WO2008068507A3 - Composés chimiques 576 - Google Patents
Composés chimiques 576 Download PDFInfo
- Publication number
- WO2008068507A3 WO2008068507A3 PCT/GB2007/004697 GB2007004697W WO2008068507A3 WO 2008068507 A3 WO2008068507 A3 WO 2008068507A3 GB 2007004697 W GB2007004697 W GB 2007004697W WO 2008068507 A3 WO2008068507 A3 WO 2008068507A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- raf
- pyrid
- phenylamino
- protein kinase
- kinase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
L'invention concerne des composés chimiques de formule (I) : ou des sels acceptables du point de vue pharmaceutique de ceux-ci, lesquels possèdent une activité d'inhibition du B-Raf et sont par conséquent utiles pour leur activité anticancéreuse et donc dans des procédés de traitement du corps de l'homme ou de l'animal. L'invention concerne également des procédés pour la fabrication desdits composés chimiques, des compositions pharmaceutiques contenant ceux-ci et l'utilisation de ceux-ci dans la fabrication de médicaments utiles pour produire un effet anticancéreux chez un animal à sang chaud et chez l'homme.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86924106P | 2006-12-08 | 2006-12-08 | |
US60/869,241 | 2006-12-08 | ||
US98573207P | 2007-11-06 | 2007-11-06 | |
US60/985,732 | 2007-11-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008068507A2 WO2008068507A2 (fr) | 2008-06-12 |
WO2008068507A3 true WO2008068507A3 (fr) | 2008-07-31 |
Family
ID=39386079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2007/004697 WO2008068507A2 (fr) | 2006-12-08 | 2007-12-07 | Composés chimiques 576 |
Country Status (5)
Country | Link |
---|---|
AR (1) | AR064208A1 (fr) |
CL (1) | CL2007003557A1 (fr) |
PE (1) | PE20081351A1 (fr) |
TW (1) | TW200829566A (fr) |
WO (1) | WO2008068507A2 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
CN101652352A (zh) * | 2006-12-22 | 2010-02-17 | 诺瓦提斯公司 | 用于抑制pdk1的喹唑啉类 |
JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
ES2400710T3 (es) | 2007-04-23 | 2013-04-11 | Janssen Pharmaceutica, N.V. | Tia(dia)zoles como antagonistas del receptor de dopamina 2 de disociación rápida |
US8906921B2 (en) | 2007-04-23 | 2014-12-09 | Janssen Pharmaceutica Nv | 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists |
EA019048B1 (ru) | 2008-07-31 | 2013-12-30 | Янссен Фармацевтика Нв | Пиперазин-1-илтрифторметилзамещенные пиридины в качестве быстро диссоциирующихся антагонистов d-рецепторов дофамина |
PE20120110A1 (es) | 2009-02-13 | 2012-02-20 | Fovea Pharmaceuticals | [1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa |
AR081960A1 (es) | 2010-06-22 | 2012-10-31 | Fovea Pharmaceuticals Sa | Compuestos heterociclicos, su preparacion y su aplicacion terapeutica |
US10554578B2 (en) | 2015-06-30 | 2020-02-04 | British Telecommunications Public Limited Company | Quality of service management in a network |
EP3507382B1 (fr) | 2016-09-02 | 2021-06-23 | New England Biolabs, Inc. | Analyse de la chromatine au moyen d'une enzyme de coupure |
CN111170986A (zh) * | 2018-11-13 | 2020-05-19 | 北京睿熙生物科技有限公司 | 布鲁顿酪氨酸激酶的抑制剂 |
AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
US20220401436A1 (en) | 2019-11-08 | 2022-12-22 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
WO2023138412A1 (fr) * | 2022-01-20 | 2023-07-27 | Insilico Medicine Ip Limited | Composés de pyrimidin-2-amine fusionnés utilisés en tant qu'inhibiteurs de cdk20 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005037285A1 (fr) * | 2003-10-16 | 2005-04-28 | Chiron Corporation | Quinoxalines, quinolines, isoquinolines et quinazolines 2,6-bisubstituees servant d'inhibiteurs a la kinase raf pour le traitement du cancer |
WO2006039718A2 (fr) * | 2004-10-01 | 2006-04-13 | Amgen Inc | Composes bicycliques azotes d'aryle et leurs procedes d'utilisation |
-
2007
- 2007-12-06 TW TW096146631A patent/TW200829566A/zh unknown
- 2007-12-07 WO PCT/GB2007/004697 patent/WO2008068507A2/fr active Application Filing
- 2007-12-07 CL CL200703557A patent/CL2007003557A1/es unknown
- 2007-12-07 PE PE2007001740A patent/PE20081351A1/es not_active Application Discontinuation
- 2007-12-07 AR ARP070105508A patent/AR064208A1/es unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005037285A1 (fr) * | 2003-10-16 | 2005-04-28 | Chiron Corporation | Quinoxalines, quinolines, isoquinolines et quinazolines 2,6-bisubstituees servant d'inhibiteurs a la kinase raf pour le traitement du cancer |
WO2006039718A2 (fr) * | 2004-10-01 | 2006-04-13 | Amgen Inc | Composes bicycliques azotes d'aryle et leurs procedes d'utilisation |
Non-Patent Citations (1)
Title |
---|
DIMAURO, ERIN ET AL: "Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity", J.MED.CHEM, vol. 49, no. 19, 2006, pages 5671 - 5686, XP002480947 * |
Also Published As
Publication number | Publication date |
---|---|
AR064208A1 (es) | 2009-03-18 |
CL2007003557A1 (es) | 2008-08-01 |
TW200829566A (en) | 2008-07-16 |
WO2008068507A2 (fr) | 2008-06-12 |
PE20081351A1 (es) | 2008-11-26 |
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