾホスファチジン酸
US11958876B2 (en) 2019-12-23 2024-04-16 Otsuka Chemical Co., Ltd. Carbacyclic phosphatidic acid compound

Also Published As

Publication number Publication date
US20110086820A1 (en) 2011-04-14
JP5077893B2 (ja) 2012-11-21
CA2672534A1 (en) 2008-07-10
CN101610775B (zh) 2012-12-12
KR20090097943A (ko) 2009-09-16
EP2098237B1 (en) 2012-08-29
JPWO2008081580A1 (ja) 2010-04-30
EP2098237A4 (en) 2010-02-24
US20090326256A1 (en) 2009-12-31
CN101610775A (zh) 2009-12-23
US8017597B2 (en) 2011-09-13
EP2098237A1 (en) 2009-09-09

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