WO2008068507A3 - Composés chimiques 576 - Google Patents

Composés chimiques 576 Download PDF

Info

Publication number
WO2008068507A3
WO2008068507A3 PCT/GB2007/004697 GB2007004697W WO2008068507A3 WO 2008068507 A3 WO2008068507 A3 WO 2008068507A3 GB 2007004697 W GB2007004697 W GB 2007004697W WO 2008068507 A3 WO2008068507 A3 WO 2008068507A3
Authority
WO
WIPO (PCT)
Prior art keywords
raf
pyrid
phenylamino
protein kinase
kinase inhibitors
Prior art date
Application number
PCT/GB2007/004697
Other languages
English (en)
Other versions
WO2008068507A2 (fr
Inventor
Brian Aquila
Donald James Cook
Craig Johnstone
Stephen Lee
Paul Lyne
David Alan Rudge
Melissa Vasbinder
Haixia Wang
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Brian Aquila
Donald James Cook
Craig Johnstone
Stephen Lee
Paul Lyne
David Alan Rudge
Melissa Vasbinder
Haixia Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39386079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008068507(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Brian Aquila, Donald James Cook, Craig Johnstone, Stephen Lee, Paul Lyne, David Alan Rudge, Melissa Vasbinder, Haixia Wang filed Critical Astrazeneca Ab
Publication of WO2008068507A2 publication Critical patent/WO2008068507A2/fr
Publication of WO2008068507A3 publication Critical patent/WO2008068507A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

L'invention concerne des composés chimiques de formule (I) : ou des sels acceptables du point de vue pharmaceutique de ceux-ci, lesquels possèdent une activité d'inhibition du B-Raf et sont par conséquent utiles pour leur activité anticancéreuse et donc dans des procédés de traitement du corps de l'homme ou de l'animal. L'invention concerne également des procédés pour la fabrication desdits composés chimiques, des compositions pharmaceutiques contenant ceux-ci et l'utilisation de ceux-ci dans la fabrication de médicaments utiles pour produire un effet anticancéreux chez un animal à sang chaud et chez l'homme.
PCT/GB2007/004697 2006-12-08 2007-12-07 Composés chimiques 576 WO2008068507A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86924106P 2006-12-08 2006-12-08
US60/869,241 2006-12-08
US98573207P 2007-11-06 2007-11-06
US60/985,732 2007-11-06

Publications (2)

Publication Number Publication Date
WO2008068507A2 WO2008068507A2 (fr) 2008-06-12
WO2008068507A3 true WO2008068507A3 (fr) 2008-07-31

Family

ID=39386079

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/004697 WO2008068507A2 (fr) 2006-12-08 2007-12-07 Composés chimiques 576

Country Status (5)

Country Link
AR (1) AR064208A1 (fr)
CL (1) CL2007003557A1 (fr)
PE (1) PE20081351A1 (fr)
TW (1) TW200829566A (fr)
WO (1) WO2008068507A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
KR20090092287A (ko) * 2006-12-22 2009-08-31 노파르티스 아게 Ｐｄｋ１ 억제를 위한 퀴나졸린
JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
AU2008240729B2 (en) 2007-04-23 2012-08-23 Janssen Pharmaceutica N.V. Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists
JP5431305B2 (ja) 2007-04-23 2014-03-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体
DK2307374T3 (en) 2008-07-31 2017-05-01 Janssen Pharmaceutica Nv PIPERAZIN-1-YLTRIFLUORMETHYL-SUBSTITUTED PYRIDINES AS QUICK DISSOCATING DOPAMIN-2 RECEPTOR ANTAGONISTS
CA2751517A1 (fr) 2009-02-13 2010-08-19 Fovea Pharmaceuticals [1, 2, 4] triazolo [1, 5 -a] pyridines servant d'inhibiteurs de kinases
TW201204723A (en) 2010-06-22 2012-02-01 Fovea Pharmaceuticals Heterocyclic compounds, their preparation and their therapeutic application
US10554578B2 (en) 2015-06-30 2020-02-04 British Telecommunications Public Limited Company Quality of service management in a network
WO2018045141A1 (fr) 2016-09-02 2018-03-08 New England Biolabs, Inc. Analyse de la chromatine au moyen d'une enzyme de coupure
CN111170986A (zh) * 2018-11-13 2020-05-19 北京睿熙生物科技有限公司 布鲁顿酪氨酸激酶的抑制剂
US20220143049A1 (en) 2019-03-21 2022-05-12 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
WO2023138412A1 (fr) * 2022-01-20 2023-07-27 Insilico Medicine Ip Limited Composés de pyrimidin-2-amine fusionnés utilisés en tant qu'inhibiteurs de cdk20

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037285A1 (fr) * 2003-10-16 2005-04-28 Chiron Corporation Quinoxalines, quinolines, isoquinolines et quinazolines 2,6-bisubstituees servant d'inhibiteurs a la kinase raf pour le traitement du cancer
WO2006039718A2 (fr) * 2004-10-01 2006-04-13 Amgen Inc Composes bicycliques azotes d'aryle et leurs procedes d'utilisation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005037285A1 (fr) * 2003-10-16 2005-04-28 Chiron Corporation Quinoxalines, quinolines, isoquinolines et quinazolines 2,6-bisubstituees servant d'inhibiteurs a la kinase raf pour le traitement du cancer
WO2006039718A2 (fr) * 2004-10-01 2006-04-13 Amgen Inc Composes bicycliques azotes d'aryle et leurs procedes d'utilisation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DIMAURO, ERIN ET AL: "Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity", J.MED.CHEM, vol. 49, no. 19, 2006, pages 5671 - 5686, XP002480947 *

Also Published As

Publication number Publication date
AR064208A1 (es) 2009-03-18
PE20081351A1 (es) 2008-11-26
WO2008068507A2 (fr) 2008-06-12
CL2007003557A1 (es) 2008-08-01
TW200829566A (en) 2008-07-16

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