WO2008070776A2 - Liquid chromatography detector and flow controller therefor - Google Patents

Liquid chromatography detector and flow controller therefor Download PDF

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Publication number
WO2008070776A2
WO2008070776A2 PCT/US2007/086641 US2007086641W WO2008070776A2 WO 2008070776 A2 WO2008070776 A2 WO 2008070776A2 US 2007086641 W US2007086641 W US 2007086641W WO 2008070776 A2 WO2008070776 A2 WO 2008070776A2
Authority
WO
WIPO (PCT)
Prior art keywords
liquid chromatography
chromatography detector
set forth
flow controller
degrees
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/086641
Other languages
English (en)
French (fr)
Other versions
WO2008070776A3 (en
Inventor
Zhi Xu
Rakesh Bose
James M. Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WR Grace and Co
University of Missouri Columbia
University of Missouri St Louis
Original Assignee
WR Grace and Co
University of Missouri Columbia
University of Missouri St Louis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002671380A priority Critical patent/CA2671380A1/en
Priority to MX2009006096A priority patent/MX2009006096A/es
Priority to AU2007329303A priority patent/AU2007329303A1/en
Priority to JP2009540475A priority patent/JP2010512514A/ja
Priority to BRPI0720261-0A priority patent/BRPI0720261A2/pt
Priority to EP07865307A priority patent/EP2089687A4/en
Application filed by WR Grace and Co, University of Missouri Columbia, University of Missouri St Louis filed Critical WR Grace and Co
Priority to US12/517,946 priority patent/US8397553B2/en
Publication of WO2008070776A2 publication Critical patent/WO2008070776A2/en
Publication of WO2008070776A3 publication Critical patent/WO2008070776A3/en
Anticipated expiration legal-status Critical
Priority to NO20092568A priority patent/NO20092568L/no
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
    • G01N11/04—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8447—Nebulising, aerosol formation or ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8447—Nebulising, aerosol formation or ionisation
    • G01N2030/847—Nebulising, aerosol formation or ionisation by pneumatic means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8447—Nebulising, aerosol formation or ionisation
    • G01N2030/8494—Desolvation chambers

Definitions

  • Evaporative light scattering detectors ELSDs
  • mass spectrometers mass spectrometers
  • charged aerosol detectors are used routinely for Liquid Chromatography (LC) analysis.
  • a liquid sample is converted to droplets by a nebulizer.
  • a carrier gas carries the droplets through a nebulizing cartridge, an impactor, and a drift tube.
  • Conventional devices place the impactor in the path of the droplets to intercept large droplets, which are collected and exit the drift tube through an outlet drain.
  • the remaining appropriately-sized sample droplets pass through the drift tube, which may be heated to aid in evaporation of a solvent portion of the droplets.
  • Conventional detection devices suffer from various drawbacks, including relatively high levels of jagged peak noise detected by the detection cell. Such excessive jagged peak noise can hamper the ability of the detection device to accurately measure the properties of the sample droplets and can decrease sensitivity overall.
  • One conventional strategy for addressing the baseline noise issue of conventional detection devices is to include a diffuser trapping device for preventing large particles, which can increase background noise, from traveling through the drift tube to the detector. Such diffusers, however, are not capable of eliminating all noise. In addition, such diffusers may cause condensation in the drift tube and peak broadening under operating conditions of the detection device.
  • FIGS. 6A-6C are exemplary preamplifier and backpanel chromatograms of 0.18 mg/mL Ginkoglide B without the flow controller of the present invention.
  • FIG. 9 is a schematic of an ELSD with two flow controllers with portions partially broken away to reveal internal construction according to another alternative embodiment of the invention.
  • Corresponding reference characters indicate corresponding parts throughout the drawings.

Landscapes

  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Flow Control (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
PCT/US2007/086641 2006-12-06 2007-12-06 Liquid chromatography detector and flow controller therefor Ceased WO2008070776A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MX2009006096A MX2009006096A (es) 2006-12-06 2007-12-06 Detector de cromatografia de liquidos y controlador de flujo para el mismo.
AU2007329303A AU2007329303A1 (en) 2006-12-06 2007-12-06 Liquid chromatography detector and flow controller therefor
JP2009540475A JP2010512514A (ja) 2006-12-06 2007-12-06 液体クロマトグラフィー検出器およびそのためのフローコントローラ
BRPI0720261-0A BRPI0720261A2 (pt) 2006-12-06 2007-12-06 Detector de cromatografia de líquido e controlador de corrente para o mesmo
EP07865307A EP2089687A4 (en) 2006-12-06 2007-12-06 LIQUID CHROMATOGRAPHY DETECTOR AND RIVER CONTROL UNIT THEREFOR
CA002671380A CA2671380A1 (en) 2006-12-06 2007-12-06 Liquid chromatography detector and flow controller therefor
US12/517,946 US8397553B2 (en) 2006-12-06 2007-12-06 Liquid chromatography detector and flow controller therefor
NO20092568A NO20092568L (no) 2006-12-06 2009-07-06 Vaeskekromatografidetektor og stomningskontroller for dette

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86892606P 2006-12-06 2006-12-06
US60/868,926 2006-12-06

Publications (2)

Publication Number Publication Date
WO2008070776A2 true WO2008070776A2 (en) 2008-06-12
WO2008070776A3 WO2008070776A3 (en) 2008-07-31

Family

ID=39493069

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/086641 Ceased WO2008070776A2 (en) 2006-12-06 2007-12-06 Liquid chromatography detector and flow controller therefor

Country Status (12)

Country Link
US (1) US8397553B2 (https=)
EP (1) EP2089687A4 (https=)
JP (1) JP2010512514A (https=)
KR (1) KR20090120457A (https=)
CN (1) CN101646933A (https=)
AU (1) AU2007329303A1 (https=)
BR (1) BRPI0720261A2 (https=)
CA (1) CA2671380A1 (https=)
MX (1) MX2009006096A (https=)
NO (1) NO20092568L (https=)
RU (1) RU2009125587A (https=)
WO (1) WO2008070776A2 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011140345A1 (en) * 2010-05-07 2011-11-10 Alltech Associates, Inc. Methods and apparatus for analyzing samples and collecting sample fractions
US20120073665A1 (en) * 2008-12-04 2012-03-29 Neil Picha Methods and Apparatus for Moving Aliquot Samples of Fluid
US8305582B2 (en) 2009-09-01 2012-11-06 Alltech Associates, Inc. Methods and apparatus for analyzing samples and collecting sample fractions
US8305581B2 (en) 2007-12-05 2012-11-06 Alltech Associates, Inc. Methods and apparatus for analyzing samples and collecting sample fractions
US9086422B2 (en) 2008-12-10 2015-07-21 Alltech Associates, Inc. Chromatography systems and system components

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009152321A1 (en) * 2008-06-11 2009-12-17 The Curators Of The University Of Missouri Liquid chromatography detector and flow controller therefor
FR3000111B1 (fr) * 2012-12-21 2015-01-02 Seb Sa Appareil de repassage a la vapeur comportant un generateur de vapeur sous pression et un fer a repasser
US11582900B2 (en) * 2020-01-17 2023-02-21 Cnh Industrial Canada, Ltd. Distribution orifice system for a dry agricultural product applicator

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8305581B2 (en) 2007-12-05 2012-11-06 Alltech Associates, Inc. Methods and apparatus for analyzing samples and collecting sample fractions
US20120073665A1 (en) * 2008-12-04 2012-03-29 Neil Picha Methods and Apparatus for Moving Aliquot Samples of Fluid
US9133833B2 (en) * 2008-12-04 2015-09-15 Alltech Associates, Inc. Methods and apparatus for moving aliquot samples of fluid
US9086422B2 (en) 2008-12-10 2015-07-21 Alltech Associates, Inc. Chromatography systems and system components
US8305582B2 (en) 2009-09-01 2012-11-06 Alltech Associates, Inc. Methods and apparatus for analyzing samples and collecting sample fractions
WO2011140345A1 (en) * 2010-05-07 2011-11-10 Alltech Associates, Inc. Methods and apparatus for analyzing samples and collecting sample fractions

Also Published As

Publication number Publication date
US20110005305A1 (en) 2011-01-13
WO2008070776A3 (en) 2008-07-31
MX2009006096A (es) 2009-10-26
BRPI0720261A2 (pt) 2014-02-25
CA2671380A1 (en) 2008-06-12
JP2010512514A (ja) 2010-04-22
CN101646933A (zh) 2010-02-10
RU2009125587A (ru) 2011-01-20
US8397553B2 (en) 2013-03-19
KR20090120457A (ko) 2009-11-24
AU2007329303A1 (en) 2008-06-12
EP2089687A2 (en) 2009-08-19
EP2089687A4 (en) 2010-04-14
NO20092568L (no) 2009-09-04

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