CA2671380A1 - Liquid chromatography detector and flow controller therefor - Google Patents
Liquid chromatography detector and flow controller therefor Download PDFInfo
- Publication number
- CA2671380A1 CA2671380A1 CA002671380A CA2671380A CA2671380A1 CA 2671380 A1 CA2671380 A1 CA 2671380A1 CA 002671380 A CA002671380 A CA 002671380A CA 2671380 A CA2671380 A CA 2671380A CA 2671380 A1 CA2671380 A1 CA 2671380A1
- Authority
- CA
- Canada
- Prior art keywords
- liquid chromatography
- chromatography detector
- set forth
- flow controller
- degrees
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000004811 liquid chromatography Methods 0.000 title claims abstract description 43
- 230000005465 channeling Effects 0.000 claims abstract description 5
- 238000001514 detection method Methods 0.000 claims description 33
- 239000006199 nebulizer Substances 0.000 claims description 27
- 239000007788 liquid Substances 0.000 claims description 9
- 239000012159 carrier gas Substances 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 238000000105 evaporative light scattering detection Methods 0.000 description 25
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 12
- 230000035945 sensitivity Effects 0.000 description 7
- 229960000890 hydrocortisone Drugs 0.000 description 6
- 239000000443 aerosol Substances 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000010276 construction Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 238000004704 ultra performance liquid chromatography Methods 0.000 description 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000002912 waste gas Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
- G01N11/04—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/74—Optical detectors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
- G01N2030/8447—Nebulising, aerosol formation or ionisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
- G01N2030/8447—Nebulising, aerosol formation or ionisation
- G01N2030/847—Nebulising, aerosol formation or ionisation by pneumatic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/84—Preparation of the fraction to be distributed
- G01N2030/8447—Nebulising, aerosol formation or ionisation
- G01N2030/8494—Desolvation chambers
Landscapes
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Sampling And Sample Adjustment (AREA)
- Flow Control (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Measuring Cells (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86892606P | 2006-12-06 | 2006-12-06 | |
| US60/868,926 | 2006-12-06 | ||
| PCT/US2007/086641 WO2008070776A2 (en) | 2006-12-06 | 2007-12-06 | Liquid chromatography detector and flow controller therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2671380A1 true CA2671380A1 (en) | 2008-06-12 |
Family
ID=39493069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002671380A Abandoned CA2671380A1 (en) | 2006-12-06 | 2007-12-06 | Liquid chromatography detector and flow controller therefor |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8397553B2 (https=) |
| EP (1) | EP2089687A4 (https=) |
| JP (1) | JP2010512514A (https=) |
| KR (1) | KR20090120457A (https=) |
| CN (1) | CN101646933A (https=) |
| AU (1) | AU2007329303A1 (https=) |
| BR (1) | BRPI0720261A2 (https=) |
| CA (1) | CA2671380A1 (https=) |
| MX (1) | MX2009006096A (https=) |
| NO (1) | NO20092568L (https=) |
| RU (1) | RU2009125587A (https=) |
| WO (1) | WO2008070776A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010540965A (ja) | 2007-12-05 | 2010-12-24 | オールテック・アソシエイツ・インコーポレーテッド | サンプルの画分を収集しサンプルを分析するための方法および装置 |
| WO2009152321A1 (en) * | 2008-06-11 | 2009-12-17 | The Curators Of The University Of Missouri | Liquid chromatography detector and flow controller therefor |
| JP5653930B2 (ja) * | 2008-12-04 | 2015-01-14 | オールテック・アソシエイツ・インコーポレーテッド | 流体のアリコットサンプルを移動させるための方法および装置 |
| WO2010068276A1 (en) | 2008-12-10 | 2010-06-17 | Alltech Associates Inc. | Chromatography systems and system components |
| US8314934B2 (en) | 2009-09-01 | 2012-11-20 | Alltech Associates, Inc. | Methods and apparatus for analyzing samples and collecting sample fractions |
| EP2467466A4 (en) * | 2010-05-07 | 2014-06-25 | Alltech Associates Inc | METHOD AND DEVICE FOR ANALYZING SAMPLES AND COLLECTING SAMPLE FRACTIONS |
| FR3000111B1 (fr) * | 2012-12-21 | 2015-01-02 | Seb Sa | Appareil de repassage a la vapeur comportant un generateur de vapeur sous pression et un fer a repasser |
| US11582900B2 (en) * | 2020-01-17 | 2023-02-21 | Cnh Industrial Canada, Ltd. | Distribution orifice system for a dry agricultural product applicator |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3808550A (en) * | 1969-12-15 | 1974-04-30 | Bell Telephone Labor Inc | Apparatuses for trapping and accelerating neutral particles |
| US3894562A (en) * | 1973-12-20 | 1975-07-15 | Jr Charles D Moseley | Fluid flow controller |
| US4426213A (en) * | 1980-11-17 | 1984-01-17 | Engineering Resources, Inc. | Condensate removal device for steam lines and the like |
| JPS62118255A (ja) * | 1985-11-19 | 1987-05-29 | Toshimitsu Musha | 磁界を用いた免疫反応の検出法 |
| US4941618A (en) * | 1986-07-07 | 1990-07-17 | Leeman Labs Inc. | Nebulizer employing a fine mesh screen |
| DE3841979A1 (de) | 1988-12-14 | 1990-06-21 | Teldix Gmbh | Rueckstreuungsfreie lichtfalle |
| US4990740A (en) * | 1989-03-06 | 1991-02-05 | The Dow Chemical Company | Intra-microspray ICP torch |
| US5061065A (en) * | 1989-10-20 | 1991-10-29 | Pacific Scientific Company | Particle contamination detection in fluids through the external section of a laser |
| US4958529A (en) * | 1989-11-22 | 1990-09-25 | Vestec Corporation | Interface for coupling liquid chromatography to solid or gas phase detectors |
| JP2633974B2 (ja) * | 1990-04-18 | 1997-07-23 | 株式会社日立製作所 | 試料のイオン化および質量分析のための装置 |
| JP3087548B2 (ja) * | 1993-12-09 | 2000-09-11 | 株式会社日立製作所 | 液体クロマトグラフ結合型質量分析装置 |
| US5529244A (en) * | 1994-10-04 | 1996-06-25 | S. C. Johnson & Son, Inc. | Aspirator liquid blending device using multiple restrictors |
| US5837826A (en) * | 1995-02-27 | 1998-11-17 | Regents Of The University Of Minnesota | Protein adsorption by very dense porous zirconium oxide particles in expanded beds |
| US5872622A (en) * | 1996-08-12 | 1999-02-16 | Met One, Inc. | Condensation nucleus counter having vapor stabilization and working fluid recovery |
| US6362880B1 (en) * | 1997-09-17 | 2002-03-26 | Alltech Associates, Inc. | Low temperature adaptor for evaporative light detection |
| WO1999032174A1 (de) | 1997-12-19 | 1999-07-01 | Arithmed Gmbh | Tragbarer medikamentspender zur zeitversetzten verabreichung von injektions- oder infusionspräparaten |
| US6024129A (en) * | 1998-07-16 | 2000-02-15 | Schima; Frank E. | Production efficient venturi insert |
| AU6045400A (en) * | 1999-02-25 | 2000-10-04 | Clemson University | Sampling and analysis of airborne particulate matter by glow discharge atomic emission and mass spectrometries |
| AU4856100A (en) * | 1999-05-17 | 2000-12-05 | Stephen T Flock | Electromagnetic energy driven separation methods |
| US6229605B1 (en) * | 2000-03-10 | 2001-05-08 | Alltech Associates, Inc. | Evaporative light scattering device |
| US20020186263A1 (en) * | 2001-06-07 | 2002-12-12 | Nanostream, Inc. | Microfluidic fraction collectors |
| JP2003222612A (ja) * | 2002-01-30 | 2003-08-08 | Hitachi High-Technologies Corp | 大気圧イオン化質量分析装置および分析方法 |
| US6903818B2 (en) * | 2002-10-28 | 2005-06-07 | Particle Measuring Systems, Inc. | Low noise intracavity laser particle counter |
| GB0304253D0 (en) | 2003-02-25 | 2003-03-26 | Polymer Lab Ltd | Apparatus |
| US7114525B2 (en) * | 2003-08-29 | 2006-10-03 | Dana Corporation | Method and apparatus for reduction of fluid-borne noise in hydraulic systems |
| US7268881B2 (en) * | 2004-02-17 | 2007-09-11 | The Curators Of The University Of Missouri | Light scattering detector |
| EP1745247B1 (en) * | 2004-04-23 | 2015-11-11 | Philip Morris Products S.a.s. | Aerosol generators and methods for producing aerosols |
| JP4453537B2 (ja) * | 2004-12-14 | 2010-04-21 | 株式会社島津製作所 | 大気圧イオン化質量分析装置 |
| JP5468206B2 (ja) * | 2005-01-18 | 2014-04-09 | ウオーターズ・テクノロジーズ・コーポレイシヨン | 蒸発光散乱検出器 |
| US7760355B2 (en) * | 2005-07-27 | 2010-07-20 | The Curators Of The University Of Missouri | Focused droplet nebulizer for evaporative light scattering detector |
| EP2043714B1 (en) * | 2006-03-30 | 2016-02-10 | CareFusion 2200, Inc. | Nebulizer with pressure-based fluidic-control |
-
2007
- 2007-12-06 JP JP2009540475A patent/JP2010512514A/ja active Pending
- 2007-12-06 WO PCT/US2007/086641 patent/WO2008070776A2/en not_active Ceased
- 2007-12-06 BR BRPI0720261-0A patent/BRPI0720261A2/pt not_active Application Discontinuation
- 2007-12-06 MX MX2009006096A patent/MX2009006096A/es unknown
- 2007-12-06 EP EP07865307A patent/EP2089687A4/en not_active Withdrawn
- 2007-12-06 KR KR1020097013942A patent/KR20090120457A/ko not_active Withdrawn
- 2007-12-06 RU RU2009125587/05A patent/RU2009125587A/ru not_active Application Discontinuation
- 2007-12-06 CN CN200780049321A patent/CN101646933A/zh active Pending
- 2007-12-06 US US12/517,946 patent/US8397553B2/en not_active Expired - Fee Related
- 2007-12-06 CA CA002671380A patent/CA2671380A1/en not_active Abandoned
- 2007-12-06 AU AU2007329303A patent/AU2007329303A1/en not_active Abandoned
-
2009
- 2009-07-06 NO NO20092568A patent/NO20092568L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20110005305A1 (en) | 2011-01-13 |
| WO2008070776A3 (en) | 2008-07-31 |
| MX2009006096A (es) | 2009-10-26 |
| BRPI0720261A2 (pt) | 2014-02-25 |
| JP2010512514A (ja) | 2010-04-22 |
| CN101646933A (zh) | 2010-02-10 |
| RU2009125587A (ru) | 2011-01-20 |
| US8397553B2 (en) | 2013-03-19 |
| KR20090120457A (ko) | 2009-11-24 |
| WO2008070776A2 (en) | 2008-06-12 |
| AU2007329303A1 (en) | 2008-06-12 |
| EP2089687A2 (en) | 2009-08-19 |
| EP2089687A4 (en) | 2010-04-14 |
| NO20092568L (no) | 2009-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |